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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Wernicke encephalopathy
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Accession:DOID:2384 term browser browse the term
Definition:A brain disease that is characterized by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1). (DO)
Synonyms:exact_synonym: Cerebral Beriberi;   Encephalopathy, Wernickes;   Gayet Wernicke Encephalopathy;   Wernicke Disease;   Wernicke Encephalopathies;   Wernicke Superior Hemorrhagic Polioencephalitis;   Wernicke Syndrome;   Wernicke's Disease;   Wernicke's Encephalopathy;   Wernicke's Superior Hemorrhagic Polioencephalitis;   Wernicke's Syndrome
 primary_id: MESH:D014899
 xref: EFO:1001241;   ICD10CM:E51.2
For additional species annotation, visit the Alliance of Genome Resources.


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Wernicke encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP RGD PMID:8229066 RGD:405100718 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP mRNA, protein:increased expression:medial thalamic group, inferior colliculus, neuron RGD PMID:18481165 RGD:2300278 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tkt transketolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:3762968 NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    Chemically-Induced Disorders 1459
      substance-related disorder 851
        Alcohol-Related Disorders 550
          Wernicke encephalopathy 3
Path 2
Term Annotations click to browse term
  disease 14566
    Nutritional and Metabolic Diseases 4637
      disease of metabolism 4637
        acquired metabolic disease 1718
          nutrition disease 909
            Malnutrition 200
              nutritional deficiency disease 180
                Avitaminosis 136
                  Vitamin B Deficiency 77
                    thiamine deficiency disease 7
                      Wernicke encephalopathy 3
paths to the root