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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:nasal cavity disease
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Accession:DOID:2163 term browser browse the term
Synonyms:xref: NCI:C27102
For additional species annotation, visit the Alliance of Genome Resources.

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allergic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 severity ISO DNA:snp:exon:c.1236C>T (human) RGD PMID:24040855 RGD:8657076 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO mRNA, protein:increased expression:nasal mucosa (rat) RGD PMID:15362690 RGD:11522724 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29028686 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 treatment ISO RGD PMID:23089405 RGD:7248414 NCBI chr16:27,792,699...27,796,437
Ensembl chr16:27,794,033...27,796,460 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO protein:increased expression:oronasal secretion (human) RGD PMID:23883806 RGD:7364793 NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875 		JBrowse link
G CD40 CD40 molecule ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:lymphocyte RGD PMID:19086656 RGD:8547782 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639 		JBrowse link
G CLDN3 claudin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr28:9,301,312...9,303,496
Ensembl chr28:9,302,446...9,303,108 		JBrowse link
G CLDN7 claudin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr16:6,632,695...6,635,994
Ensembl chr16:6,630,412...6,635,327 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 treatment ISO RGD PMID:10436391 RGD:11344920 NCBI chr10:89,637,176...89,644,436
Ensembl chr10:89,638,314...89,642,344 		JBrowse link
G FLG filaggrin susceptibility ISO associated with atopic dermatitis;DNA:SNP:cds:p.P478S (rs11584340) RGD PMID:21219289 RGD:628398356
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr23:55,944,128...56,265,748
Ensembl chr23:56,101,294...56,265,849 		JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34624383 NCBI chr 7:103,808,789...103,957,947
Ensembl chr 7:103,808,797...103,953,040 		JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36127783 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G HRH1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23333628 NCBI chr22:47,187,156...47,298,761
Ensembl chr22:47,295,011...47,296,471 		JBrowse link
G IFNG interferon gamma treatment ISO associated with Asthma
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:12787306 PMID:18510219 PMID:29871060 RGD:10755770 RGD:7829803 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL10 interleukin 10 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:23253209 PMID:23883806 PMID:36127783 RGD:7364793 RGD:7364818 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL13 interleukin 13 susceptibility
no_association 		ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human) 		OMIM
CTD
RGD		 PMID:12928861 RGD:8549516 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO protein:increased expression:serum RGD PMID:21462799 RGD:8549521 NCBI chr  X:102,589,947...102,628,853
Ensembl chr  X:102,590,045...102,603,260 		JBrowse link
G IL17A interleukin 17A susceptibility ISO mRNA:increased expression:peripheral blood mononuclear cell (human)
DNA:snp:promoter:c.-444A>G (human) 		RGD PMID:21535180 PMID:22507625 RGD:5147409 RGD:9068429 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 no_association
severity 		ISO DNA:SNP:promoter:-140C>G (rs360721) (human)
DNA:SNP:promoter:-137G>C (rs187238) (human) 		RGD PMID:22840759 RGD:8655914 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:nasal mucus RGD PMID:7750009 RGD:7401199 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:12592663 RGD:8662963 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL4 interleukin 4 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662 PMID:36127783 RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL5 interleukin 5 treatment ISO RGD PMID:23934070 PMID:24620662 RGD:11354976 RGD:11522769 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G ITGB2 integrin subunit beta 2 treatment ISO RGD PMID:12046991 RGD:9698435 NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025 		JBrowse link
G LOC103223675 low affinity immunoglobulin gamma Fc region receptor III-A susceptibility ISO DNA:polymorphism:exon:p.F158V(rs396991)(human) RGD PMID:18199088 RGD:5508449 NCBI chr20:2,466,492...2,475,579 JBrowse link
G LTC4S leukotriene C4 synthase ISO DNA:SNP:promoter:g.-444A>C RGD PMID:16730545 RGD:626168264 NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179 		JBrowse link
G MRC1 mannose receptor C-type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36127783 NCBI chr 9:17,751,053...17,849,258
Ensembl chr 9:17,751,133...17,849,406 		JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO mRNA,protein:decreased expression:nasal mucosa RGD PMID:31425778 RGD:127345100 NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:22972875 RGD:7364746 NCBI chr 1:981,515...1,018,242 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:23858718 RGD:8547523 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G OCLN occludin ISO CTD Direct Evidence: marker/mechanism CTD PMID:33441633 NCBI chr 4:65,581,943...65,641,516
Ensembl chr 4:65,582,460...65,644,787 		JBrowse link
G PON1 paraoxonase 1 severity ISO protein:decreased activity:plasma (human) RGD PMID:23406590 RGD:8547583 NCBI chr21:53,713,434...53,739,658
Ensembl chr21:53,714,012...53,739,875 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO protein:increased expression:nasal cavity epithelium RGD PMID:24012634 RGD:7775060 NCBI chr 9:78,858,269...80,188,163 JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16979129 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G RORA RAR related orphan receptor A ameliorates ISO DNA:SNP:multiple:multiple RGD PMID:35636076 RGD:626469566 NCBI chr26:22,263,889...23,002,224
Ensembl chr26:22,812,445...22,993,021 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO mRNA:decreased expression:nasal mucosa, lung RGD PMID:17882576 RGD:5144135 NCBI chr 1:11,470,091...11,474,915
Ensembl chr 1:11,470,195...11,474,149 		JBrowse link
G SCGB3A2 secretoglobin family 3A member 2 susceptibility ISO DNA:SNP: :rs7726552 (human) RGD PMID:21410962 RGD:5144225 NCBI chr23:50,327,428...50,417,518
Ensembl chr23:50,414,139...50,417,373 		JBrowse link
G SERPINE1 serpin family E member 1 ISO mRNA:increased expression:nasal mucosa (mouse) RGD PMID:21339035 RGD:8547809 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G TACR1 tachykinin receptor 1 ISO mRNA:increased expression:nasal mucosa RGD PMID:12768696 RGD:5147835 NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:31368266 RGD:14995445 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TLR2 toll like receptor 2 severity ISO DNA:polymorphism:cds:p.R753Q(human)
protein:increased expression:neutrophil:
mRNA:decreased expression:nasal mucosa: 		RGD PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057 RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 severity
susceptibility
no_association
treatment 		ISO DNA:polymorphism:cds:p.D299G(human)
DNA:SNP: :rs1927911(human)
protein:decreased expression:nasal mucosa:
DNA:polymorphism: :4216G>C(human)
protein:increased expression:nasal lavage,leukocyte, bone marrow: 		RGD PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 More... RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
Allergic Rhinoconjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment ISO associated with Eosinophilic Esophagitis; DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G IL3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human) RGD PMID:23953855 RGD:13506915 NCBI chr23:34,894,630...34,899,105 JBrowse link
Arhinia, Choanal Atresia, and Microphthalmia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO ClinVar Annotator: match by term: Arhinia, choanal atresia, and microphthalmia OMIM
ClinVar		 PMID:672092 PMID:5032329 PMID:6802865 PMID:8446727 PMID:8723126 More... NCBI chr18:61,921,477...62,069,187
Ensembl chr18:61,921,124...62,070,878 		JBrowse link
BRANCHIAL ARCH ABNORMALITIES, CHOANAL ATRESIA, ATHELIA, HEARING LOSS, AND HYPOTHYROIDISM SYNDROME term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KMT2D lysine methyltransferase 2D ISO ClinVar Annotator: match by term: BRANCHIAL ARCH ABNORMALITIES, CHOANAL ATRESIA, ATHELIA, HEARING LOSS, AND HYPOTHYROIDISM SYNDROME | ClinVar Annotator: match by term: Choanal atresia-athelia-hypothyroidism-delayed puberty-short stature syndrome OMIM
ClinVar		 PMID:9536098 PMID:12002153 PMID:17576681 PMID:18414213 PMID:21658225 More... NCBI chr11:45,260,873...45,303,898
Ensembl chr11:45,263,408...45,302,423 		JBrowse link
Burn-McKeown syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TXNL4A thioredoxin like 4A ISO ClinVar Annotator: match by term: Burn-McKeown syndrome | ClinVar Annotator: match by term: TXNL4A-related condition OMIM
ClinVar		 PMID:1342861 PMID:14564154 PMID:16523509 PMID:25434003 PMID:25741868 More... NCBI chr18:270,392...286,243
Ensembl chr18:270,938...285,966 		JBrowse link
choanal atresia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KMT2D lysine methyltransferase 2D ISO ClinVar Annotator: match by term: Choanal atresia ClinVar PMID:25741868 PMID:31395954 NCBI chr11:45,260,873...45,303,898
Ensembl chr11:45,263,408...45,302,423 		JBrowse link
Choanal Atresia and Lymphedema term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN14 protein tyrosine phosphatase non-receptor type 14 ISO ClinVar Annotator: match by term: Lymphedema-posterior choanal atresia syndrome | ClinVar Annotator: match by term: PTPN14-related condition OMIM
ClinVar		 PMID:20826270 PMID:25741868 PMID:28492532 NCBI chr25:15,023,914...15,228,680
Ensembl chr25:15,110,687...15,219,492 		JBrowse link
chronic rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 ISO protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human) RGD PMID:8845175 RGD:8661738 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
Chronic Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD8A CD8 subunit alpha ameliorates ISO protein:decreased expression:blood, T cell (human) RGD PMID:24639246 RGD:124715444 NCBI chr14:18,878,013...18,885,183
Ensembl chr14:18,878,622...18,883,885 		JBrowse link
G CDHR3 cadherin related family member 3 ISO DNA:SNP:intron:rs6967330 RGD PMID:34076350 RGD:626467892 NCBI chr21:74,875,272...74,947,964 JBrowse link
G GLCCI1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr21:50,121,781...50,243,181
Ensembl chr21:50,124,311...50,241,380 		JBrowse link
G GSDMB gasdermin B ISO DNA:SNP:intron:rs7216389 RGD PMID:34076350 RGD:626467892 NCBI chr16:66,253,562...66,266,391 JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:uncinate process, nasal mucosa (human) RGD PMID:23613503 RGD:8696039 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human) RGD PMID:16549749 RGD:8549791 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G LTC4S leukotriene C4 synthase ISO mRNA:increased expression:sinonasal mucosa RGD PMID:15940133 RGD:626168282 NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179 		JBrowse link
G MBL2 mannose binding lectin 2 ISO protein:decreased activity:serum: RGD PMID:23144819 RGD:8693716 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G PRG2 proteoglycan 2, pro eosinophil major basic protein disease_progression ISO associated with Nasal Polyps; RGD PMID:24450586 RGD:13506943 NCBI chr 1:15,850,181...15,854,511
Ensembl chr 1:15,850,913...15,854,517 		JBrowse link
chronic rhinosinusitis with nasal polyps term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G GLCCI1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr21:50,121,781...50,243,181
Ensembl chr21:50,124,311...50,241,380 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL5 interleukin 5 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G LTC4S leukotriene C4 synthase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179 		JBrowse link
G PTGDS prostaglandin D2 synthase treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr12:1,210,567...1,214,631
Ensembl chr12:1,211,487...1,214,531 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 treatment ISO RGD PMID:23751068 RGD:626419675 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G SPINK5 serine peptidase inhibitor Kazal type 5 ISO associated with aspirin-induced respiratory disease;mRNA:decreased expression:nasal cavity mucosa
mRNA, protein:decreased expression:nasal cavity mucosa 		RGD PMID:18588753 PMID:22570283 RGD:628359029 RGD:628359036 NCBI chr23:50,587,698...50,667,219
Ensembl chr23:50,592,412...50,663,302 		JBrowse link
eosinophilic chronic rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSTA cystatin A ISO mRNA, protein:decreased expression:nasal cavity epithelium RGD PMID:27779422 RGD:628359037 NCBI chr22:58,519,085...58,536,163
Ensembl chr22:58,519,085...58,536,339 		JBrowse link
G GLCCI1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:30256538 RGD:628359914 NCBI chr21:50,121,781...50,243,181
Ensembl chr21:50,124,311...50,241,380 		JBrowse link
G SPINK5 serine peptidase inhibitor Kazal type 5 ISO protein:decreased expression:nose, oronasal secretion
mRNA, protein:decreased expression:nasal cavity epithelium 		RGD PMID:27779422 RGD:628359037 NCBI chr23:50,587,698...50,667,219
Ensembl chr23:50,592,412...50,663,302 		JBrowse link
nasal cavity adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLU clusterin ISO RGD PMID:19903339 RGD:9014708 NCBI chr 8:25,704,441...25,721,789
Ensembl chr 8:25,703,257...25,721,789 		JBrowse link
nasal cavity cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX2 SRY-box transcription factor 2 ISO DNA:amplification RGD PMID:23544055 RGD:8661654 NCBI chr15:7,673,581...7,676,812
Ensembl chr15:7,674,867...7,675,826 		JBrowse link
G TP53 tumor protein p53 ISO RGD PMID:19950227 RGD:8547762 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
nasal type extranodal NK/T-cell lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 severity ISO Nasal Type;protein:increased expression:nasal cavity (human) RGD PMID:18756548 RGD:8657087 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274 		JBrowse link
G CD274 CD274 molecule disease_progression ISO associated with Epstein-Barr Virus Infections RGD PMID:27595782 RGD:41412182 NCBI chr12:74,038,844...74,060,662
Ensembl chr12:74,041,767...74,056,806 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:15924153 NCBI chr10:86,768,252...86,819,963
Ensembl chr10:86,782,240...86,816,652 		JBrowse link
G GPX3 glutathione peroxidase 3 treatment ISO associated with ethmoid sinus cancer and Neoplasm Metastasis RGD PMID:29496492 RGD:151708712 NCBI chr23:53,576,950...53,585,321 JBrowse link
G JAK3 Janus kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22705984 PMID:23689514 NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29200404 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G PRDM1 PR/SET domain 1 disease_progression ISO RGD PMID:24438193 RGD:150530467 NCBI chr13:67,695,436...67,719,487
Ensembl chr13:67,695,309...67,718,931 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:increased expression:nasal cavity (human) RGD PMID:17225522 RGD:153298933 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
Perennial Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:serum RGD PMID:19725899 RGD:5686851 NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391 		JBrowse link
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19389874 NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein ISO protein:increased expression:nasal turbinate RGD PMID:19364335 RGD:5147461 NCBI chr 3:9,618,030...9,642,990
Ensembl chr 3:9,617,949...9,643,184 		JBrowse link
G CAT catalase ISO protein:decreased expression:plasma RGD PMID:20493834 RGD:5130771 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:Nasal Mucosa RGD PMID:17982926 RGD:4145109 NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:nasal mucosa (human) RGD PMID:17982926 RGD:4145109 NCBI chr22:7,803,794...7,818,112 JBrowse link
G CD40 CD40 molecule ISO RGD PMID:20226305 RGD:5132269 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CD86 CD86 molecule ISO protein:increased expression:nasal mucosa, dendritic cell (human) RGD PMID:17088138 RGD:4892343 NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366 		JBrowse link
G CHIA chitinase acidic ISO mRNA, protein:increased expression:turbinate, mucosa (human) RGD PMID:20422678 RGD:5037226 NCBI chr20:22,273,628...22,282,097 JBrowse link
G EGR1 early growth response 1 ISO DNA:snp:5' utr:g.-4071A>G rs7729723 (human) RGD PMID:19833116 RGD:5131984 NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISO RGD PMID:17727088 RGD:4892590 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD PMID:17181111 RGD:4142523 NCBI chr 1:6,676,897...6,679,936 JBrowse link
G HMOX1 heme oxygenase 1 ISO mRNA, protein:increased expression: nasal mucosa RGD PMID:16540907 RGD:4145406 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx (human)
protein:increased expression:lung, endothelium (mouse) 		RGD PMID:19047814 PMID:19968652 RGD:4145464 RGD:4145520 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IFNGR1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542 		JBrowse link
G IL13 interleukin 13 ISO mRNA, protein:increased expression:nasal mucosa RGD PMID:8520776 RGD:4782826 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL17A interleukin 17A severity ISO protein:increased expression:serum RGD PMID:19226302 RGD:4889151 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 susceptibility ISO DNA:SNP:promoter:c. -607A>C (rs1946518) (human) RGD PMID:16406079 RGD:4889924 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL1A interleukin 1 alpha ISO DNA:polymorphism:exon:c.4845G>T (human) RGD PMID:14533660 RGD:4142859 NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:18637763 RGD:5037238 NCBI chr14:5,781,486...5,852,872
Ensembl chr14:5,781,479...5,855,942 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17608155 RGD:8662959 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL4 interleukin 4 treatment ISO protein:increased expression:serum RGD PMID:9237816 PMID:15329007 PMID:21171297 RGD:5128559 RGD:7829804 RGD:7829817 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL5 interleukin 5 ISO protein: increased levels: sputum RGD PMID:22186238 RGD:5687140 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G LOC103242710 C-C motif chemokine 2 ISO protein:increased expression:nasal turbinate, mucosa (human) RGD PMID:9865755 RGD:8548839 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:nasal mucosa: RGD PMID:19786210 RGD:5130872 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:14587983 RGD:4892078 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO DNA:snp:promoter:g.-786T>C (human) RGD PMID:18086269 RGD:4892054 NCBI chr21:119,174,829...119,196,840 JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO protein:altered expression:nasal mucosa RGD PMID:20185258 RGD:4892593 NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO mRNA, protein:increased expression:nasal mucosa (human) RGD PMID:17116814 RGD:8552811 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G TBXA2R thromboxane A2 receptor treatment ISO RGD PMID:15247523 RGD:11059532 NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761 		JBrowse link
rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNPs: :multiple (human) RGD PMID:15298558 PMID:18778489 RGD:4145378 RGD:4145383 NCBI chr 2:34,352,514...34,366,694
Ensembl chr 2:34,353,505...34,366,559 		JBrowse link
G ANG angiogenin ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr29:21,215,985...21,226,927 JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:12165532 RGD:5129220 NCBI chr24:74,136,464...74,146,668
Ensembl chr24:74,145,531...74,146,592 		JBrowse link
G BDKRB2 bradykinin receptor B2 ISO RGD PMID:1890650 PMID:11149999 RGD:4891033 RGD:4891044 NCBI chr24:74,084,907...74,125,604
Ensembl chr24:74,118,210...74,122,909 		JBrowse link
G BDNF brain derived neurotrophic factor susceptibility ISO DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
mRNA:increased expression:nasal cavity epithelium 		RGD PMID:20464992 PMID:21723144 RGD:4891116 RGD:8655967 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G C3 complement C3 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:17345707 PMID:20109314 RGD:5129524 RGD:5129539 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G C3AR1 complement C3a receptor 1 severity ISO protein:increased expression:nasal cavity RGD PMID:18538384 RGD:5129559 NCBI chr11:8,128,192...8,135,517
Ensembl chr11:8,128,620...8,130,062 		JBrowse link
G C5AR1 complement C5a receptor 1 ISO RGD PMID:18538384 RGD:5129559 NCBI chr 6:40,633,540...40,651,839
Ensembl chr 6:40,633,448...40,652,845 		JBrowse link
G CAT catalase treatment ISO protein:increased activity:blood,nasal cavity mucosa: RGD PMID:21541033 RGD:9479054 NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:17982926 RGD:4145109 NCBI chr16:27,868,925...27,890,143 JBrowse link
G CCL11 C-C motif chemokine ligand 11 severity ISO associated with Sinusitis;protein:increased expression:paranasal sinus
mRNA:increased expression:lung, nose
protein:increased expression:nasal mucus 		RGD PMID:16120080 PMID:16765544 PMID:17999785 RGD:4145411 RGD:4145455 RGD:4145462 NCBI chr16:27,792,699...27,796,437
Ensembl chr16:27,794,033...27,796,460 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr 5:43,343,525...43,350,096
Ensembl chr 5:43,346,329...43,348,599 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 ISO RGD PMID:17947663 RGD:5130909 NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO protein:increased expression:blood, mononuclear cell RGD PMID:17517104 RGD:4145498 NCBI chr 5:43,297,206...43,305,662
Ensembl chr 5:43,297,897...43,305,642 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 ISO mRNA:increased expression:nasal cavity epithelium
DNA:SNPs: :179T>C, 275C>T (human) 		RGD PMID:15580493 PMID:17982926 RGD:4145109 RGD:4891493 NCBI chr28:10,067,482...10,069,992
Ensembl chr28:10,066,664...10,069,695 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 ISO DNA:polymorphism: :2497T>G (human)
associated with Eosinophilia;protein:increased expression:oronasal secretion (human) 		RGD PMID:15580493 PMID:24989688 RGD:11531119 RGD:4891493 NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875 		JBrowse link
G CCL8 C-C motif chemokine ligand 8 ISO RGD PMID:20625511 RGD:5131089 NCBI chr16:27,821,149...27,823,919
Ensembl chr16:27,821,970...27,823,528 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 susceptibility ISO Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human) RGD PMID:17135764 RGD:4145111 NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO mRNA:increased expression:nose
protein:increased expression:blood, T cell
DNA:SNP:exon:51T>C (human) 		RGD PMID:17135764 PMID:17156343 PMID:20696593 RGD:4145111 RGD:4145454 RGD:4145645 NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135 		JBrowse link
G CD14 CD14 molecule resistance
susceptibility 		ISO DNA:polymorphism:promoter:c. -159c>T (human) RGD PMID:16950285 PMID:20109306 RGD:4144795 RGD:4144810 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CD28 CD28 molecule ISO RGD PMID:21356099 RGD:5131612 NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387 		JBrowse link
G CD80 CD80 molecule ISO RGD PMID:21108691 RGD:5132622 NCBI chr22:61,258,281...61,294,772 JBrowse link
G CDC42 cell division cycle 42 ISO mRNA:increased expression:nasal turbinate RGD PMID:19432938 RGD:5688273 NCBI chr20:110,568,004...110,608,318
Ensembl chr20:110,569,352...110,582,562 		JBrowse link
G CFTR CF transmembrane conductance regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:16083808 NCBI chr21:86,154,313...86,332,436 JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 ISO mRNA, protein:increased expression:nasal cavity epithelium RGD PMID:17597629 RGD:5130940 NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO protein:increased expression:T cell RGD PMID:17625281 RGD:4891512 NCBI chr10:89,637,176...89,644,436
Ensembl chr10:89,638,314...89,642,344 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:plasma RGD PMID:14657873 RGD:4891906 NCBI chr 5:43,310,711...43,323,533
Ensembl chr 5:43,310,753...43,323,529 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO protein:increased expression:nasal mucus RGD PMID:20659080 RGD:4892030 NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO DNA:SNP:3' utr:*1934G>A (human) RGD PMID:20088379 RGD:5143945 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:15379985 PMID:16689996 PMID:17627772 PMID:18946234 RGD:4781451 RGD:4783198 RGD:4847512 RGD:4888516 NCBI chr  X:67,218,777...67,300,655
Ensembl chr  X:67,220,048...67,221,061
Ensembl chr  X:67,220,048...67,221,061 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 ISO associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium RGD PMID:16689996 RGD:4783198 NCBI chr 3:26,578,248...26,624,364 JBrowse link
G FCER1A Fc epsilon receptor Ia ISO RGD PMID:20650300 RGD:5128714 NCBI chr20:4,635,316...4,640,787
Ensembl chr20:4,635,328...4,640,590 		JBrowse link
G FIS1 fission, mitochondrial 1 ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr28:11,934,848...11,940,230
Ensembl chr28:11,934,821...11,941,901 		JBrowse link
G HDC histidine decarboxylase ISO DNA:SNP: :p.E644D (rs2073440) (human) RGD PMID:15054596 PMID:20608921 RGD:5128884 RGD:5143921 NCBI chr26:33,051,048...33,074,872
Ensembl chr26:33,051,966...33,074,563 		JBrowse link
G HNMT histamine N-methyltransferase no_association ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17651147 RGD:5128885 NCBI chr10:22,188,151...22,238,665
Ensembl chr10:22,188,110...22,238,671 		JBrowse link
G HRH1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr22:47,187,156...47,298,761
Ensembl chr22:47,295,011...47,296,471 		JBrowse link
G IL13 interleukin 13 disease_progression
susceptibility 		ISO mRNA:increased expression:nose
DNA:polymorphism: :rs1800925 (human)
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human) 		RGD PMID:16120094 PMID:17088137 PMID:20358028 PMID:20484924 PMID:20696593 RGD:4145454 RGD:4145534 RGD:4145767 RGD:4159171 RGD:4206706 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17088137 RGD:4159171 NCBI chr  X:102,589,947...102,628,853
Ensembl chr  X:102,590,045...102,603,260 		JBrowse link
G IL15 interleukin 15 ISO RGD PMID:16750998 RGD:5000756 NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488 		JBrowse link
G IL16 interleukin 16 ISO protein:increased expression:serum
protein:increased expression:nasal cavity epithelium, serum 		RGD PMID:18254318 PMID:19295235 RGD:5024931 RGD:5024932 NCBI chr26:2,080,985...2,208,764
Ensembl chr26:2,077,228...2,208,431 		JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:nasal mucosa RGD PMID:19927541 PMID:20506642 RGD:4889137 RGD:4889144 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL18 interleukin 18 disease_progression ISO rhinitis allergic, seasonal; protein:increased expression:plasma
protein:increased expression:serum
protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid 		RGD PMID:15934281 PMID:17305282 PMID:17323858 RGD:4889916 RGD:4889917 RGD:4889927 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL1B interleukin 1 beta susceptibility ISO associated with Hypersensitivity;protein:increased expression:nasal mucus
mRNA:increased expression:nasal cavity epithelium
associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human) 		RGD PMID:10224452 PMID:14533660 PMID:20490816 RGD:4142821 RGD:4142859 RGD:4143227 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 severity ISO associated with Sinusitis;DNA:SNPs: :multiple (human) RGD PMID:19671251 RGD:5144228 NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO associated with Hypersensitivity
associated with Hypersensitivity;DNA:repeat:intron (human) 		RGD PMID:10224452 PMID:14533660 PMID:15178892 RGD:4142859 RGD:4143215 RGD:4143227 NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326 		JBrowse link
G IL2 interleukin 2 susceptibility ISO DNA:SNP:promoter:rs2069762(human) RGD PMID:16333313 RGD:8663473 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL21 interleukin 21 ISO RGD PMID:17982108 RGD:5147397 NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025 		JBrowse link
G IL22 interleukin 22 severity ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:21535180 RGD:5147409 NCBI chr11:63,881,743...63,887,695
Ensembl chr11:63,882,093...63,886,761 		JBrowse link
G IL23R interleukin 23 receptor susceptibility ISO DNA:SNP,haplotype: :rs7517847(human) RGD PMID:23696856 RGD:8549605 NCBI chr20:65,853,379...65,946,000
Ensembl chr20:65,854,349...65,938,024 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha ISO RGD PMID:19354069 RGD:5128480 NCBI chr 6:12,679,270...12,699,254
Ensembl chr 6:12,686,838...12,701,867 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
mRNA:increased expression:nasal cavity epithelium 		CTD
RGD		 PMID:18826099 PMID:19672097 PMID:21208219 RGD:2317285 RGD:5128558 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL4R interleukin 4 receptor ISO DNA:polymorphism: :c.1432T>C (human) RGD PMID:15564773 RGD:4890394 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G IL5 interleukin 5 ISO RGD PMID:11884474 RGD:5128622 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G IL9 interleukin 9 ISO RGD PMID:20525149 RGD:5128687 NCBI chr23:38,641,228...38,645,810
Ensembl chr23:38,641,741...38,645,276 		JBrowse link
G LEP leptin ISO RGD PMID:19860581 RGD:5128850 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220 		JBrowse link
G LOC103242711 C-C motif chemokine 7 ISO RGD PMID:17982926 RGD:4145109 NCBI chr16:27,777,795...27,780,413 JBrowse link
G LOC103248365 caspase-1 ISO protein:increased expression:serum RGD PMID:12396474 PMID:20974310 RGD:5130187 RGD:5130192 NCBI chr 1:96,389,697...96,400,610
Ensembl chr 1:96,389,657...96,400,849 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism: : RGD PMID:18831943 RGD:8693717 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G MFN1 mitofusin 1 ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr15:10,050,616...10,093,118
Ensembl chr15:10,047,599...10,093,126 		JBrowse link
G MHC-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility ISO DNA:polymorphisms:cds:HLA-DQA1*0201, HLA-DQA1*0302 (human) RGD PMID:14990915 RGD:5147798 NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871 		JBrowse link
G MIF macrophage migration inhibitory factor severity ISO protein:increased expression:serum, nasal mucosa RGD PMID:15053202 PMID:15922619 RGD:4891045 RGD:4891056 NCBI chr19:7,000,837...7,001,700
Ensembl chr19:7,000,793...7,001,757 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO RGD PMID:15480314 RGD:5131152 NCBI chr 1:13,657,842...13,666,314
Ensembl chr 1:13,654,696...13,665,925 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:nose RGD PMID:15715404 PMID:20696593 RGD:4145454 RGD:7364740 NCBI chr 1:981,515...1,018,242 JBrowse link
G NGF nerve growth factor ISO associated with Sinusitis;protein:increased expression:respiratory system mucosa
protein:increased expression:respiratory system fluid/secretion 		RGD PMID:10224365 PMID:19958603 RGD:4891064 RGD:4891115 NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833 		JBrowse link
G NGFR nerve growth factor receptor ISO protein:increased expression:blood, eosinophil RGD PMID:18647313 RGD:5144116 NCBI chr16:69,894,000...69,914,209
Ensembl chr16:69,894,139...69,912,189 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO mRNA:decreased expression:nose RGD PMID:20384614 RGD:5131446 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:cds:2104C>T,2722G>C (human) RGD PMID:12704363 RGD:5131484 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:nasal mucosa RGD PMID:18254476 RGD:4891910 NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257 		JBrowse link
G NPY neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 NCBI chr21:34,068,533...34,076,205
Ensembl chr21:34,068,530...34,075,127 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO protein:increased expression:eosinophil RGD PMID:18647313 RGD:5144116 NCBI chr20:6,987,903...7,027,381
Ensembl chr20:6,987,905...7,008,670 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD PMID:28146064 RGD:13204839 NCBI chr15:87,679,656...87,778,767
Ensembl chr15:87,679,077...87,779,102 		JBrowse link
G PLAU plasminogen activator, urokinase ISO mRNA:increased expression:nasal cavity epithelium RGD PMID:21339035 RGD:8547809 NCBI chr 9:57,452,904...57,459,345
Ensembl chr 9:57,452,761...57,459,286 		JBrowse link
G PTGDR2 prostaglandin D2 receptor 2 ISO RGD PMID:19230460 PMID:19608418 RGD:5135017 RGD:5135021 NCBI chr 1:12,989,750...12,994,979
Ensembl chr 1:12,992,188...12,993,378 		JBrowse link
G SCGB3A2 secretoglobin family 3A member 2 ISO mRNA,protein:decreased expression:nasal mucosa
protein:increased expression:sputum 		RGD PMID:17218572 PMID:21385388 RGD:5144232 RGD:5147389 NCBI chr23:50,327,428...50,417,518
Ensembl chr23:50,414,139...50,417,373 		JBrowse link
G SERPINE1 serpin family E member 1 susceptibility ISO DNA:polymorphism:promoter:rs1799768 (human) RGD PMID:19063817 RGD:4144832 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SFTPD surfactant protein D susceptibility ISO associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human) RGD PMID:19493231 RGD:4143494 NCBI chr 9:51,809,241...51,820,974
Ensembl chr 9:51,811,052...51,820,650 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member no_association
susceptibility 		ISO DNA:SNPs: : RGD PMID:12018331 PMID:17982230 RGD:6482262 RGD:6482274 NCBI chr17:39,252,000...39,260,195 JBrowse link
G TBXA2R thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12167471 NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO associated with Sinusitis RGD PMID:18423831 RGD:4145277 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TLR2 toll like receptor 2 no_association
susceptibility 		ISO associated with Sinusitis;DNA:SNPs: :multiple (human)
mRNA:decreased expression:nasal mucosa:
DNA:SNPs: :597T>C, 1350T>C (human) 		RGD PMID:18219831 PMID:19128592 PMID:19763595 RGD:4145354 RGD:4145356 RGD:7800742 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR6 toll like receptor 6 ISO associated with Asthma;DNA:SNP: :rs2381289 (human) RGD PMID:20815312 RGD:4145352 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TNF tumor necrosis factor ISO mRNA:increased expression:nose RGD PMID:15120189 PMID:20696593 RGD:4143470 RGD:4145454
G VEGFA vascular endothelial growth factor A ISO protein:increased expression:sputum RGD PMID:19178538 RGD:6892723 NCBI chr17:28,377,959...28,394,508 JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12746121 PMID:14680090 NCBI chr13:80,217,602...80,228,320
Ensembl chr13:80,218,572...80,228,278 		JBrowse link
Rhinosinusitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO associated with Nasal Polyps RGD PMID:22279949 RGD:7421555 NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562 		JBrowse link
G C3 complement C3 ISO protein:increased expression:serum RGD PMID:19593977 RGD:4889484 NCBI chr 6:6,250,422...6,289,264 JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:16702571 RGD:7483585 NCBI chr10:113,815,099...113,836,562
Ensembl chr10:113,832,573...113,835,736 		JBrowse link
G HGF hepatocyte growth factor susceptibility ISO DNA:haplotype::rs38850,rs38855,rs38857(human) RGD PMID:20416453 RGD:8548615 NCBI chr21:67,118,785...67,193,506
Ensembl chr21:67,120,722...67,193,504 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:increased expression:nose: RGD PMID:20713758 RGD:8548883 NCBI chr11:97,624,498...97,708,730
Ensembl chr11:97,631,189...97,707,308 		JBrowse link
G IL10 interleukin 10 ISO protein:decreased expression:blood, mononuclear cell RGD PMID:23168151 RGD:7364820 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL17A interleukin 17A ISO associated with Asthma;mRNA, protein:increased expression:nasal polyps (human) RGD PMID:19672092 RGD:4889146 NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 RGD:7401169 NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729 		JBrowse link
G IL22RA1 interleukin 22 receptor subunit alpha 1 susceptibility ISO DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human) RGD PMID:19393422 RGD:5147411 NCBI chr20:108,545,400...108,568,272
Ensembl chr20:108,550,271...108,568,371 		JBrowse link
G IL4 interleukin 4 treatment ISO associated with Asthma RGD PMID:12787306 RGD:7829803 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:23401274 RGD:8547880 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming treatment ISO RGD PMID:19389874 PMID:23131200 RGD:7349403 RGD:7364734 NCBI chr 1:981,515...1,018,242 JBrowse link
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 severity ISO associated with Nasal Polyps RGD PMID:22961479 RGD:7777146 NCBI chr10:63,982,784...64,003,919 JBrowse link
G SERPINE1 serpin family E member 1 ISO protein:increased expression:nasal mucosa (human) RGD PMID:21711960 RGD:6483796 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO DNA:polymorphisms:: rs3804099,rs3804100(human)
mRNA,protein:increased expression:paranasal sinus 		RGD PMID:21493395 PMID:22182736 RGD:7800733 RGD:8552975 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:paranasal sinus RGD PMID:22182736 RGD:7800733 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:nasal cavity epithelium RGD PMID:11197112 PMID:20147558 RGD:7401169 RGD:7401236
Seasonal Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:16677242 RGD:5147463 NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331 		JBrowse link
G APOA4 apolipoprotein A4 resistance ISO protein:increased expression:blood serum (human) RGD PMID:20810159 RGD:5685642 NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698 		JBrowse link
G BDNF brain derived neurotrophic factor severity ISO protein:increased expression:blood, nasal cavity epithelium RGD PMID:18266897 RGD:5144117 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:inferior turbinate, epithelium (human) RGD PMID:20459697 RGD:4891379 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CMA1 chymase 1 ISO protein:increased expression:nasal mucosa, mast cell (human) RGD PMID:11549546 RGD:5128839 NCBI chr24:1,471,767...1,475,062
Ensembl chr24:1,471,725...1,474,692 		JBrowse link
G FGA fibrinogen alpha chain ISO RGD PMID:21887273 RGD:5688767 NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405 		JBrowse link
G GLCCI1 glucocorticoid induced 1 treatment ISO DNA:SNP: :rs37973 RGD PMID:29981236 RGD:628359913 NCBI chr21:50,121,781...50,243,181
Ensembl chr21:50,124,311...50,241,380 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO protein:decreased expression;T lymphocyte: RGD PMID:21410266 RGD:5491008 NCBI chr 9:97,305,094...97,317,892 JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx, secretion (human) RGD PMID:20128420 RGD:4145459 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G IFNGR1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:19505388 RGD:7365025 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL18 interleukin 18 no_association
susceptibility 		ISO DNA:SNPs:promoters:multiple
DNA:SNPs:promoters, exon:multiple 		RGD PMID:12532106 RGD:8655871 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL4 interleukin 4 ISO protein:increased expression:serum
mRNA:increased expression:nose: 		RGD PMID:7551298 PMID:9237816 RGD:7829817 RGD:8662960 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G KDR kinase insert domain receptor ISO protein:increased expression:nasal cavity of mucosa: RGD PMID:17651148 RGD:8551771 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human) RGD PMID:22237587 RGD:8547819 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 susceptibility ISO DNA:SNP: :rs2075817 (human) RGD PMID:16918516 RGD:5131519 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human) RGD PMID:16008671 RGD:5131477 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO mRNA, protein:decreased expression:nasal lavage fluid RGD PMID:15836756 RGD:5144234 NCBI chr 1:11,470,091...11,474,915
Ensembl chr 1:11,470,195...11,474,149 		JBrowse link
G TLR3 toll like receptor 3 ISO protein:decreased expression:bone marrow, blood, eosinophil (human) RGD PMID:19752565 RGD:5129130 NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232 		JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18517079 RGD:4144192 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid: RGD PMID:12633568 RGD:7483595 NCBI chr17:28,377,959...28,394,508 JBrowse link
sinonasal undifferentiated carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAML3 mastermind like transcriptional coactivator 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24859338 NCBI chr 7:86,673,649...87,107,768
Ensembl chr 7:86,673,346...86,848,086 		JBrowse link
G PAX3 paired box 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24859338 NCBI chr10:108,125,198...108,225,217
Ensembl chr10:108,125,747...108,224,478 		JBrowse link
G SMARCB1 SWI/SNF related BAF chromatin remodeling complex subunit B1 ISO RGD PMID:30120966 RGD:127285653 NCBI chr19:6,902,985...6,945,111
Ensembl chr19:6,902,951...6,944,784 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 10941
    sensory system disease 4393
      Otorhinolaryngologic Diseases 1108
        nose disease 213
          nasal cavity disease 172
            Binder syndrome 0
            choanal atresia + 4
            nasal cavity benign neoplasm + 0
            nasal cavity cancer + 14
            rhinitis + 155
Path 2
Term Annotations click to browse term
  disease 10941
    disease of anatomical entity 10388
      nervous system disease 7508
        Neurologic Manifestations 5412
          sensory system disease 4393
            Otorhinolaryngologic Diseases 1108
              nose disease 213
                nasal cavity disease 172
                  Binder syndrome 0
                  choanal atresia + 4
                  nasal cavity benign neoplasm + 0
                  nasal cavity cancer + 14
                  rhinitis + 155
paths to the root