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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:post-traumatic stress disorder
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Accession:DOID:2055 term browser browse the term
Definition:An anxiety disorder which results from a traumatic experience that results in psychological trauma. (DO)
Synonyms:exact_synonym: PTSD;   acute post traumatic stress disorder;   chronic post traumatic stress disorder;   delayed onset post traumatic stress disorder;   post-traumatic neuroses;   posttraumatic neuroses;   posttraumatic stress disorder;   posttraumatic stress disorders;   traumatic neurosis
 primary_id: MESH:D013313
 xref: EFO:0001358;   ICD10CM:F43.1;   ICD9CM:309.81;   NCI:C3389
For additional species annotation, visit the Alliance of Genome Resources.


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post-traumatic stress disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 ISO DNA:SNP:multiple:multiple RGD PMID:23796624 RGD:597830075 NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP RGD PMID:23381833 RGD:10054113 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor susceptibility
treatment 		ISO
IEP 		DNA:missense mutation:cds:196G>A (p.V66M) (human) RGD PMID:23319005 PMID:28791385 RGD:10059367, RGD:401940159 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:32332995 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Casp12 caspase 12 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp9 caspase 9 IEP RGD PMID:25331812 RGD:13782181 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34262461 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 ISO ClinVar Annotator: match by term: Post-traumatic stress disorder ClinVar PMID:18349090 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:27421892 RGD:405255654 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A treatment IEP RGD PMID:28791385 RGD:401940159 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:21714072 RGD:5147887 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Mdm2 MDM2 proto-oncogene IDA RGD PMID:23174211 RGD:10412309 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IEP mRNA, protein:altered expression:locus coeruleus (rat) RGD PMID:21584742 RGD:5686336 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP protein:increased expression:hippocampus RGD PMID:20863519 RGD:5684783 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Oprm1 opioid receptor, mu 1 severity ISO DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) RGD PMID:22143634 RGD:401827931 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:25331812 RGD:13782181 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 treatment IMP RGD PMID:28791385 RGD:401940159 NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:61,700,021...61,702,855 		JBrowse link
G Tph2 tryptophan hydroxylase 2 treatment IEP RGD PMID:31494960 RGD:597830162 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein treatment IEP RGD PMID:17968352 RGD:8694407 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:78,034,864...78,060,459 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            disease of mental health 8496
              cognitive disorder 2320
                anxiety disorder 187
                  post-traumatic stress disorder 22
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            disease of mental health 8496
              cognitive disorder 2320
                anxiety disorder 187
                  acute stress disorder 28
                    post-traumatic stress disorder 22
paths to the root