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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:drug-induced hepatitis
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Accession:DOID:2044 term browser browse the term
Definition:Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an idiosyncratic response to a drug or metabolite.
Synonyms:exact_synonym: Drug-Induced Hepatitides;   Drug-Induced Liver Injury, Chronic;   chronic hepatitis, drug-induced;   chronic hepatitis, drug-related
 primary_id: MESH:D056487
 alt_id: RDO:0007743
 xref: EFO:1000905
For additional species annotation, visit the Alliance of Genome Resources.


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drug-induced hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 susceptibility
no_association 		ISO DNA:polymorphisms,haplotype:promoter:g.-1774delG,g.-1549G>A(human)
DNA:SNPs:multiple: 		RGD PMID:17502832 PMID:22178260 RGD:14700816, RGD:14700817 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IDA DNA:hypermethylation:promoter RGD PMID:23619520 RGD:14700910 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IDA RGD PMID:16140414 RGD:2316848 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 ISO protein:increased expression:liver (mouse) RGD PMID:12201952 RGD:10054288 NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:78,024,139...78,142,188 		JBrowse link
G Mir22 microRNA 22 ISO in male; RNA:increased expression:liver: RGD PMID:21750200 RGD:14700876 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,805,331...60,805,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Chemically-Induced Disorders 1510
      Poisoning 795
        Chemical and Drug Induced Liver Injury 451
          drug-induced hepatitis 5
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      gastrointestinal system disease 7168
        hepatobiliary disease 3079
          liver disease 2964
            Liver Injury 539
              Chemical and Drug Induced Liver Injury 451
                drug-induced hepatitis 5
paths to the root