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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:endodermal sinus tumor
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Accession:DOID:1911 term browser browse the term
Definition:A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo. (DO)
Synonyms:exact_synonym: EFO:0007252;   endodermal sinus tumors;   endodermal sinus tumour;   hepatoid yolk sac tumour;   infantile embryonal carcinoma;   yolk sac neoplasm;   yolk sac tumor;   yolk sac tumors;   yolk sac tumour
 primary_id: MESH:D018240
 xref: EFO:0007252;   ICDO:9071/3;   NCI:C3011
For additional species annotation, visit the Alliance of Genome Resources.


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endodermal sinus tumor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein ISO protein:increased expression:serum RGD PMID:17525908 RGD:2292040 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ctnnb1 catenin beta 1 ISO RGD PMID:16822086 RGD:2298800 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fgf8 fibroblast growth factor 8 ISO testicular germ cell neoplasms RGD PMID:11764380 RGD:2289339 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Sall4 spalt-like transcription factor 4 ISO protein:increased expression:testis, nucleus (human) RGD PMID:23347651 RGD:11557983 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9111512 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
G Wnt2b Wnt family member 2B ISO RGD PMID:16822086 RGD:2298800 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19102
    disease of cellular proliferation 7914
      Neoplasms by Histologic Type 5403
        Germ Cell and Embryonal Neoplasms 581
          germ cell and embryonal cancer 71
            endodermal sinus tumor 6
              adult endodermal sinus tumor 0
              central nervous system endodermal sinus tumor 0
              childhood endodermal sinus tumor 0
Path 2
Term Annotations click to browse term
  disease 19102
    disease of cellular proliferation 7914
      cancer 5769
        cell type cancer 3842
          sarcoma 285
            germ cell and embryonal cancer 71
              endodermal sinus tumor 6
                adult endodermal sinus tumor 0
                central nervous system endodermal sinus tumor 0
                childhood endodermal sinus tumor 0
paths to the root