RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: sexual dysfunction
Accession: DOID:1876
browse the term
Definition: A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms: exact_synonym: Physiological Sexual Disorder; physiological sexual disorders; physiological sexual dysfunction; physiological sexual dysfunctions; sex disorders
narrow_synonym: antidepressant-induced sexual dysfunction
primary_id: MESH:D012735
xref: EFO:0004714 ; EFO:0006322 ; ICD10CM:F52.9 ; ICD10CM:R37 ; NCI:C3347
For additional species annotation, visit the
Alliance of Genome Resources .
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Ddo
D-aspartate oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16525061
NCBI chrNW_004624916:1,488,912...1,522,175
Ensembl chrNW_004624916:1,490,226...1,522,212
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Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10084644 PMID:15677431
NCBI chrNW_004624756:4,585,542...4,593,285
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Ptger2
prostaglandin E receptor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chrNW_004624731:16,729,846...16,741,529
Ensembl chrNW_004624731:16,726,975...16,741,557
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Ptger4
prostaglandin E receptor 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chrNW_004624759:14,243,887...14,259,090
Ensembl chrNW_004624759:14,244,899...14,258,445
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Adamtsl2
ADAMTS like 2
ISO
MouseDO
NCBI chrNW_004624760:1,948,302...1,977,459
Ensembl chrNW_004624760:1,949,907...1,976,894
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Ager
advanced glycosylation end-product specific receptor
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:23698784
RGD:7244246
NCBI chrNW_004624754:24,138,086...24,140,900
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Agt
angiotensinogen
treatment
ISO
RGD
PMID:17616753
RGD:8548892
NCBI chrNW_004624775:18,846,222...18,856,093
Ensembl chrNW_004624775:18,849,118...18,855,577
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Akt1
AKT serine/threonine kinase 1
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295
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Bad
BCL2 associated agonist of cell death
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004624767:22,025,721...22,037,283
Ensembl chrNW_004624767:22,026,133...22,037,277
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Bax
BCL2 associated X, apoptosis regulator
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506
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Bcl2
BCL2 apoptosis regulator
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Experimental
RGD CTD
PMID:12394778 PMID:21235725
RGD:10053666 RGD:1579980
NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344
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Bcl2l1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12394778
RGD:1579980
NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507
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Ccnd1
cyclin D1
ISO
mRNA:decreased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191
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Ccnd2
cyclin D2
ISO
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis
RGD
PMID:18068478
RGD:2289159
NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107
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Cfl1
cofilin 1
treatment
ISO
protein:increased phosphorylation:corpus cavernosum penis (rat)
RGD
PMID:25444982 PMID:25923835
RGD:11568706 RGD:11570410
NCBI chrNW_004624767:20,574,884...20,578,413
Ensembl chrNW_004624767:20,574,966...20,579,796
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Cnr1
cannabinoid receptor 1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:17850365
RGD:2314634
NCBI chrNW_004624799:6,100,709...6,126,530
Ensembl chrNW_004624799:6,101,728...6,126,520
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Dynll1
dynein light chain LC8-type 1
treatment
ISO
RGD
PMID:17433082
RGD:13207433
NCBI chrNW_004624747:13,169,865...13,172,592
Ensembl chrNW_004624747:13,169,865...13,172,525
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma
CTD RGD
PMID:12002441 PMID:17420087
RGD:2292142
NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029
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Ednra
endothelin receptor type A
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17420087 PMID:18823320
RGD:2292142
NCBI chrNW_004624853:6,298,406...6,362,353
Ensembl chrNW_004624853:6,302,751...6,360,089
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Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:15758817
RGD:2315866
NCBI chrNW_004624777:3,268,674...3,321,424
Ensembl chrNW_004624777:3,268,953...3,321,145
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Gja1
gap junction protein alpha 1
ISO
mRNA, protein:decreased expression:corpus cavernosum penis
RGD
PMID:17146929
RGD:8662385
NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313
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Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19295509
NCBI chrNW_004624758:9,579,750...9,756,396
Ensembl chrNW_004624758:9,579,752...9,756,525
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Grk2
G protein-coupled receptor kinase 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:30226217
RGD:13792691
NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082
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Hdac3
histone deacetylase 3
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chrNW_004624774:845,970...864,080
Ensembl chrNW_004624774:845,358...863,809
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Hdac4
histone deacetylase 4
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chrNW_004624847:3,846,196...4,101,537
Ensembl chrNW_004624847:3,845,858...4,101,487
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Igfbp3
insulin like growth factor binding protein 3
treatment
ISO
mRNA, protein:increased expression:penis
RGD
PMID:21595839 PMID:24576658
RGD:10402763 RGD:10402765
NCBI chrNW_004624740:6,878,818...6,886,512
Ensembl chrNW_004624740:6,877,348...6,886,512
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Il6
interleukin 6
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:21492407 PMID:24467772
RGD:10402827 RGD:9495931
NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318
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Kdr
kinase insert domain receptor
ISO
RGD
PMID:16422887
RGD:5684417
NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051
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Mcam
melanoma cell adhesion molecule
ISO
protein:decreased expression:penis erectile tissue
RGD
PMID:24023647
RGD:7364777
NCBI chrNW_004624784:14,671,524...14,681,151
Ensembl chrNW_004624784:14,673,060...14,681,423
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Nos1
nitric oxide synthase 1
treatment
ISO
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue associated with Diabetes Mellitus, Experimental
RGD
PMID:23522997 PMID:23535456 PMID:23698784
RGD:7244246 RGD:7257656 RGD:7257657
NCBI chrNW_004624747:15,940,614...16,118,051
Ensembl chrNW_004624747:16,003,969...16,113,165
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Nos2
nitric oxide synthase 2
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:19554009
RGD:2313212
NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271
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Nos3
nitric oxide synthase 3
treatment
ISO
CTD Direct Evidence: marker/mechanism|therapeutic associated with Cocaine-Related Disorders;protein:decreased expression:penis associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
RGD CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891
RGD:13504711 RGD:2292142 RGD:4891999
NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004
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P2ry1
purinergic receptor P2Y1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chrNW_004624730:30,470,894...30,478,269
Ensembl chrNW_004624730:30,471,610...30,476,941
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P2ry2
purinergic receptor P2Y2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chrNW_004624817:3,706,017...3,721,045
Ensembl chrNW_004624817:3,706,017...3,719,649
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Pde5a
phosphodiesterase 5A
ISO
associated with Hypercholesterolemia associated with Diabetes Mellitus, Experimental
RGD
PMID:15578039 PMID:15667904 PMID:15920460
RGD:2314519 RGD:2314520 RGD:2314521
NCBI chrNW_004624964:11,085...126,027
Ensembl chrNW_004624964:14,216...126,553
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Prkg1
protein kinase cGMP-dependent 1
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue
RGD
PMID:17355372
RGD:7775062
NCBI chrNW_004624791:11,334,146...12,656,480
Ensembl chrNW_004624791:11,338,510...12,654,812
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Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128
NCBI chrNW_004624756:4,585,542...4,593,285
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Shbg
sex hormone binding globulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17961146
NCBI chrNW_004624786:10,234,484...10,239,034
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Sirt1
sirtuin 1
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946
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Tgfb1
transforming growth factor beta 1
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:18778311 PMID:27051243
RGD:14995446 RGD:2306738
NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605
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Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:11596671
RGD:2312459
NCBI chrNW_004624741:22,880,481...22,883,962
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Tnf
tumor necrosis factor
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441
NCBI chrNW_004624754:15,929,414...15,943,637
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Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10233493
NCBI chrNW_004624785:5,466,429...5,487,763
Ensembl chrNW_004624785:5,468,563...5,488,143
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Xrcc1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H
RGD
PMID:18582155
RGD:2302570
NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266
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Angpt2
angiopoietin 2
ISO
associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat)
RGD
PMID:16750245
RGD:2314210
NCBI chrNW_004624861:4,457,519...4,510,035
Ensembl chrNW_004624861:4,457,158...4,509,623
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Apod
apolipoprotein D
ISO
mRNA:increased expression:penis erectile tissue
RGD
PMID:11444882
RGD:2311196
NCBI chrNW_004624730:62,535,005...62,552,405
Ensembl chrNW_004624730:62,530,673...62,555,129
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Pde5a
phosphodiesterase 5A
ISO
RGD
PMID:17287493
RGD:2314469
NCBI chrNW_004624964:11,085...126,027
Ensembl chrNW_004624964:14,216...126,553
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Tgfbr2
transforming growth factor beta receptor 2
ISO
protein:increased expression:penis erectile tissue
RGD
PMID:14718046
RGD:1601627
NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959
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