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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms:exact_synonym: Physiological Sexual Disorder;   physiological sexual disorders;   physiological sexual dysfunction;   physiological sexual dysfunctions;   sex disorders
 narrow_synonym: antidepressant-induced sexual dysfunction
 primary_id: MESH:D012735
 xref: EFO:0004714;   EFO:0006322;   ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.


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sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chrNW_004624916:1,488,912...1,522,175
Ensembl chrNW_004624916:1,490,226...1,522,212
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Ptger2 prostaglandin E receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chrNW_004624731:16,729,846...16,741,529
Ensembl chrNW_004624731:16,726,975...16,741,557
JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chrNW_004624759:14,243,887...14,259,090
Ensembl chrNW_004624759:14,244,899...14,258,445
JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamtsl2 ADAMTS like 2 ISO MouseDO NCBI chrNW_004624760:1,948,302...1,977,459
Ensembl chrNW_004624760:1,949,907...1,976,894
JBrowse link
G Ager advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chrNW_004624754:24,138,086...24,140,900 JBrowse link
G Agt angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chrNW_004624775:18,846,222...18,856,093
Ensembl chrNW_004624775:18,849,118...18,855,577
JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295
JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004624767:22,025,721...22,037,283
Ensembl chrNW_004624767:22,026,133...22,037,277
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506
JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
RGD
CTD
PMID:12394778 PMID:21235725 RGD:10053666 RGD:1579980 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344
JBrowse link
G Bcl2l1 BCL2 like 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12394778 RGD:1579980 NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507
JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191
JBrowse link
G Ccnd2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107
JBrowse link
G Cfl1 cofilin 1 treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25444982 PMID:25923835 RGD:11568706 RGD:11570410 NCBI chrNW_004624767:20,574,884...20,578,413
Ensembl chrNW_004624767:20,574,966...20,579,796
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chrNW_004624799:6,100,709...6,126,530
Ensembl chrNW_004624799:6,101,728...6,126,520
JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chrNW_004624747:13,169,865...13,172,592
Ensembl chrNW_004624747:13,169,865...13,172,525
JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD
RGD
PMID:12002441 PMID:17420087 RGD:2292142 NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029
JBrowse link
G Ednra endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:17420087 PMID:18823320 RGD:2292142 NCBI chrNW_004624853:6,298,406...6,362,353
Ensembl chrNW_004624853:6,302,751...6,360,089
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chrNW_004624777:3,268,674...3,321,424
Ensembl chrNW_004624777:3,268,953...3,321,145
JBrowse link
G Gja1 gap junction protein alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chrNW_004624758:9,579,750...9,756,396
Ensembl chrNW_004624758:9,579,752...9,756,525
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082
JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chrNW_004624774:845,970...864,080
Ensembl chrNW_004624774:845,358...863,809
JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chrNW_004624847:3,846,196...4,101,537
Ensembl chrNW_004624847:3,845,858...4,101,487
JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:21595839 PMID:24576658 RGD:10402763 RGD:10402765 NCBI chrNW_004624740:6,878,818...6,886,512
Ensembl chrNW_004624740:6,877,348...6,886,512
JBrowse link
G Il6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827 RGD:9495931 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318
JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051
JBrowse link
G Mcam melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chrNW_004624784:14,671,524...14,681,151
Ensembl chrNW_004624784:14,673,060...14,681,423
JBrowse link
G Nos1 nitric oxide synthase 1 treatment ISO associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
associated with Diabetes Mellitus, Experimental
RGD PMID:23522997 PMID:23535456 PMID:23698784 RGD:7244246 RGD:7257656 RGD:7257657 NCBI chrNW_004624747:15,940,614...16,118,051
Ensembl chrNW_004624747:16,003,969...16,113,165
JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271
JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic
associated with Cocaine-Related Disorders;protein:decreased expression:penis
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
RGD
CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891 RGD:13504711 RGD:2292142 RGD:4891999 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004
JBrowse link
G P2ry1 purinergic receptor P2Y1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chrNW_004624730:30,470,894...30,478,269
Ensembl chrNW_004624730:30,471,610...30,476,941
JBrowse link
G P2ry2 purinergic receptor P2Y2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chrNW_004624817:3,706,017...3,721,045
Ensembl chrNW_004624817:3,706,017...3,719,649
JBrowse link
G Pde5a phosphodiesterase 5A ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15578039 PMID:15667904 PMID:15920460 RGD:2314519 RGD:2314520 RGD:2314521 NCBI chrNW_004624964:11,085...126,027
Ensembl chrNW_004624964:14,216...126,553
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chrNW_004624791:11,334,146...12,656,480
Ensembl chrNW_004624791:11,338,510...12,654,812
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chrNW_004624786:10,234,484...10,239,034 JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946
JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:14995446 RGD:2306738 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605
JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chrNW_004624741:22,880,481...22,883,962 JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chrNW_004624754:15,929,414...15,943,637 JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chrNW_004624785:5,466,429...5,487,763
Ensembl chrNW_004624785:5,468,563...5,488,143
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266
JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chrNW_004624861:4,457,519...4,510,035
Ensembl chrNW_004624861:4,457,158...4,509,623
JBrowse link
G Apod apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chrNW_004624730:62,535,005...62,552,405
Ensembl chrNW_004624730:62,530,673...62,555,129
JBrowse link
G Pde5a phosphodiesterase 5A ISO RGD PMID:17287493 RGD:2314469 NCBI chrNW_004624964:11,085...126,027
Ensembl chrNW_004624964:14,216...126,553
JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14230
    disease of anatomical entity 13932
      reproductive system disease 2889
        male reproductive system disease 1829
          sexual dysfunction 47
            impotence + 44
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 14230
    disease of anatomical entity 13932
      Urogenital Diseases 4530
        reproductive system disease 2889
          male reproductive system disease 1829
            sexual dysfunction 47
              impotence + 44
              premature ejaculation 0
              psychologic dyspareunia 0
              psychologic vaginismus 0
paths to the root