RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: sexual dysfunction
Accession: DOID:1876
browse the term
Definition: A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms: exact_synonym: Physiological Sexual Disorder; physiological sexual disorders; physiological sexual dysfunction; physiological sexual dysfunctions; sex disorders
narrow_synonym: antidepressant-induced sexual dysfunction
primary_id: MESH:D012735
xref: EFO:0004714 ; EFO:0006322 ; ICD10CM:F52.9 ; ICD10CM:R37 ; NCI:C3347
For additional species annotation, visit the
Alliance of Genome Resources .
G
Ddo
D-aspartate oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16525061
NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843
G
Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10084644 PMID:15677431
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
G
Ptger1
prostaglandin E receptor 1 (subtype EP1)
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr 8:84,393,171...84,399,385
Ensembl chr 8:84,393,307...84,399,382
G
Ptger2
prostaglandin E receptor 2 (subtype EP2)
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277
G
Ptger4
prostaglandin E receptor 4 (subtype EP4)
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668
G
Adamtsl2
ADAMTS-like 2
IAGP
MouseDO
NCBI chr 2:26,969,348...26,998,993
Ensembl chr 2:26,969,391...26,998,993
G
Ager
advanced glycosylation end product-specific receptor
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:23698784
RGD:7244246
NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
G
Agt
angiotensinogen
treatment
ISO
RGD
PMID:17616753
RGD:8548892
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
G
Akt1
thymoma viral proto-oncogene 1
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
G
Bad
BCL2-associated agonist of cell death
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
G
Bax
BCL2-associated X protein
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
G
Bcl2
B cell leukemia/lymphoma 2
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Experimental
CTD RGD
PMID:12394778 PMID:12394778 PMID:21235725
RGD:1579980 , RGD:10053666
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Bcl2l1
BCL2-like 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12394778 PMID:12394778
RGD:1579980
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
G
Casp3
caspase 3
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Ccnd1
cyclin D1
ISO
mRNA:decreased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
G
Ccnd2
cyclin D2
ISO
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis
RGD
PMID:18068478
RGD:2289159
NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
G
Cfl1
cofilin 1, non-muscle
treatment
ISO
protein:increased phosphorylation:corpus cavernosum penis (rat)
RGD
PMID:25923835 PMID:25444982
RGD:11568706 , RGD:11570410
NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229
G
Cnr1
cannabinoid receptor 1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:17850365
RGD:2314634
NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
G
Dynll1
dynein light chain LC8-type 1
treatment
ISO
RGD
PMID:17433082
RGD:13207433
NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058
G
Edn1
endothelin 1
ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12002441 PMID:17420087
RGD:2292142
NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
G
Ednra
endothelin receptor type A
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18823320 PMID:17420087
RGD:2292142
NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
G
Fabp4
fatty acid binding protein 4, adipocyte
ISO
associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
G
Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:15758817
RGD:2315866
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
G
Gja1
gap junction protein, alpha 1
ISO
mRNA, protein:decreased expression:corpus cavernosum penis
RGD
PMID:17146929
RGD:8662385
NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
G
Grin3a
glutamate receptor ionotropic, NMDA3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19295509
NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744
G
Grk2
G protein-coupled receptor kinase 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:30226217
RGD:13792691
NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250
G
Hdac3
histone deacetylase 3
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
G
Hdac4
histone deacetylase 4
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
G
Igfbp3
insulin-like growth factor binding protein 3
treatment
ISO
mRNA, protein:increased expression:penis
RGD
PMID:24576658 PMID:21595839
RGD:10402763 , RGD:10402765
NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
G
Il6
interleukin 6
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:21492407 PMID:24467772
RGD:10402827 , RGD:9495931
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Kdr
kinase insert domain protein receptor
ISO
RGD
PMID:16422887
RGD:5684417
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
G
Mcam
melanoma cell adhesion molecule
ISO
protein:decreased expression:penis erectile tissue
RGD
PMID:24023647
RGD:7364777
NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024
G
Nos1
nitric oxide synthase 1, neuronal
treatment
ISO
associated with Diabetes Mellitus, Experimental associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD
PMID:23698784 PMID:23522997 PMID:23535456
RGD:7244246 , RGD:7257657 , RGD:7257656
NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
G
Nos2
nitric oxide synthase 2, inducible
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:19554009
RGD:2313212
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
G
Nos3
nitric oxide synthase 3, endothelial cell
treatment
ISO
associated with Cocaine-Related Disorders;protein:decreased expression:penis CTD Direct Evidence: marker/mechanism|therapeutic associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD RGD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:29260891 PMID:20807325
RGD:2292142 , RGD:13504711 , RGD:4891999
NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
G
P2ry1
purinergic receptor P2Y, G-protein coupled 1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403
G
P2ry2
purinergic receptor P2Y, G-protein coupled 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr 7:100,645,775...100,661,260
Ensembl chr 7:100,645,775...100,662,073
G
Pde5a
phosphodiesterase 5A, cGMP-specific
ISO
associated with Hypercholesterolemia associated with Diabetes Mellitus, Experimental
RGD
PMID:15667904 PMID:15920460 PMID:15578039
RGD:2314520 , RGD:2314519 , RGD:2314521
NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
G
Prkg1
protein kinase, cGMP-dependent, type I
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue
RGD
PMID:17355372
RGD:7775062
NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
G
Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
G
Shbg
sex hormone binding globulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17961146
NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
G
Sirt1
sirtuin 1
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
G
Tgfb1
transforming growth factor, beta 1
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:18778311 PMID:27051243
RGD:2306738 , RGD:14995446
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
G
Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:11596671
RGD:2312459
NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
G
Tnf
tumor necrosis factor
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
G
Vip
vasoactive intestinal polypeptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10233493
NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
G
Xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
susceptibility
ISO
associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H
RGD
PMID:18582155
RGD:2302570
NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865
G
Angpt2
angiopoietin 2
ISO
associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat)
RGD
PMID:16750245
RGD:2314210
NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578
G
Apod
apolipoprotein D
ISO
mRNA:increased expression:penis erectile tissue
RGD
PMID:11444882
RGD:2311196
NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626
G
Pde5a
phosphodiesterase 5A, cGMP-specific
ISO
RGD
PMID:17287493
RGD:2314469
NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
G
Tgfbr2
transforming growth factor, beta receptor II
ISO
protein:increased expression:penis erectile tissue
RGD
PMID:14718046
RGD:1601627
NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all