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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms:exact_synonym: Physiological Sexual Disorder;   physiological sexual disorders;   physiological sexual dysfunction;   physiological sexual dysfunctions;   sex disorders
 narrow_synonym: antidepressant-induced sexual dysfunction
 primary_id: MESH:D012735
 xref: EFO:0004714;   EFO:0006322;   ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Ptger1 prostaglandin E receptor 1 (subtype EP1) ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 8:84,393,171...84,399,385
Ensembl chr 8:84,393,307...84,399,382
JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277
JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668
JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamtsl2 ADAMTS-like 2 IAGP MouseDO NCBI chr 2:26,969,348...26,998,993
Ensembl chr 2:26,969,391...26,998,993
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Agt angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bad BCL2-associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
JBrowse link
G Bax BCL2-associated X protein treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
CTD
RGD
PMID:12394778 PMID:12394778 PMID:21235725 RGD:1579980, RGD:10053666 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12394778 PMID:12394778 RGD:1579980 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
JBrowse link
G Cfl1 cofilin 1, non-muscle treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25923835 PMID:25444982 RGD:11568706, RGD:11570410 NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058
JBrowse link
G Edn1 endothelin 1 ISO protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:12002441 PMID:17420087 RGD:2292142 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednra endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18823320 PMID:17420087 RGD:2292142 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Gja1 gap junction protein, alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250
JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:24576658 PMID:21595839 RGD:10402763, RGD:10402765 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Il6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827, RGD:9495931 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Kdr kinase insert domain protein receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Mcam melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr 9:44,045,958...44,054,024
Ensembl chr 9:44,045,766...44,054,024
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal treatment ISO associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD PMID:23698784 PMID:23522997 PMID:23535456 RGD:7244246, RGD:7257657, RGD:7257656 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD
RGD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:29260891 PMID:20807325 RGD:2292142, RGD:13504711, RGD:4891999 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403
JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 7:100,645,775...100,661,260
Ensembl chr 7:100,645,775...100,662,073
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15667904 PMID:15920460 PMID:15578039 RGD:2314520, RGD:2314519, RGD:2314521 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:2306738, RGD:14995446 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vip vasoactive intestinal polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865
JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578
JBrowse link
G Apod apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific ISO RGD PMID:17287493 RGD:2314469 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15862
      reproductive system disease 3167
        male reproductive system disease 2011
          sexual dysfunction 50
            impotence + 46
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15862
      Urogenital Diseases 5059
        reproductive system disease 3167
          male reproductive system disease 2011
            sexual dysfunction 50
              impotence + 46
              premature ejaculation 0
              psychologic dyspareunia 0
              psychologic vaginismus 0
paths to the root