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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sexual dysfunction
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Accession:DOID:1876 term browser browse the term
Definition:A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms:exact_synonym: Physiological Sexual Disorder;   physiological sexual disorders;   physiological sexual dysfunction;   physiological sexual dysfunctions;   sex disorders
 narrow_synonym: antidepressant-induced sexual dysfunction
 primary_id: MESH:D012735
 xref: EFO:0004714;   EFO:0006322;   ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase EXP CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chr 6:110,388,321...110,415,575
Ensembl chr 6:110,391,771...110,415,575 		JBrowse link
G PRL prolactin EXP CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PTGER1 prostaglandin E receptor 1 EXP CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr19:14,472,466...14,475,354
Ensembl chr19:14,472,466...14,475,354 		JBrowse link
G PTGER2 prostaglandin E receptor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,329,822 		JBrowse link
G PTGER4 prostaglandin E receptor 4 EXP CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTSL2 ADAMTS like 2 ISS MouseDO NCBI chr 9:133,532,164...133,575,519
Ensembl chr 9:133,532,164...133,575,519 		JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AGT angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO
EXP		 CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:12394778 PMID:12394778 PMID:21235725 RGD:1579980, RGD:10053666 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12394778 PMID:12394778 RGD:1579980 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCND1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353 		JBrowse link
G CFL1 cofilin 1 treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25923835 PMID:25444982 RGD:11568706, RGD:11570410 NCBI chr11:65,854,673...65,858,180
Ensembl chr11:65,823,022...65,862,026 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G DYNLL1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493 		JBrowse link
G EDN1 endothelin 1 ISO
EXP		 protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12002441 PMID:17420087 RGD:2292142 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18823320 PMID:17420087 RGD:2292142 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G FABP4 fatty acid binding protein 4 ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FGF2 fibroblast growth factor 2 IDA associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A EXP CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 9:101,569,352...101,738,647
Ensembl chr 9:101,569,352...101,738,647 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G HDAC3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849 		JBrowse link
G HDAC4 histone deacetylase 4 IEP protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 2:239,048,168...239,401,649
NCBI chr 2:239,193,331...239,195,457
Ensembl chr 2:239,048,168...239,401,654 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:24576658 PMID:21595839 RGD:10402763, RGD:10402765 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874 		JBrowse link
G IL6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827, RGD:9495931 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G MCAM melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr11:119,308,529...119,317,130
Ensembl chr11:119,308,529...119,321,521 		JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue		 RGD PMID:23698784 PMID:23535456 PMID:23522997 RGD:7244246, RGD:7257656, RGD:7257657 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO
EXP		 associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity		 CTD
RGD		 PMID:12002441 PMID:17071732 PMID:17420087 PMID:29260891 PMID:20807325 RGD:2292142, RGD:13504711, RGD:4891999 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G P2RY1 purinergic receptor P2Y1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439 		JBrowse link
G P2RY2 purinergic receptor P2Y2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr11:73,218,281...73,242,427
Ensembl chr11:73,218,281...73,242,427 		JBrowse link
G PDE5A phosphodiesterase 5A ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental		 RGD PMID:15667904 PMID:15920460 PMID:15578039 RGD:2314520, RGD:2314519, RGD:2314521 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423 		JBrowse link
G PRL prolactin EXP CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G SHBG sex hormone binding globulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G SIRT1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:2306738, RGD:14995446 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THBD thrombomodulin IEP associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672 		JBrowse link
G TNF tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G VEGFA vascular endothelial growth factor A EXP CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIP vasoactive intestinal peptide EXP CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility IAGP associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473 		JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409 		JBrowse link
G APOD apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr 3:195,568,705...195,583,940
Ensembl chr 3:195,568,705...195,584,033 		JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:17287493 RGD:2314469 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 IEP protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 121159
    disease of anatomical entity 111930
      reproductive system disease 9559
        male reproductive system disease 5926
          sexual dysfunction 120
            impotence + 103
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 121159
    disease of anatomical entity 111930
      Urogenital Diseases 14367
        reproductive system disease 9559
          male reproductive system disease 5926
            sexual dysfunction 120
              impotence + 103
              premature ejaculation 0
              psychologic dyspareunia 0
              psychologic vaginismus 0
paths to the root