RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: sexual dysfunction
Accession: DOID:1876
browse the term
Definition: A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms: exact_synonym: Physiological Sexual Disorder; physiological sexual disorders; physiological sexual dysfunction; physiological sexual dysfunctions; sex disorders
narrow_synonym: antidepressant-induced sexual dysfunction
primary_id: MESH:D012735
xref: EFO:0004714 ; EFO:0006322 ; ICD10CM:F52.9 ; ICD10CM:R37 ; NCI:C3347
For additional species annotation, visit the
Alliance of Genome Resources .
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Ddo
D-aspartate oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16525061
NCBI chrNW_004955411:35,142,415...35,163,234
Ensembl chrNW_004955411:35,143,735...35,163,276
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Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10084644 PMID:15677431
NCBI chrNW_004955483:4,495,257...4,503,377
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Ptger1
prostaglandin E receptor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chrNW_004955415:33,063,052...33,067,580
Ensembl chrNW_004955415:33,063,052...33,067,580
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Ptger2
prostaglandin E receptor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chrNW_004955409:10,760,801...10,775,197
Ensembl chrNW_004955409:10,757,888...10,774,688
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Ptger4
prostaglandin E receptor 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822
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Adamtsl2
ADAMTS like 2
ISO
MouseDO
NCBI chrNW_004955513:2,849,310...2,879,130
Ensembl chrNW_004955513:2,849,271...2,879,848
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Ager
advanced glycosylation end-product specific receptor
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:23698784
RGD:7244246
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Agt
angiotensinogen
treatment
ISO
RGD
PMID:17616753
RGD:8548892
NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
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Akt1
AKT serine/threonine kinase 1
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Bad
BCL2 associated agonist of cell death
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245
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Bax
BCL2 associated X, apoptosis regulator
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
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Bcl2
BCL2 apoptosis regulator
treatment
ISO
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Experimental
CTD RGD
PMID:12394778 PMID:21235725
RGD:10053666 RGD:1579980
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
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Bcl2l1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12394778
RGD:1579980
NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
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Casp3
caspase 3
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chrNW_004955403:24,315,712...24,326,271
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Ccnd1
cyclin D1
ISO
mRNA:decreased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chrNW_004955422:16,449,921...16,462,676
Ensembl chrNW_004955422:16,448,770...16,463,300
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Ccnd2
cyclin D2
ISO
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis
RGD
PMID:18068478
RGD:2289159
NCBI chrNW_004955413:2,083,351...2,108,450
Ensembl chrNW_004955413:2,083,351...2,103,430
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Cfl1
cofilin 1
treatment
ISO
protein:increased phosphorylation:corpus cavernosum penis (rat)
RGD
PMID:25444982 PMID:25923835
RGD:11568706 RGD:11570410
NCBI chrNW_004955422:19,479,181...19,482,571
Ensembl chrNW_004955422:19,479,181...19,482,571
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Cnr1
cannabinoid receptor 1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:17850365
RGD:2314634
NCBI chrNW_004955411:15,052,151...15,077,320
Ensembl chrNW_004955411:15,052,163...15,077,320
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Dynll1
dynein light chain LC8-type 1
treatment
ISO
RGD
PMID:17433082
RGD:13207433
NCBI chrNW_004955455:11,148,041...11,150,860
Ensembl chrNW_004955455:11,148,047...11,150,859
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Edn1
endothelin 1
ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12002441 PMID:17420087
RGD:2292142
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Ednra
endothelin receptor type A
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17420087 PMID:18823320
RGD:2292142
NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761
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Fabp4
fatty acid binding protein 4
ISO
associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chrNW_004955444:141,955...146,279
Ensembl chrNW_004955444:141,840...148,467
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Fgf2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:15758817
RGD:2315866
NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773
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Gja1
gap junction protein alpha 1
ISO
mRNA, protein:decreased expression:corpus cavernosum penis
RGD
PMID:17146929
RGD:8662385
NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
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Grin3a
glutamate ionotropic receptor NMDA type subunit 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19295509
NCBI chrNW_004955419:24,105,360...24,272,533
Ensembl chrNW_004955419:24,104,820...24,273,113
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Grk2
G protein-coupled receptor kinase 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:30226217
RGD:13792691
NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
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Hdac3
histone deacetylase 3
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chrNW_004955415:12,138,520...12,154,234
Ensembl chrNW_004955415:12,138,870...12,154,234
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Hdac4
histone deacetylase 4
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chrNW_004955542:1,629,691...1,886,160
Ensembl chrNW_004955542:1,629,691...1,886,210
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Igfbp3
insulin like growth factor binding protein 3
treatment
ISO
mRNA, protein:increased expression:penis
RGD
PMID:21595839 PMID:24576658
RGD:10402763 RGD:10402765
NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845
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Il6
interleukin 6
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:21492407 PMID:24467772
RGD:10402827 RGD:9495931
NCBI chrNW_004955410:25,079,835...25,084,390
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Kdr
kinase insert domain receptor
ISO
RGD
PMID:16422887
RGD:5684417
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Mcam
melanoma cell adhesion molecule
ISO
protein:decreased expression:penis erectile tissue
RGD
PMID:24023647
RGD:7364777
NCBI chrNW_004955412:20,396,056...20,404,777
Ensembl chrNW_004955412:20,397,051...20,404,780
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Nos1
nitric oxide synthase 1
treatment
ISO
associated with Diabetes Mellitus, Experimental associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD
PMID:23522997 PMID:23535456 PMID:23698784
RGD:7244246 RGD:7257656 RGD:7257657
NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566
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Nos2
nitric oxide synthase 2
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:19554009
RGD:2313212
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
treatment
ISO
associated with Cocaine-Related Disorders;protein:decreased expression:penis associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891
RGD:13504711 RGD:2292142 RGD:4891999
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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P2ry1
purinergic receptor P2Y1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chrNW_004955448:4,366,706...4,372,626
Ensembl chrNW_004955448:4,366,706...4,372,626
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P2ry2
purinergic receptor P2Y2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chrNW_004955414:18,248,082...18,271,047
Ensembl chrNW_004955414:18,248,082...18,260,450
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Pde5a
phosphodiesterase 5A
ISO
associated with Hypercholesterolemia associated with Diabetes Mellitus, Experimental
RGD
PMID:15578039 PMID:15667904 PMID:15920460
RGD:2314519 RGD:2314520 RGD:2314521
NCBI chrNW_004955428:20,785,497...20,904,717
Ensembl chrNW_004955428:20,785,423...20,904,717
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Prkg1
protein kinase cGMP-dependent 1
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue
RGD
PMID:17355372
RGD:7775062
NCBI chrNW_004955425:6,176,335...7,335,867
Ensembl chrNW_004955425:6,176,432...7,331,446
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Prl
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128
NCBI chrNW_004955483:4,495,257...4,503,377
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Shbg
sex hormone binding globulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17961146
NCBI chrNW_004955467:9,301,173...9,305,010
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Sirt1
sirtuin 1
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
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Tgfb1
transforming growth factor beta 1
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:18778311 PMID:27051243
RGD:14995446 RGD:2306738
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Thbd
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:11596671
RGD:2312459
NCBI chrNW_004955415:30,222,830...30,226,406
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Tnf
tumor necrosis factor
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441
NCBI chrNW_004955437:9,527,445...9,541,908
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Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10233493
NCBI chrNW_004955439:9,021,923...9,031,783
Ensembl chrNW_004955439:9,021,904...9,031,792
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Xrcc1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H
RGD
PMID:18582155
RGD:2302570
NCBI chrNW_004955555:1,293,416...1,315,839
Ensembl chrNW_004955555:1,293,416...1,315,839
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Angpt2
angiopoietin 2
ISO
associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat)
RGD
PMID:16750245
RGD:2314210
NCBI chrNW_004955403:54,139,823...54,193,740
Ensembl chrNW_004955403:54,139,823...54,195,032
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Apod
apolipoprotein D
ISO
mRNA:increased expression:penis erectile tissue
RGD
PMID:11444882
RGD:2311196
NCBI chrNW_004955420:13,553,254...13,570,357
Ensembl chrNW_004955420:13,553,058...13,573,690
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Pde5a
phosphodiesterase 5A
ISO
RGD
PMID:17287493
RGD:2314469
NCBI chrNW_004955428:20,785,497...20,904,717
Ensembl chrNW_004955428:20,785,423...20,904,717
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Tgfbr2
transforming growth factor beta receptor 2
ISO
protein:increased expression:penis erectile tissue
RGD
PMID:14718046
RGD:1601627
NCBI chrNW_004955430:21,919,338...21,999,688
Ensembl chrNW_004955430:21,932,553...22,001,837
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