Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:sexual dysfunction
go back to main search page
Accession:DOID:1876 term browser browse the term
Definition:A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms:exact_synonym: Physiological Sexual Disorder;   physiological sexual disorders;   physiological sexual dysfunction;   physiological sexual dysfunctions;   sex disorders
 narrow_synonym: antidepressant-induced sexual dysfunction
 primary_id: MESH:D012735
 xref: EFO:0004714;   EFO:0006322;   ICD10CM:F52.9;   ICD10CM:R37;   NCI:C3347
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
sexual dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16525061 NCBI chr 6:108,199,861...108,223,844
Ensembl chr 6:112,269,271...112,292,980
JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10084644 PMID:15677431 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
JBrowse link
G PTGER1 prostaglandin E receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr19:14,035,876...14,038,812 JBrowse link
G PTGER2 prostaglandin E receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr14:32,910,755...32,926,138
Ensembl chr14:51,195,381...51,209,686
JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18726914 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
JBrowse link
impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTSL2 ADAMTS like 2 ISO MouseDO NCBI chr 9:104,658,540...104,698,854
Ensembl chr 9:133,269,369...133,309,602
JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G AGT angiotensinogen treatment ISO RGD PMID:17616753 RGD:8548892 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G AKT1 AKT serine/threonine kinase 1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G BAD BCL2 associated agonist of cell death treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:12394778 PMID:21235725 RGD:10053666 RGD:1579980 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
JBrowse link
G BCL2L1 BCL2 like 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:12394778 RGD:1579980 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585
JBrowse link
G CASP3 caspase 3 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
JBrowse link
G CCND1 cyclin D1 ISO mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr11:64,737,006...64,750,353 JBrowse link
G CCND2 cyclin D2 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr12:4,385,957...4,417,602
Ensembl chr12:4,309,272...4,335,551
JBrowse link
G CFL1 cofilin 1 treatment ISO protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25444982 PMID:25923835 RGD:11568706 RGD:11570410 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806
JBrowse link
G CNR1 cannabinoid receptor 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 6:86,017,141...86,044,889 JBrowse link
G DYNLL1 dynein light chain LC8-type 1 treatment ISO RGD PMID:17433082 RGD:13207433 NCBI chr12:118,078,401...118,080,822
Ensembl chr12:121,452,118...121,454,550
JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD
RGD
PMID:12002441 PMID:17420087 RGD:2292142 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G EDNRA endothelin receptor type A ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:17420087 PMID:18823320 RGD:2292142 NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497
JBrowse link
G FABP4 fatty acid binding protein 4 ISO associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 8:78,001,476...78,006,006
Ensembl chr 8:79,624,899...79,630,168
JBrowse link
G FGF2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942
JBrowse link
G GJA1 gap junction protein alpha 1 ISO mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GRIN3A glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 9:72,773,866...72,943,790
Ensembl chr 9:100,767,715...100,941,323
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G HDAC3 histone deacetylase 3 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 5:136,981,790...136,997,786
Ensembl chr 5:143,094,406...143,110,322
JBrowse link
G HDAC4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 treatment ISO mRNA, protein:increased expression:penis RGD PMID:21595839 PMID:24576658 RGD:10402763 RGD:10402765 NCBI chr 7:46,564,234...46,573,145 JBrowse link
G IL6 interleukin 6 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827 RGD:9495931 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:16422887 RGD:5684417 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G MCAM melanoma cell adhesion molecule ISO protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr11:114,149,583...114,158,234
Ensembl chr11:118,078,179...118,083,893
JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
associated with Diabetes Mellitus, Experimental
RGD PMID:23522997 PMID:23535456 PMID:23698784 RGD:7244246 RGD:7257656 RGD:7257657 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005
JBrowse link
G NOS2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
RGD
CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891 RGD:13504711 RGD:2292142 RGD:4891999 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
JBrowse link
G P2RY1 purinergic receptor P2Y1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 3:149,859,748...149,865,873
Ensembl chr 3:157,426,692...157,427,813
JBrowse link
G P2RY2 purinergic receptor P2Y2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr11:68,294,366...68,319,118
Ensembl chr11:71,532,958...71,534,091
JBrowse link
G PDE5A phosphodiesterase 5A ISO associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15578039 PMID:15667904 PMID:15920460 RGD:2314519 RGD:2314520 RGD:2314521 NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882
JBrowse link
G PRL prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
JBrowse link
G SHBG sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr17:7,658,831...7,664,631
Ensembl chr17:7,645,187...7,650,552
JBrowse link
G SIRT1 sirtuin 1 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G TGFB1 transforming growth factor beta 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:14995446 RGD:2306738 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
JBrowse link
G THBD thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
JBrowse link
G TNF tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
JBrowse link
G XRCC1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520
JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT2 angiopoietin 2 ISO associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915
JBrowse link
G APOD apolipoprotein D ISO mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr 3:192,852,887...192,868,233
Ensembl chr 3:203,152,476...203,168,060
JBrowse link
G PDE5A phosphodiesterase 5A ISO RGD PMID:17287493 RGD:2314469 NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15834
    disease of anatomical entity 15490
      reproductive system disease 3125
        male reproductive system disease 1988
          sexual dysfunction 50
            impotence + 46
            premature ejaculation 0
            psychologic dyspareunia 0
            psychologic vaginismus 0
Path 2
Term Annotations click to browse term
  disease 15834
    disease of anatomical entity 15490
      Urogenital Diseases 4909
        reproductive system disease 3125
          male reproductive system disease 1988
            sexual dysfunction 50
              impotence + 46
              premature ejaculation 0
              psychologic dyspareunia 0
              psychologic vaginismus 0
paths to the root