RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: sexual dysfunction
Accession: DOID:1876
browse the term
Definition: A male reproductive system disease that is characterized by disturbances in sexual desire or performance. (DO)
Synonyms: exact_synonym: Physiological Sexual Disorder; physiological sexual disorders; physiological sexual dysfunction; physiological sexual dysfunctions; sex disorders
narrow_synonym: antidepressant-induced sexual dysfunction
primary_id: MESH:D012735
xref: EFO:0004714 ; EFO:0006322 ; ICD10CM:F52.9 ; ICD10CM:R37 ; NCI:C3347
For additional species annotation, visit the
Alliance of Genome Resources .
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DDO
D-aspartate oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16525061
NCBI chr 6:108,199,861...108,223,844
Ensembl chr 6:112,269,271...112,292,980
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PRL
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10084644 PMID:15677431
NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
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PTGER1
prostaglandin E receptor 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr19:14,035,876...14,038,812
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PTGER2
prostaglandin E receptor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr14:32,910,755...32,926,138
Ensembl chr14:51,195,381...51,209,686
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PTGER4
prostaglandin E receptor 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18726914
NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148
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ADAMTSL2
ADAMTS like 2
ISO
MouseDO
NCBI chr 9:104,658,540...104,698,854
Ensembl chr 9:133,269,369...133,309,602
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AGER
advanced glycosylation end-product specific receptor
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:23698784
RGD:7244246
NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
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AGT
angiotensinogen
treatment
ISO
RGD
PMID:17616753
RGD:8548892
NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
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AKT1
AKT serine/threonine kinase 1
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
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BAD
BCL2 associated agonist of cell death
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257
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BAX
BCL2 associated X, apoptosis regulator
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468
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BCL2
BCL2 apoptosis regulator
treatment
ISO
associated with Diabetes Mellitus, Experimental CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12394778 PMID:21235725
RGD:10053666 RGD:1579980
NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
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BCL2L1
BCL2 like 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12394778
RGD:1579980
NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585
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CASP3
caspase 3
treatment
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:21235725
RGD:10053666
NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185
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CCND1
cyclin D1
ISO
mRNA:decreased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr11:64,737,006...64,750,353
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CCND2
cyclin D2
ISO
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis
RGD
PMID:18068478
RGD:2289159
NCBI chr12:4,385,957...4,417,602
Ensembl chr12:4,309,272...4,335,551
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CFL1
cofilin 1
treatment
ISO
protein:increased phosphorylation:corpus cavernosum penis (rat)
RGD
PMID:25444982 PMID:25923835
RGD:11568706 RGD:11570410
NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806
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CNR1
cannabinoid receptor 1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:17850365
RGD:2314634
NCBI chr 6:86,017,141...86,044,889
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DYNLL1
dynein light chain LC8-type 1
treatment
ISO
RGD
PMID:17433082
RGD:13207433
NCBI chr12:118,078,401...118,080,822
Ensembl chr12:121,452,118...121,454,550
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EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma
CTD RGD
PMID:12002441 PMID:17420087
RGD:2292142
NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
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EDNRA
endothelin receptor type A
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17420087 PMID:18823320
RGD:2292142
NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497
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FABP4
fatty acid binding protein 4
ISO
associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue
RGD
PMID:17137605
RGD:1625408
NCBI chr 8:78,001,476...78,006,006
Ensembl chr 8:79,624,899...79,630,168
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FGF2
fibroblast growth factor 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:15758817
RGD:2315866
NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942
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GJA1
gap junction protein alpha 1
ISO
mRNA, protein:decreased expression:corpus cavernosum penis
RGD
PMID:17146929
RGD:8662385
NCBI chr 6:119,213,513...119,227,617
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GRIN3A
glutamate ionotropic receptor NMDA type subunit 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19295509
NCBI chr 9:72,773,866...72,943,790
Ensembl chr 9:100,767,715...100,941,323
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GRK2
G protein-coupled receptor kinase 2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:30226217
RGD:13792691
NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
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HDAC3
histone deacetylase 3
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr 5:136,981,790...136,997,786
Ensembl chr 5:143,094,406...143,110,322
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HDAC4
histone deacetylase 4
ISO
protein:increased expression:penis:
RGD
PMID:24636283
RGD:9590194
NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054
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IGFBP3
insulin like growth factor binding protein 3
treatment
ISO
mRNA, protein:increased expression:penis
RGD
PMID:21595839 PMID:24576658
RGD:10402763 RGD:10402765
NCBI chr 7:46,564,234...46,573,145
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IL6
interleukin 6
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:21492407 PMID:24467772
RGD:10402827 RGD:9495931
NCBI chr 7:23,415,922...23,420,767
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KDR
kinase insert domain receptor
ISO
RGD
PMID:16422887
RGD:5684417
NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
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MCAM
melanoma cell adhesion molecule
ISO
protein:decreased expression:penis erectile tissue
RGD
PMID:24023647
RGD:7364777
NCBI chr11:114,149,583...114,158,234
Ensembl chr11:118,078,179...118,083,893
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NOS1
nitric oxide synthase 1
treatment
ISO
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue associated with Diabetes Mellitus, Experimental
RGD
PMID:23522997 PMID:23535456 PMID:23698784
RGD:7244246 RGD:7257656 RGD:7257657
NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005
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NOS2
nitric oxide synthase 2
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:19554009
RGD:2313212
NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093
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NOS3
nitric oxide synthase 3
treatment
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity associated with Cocaine-Related Disorders;protein:decreased expression:penis CTD Direct Evidence: marker/mechanism|therapeutic
RGD CTD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:20807325 PMID:29260891
RGD:13504711 RGD:2292142 RGD:4891999
NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233
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P2RY1
purinergic receptor P2Y1
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr 3:149,859,748...149,865,873
Ensembl chr 3:157,426,692...157,427,813
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P2RY2
purinergic receptor P2Y2
ISO
associated with Diabetes Mellitus, Experimental
RGD
PMID:19303093
RGD:2315809
NCBI chr11:68,294,366...68,319,118
Ensembl chr11:71,532,958...71,534,091
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PDE5A
phosphodiesterase 5A
ISO
associated with Hypercholesterolemia associated with Diabetes Mellitus, Experimental
RGD
PMID:15578039 PMID:15667904 PMID:15920460
RGD:2314519 RGD:2314520 RGD:2314521
NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636
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PRKG1
protein kinase cGMP-dependent 1
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue
RGD
PMID:17355372
RGD:7775062
NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882
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PRL
prolactin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128
NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
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SHBG
sex hormone binding globulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17961146
NCBI chr17:7,658,831...7,664,631
Ensembl chr17:7,645,187...7,650,552
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SIRT1
sirtuin 1
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
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TGFB1
transforming growth factor beta 1
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expression:penis
RGD
PMID:18778311 PMID:27051243
RGD:14995446 RGD:2306738
NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973
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THBD
thrombomodulin
ISO
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
RGD
PMID:11596671
RGD:2312459
NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812
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TNF
tumor necrosis factor
treatment
ISO
associated with Diabetes Mellitus, Type 2
RGD
PMID:24467772
RGD:9495931
NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
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VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12002441
NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
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VIP
vasoactive intestinal peptide
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:10233493
NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730
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XRCC1
X-ray repair cross complementing 1
susceptibility
ISO
associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H
RGD
PMID:18582155
RGD:2302570
NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520
G
ANGPT2
angiopoietin 2
ISO
associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat)
RGD
PMID:16750245
RGD:2314210
NCBI chr 8:718,367...782,534
Ensembl chr 8:6,506,014...6,566,915
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APOD
apolipoprotein D
ISO
mRNA:increased expression:penis erectile tissue
RGD
PMID:11444882
RGD:2311196
NCBI chr 3:192,852,887...192,868,233
Ensembl chr 3:203,152,476...203,168,060
G
PDE5A
phosphodiesterase 5A
ISO
RGD
PMID:17287493
RGD:2314469
NCBI chr 4:111,682,772...111,817,234
Ensembl chr 4:122,832,175...122,966,636
G
TGFBR2
transforming growth factor beta receptor 2
ISO
protein:increased expression:penis erectile tissue
RGD
PMID:14718046
RGD:1601627
NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856
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