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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:impotence
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Accession:DOID:1875 term browser browse the term
Definition:A sexual dysfunction that is characterized by persistent or recurrent inability to achieve or to maintain an erection during sexual activity. (DO)
Synonyms:exact_synonym: erectile dysfunction;   male impotence;   male sexual impotence;   sexual impotence
 primary_id: MESH:D007172
 xref: EFO:0004234;   NCI:C3133
For additional species annotation, visit the Alliance of Genome Resources.



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impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamtsl2 ADAMTS-like 2 ISS MouseDO NCBI chr 3:10,397,774...10,434,557 JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:23698784 RGD:7244246 NCBI chr20:4,152,758...4,155,956 JBrowse link
G Agt angiotensinogen treatment IDA RGD PMID:17616753 RGD:8548892 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 1:213,562,719...213,572,034 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
CTD
RGD
PMID:12394778 PMID:12394778 PMID:21235725 RGD:1579980, RGD:10053666 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l1 Bcl2-like 1 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12394778 PMID:12394778 RGD:1579980 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Casp3 caspase 3 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21235725 RGD:10053666 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Ccnd1 cyclin D1 IEP mRNA:decreased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Ccnd2 cyclin D2 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:penis RGD PMID:18068478 RGD:2289159 NCBI chr 4:161,653,048...161,675,422 JBrowse link
G Cfl1 cofilin 1 treatment IEP protein:increased phosphorylation:corpus cavernosum penis (rat) RGD PMID:25923835 PMID:25444982 RGD:11568706, RGD:11570410 NCBI chr 1:212,227,124...212,230,656 JBrowse link
G Cnr1 cannabinoid receptor 1 IMP associated with Diabetes Mellitus, Experimental RGD PMID:17850365 RGD:2314634 NCBI chr 5:53,204,867...53,230,396 JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment IMP RGD PMID:17433082 RGD:13207433 NCBI chr12:46,945,291...46,976,867 JBrowse link
G Edn1 endothelin 1 IEP
ISO
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:12002441 PMID:17420087 RGD:2292142 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Ednra endothelin receptor type A IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18823320 PMID:17420087 RGD:2292142 NCBI chr19:47,137,360...47,207,961 JBrowse link
G Fabp4 fatty acid binding protein 4 IEP associated with hypercholesterolemia;mRNA:increased expression:penis erectile tissue RGD PMID:17137605 RGD:1625408 NCBI chr 2:93,488,251...93,492,961 JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:15758817 RGD:2315866 NCBI chr 2:122,164,454...122,218,796 JBrowse link
G Gja1 gap junction protein, alpha 1 IEP mRNA, protein:decreased expression:corpus cavernosum penis RGD PMID:17146929 RGD:8662385 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr 5:64,006,847...64,206,408 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP associated with Diabetes Mellitus, Experimental RGD PMID:30226217 RGD:13792691 NCBI chr 1:211,010,259...211,031,013 JBrowse link
G Hdac3 histone deacetylase 3 IEP protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr18:29,770,637...29,789,850 JBrowse link
G Hdac4 histone deacetylase 4 ISO protein:increased expression:penis: RGD PMID:24636283 RGD:9590194 NCBI chr 9:99,950,972...100,200,994 JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment IMP
IEP
mRNA, protein:increased expression:penis RGD PMID:24576658 PMID:21595839 RGD:10402763, RGD:10402765 NCBI chr14:86,270,208...86,277,944 JBrowse link
G Il6 interleukin 6 treatment IMP
IEP
associated with Diabetes Mellitus, Type 2 RGD PMID:21492407 PMID:24467772 RGD:10402827, RGD:9495931 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:16422887 RGD:5684417 NCBI chr14:32,572,031...32,615,204 JBrowse link
G Mcam melanoma cell adhesion molecule IEP protein:decreased expression:penis erectile tissue RGD PMID:24023647 RGD:7364777 NCBI chr 8:44,479,391...44,487,575 JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA
IEP
associated with Diabetes Mellitus, Experimental
associated with Urethral Obstruction;protein:decreased expression:penis erectile tissue
RGD PMID:23698784 PMID:23522997 PMID:23535456 RGD:7244246, RGD:7257657, RGD:7257656 NCBI chr12:44,276,011...44,456,371 JBrowse link
G Nos2 nitric oxide synthase 2 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:19554009 RGD:2313212 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
ISO
associated with Cocaine-Related Disorders;protein:decreased expression:penis
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression, decreased activity
CTD
RGD
PMID:12002441 PMID:17071732 PMID:17420087 PMID:29260891 PMID:20807325 RGD:2292142, RGD:13504711, RGD:4891999 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G P2ry1 purinergic receptor P2Y1 IDA associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 2:145,241,975...145,248,186 JBrowse link
G P2ry2 purinergic receptor P2Y2 IDA associated with Diabetes Mellitus, Experimental RGD PMID:19303093 RGD:2315809 NCBI chr 1:164,764,119...164,779,578 JBrowse link
G Pde5a phosphodiesterase 5A IMP associated with Hypercholesterolemia
associated with Diabetes Mellitus, Experimental
RGD PMID:15920460 PMID:15578039 PMID:15667904 RGD:2314519, RGD:2314521, RGD:2314520 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IEP associated with Diabetes Mellitus, Experimental;protein:decreased expression:penis erectile tissue RGD PMID:17355372 RGD:7775062 NCBI chr 1:237,818,950...239,052,184 JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:387166 PMID:4001434 PMID:7878608 PMID:8845563 PMID:15829128 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17961146 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Sirt1 sirtuin 1 treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:penis RGD PMID:18778311 PMID:27051243 RGD:2306738, RGD:14995446 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11596671 RGD:2312459 NCBI chr 3:156,316,526...156,320,178 JBrowse link
G Tnf tumor necrosis factor treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:24467772 RGD:9495931 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12002441 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:10233493 NCBI chr 1:44,470,232...44,478,561 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO associated with Prostatic Neoplasms;DNA:polymorphism: :p.R280H RGD PMID:18582155 RGD:2302570 NCBI chr 1:89,268,721...89,296,619 JBrowse link
vasculogenic impotence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 IEP associated with Hypercholesterolemia; mRNA, protein:decreased expression:cavernous body of penis (rat) RGD PMID:16750245 RGD:2314210 NCBI chr16:71,088,364...71,138,805 JBrowse link
G Apod apolipoprotein D IEP mRNA:increased expression:penis erectile tissue RGD PMID:11444882 RGD:2311196 NCBI chr11:82,936,216...82,957,264 JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:17287493 RGD:2314469 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO protein:increased expression:penis erectile tissue RGD PMID:14718046 RGD:1601627 NCBI chr 8:124,672,677...124,761,741 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      reproductive system disease 3191
        male reproductive system disease 2044
          sexual dysfunction 50
            impotence 46
              vasculogenic impotence 4
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      Urogenital Diseases 5391
        reproductive system disease 3191
          male reproductive system disease 2044
            sexual dysfunction 50
              impotence 46
                vasculogenic impotence 4
paths to the root