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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:A bladder disease that is characterized by inflammation of the bladder. (DO)
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556
 xref: EFO:1000025;   ICD10CM:N30;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.

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cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chrNW_004936672:3,461,387...3,468,053
Ensembl chrNW_004936672:3,460,383...3,468,255 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I ISO mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chrNW_004936478:7,278,081...7,322,970
Ensembl chrNW_004936478:7,278,147...7,318,458 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:9631447 PMID:20079809 RGD:5684910 RGD:8657090 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014 		JBrowse link
G Cat catalase ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Csf3 colony stimulating factor 3 ISO protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936490:15,142,526...15,146,375
Ensembl chrNW_004936490:15,142,808...15,144,487 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627 		JBrowse link
G Esr2 estrogen receptor 2 ISO protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chrNW_004936886:617,531...620,661
Ensembl chrNW_004936886:618,419...621,772 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118 RGD:7175333 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:21412823 RGD:5684428 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Lta lymphotoxin alpha ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004936727:1,940,081...1,941,022
Ensembl chrNW_004936727:1,940,081...1,941,022 		JBrowse link
G Mif macrophage migration inhibitory factor ISO mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002 RGD:4890977 NCBI chrNW_004936619:1,207,058...1,208,010
Ensembl chrNW_004936619:1,203,746...1,208,442 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004936816:60,499...91,628
Ensembl chrNW_004936816:60,499...91,628 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Ngf nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11350415 PMID:16889433 PMID:19996110 PMID:20127836 RGD:7242782 RGD:7242802 RGD:7242808 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Ngfr nerve growth factor receptor ISO protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chrNW_004936490:12,038,500...12,057,257
Ensembl chrNW_004936490:12,035,769...12,057,263 		JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chrNW_004936745:152,571...163,712
Ensembl chrNW_004936745:152,612...161,587 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chrNW_004936493:7,060,747...7,065,276
Ensembl chrNW_004936493:7,061,587...7,065,109 		JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004936518:1,903,636...1,916,746
Ensembl chrNW_004936518:1,903,725...1,916,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20602232 RGD:5135058 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Sod1 superoxide dismutase 1 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867 		JBrowse link
G Sod2 superoxide dismutase 2 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17382773 RGD:2304340 NCBI chrNW_004936556:1,266,621...1,421,271
Ensembl chrNW_004936556:1,266,613...1,421,275 		JBrowse link
G Tlr5 toll like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chrNW_004936526:383,490...387,007
Ensembl chrNW_004936526:383,418...401,552 		JBrowse link
G Tnf tumor necrosis factor ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tph2 tryptophan hydroxylase 2 ISO protein:increased expression:neuron, rostral ventromedial medulla RGD PMID:34628661 RGD:597830168 NCBI chrNW_004936568:974,575...1,065,800
Ensembl chrNW_004936568:974,767...1,065,804 		JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chrNW_004936487:15,721,752...15,725,396
Ensembl chrNW_004936487:15,721,684...15,728,221 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase ISO protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chrNW_004936504:5,985,407...5,987,453
Ensembl chrNW_004936504:5,985,960...5,987,210 		JBrowse link
G Aif1 allograft inflammatory factor 1 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004936727:1,907,493...1,909,350
Ensembl chrNW_004936727:1,907,505...1,909,338 		JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 Ensembl chrNW_004936599:973,838...983,316 JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004936646:379,849...385,648
Ensembl chrNW_004936646:379,842...385,877 		JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004936803:1,025,047...1,229,396
Ensembl chrNW_004936803:1,024,779...1,227,516 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chrNW_004936704:1,372,137...1,393,355
Ensembl chrNW_004936704:1,378,103...1,393,542 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chrNW_004936676:72,383...73,697
Ensembl chrNW_004936676:71,667...73,738 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chrNW_004936495:7,956,168...8,018,356
Ensembl chrNW_004936495:7,956,766...8,004,357 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004936476:23,237,762...23,310,211
Ensembl chrNW_004936476:23,237,277...23,310,232 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chrNW_004936486:15,561,327...15,587,109 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Ngf nerve growth factor treatment ISO protein:increased expression:serum, urine
mRNA:increased expression:urinary bladder 		RGD PMID:18162370 PMID:20227820 PMID:23028581 PMID:38842512 RGD:407445927 RGD:7242773 RGD:7242781 RGD:7242805 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nrg1 neuregulin 1 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004936766:1,104,841...1,306,368
Ensembl chrNW_004936766:1,104,728...1,305,972 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
trigonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Trigonitis ClinVar PMID:25741868 NCBI chrNW_004936602:1,089,979...1,114,376
Ensembl chrNW_004936602:1,051,205...1,117,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14641
    disease of anatomical entity 14330
      Urogenital Diseases 4671
        urinary system disease 2283
          bladder disease 408
            cystitis 55
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 24
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 1
paths to the root