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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:A bladder disease that is characterized by inflammation of the bladder. (DO)
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556
 xref: EFO:1000025;   ICD10CM:N30;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 ISO mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chr 6:55,428,486...55,478,440
Ensembl chr 6:55,428,963...55,478,436 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:20079809 PMID:9631447 RGD:5684910, RGD:8657090 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Cat catalase ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) ISO protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118, RGD:7175333 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:20860016 RGD:5147913 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Kdr kinase insert domain protein receptor ISO RGD PMID:21412823 RGD:5684428 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Lta lymphotoxin A ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002, RGD:4890977 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Muc2 mucin 2 ISO RGD PMID:17659847 RGD:7349345 NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO RGD PMID:17659847 RGD:7349345 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Ngf nerve growth factor treatment IDA
ISO
IEP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16889433 PMID:20127836 PMID:19996110 PMID:11350415 RGD:7242782, RGD:7242802, RGD:7242808 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO protein, mRNA:increased expression:lumbosacral dorsal root ganglia (rat) RGD PMID:18189308 RGD:5508447 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Pdcd1 programmed cell death 1 IMP RGD PMID:22432050 RGD:7248677 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) ISO RGD PMID:20860016 RGD:5147913 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20602232 RGD:5135058 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17382773 RGD:2304340 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tlr5 toll-like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010 		JBrowse link
G Tnf tumor necrosis factor ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tph2 tryptophan hydroxylase 2 ISO protein:increased expression:neuron, rostral ventromedial medulla RGD PMID:34628661 RGD:597830168 NCBI chr10:114,914,546...115,020,927
Ensembl chr10:114,914,546...115,020,927 		JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione reductase ISO protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenergic receptor, beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Aif1 allograft inflammatory factor 1 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:urinary bladder RGD PMID:38842512 RGD:407445927 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl11 chemokine (C-X-C motif) ligand 11 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chr 5:92,507,403...92,511,155
Ensembl chr 5:92,507,403...92,513,344 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Esr2 estrogen receptor 2 (beta) IMP RGD PMID:17522255 RGD:7364800 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 ISO RGD PMID:21166752 RGD:6483539 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Ngf nerve growth factor treatment ISO
IDA 		protein:increased expression:serum, urine
mRNA:increased expression:urinary bladder 		RGD PMID:23028581 PMID:38842512 PMID:18162370 PMID:20227820 RGD:7242773, RGD:407445927, RGD:7242805, RGD:7242781 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nrg1 neuregulin 1 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:16622179 RGD:7245525 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
trigonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Raf1 v-raf-leukemia viral oncogene 1 ISO ClinVar Annotator: match by term: Trigonitis ClinVar PMID:25741868 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15863
      Urogenital Diseases 5076
        urinary system disease 2512
          bladder disease 462
            cystitis 57
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 25
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 1
paths to the root