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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
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Accession:DOID:1679 term browser browse the term
Definition:A bladder disease that is characterized by inflammation of the bladder. (DO)
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556
 xref: EFO:1000025;   ICD10CM:N30;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chrNW_004955402:9,091,927...9,099,803
Ensembl chrNW_004955402:9,091,725...9,099,803 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I ISO mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chrNW_004955410:32,176,683...32,229,187
Ensembl chrNW_004955410:32,176,536...32,229,431 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:9631447 PMID:20079809 RGD:5684910 RGD:8657090 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588 		JBrowse link
G Cat catalase ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464 		JBrowse link
G Csf3 colony stimulating factor 3 ISO protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230 		JBrowse link
G Esr2 estrogen receptor 2 ISO protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chrNW_004955567:868,272...883,563
Ensembl chrNW_004955567:871,489...883,563 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118 RGD:7175333 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Kdr kinase insert domain receptor ISO RGD PMID:21412823 RGD:5684428 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583 		JBrowse link
G Lta lymphotoxin alpha ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529 		JBrowse link
G Mif macrophage migration inhibitory factor ISO mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002 RGD:4890977 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Ngf nerve growth factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11350415 PMID:16889433 PMID:19996110 PMID:20127836 RGD:7242782 RGD:7242802 RGD:7242808 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059 		JBrowse link
G Ngfr nerve growth factor receptor ISO protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305 		JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386 		JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:20860016 RGD:5147913 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:20602232 RGD:5135058 NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Sod1 superoxide dismutase 1 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Sod2 superoxide dismutase 2 ISO mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17382773 RGD:2304340 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872 		JBrowse link
G Tlr5 toll like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093 		JBrowse link
G Tnf tumor necrosis factor ISO mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Tph2 tryptophan hydroxylase 2 ISO protein:increased expression:neuron, rostral ventromedial medulla RGD PMID:34628661 RGD:597830168 NCBI chrNW_004955405:11,877,474...11,981,035
Ensembl chrNW_004955405:11,886,206...11,982,550 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase ISO protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980 		JBrowse link
G Aif1 allograft inflammatory factor 1 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004955437:157,509...158,919
Ensembl chrNW_004955437:157,509...158,919 		JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004955422:16,449,921...16,462,676
Ensembl chrNW_004955422:16,448,770...16,463,300 		JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004955458:3,555,603...3,561,063
Ensembl chrNW_004955458:3,555,603...3,562,120 		JBrowse link
G Cdk6 cyclin dependent kinase 6 ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004955432:9,521,794...9,727,772
Ensembl chrNW_004955432:9,521,794...9,726,417 		JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chrNW_004955435:13,404,236...13,423,059
Ensembl chrNW_004955435:13,404,508...13,424,247 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder 		CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chrNW_004955433:769,449...771,137
Ensembl chrNW_004955433:766,272...771,231 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004955451:14,442,816...14,456,009
Ensembl chrNW_004955451:14,442,816...14,459,379 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chrNW_004955466:5,587,003...5,644,765
Ensembl chrNW_004955466:5,575,088...5,638,946 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004955437:3,836,331...3,884,083
Ensembl chrNW_004955437:3,838,232...3,884,083 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chrNW_004955477:5,847,288...5,875,970 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Ngf nerve growth factor treatment ISO mRNA:increased expression:urinary bladder
protein:increased expression:serum, urine 		RGD PMID:18162370 PMID:20227820 PMID:23028581 PMID:38842512 RGD:407445927 RGD:7242773 RGD:7242781 RGD:7242805 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961 		JBrowse link
G Nrg1 neuregulin 1 disease_progression ISO RGD PMID:30989724 RGD:405295490 NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chrNW_004955435:5,390,745...5,410,025
Ensembl chrNW_004955435:5,390,751...5,411,691 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
trigonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Trigonitis ClinVar PMID:25741868 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14341
    disease of anatomical entity 14034
      Urogenital Diseases 4572
        urinary system disease 2238
          bladder disease 399
            cystitis 54
              Pyelocystitis 0
              acute cystitis + 0
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 23
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 1
paths to the root