Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cystitis
go back to main search page
Accession:DOID:1679 term browser browse the term
Definition:A bladder disease that is characterized by inflammation of the bladder. (DO)
Synonyms:exact_synonym: Cystitides
 primary_id: MESH:D003556
 xref: EFO:1000025;   ICD10CM:N30;   ICD9CM:595;   NCI:C26738
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IEP mRNA:increased expression:urinary bladder urothelium RGD PMID:18563302 RGD:2315964 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I IEP mRNA:increased expression:urothelium, detrusor muscle (rat) RGD PMID:18563302 RGD:2315964 NCBI chr 4:85,924,171...85,972,973
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
IEP		 RGD PMID:20079809 PMID:9631447 RGD:5684910, RGD:8657090 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Csf3 colony stimulating factor 3 IEP protein:increased expression:urinary bladder RGD PMID:18848347 RGD:2317284 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP protein:increased expression:urinary bladder urothelium RGD PMID:16651033 RGD:4891972 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Esr2 estrogen receptor 2 IEP protein:decreased expression:bladder RGD PMID:16894621 RGD:5508847 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: therapeutic CTD PMID:17980069 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il18 interleukin 18 IEP protein:increased expression:urine, bladder RGD PMID:18848347 RGD:2317284 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta IEP
IDA		 mRNA, protein:increased expression:urinary bladder RGD PMID:11948286 PMID:23000860 RGD:6907118, RGD:7175333 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kdr kinase insert domain receptor IDA RGD PMID:21412823 RGD:5684428 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lta lymphotoxin alpha IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mif macrophage migration inhibitory factor IEP mRNA, protein:increased expression:nervous system RGD PMID:12853844 PMID:19066630 RGD:1642002, RGD:4890977 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:bladder RGD PMID:19418724 RGD:7174704 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO RGD PMID:17659847 RGD:7349345 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ngf nerve growth factor treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16889433 PMID:20127836 PMID:19996110 PMID:11350415 RGD:7242782, RGD:7242802, RGD:7242808 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IEP protein, mRNA:increased expression:lumbosacral dorsal root ganglia RGD PMID:18189308 RGD:5508447 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Pdcd1 programmed cell death 1 ISO RGD PMID:22432050 RGD:7248677 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1267567 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IDA RGD PMID:20860016 RGD:5147913 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:20602232 RGD:5135058 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099998 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 IEP mRNA:decreased expression:urinary bladder RGD PMID:26109091 RGD:11035303 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17382773 RGD:2304340 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tlr5 toll-like receptor 5 severity ISO DNA:nonsense mutation:cds:p.R392X (human) RGD PMID:19543401 RGD:7246906 NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA:increased expression:urinary bladder RGD PMID:11948286 RGD:6907118 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tph2 tryptophan hydroxylase 2 IEP protein:increased expression:neuron, rostral ventromedial medulla RGD PMID:34628661 RGD:597830168 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
acute cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcn2 lipocalin 2 disease_progression ISO associated with urinary tract infection; RGD PMID:25398327 RGD:126779559 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
hemorrhagic cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase IEP protein:increased activity:urinary bladder: RGD PMID:19107871 RGD:7257548 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
interstitial cystitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphism:cds:p.R16G (human) RGD PMID:12442007 RGD:7175285 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Aif1 allograft inflammatory factor 1 treatment IEP RGD PMID:30989724 RGD:405295490 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Ccnd1 cyclin D1 IEP protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IEP protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEP protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf1 colony stimulating factor 1 treatment ISO RGD PMID:22441309 RGD:7241234 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 IEP protein:increased expression:urine RGD PMID:18848347 RGD:2317284 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP mRNA:increased expression:urinary bladder RGD PMID:38842512 RGD:407445927 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder		 CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO
IEP		 CTD Direct Evidence: marker/mechanism
mRNA:increased expression:urinary bladder		 CTD
RGD		 PMID:18957084 PMID:38842512 RGD:407445927 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18957084 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression IEP RGD PMID:30989724 RGD:405295490 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression IEP RGD PMID:30989724 RGD:405295490 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:17522255 RGD:7364800 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 treatment IEP RGD PMID:30989724 RGD:405295490 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mki67 marker of proliferation Ki-67 ISO RGD PMID:21166752 RGD:6483539 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:22738385 RGD:7245526 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ngf nerve growth factor treatment ISO
IEP		 protein:increased expression:serum, urine
mRNA:increased expression:urinary bladder		 RGD PMID:23028581 PMID:38842512 PMID:18162370 PMID:20227820 RGD:7242773, RGD:407445927, RGD:7242805, RGD:7242781 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 IEP protein:increased expression:bladder RGD PMID:21179332 RGD:4891153 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nrg1 neuregulin 1 disease_progression IEP RGD PMID:30989724 RGD:405295490 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:16622179 RGD:7245525 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:bladder, urine RGD PMID:22441309 RGD:7241234 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP protein:increased expression:urinary bladder: RGD PMID:38842512 RGD:407445927 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
trigonitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Trigonitis ClinVar PMID:25741868 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18451
      Urogenital Diseases 5402
        urinary system disease 2836
          bladder disease 455
            cystitis 57
              Pyelocystitis 0
              acute cystitis + 1
              chronic cystitis + 0
              cystitis cystica 0
              diphtheritic cystitis 0
              hemorrhagic cystitis 1
              interstitial cystitis + 25
              prostatocystitis 0
              radiation cystitis 0
              trigonitis 1
paths to the root