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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:lymphadenitis
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Accession:DOID:1602 term browser browse the term
Definition:A lymph node disease that is characterized by an acute or chronic inflammation of one or more lymph nodes. (DO)
Synonyms:exact_synonym: Adenitides;   Adenitis;   Lymphadenitides;   acute adenitis;   acute lymphadenitis;   chronic adenitis;   chronic lymphadenitis;   inflammation of lymph node
 primary_id: MESH:D008199
 xref: ICD10CM:I88.1;   ICD10CM:L04;   ICD10CM:L04.9;   ICD9CM:289.1;   ICD9CM:683;   NCI:C26821;   NCI:C26966;   NCI:C26978
For additional species annotation, visit the Alliance of Genome Resources.


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lymphadenitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sting1 stimulator of interferon response cGAMP interactor 1 disease_progression ISO associated with herpes simplex RGD PMID:27511736 RGD:39128217 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947 		JBrowse link
Kawasaki disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:16982510 RGD:5686751 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Ager advanced glycosylation end product-specific receptor severity ISO RGD PMID:22337222 RGD:8695960 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22446961 NCBI chr15:41,802,701...41,841,004
Ensembl chr15:41,802,994...41,840,982 		JBrowse link
G Btnl2 butyrophilin-like 2 susceptibility ISO DNA:SNP: :rs 1555115(human) RGD PMID:19882345 RGD:9685030 NCBI chr20:4,492,100...4,505,932
Ensembl chr20:4,492,111...4,505,932 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism,haplotype:cds:p.V64I(human) RGD PMID:17672867 RGD:8551811 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 susceptibility
treatment 		ISO DNA:frameshift mutation: :p.S185_T195del (rs333) (human)
DNA:polymorphisms, haplotype:multiple
DNA:frameshift mutation, haplotypes: :p.S185_T195del (rs333) (human) 		RGD PMID:17672867 PMID:20628649 PMID:15962231 RGD:8551811, RGD:8551812, RGD:8551815 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cd40 CD40 molecule susceptibility ISO DNA:SNP:intron:c.51+1066C>T, (rs1535045) (human)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:22446961 PMID:22446962 PMID:22645426 RGD:8547776 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:12563087 RGD:11352236 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Clu clusterin treatment ISO RGD PMID:23956692 RGD:8975365 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Crp C-reactive protein susceptibility ISO DNA:SNP: :1444 C-->T(human) RGD PMID:18710885 RGD:9495921 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Eln elastin ISO RGD PMID:21356372 RGD:9585741 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:27,604,680...27,648,413 		JBrowse link
G Fcgr2a Fc gamma receptor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22081228 PMID:22446962 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO RGD PMID:11839635 RGD:1582494 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Hmgb1 high mobility group box 1 ISO protein:increased expression:serum RGD PMID:18720262 RGD:8695977 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 no_association ISO RGD PMID:14521259 RGD:1598409 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin ISO RGD PMID:20957478 RGD:5147383 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO DNA:polymorphism:5' utr:190G>C (rs1043618) (human) RGD PMID:23870089 RGD:8662464 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like ISO DNA:missense mutation, haplotype:cds:2437T>C (p.M493T) (rs2227956) (human) RGD PMID:23870089 RGD:8662464 NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:21958311 RGD:5684363 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il18 interleukin 18 susceptibility
disease_progression 		ISO DNA:SNPs, haplotype:promoter:-137G>C, -607C>A, -656G>T (rs187238, rs1946519, rs1946518) (human)
DNA:silent mutation, haplotypes:cds:c.105A>C (rs549908) (human) 		RGD PMID:18484687 PMID:19288449 PMID:15345916 RGD:8655874, RGD:8655898, RGD:8655924 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22361326 PMID:8777922 RGD:6482661, RGD:7401221 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 treatment ISO RGD PMID:22367425 RGD:7829825 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Itpkc inositol-trisphosphate 3-kinase C ISO CTD Direct Evidence: marker/mechanism CTD PMID:18084290 NCBI chr 1:91,628,606...91,650,182
Ensembl chr 1:91,628,608...91,653,350 		JBrowse link
G Mbl1 mannose binding lectin 1 ISO RGD PMID:24721319 RGD:8693744 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,060,703...17,069,271 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:polymorphism:cds: RGD PMID:24721319 PMID:15144709 RGD:8693744, RGD:8693748 NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:blood RGD PMID:12626459 PMID:18311803 RGD:1580170, RGD:8547899 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nppb natriuretic peptide B ISO protein:increased expression:plasma RGD PMID:21410593 RGD:5685654 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Selp selectin P ISO RGD PMID:20079717 RGD:6478695 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO protein:increased expression:blood RGD PMID:12626459 RGD:1580170 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA:increased expression:monocyte: RGD PMID:18353240 RGD:7777156 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor treatment
susceptibility 		ISO DNA:SNP: :-308G>A (human) RGD PMID:14703611 PMID:14744383 PMID:8777922 PMID:18710885 RGD:1580318, RGD:7401183, RGD:7401221, RGD:9495921 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:15470196 RGD:1580572 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      immune system disease 2985
        lymphatic system disease 1081
          lymph node disease 48
            lymphadenitis 33
              Histiocytic Necrotizing Lymphadenitis 0
              Kawasaki disease 32
              Kimura disease 0
              axillary adenitis 0
              cat-scratch disease 0
              cervical adenitis + 0
              mesenteric lymphadenitis 0
              postauricular lymphadenitis 0
              suppurative lymphadenitis 0
Path 2
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      Immune & Inflammatory Diseases 3597
        immune system disease 2985
          lymphatic system disease 1081
            lymph node disease 48
              lymphadenitis 33
                Histiocytic Necrotizing Lymphadenitis 0
                Kawasaki disease 32
                Kimura disease 0
                axillary adenitis 0
                cat-scratch disease 0
                cervical adenitis + 0
                mesenteric lymphadenitis 0
                postauricular lymphadenitis 0
                suppurative lymphadenitis 0
paths to the root