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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:alcoholic cardiomyopathy
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Accession:DOID:12935 term browser browse the term
Definition:Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
Synonyms:exact_synonym: alcohol-induced heart muscle disease;   dilated cardiomyopathy secondary to alcohol
 primary_id: MESH:D002310
 xref: EFO:1000801;   ICD10CM:I42.6;   ICD9CM:425.5;   NCI:C53653
For additional species annotation, visit the Alliance of Genome Resources.



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alcoholic cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO GAD PMID:15118671 RGD:1331525 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22497828 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Atg3 autophagy related 3 treatment ISO RGD PMID:29039471 RGD:407532638 NCBI chr11:55,624,914...55,653,249 JBrowse link
G Atg7 autophagy related 7 treatment ISO RGD PMID:29039471 RGD:407532638 NCBI chr 4:149,390,000...149,597,534 JBrowse link
G Becn1 beclin 1 treatment ISO RGD PMID:29039471 RGD:407532638 NCBI chr10:86,731,649...86,747,002 JBrowse link
G Nos1 nitric oxide synthase 1 IEP protein:decreased expression:skeletal muscle, membrane RGD PMID:17607508 RGD:1642138 NCBI chr12:44,276,011...44,456,371 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP protein:increased expression:heart myocardium RGD PMID:18783396 RGD:2301868 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Rxra retinoid X receptor alpha IEP RGD PMID:19791468 RGD:2317465 NCBI chr 3:31,387,892...31,474,415 JBrowse link
G Slc25a4 solute carrier family 25 member 4 IEP mRNA, protein:decreased expression:myocardium RGD PMID:21169901 RGD:9681464 NCBI chr16:46,072,935...46,076,730 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Chemically-Induced Disorders 1443
      substance-related disorder 776
        Alcohol-Related Disorders 475
          alcoholic cardiomyopathy 9
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      nervous system disease 14359
        central nervous system disease 12634
          brain disease 11853
            disease of mental health 8450
              substance-related disorder 776
                Alcohol-Related Disorders 475
                  alcoholic cardiomyopathy 9
paths to the root