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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thromboangiitis obliterans
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Accession:DOID:12918 term browser browse the term
Definition:A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Synonyms:exact_synonym: Buerger disease;   Buerger's disease;   Buergers disease;   presenile gangrene;   thromboangitis obliterans
 primary_id: MESH:D013919
 alt_id: MIM:211480
 xref: EFO:1001211;   ICD10CM:I73.1;   ICD9CM:443.1;   NCI:C35070
For additional species annotation, visit the Alliance of Genome Resources.


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thromboangiitis obliterans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment IEP
IDA		 mRNA, protein:increased expression:femoral artery (rat) RGD PMID:23069071 PMID:23069071 RGD:7207785, RGD:7207785 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP mRNA:increased expression:femoral artery (rat) RGD PMID:19572944 RGD:5508315 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Eln elastin ISO protein:increased expression:blood: RGD PMID:8763587 RGD:9585753 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 susceptibility ISO DNA:polymorphisms,haplotypes::HLA���A*03:01,HLA���A*29:01 (human) RGD PMID:32567246 RGD:401827144 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:polymorphisms, haplotype: :HLA���DRB1*04:02, HLA���DRB1*16:01, HLA���DRB1*01:01 (human) RGD PMID:32567246 RGD:401827144 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Ucn urocortin IEP
IDA		 mRNA:increased expression:femoral artery (rat) RGD PMID:19572944 PMID:19572944 RGD:5508315, RGD:5508315 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO
IEP		 protein:increased expression:femoral artery: RGD PMID:12086338 PMID:23069071 RGD:1580352, RGD:7207785 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19055
    disease of anatomical entity 18391
      cardiovascular system disease 5515
        vascular disease 4018
          peripheral vascular disease 390
            thromboangiitis obliterans 7
paths to the root