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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:mononeuropathy
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Accession:DOID:1188 term browser browse the term
Definition:A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve. (DO)
Synonyms:exact_synonym: mononeuropathies;   mononeuropathy multiplex syndrome;   mononeuropathy multiplex syndromes
 primary_id: MESH:D020422
 xref: EFO:0009558;   ICD10CM:G58.9
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
mononeuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide IEP RGD PMID:17383023 RGD:1624339 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
carpal tunnel syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Carpal tunnel syndrome | ClinVar Annotator: match by term: Carpal tunnel syndrome, familial		 CTD
ClinVar		 PMID:192115 PMID:1335038 PMID:1351039 PMID:1353008 PMID:1358785 More... NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
carpal tunnel syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin ISO ClinVar Annotator: match by term: Carpal tunnel syndrome 1 OMIM
ClinVar		 PMID:192115 PMID:1335038 PMID:1351039 PMID:1353008 PMID:1358785 More... NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
carpal tunnel syndrome 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comp cartilage oligomeric matrix protein ISO ClinVar Annotator: match by term: Carpal tunnel syndrome 2 OMIM
ClinVar		 PMID:12483304 PMID:14684695 PMID:21834907 PMID:21965141 PMID:24595329 More... NCBI chr16:19,081,172...19,089,548
Ensembl chr16:19,047,207...19,055,845 		JBrowse link
lesion of sciatic nerve term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag1 BAG cochaperone 1 IEP RGD PMID:23108487 RGD:13506903 NCBI chr 5:60,864,476...60,877,059
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Car3 carbonic anhydrase 3 treatment IEP RGD PMID:7969243 RGD:408427352 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 IEP mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Sox2 SRY-box transcription factor 2 IEP mRNA,protein:increased expression:sciatic nerve RGD PMID:32029747 RGD:407985733 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP protein:increased expression:neuron, schwann, sciatic nerve RGD PMID:12655602 RGD:597538601 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
median neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor IEP RGD PMID:18845940 RGD:126790486 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEP RGD PMID:19296522 RGD:10449020 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP RGD PMID:19296522 PMID:18845940 RGD:10449020, RGD:126790486 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP RGD PMID:19296522 PMID:18845940 RGD:10449020, RGD:126790486 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Mt1 metallothionein 1 IEP RGD PMID:22253198 RGD:6483815 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt2 metallothionein 2 IEP mRNA:decreased expression:left median nerve (rat) RGD PMID:22253198 RGD:6483815 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 treatment IEP RGD PMID:22253198 RGD:6483815 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Npy neuropeptide Y IEP RGD PMID:19456245 RGD:10448955 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nrg1 neuregulin 1 IEP RGD PMID:19296522 RGD:10449020 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 ISO ClinVar Annotator: match by term: Mononeuropathy of the Median Nerve ClinVar PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr18:55,416,383...55,477,419
Ensembl chr18:55,416,413...55,483,083 		JBrowse link
Mononeuropathy of the Median Nerve, Mild term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 ISO ClinVar Annotator: match by term: CARPAL TUNNEL SYNDROME, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Mononeuropathy of the median nerve, mild | ClinVar Annotator: match by term: SH3TC2-related condition OMIM
ClinVar		 PMID:9536098 PMID:14574644 PMID:16806930 PMID:16924012 PMID:17576681 More... NCBI chr18:55,416,383...55,477,419
Ensembl chr18:55,416,413...55,483,083 		JBrowse link
sciatic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Adrb2 adrenoceptor beta 2 treatment ISO RGD PMID:19912227 RGD:8548489 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agt angiotensinogen IDA RGD PMID:20886512 RGD:5129198 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akap12 A-kinase anchoring protein 12 IEP mRNA,protein:increased expression:spinal cord: RGD PMID:19937403 RGD:14348968 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886 		JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555 		JBrowse link
G Apoa1 apolipoprotein A1 IEP protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoe apolipoprotein E IEP protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:18182225 RGD:5129227 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IEP RGD PMID:18182225 RGD:5129227 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
IDA		 protein:increased expression:dorsal root ganglion: RGD PMID:22309829 PMID:24388817 RGD:8657100, RGD:10059363 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G C3 complement C3 IEP protein:increased expression:sciatic nerve RGD PMID:18052971 PMID:1799436 RGD:5129535, RGD:408427358 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEP mRNA:decreased expression:spinal cord dorsal horn RGD PMID:16026470 RGD:6906922 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IEP mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IEP mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:19852068 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Capn1 calpain 1 IEP protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 IEP protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 IDA mRNA, protein:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase IEP protein:decreased activity:sciatic nerve, spinal cord, dorsal root ganglion: RGD PMID:19675389 RGD:9479064 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 IEP protein:decreased expression:spinal cord, blood vessel RGD PMID:21795534 RGD:6784526 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO		 protein:increased expression:spinal cord dorsal horn, axon terminal (rat)
protein:increased expression:lumbar dorsal root ganglion (mouse)		 RGD PMID:19059387 PMID:22564672 RGD:2307005, RGD:8549487 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA:increased expression:sciatic nerve (rat) RGD PMID:19152028 RGD:4890004 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:24907405 RGD:8661781 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP protein:decreased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cers2 ceramide synthase 2 IEP mRNA,protein:decreased expression:sciatic nerve: RGD PMID:22393241 RGD:11041067 NCBI chr 2:182,890,527...182,898,805
Ensembl chr 2:182,890,493...182,933,314 		JBrowse link
G Cnr2 cannabinoid receptor 2 treatment IDA RGD PMID:19345493 RGD:2316195 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Crcp CGRP receptor component IEP RGD PMID:12895509 RGD:727768 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IEP
IDA		 protein:increased phosphorylation:nucleus RGD PMID:19918364 PMID:33596416 RGD:10059430, RGD:401960870 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone IEP mRNA:increased expression:central nucleus of amygdala, bed nucleus of stria terminalis (rat) RGD PMID:21684787 RGD:5490542 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment ISO
IEP		 RGD PMID:20524966 PMID:15341587 PMID:20921832 RGD:9354422, RGD:1358720, RGD:9491396 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:16632873 RGD:4889134 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 IEP mRNA:decreased expression:spinal cord (rat) RGD PMID:17720801 RGD:4889112 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Dbn1 drebrin 1 IEP protein:increased expression:neuron: RGD PMID:11578820 RGD:10398813 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO protein:increased expression:brain: RGD PMID:22031875 RGD:9589072 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 IEP RGD PMID:12957493 RGD:1579851 NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446 		JBrowse link
G Fas Fas cell surface death receptor IEP RGD PMID:29970988 RGD:13792563 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEP mRNA:increased expression:neuron: RGD PMID:8971765 RGD:10402092 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase IMP RGD PMID:36545239 PMID:33829413 RGD:329951012, RGD:329951014 NCBI chr19:31,456,749...31,865,011
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Fubp1 far upstream element binding protein 1 IEP RGD PMID:23939805 RGD:13673880 NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gc GC, vitamin D binding protein ISO protein:increased expression:nerve RGD PMID:15509515 RGD:2316214 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IEP protein:increased expression:dorsal horn of spinal cord RGD PMID:23515624 RGD:401700393 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdnf glial cell derived neurotrophic factor IEP mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 IEP protein:increased expression:spinal cord dorsal horn RGD PMID:20533358 RGD:6218963 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gfra3 GDNF family receptor alpha 3 IEP mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment IEP RGD PMID:28508406 RGD:401827908 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEP RGD PMID:26656067 RGD:13792690 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEP RGD PMID:26656067 RGD:13792690 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IDA RGD PMID:27125978 RGD:13792740 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:18941443 RGD:8548631 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IMP RGD PMID:23991202 RGD:10402062 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IDA RGD PMID:23224421 RGD:10755722 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:17350523 RGD:1626418 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP mRNA:increased expression:fourth lumbar dorsal root ganglion (rat) RGD PMID:12648755 RGD:632873 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:20546684 RGD:8547739 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 treatment IDA
IEP		 associated with Constriction, Pathologic RGD PMID:22889616 PMID:22173123 RGD:7364826, RGD:7364836 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta treatment IEP RGD PMID:22173123 RGD:7364836 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:12574433 RGD:7175064 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor IEP protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Jak1 Janus kinase 1 IEP mRNA:increased expression:spinal cord RGD PMID:32012267 RGD:150527842 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jam3 junctional adhesion molecule 3 IEP RGD PMID:22950044 RGD:7488944 NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:25,507,057...25,569,355 		JBrowse link
G Kars1 lysyl-tRNA synthetase 1 IEP mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IEP RGD PMID:17855600 RGD:10411908 NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP mRNA:increased expression:dorsal root ganglion RGD PMID:17108688 RGD:7297043 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 IEP protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 treatment IEP RGD PMID:30015858 RGD:13703060 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Lrp1 LDL receptor related protein 1 treatment IEP
ISO		 RGD PMID:26656067 PMID:18060043 RGD:13792690, RGD:13800561 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Mag myelin-associated glycoprotein treatment IDA RGD PMID:17705198 RGD:9685295 NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Map2 microtubule-associated protein 2 IEP protein:decrease expression:dorsal root ganglion RGD PMID:21933624 RGD:6483083 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mc4r melanocortin 4 receptor IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:21985621 RGD:6484557 NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mir182 microRNA 182 IEP RNA:increased expression:schwann cell RGD PMID:22917588 RGD:596948403 NCBI chr 4:58,784,818...58,784,879
Ensembl chr 4:58,784,818...58,784,879 		JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:dorsal root ganglion neuron RGD PMID:25484256 RGD:151893491 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir221 microRNA 221 IEP RNA:increased expression:sciatic nerve: RGD PMID:22393241 RGD:11041067 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 IEP RNA:increased expression:dorsal root ganglion neuron
RNA:increased expression:sciatic nerve:		 RGD PMID:25484256 PMID:22393241 RGD:151893491, RGD:11041067 NCBI chr  X:6,022,621...6,022,723
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir381 microRNA 381 IEP RNA:decreased expression:spinal cord RGD PMID:30142543 RGD:13838658 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mir96 microRNA 96 IEP RNA:decreased expression:dorsal root ganglion: RGD PMID:24234845 RGD:11553932 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:25172308 RGD:13207330 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpz myelin protein zero treatment IEP RGD PMID:23545781 RGD:9685778 NCBI chr13:86,103,290...86,109,156
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:20452291 RGD:10041037 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myh4 myosin heavy chain 4 treatment IEP RGD PMID:14973145 RGD:9686059 NCBI chr10:52,422,148...52,445,296
Ensembl chr10:51,885,913...51,946,295 		JBrowse link
G Nefh neurofilament heavy chain treatment IEP RGD PMID:3135913 PMID:12445968 RGD:9693730, RGD:9743941 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain IEP associated with Diabetes Mellitus, Type 1 RGD PMID:12445968 PMID:3135913 PMID:12638730 RGD:9743941, RGD:9693730, RGD:9743948 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain treatment IEP associated with Diabetes Mellitus, Type 1 RGD PMID:12445968 PMID:3135913 PMID:12638730 RGD:9743941, RGD:9693730, RGD:9743948 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nf1 neurofibromin 1 IEP protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IDA RGD PMID:18938092 RGD:10413869 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor treatment ISO protein:increased expression:sciatic nerve RGD PMID:22776032 PMID:32652504 RGD:7242913, RGD:401976543 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor ISO
IEP		 RGD PMID:17576803 PMID:23138653 RGD:5144067, RGD:10414078 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nlgn2 neuroligin 2 IEP mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434 		JBrowse link
G Nlgn3 neuroligin 3 IEP mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 IEP mRNA:increased expression:dorsal root ganglion: RGD PMID:16914673 RGD:13781948 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein IEP mRNA:increased expression:sciatic nerve RGD PMID:17768032 RGD:7327169 NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949 		JBrowse link
G Nrg1 neuregulin 1 treatment IMP RGD PMID:20957456 RGD:10449012 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nts neurotensin IEP RGD PMID:8518953 RGD:9743903 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IEP mRNA:increased expression:brain: RGD PMID:15862535 RGD:9835022 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 IEP mRNA, protein:decreased expression:dorsal root ganglion RGD PMID:26917724 PMID:31836522 RGD:11531866, RGD:401842373 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP RGD PMID:23014974 RGD:10448976 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IEP mRNA,protein:increased expression:nerve: RGD PMID:9729404 RGD:11556234 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:19909480 RGD:11080976 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP RGD PMID:19909480 RGD:11080976 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Plat plasminogen activator, tissue type IEP RGD PMID:18716863 RGD:6483827 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase treatment IEP
IDA		 mRNA:increased expression:sciatic nerve (rat) RGD PMID:18716863 PMID:21151668 RGD:6483827, RGD:7241585 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pmp22 peripheral myelin protein 22 IEP RGD PMID:1556154 RGD:1358785 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IDA associated with Diabetes Mellitus, Experimental RGD PMID:22996345 RGD:7242051 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptafr platelet-activating factor receptor IEP mRNA:increased expression:spinal cord, microglia (rat) RGD PMID:22296727 RGD:9999207 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptn pleiotrophin IEP mRNA:altered expression:dorsal root ganglia (rat) RGD PMID:18365878 RGD:9831453 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 IEP mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chr 8:118,086,243...118,094,274
Ensembl chr 8:109,207,705...109,215,739 		JBrowse link
G Ran RAN, member RAS oncogene family IDA RGD PMID:18667152 RGD:9835000 NCBI chr12:33,311,155...33,314,339
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Ranbp1 RAN binding protein 1 IEP protein:increased expression:sciatic nerve (rat) RGD PMID:18667152 RGD:9835000 NCBI chr11:96,246,912...96,255,145
Ensembl chr11:82,742,600...82,750,838 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 IEP protein:increased expression:sciatic nerve, axon, cytoplasm (rat) RGD PMID:18667152 RGD:9835000 NCBI chr 7:115,104,820...115,130,564
Ensembl chr 7:113,224,703...113,250,438 		JBrowse link
G Rara retinoic acid receptor, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 IEP protein:increased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chr14:16,397,533...16,413,286
Ensembl chr14:16,113,224...16,129,167 		JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:lumbar spinal cord, dorsal root ganglia (rat) RGD PMID:21561713 RGD:9831430 NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a IEP RGD PMID:16863689 RGD:9850145 NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918 		JBrowse link
G Rpsa ribosomal protein SA IEP RGD PMID:19196078 RGD:11041651 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Runx1 RUNX family transcription factor 1 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:22216140 RGD:6482827 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Rxra retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IMP RGD PMID:21965668 RGD:6484251 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Serpine1 serpin family E member 1 treatment IDA RGD PMID:25967608 RGD:11075075 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:10441236 RGD:8554886 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 IEP protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Snw1 SNW domain containing 1 IDA protein:increased expression:sciatic nerve (rat) RGD PMID:23389663 RGD:11035242 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Sod1 superoxide dismutase 1 severity
treatment		 ISO
IDA		 human gene in a rat model;DNA:missense mutation:cds:p.G93A (human) RGD PMID:21489258 PMID:15707675 RGD:8655638, RGD:8655979 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP RNA:decreased expression:dorsal root ganglion neuron RGD PMID:25484256 RGD:151893491 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression:sciatic nerve: RGD PMID:21125644 RGD:8553062 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IEP
ISO
IMP		 mRNA,protein:increased expression:spinal cord:
mRNA:increased expression:spinal cord:		 RGD PMID:22173123 PMID:18615568 PMID:22173123 RGD:7364836, RGD:7815041, RGD:7364836 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor treatment IEP RGD PMID:22173123 RGD:7364836 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IEP		 protein:increased expression:dorsal root ganglia (rat) RGD PMID:9582261 PMID:11240015 RGD:5130898, RGD:5130963 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:11240015 RGD:5130963 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IMP RGD PMID:16176350 RGD:2302154 NCBI chr 1:252,973,818...252,980,873
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment IDA RGD PMID:22425187 RGD:7245944 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        peripheral nervous system disease 4385
          mononeuropathy 155
            Mononeuropathy of the Median Nerve, Mild 1
            femoral neuropathy 0
            mononeuritis + 154
            peroneal nerve paralysis + 0
            peroneal neuropathy 0
            radial neuropathy + 0
            tibial neuropathy + 0
            ulnar neuropathy + 0
Path 2
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        peripheral nervous system disease 4385
          neuropathy 4173
            mononeuropathy 155
              Mononeuropathy of the Median Nerve, Mild 1
              femoral neuropathy 0
              mononeuritis + 154
              peroneal nerve paralysis + 0
              peroneal neuropathy 0
              radial neuropathy + 0
              tibial neuropathy + 0
              ulnar neuropathy + 0
paths to the root