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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:onchocerciasis
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Accession:DOID:11678 term browser browse the term
Definition:A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. (DO)
Synonyms:exact_synonym: Onchocerca volvulus infection;   Onchocerciases;   infection by Onchocerca volvulus;   volvulosis
 primary_id: MESH:D009855
 xref: EFO:0007402;   GARD:7252;   ICD10CM:B73;   ICD9CM:125.3;   NCI:C34861
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL13 interleukin 13 severity ISO protein:increased expression:serum RGD PMID:22805723 RGD:8549600 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548
JBrowse link
G LOC100995577 HLA class II histocompatibility antigen, DP alpha 1 chain ISO RGD PMID:8854084 RGD:6480649 NCBI chr 6:32,637,826...32,646,501
Ensembl chr 6:33,752,638...33,761,417
JBrowse link
Ocular Onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:19168746 RGD:8662882 Ensembl chr2A:103,193,131...103,230,005 JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:11884755 RGD:7794682 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15805
    sensory system disease 7021
      skin disease 4121
        filariasis 6
          onchocerciasis 4
            Ocular Onchocerciasis 2
Path 2
Term Annotations click to browse term
  disease 15805
    Pathological Conditions, Signs and Symptoms 12318
      Signs and Symptoms 10355
        Neurologic Manifestations 10032
          sensory system disease 7021
            skin disease 4121
              Infectious Skin Diseases 285
                Parasitic Skin Diseases 65
                  onchocerciasis 4
                    Ocular Onchocerciasis 2
paths to the root