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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:prostatic hypertrophy
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Accession:DOID:11132 term browser browse the term
Definition:Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Synonyms:exact_synonym: benign prostatic hyperplasia;   benign prostatic hypertrophy;   prostatic hyperplasia
 primary_id: MESH:D011470
 alt_id: MIM:600082
 xref: EFO:0000284;   NCI:C2897
For additional species annotation, visit the Alliance of Genome Resources.


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prostatic hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor treatment IMP RGD PMID:22430536 PMID:24872436 RGD:10043335, RGD:10045676 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf4 activating transcription factor 4 ISO RGD PMID:28988820 RGD:13504679 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO protein:increased expression:prostate gland RGD PMID:11781193 RGD:2292676 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Casp1 caspase 1 ISO protein:decreased expression:prostate gland RGD PMID:16333955 RGD:2315883 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp6 caspase 6 ISO RGD PMID:15507514 RGD:2301337 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Ccnb1 cyclin B1 ISO RGD PMID:12670908 RGD:2315046 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEP protein:decreased expression:prostate gland RGD PMID:17962342 RGD:2289135 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO protein:decreased expression:prostate gland RGD PMID:25546515 RGD:11566048 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clu clusterin IEP mRNA, protein:increased expression:prostate gland RGD PMID:19443575 RGD:9068410 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Esr1 estrogen receptor 1 treatment IMP RGD PMID:24872436 RGD:10045676 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 treatment ISO RGD PMID:17068134 RGD:8552985 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fadd Fas associated via death domain treatment IDA RGD PMID:27441629 RGD:13792501 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fgf7 fibroblast growth factor 7 no_association ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14999240 PMID:9285567 PMID:11482780 PMID:9000125 RGD:2289086, RGD:2289085, RGD:2301094 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fgf8 fibroblast growth factor 8 ISO RGD PMID:10343609 RGD:2289343 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Ghrh growth hormone releasing hormone treatment IMP RGD PMID:22341819 PMID:21321192 RGD:10401238, RGD:10401264 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 treatment IMP RGD PMID:22341819 RGD:10401238 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 treatment IEP RGD PMID:24205794 RGD:10401934 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO mRNA: increased expression: prostate RGD PMID:9215294 RGD:7242915 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il13 interleukin 13 IEP mRNA:increased expression:prostate gland RGD PMID:20945403 RGD:5684375 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il3 interleukin 3 IEP mRNA: increased expression: prostate RGD PMID:20945403 RGD:5684375 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il5 interleukin 5 treatment IEP RGD PMID:20945403 RGD:5684375 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:15999482 RGD:2292079 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21128595 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IDA RGD PMID:22684563 RGD:7240520 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 ISO RGD PMID:7693635 RGD:2299076 NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:22689130 RGD:13506770 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfd platelet derived growth factor D disease_progression ISO RGD PMID:22689130 RGD:13506770 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2208075 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:11175795 RGD:1302553 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:prostate gland RGD PMID:25546515 RGD:11566048 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:prostate gland RGD PMID:25546515 RGD:11566048 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 severity ISO DNA:SNPs:cds RGD PMID:15136785 RGD:2302559 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20823678 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Tmprss2 transmembrane serine protease 2 ISO protein:increased expression:prostate gland RGD PMID:18338334 RGD:2324904 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tp73 tumor protein p73 ISO mRNA:alternative forms RGD PMID:15492805 RGD:2298529 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19143
    disease of anatomical entity 18456
      reproductive system disease 3194
        male reproductive system disease 2048
          prostate disease 1321
            prostatic hypertrophy 35
              Prostatic Stromal Proliferation of Uncertain Malignant Potential 0
              nodular prostate 0
              prostatic cyst 0
Path 2
Term Annotations click to browse term
  disease 19143
    disease of anatomical entity 18456
      Urogenital Diseases 5402
        reproductive system disease 3194
          male reproductive system disease 2048
            prostate disease 1321
              prostatic hypertrophy 35
                Prostatic Stromal Proliferation of Uncertain Malignant Potential 0
                nodular prostate 0
                prostatic cyst 0
paths to the root