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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:gastric ulcer
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Accession:DOID:10808 term browser browse the term
Definition:Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Synonyms:exact_synonym: Stomach Ulcer;   acute gastric ulcer with haemorrhage and perforation;   acute gastric ulcer with hemorrhage AND with perforation but without obstruction;   acute gastric ulcer with hemorrhage and obstruction;   acute gastric ulcer with hemorrhage and perforation;   acute gastric ulcer with hemorrhage and perforation, with obstruction;   acute gastric ulcer with hemorrhage and perforation, without mention of obstruction;   acute gastric ulcer with hemorrhage, with obstruction;   acute gastric ulcer with hemorrhage, with perforation AND with obstruction;   acute gastric ulcer with perforation;   acute gastric ulcer with perforation AND obstruction;   acute gastric ulcer with perforation, with obstruction;   acute gastric ulcer without hemorrhage and without perforation;   acute gastric ulcer without hemorrhage, without perforation AND without obstruction;   acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction;   bleeding acute gastric ulcer;   chronic gastric ulcer without hemorrhage AND without perforation;   chronic gastric ulcer without hemorrhage AND without perforation but with obstruction;   chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction;   gastric ulcers;   stomach ulcers
 primary_id: MESH:D013276
 xref: EFO:0009454;   ICD10CM:K25;   ICD9CM:531;   NCI:C3388
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
gastric ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:decreased activity:stomach: RGD PMID:20029210 RGD:152998951 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:9845272 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Agt angiotensinogen treatment IDA RGD PMID:24231511 RGD:11039418 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Angpt1 angiopoietin 1 IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Angpt2 angiopoietin 2 IEP protein:increased expression:stomach (rat) RGD PMID:12768384 RGD:1601496 NCBI chr16:77,790,760...77,841,241
Ensembl chr16:77,790,563...77,841,239 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase IEP
ISO 		protein:increased expression:stomach
CTD Direct Evidence: therapeutic 		CTD
RGD		 PMID:1887894 PMID:17895592 RGD:5130860 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cblif cobalamin binding intrinsic factor ISO associated with Polycythemia; mRNA:decreased expression:gastric mucosa: RGD PMID:26485402 RGD:11049581 NCBI chr 1:218,030,756...218,045,004
Ensembl chr 1:218,030,731...218,045,117 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9872509 PMID:10422768 PMID:10458643 PMID:11025360 PMID:11787760 More... NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686 		JBrowse link
G Cftr CF transmembrane conductance regulator treatment IDA RGD PMID:23596793 RGD:11567229 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain IEP Protein:decreased expression:serum RGD PMID:11353854 RGD:1600910 NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112 		JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:9324159 PMID:9479624 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:20723003 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725 		JBrowse link
G F13a1 coagulation factor XIII A1 chain IEP RGD PMID:11435721 RGD:708325 NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fgf2 fibroblast growth factor 2 treatment ISO RGD PMID:9127818 RGD:8655642 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP
IMP 		RGD PMID:37637418 PMID:24496494 RGD:405650590, RGD:405650591 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Foxo4 forkhead box O4 IEP mRNA,protein:increased expression:gastric mucosa: RGD PMID:22735908 RGD:10402364 NCBI chr  X:70,425,218...70,432,120
Ensembl chr  X:70,425,563...70,432,120 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:15177919 PMID:16259727 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:15680274 RGD:1626428 NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259 		JBrowse link
G Iapp islet amyloid polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:9286623 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:176,968,097...176,975,363 		JBrowse link
G Idua alpha-L-iduronidase IEP RGD PMID:3713687 RGD:12910841 NCBI chr14:1,175,994...1,203,913
Ensembl chr14:1,176,577...1,204,066 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11376495 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il23a interleukin 23 subunit alpha treatment ISO RGD PMID:23874957 RGD:39458037 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il25 interleukin 25 treatment IEP RGD PMID:26054198 RGD:40902976 NCBI chr15:32,378,750...32,382,141
Ensembl chr15:32,378,750...32,382,141 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:10422768 PMID:11025360 PMID:11787760 PMID:15024038 PMID:16015682 More... NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA RGD PMID:25518106 RGD:13800896 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA RGD PMID:25518106 RGD:13800896 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp13 matrix metallopeptidase 13 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP
ISO 		protein:increased expression:stomach secretion
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:17603938 PMID:17603938 RGD:1642033 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming treatment IEP
IDA 		mRNA, protein:decreased expression:stomach RGD PMID:11956390 PMID:16240224 RGD:2324968, RGD:7364759 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006 		JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming treatment IDA RGD PMID:16240224 RGD:7364759 NCBI chr 1:206,155,826...206,194,384
Ensembl chr 1:206,155,593...206,191,864 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:15138204 PMID:19066340 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO
IEP 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19066340 PMID:29095895 RGD:13446410 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357062 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:11764003 RGD:2304192 NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594 		JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:11764003 RGD:2304192 NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:147,154,374...147,170,750 		JBrowse link
G Ptger1 prostaglandin E receptor 1 treatment IMP
ISO 		RGD PMID:10807413 PMID:10807413 RGD:10043357, RGD:10043357 NCBI chr19:41,374,983...41,379,593
Ensembl chr19:41,374,471...41,378,284 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10594344 PMID:19066340 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9024292 PMID:10594344 PMID:11376495 PMID:12481160 PMID:19066340 More... RGD:2300260, RGD:2300260 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Sst somatostatin IEP RGD PMID:17990461 RGD:2303186 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823 		JBrowse link
G Tek TEK receptor tyrosine kinase IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991 		JBrowse link
G Tff1 trefoil factor 1 IEP mRNA, protein:increased expression:stomach mucosa RGD PMID:11350545 RGD:2292012 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138204 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 treatment IDA RGD PMID:15125461 RGD:598136405 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11353854 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vgf VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:20805684 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      gastrointestinal system disease 7168
        stomach disease 1068
          peptic ulcer disease 89
            gastric ulcer 54
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      gastrointestinal system disease 7168
        intestinal disease 3134
          duodenum disease 94
            peptic ulcer disease 89
              gastric ulcer 54
paths to the root