RGD DISEASE ONTOLOGY - ANNOTATIONS |
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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Term: | kidney failure |
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Accession: | DOID:1074
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browse the term
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Definition: | A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. (DO) |
Synonyms: | exact_synonym: | Kidney Insufficiencies; Kidney Insufficiency; Renal Failure; Renal Failures; Renal Insufficiencies; kidney failures; renal unsufficiency |
| primary_id: | MESH:D051437 |
| xref: | EFO:1002048; ICD10CM:N19; ICD9CM:586; NCI:C4376 |
For additional species annotation, visit the
Alliance of Genome Resources.
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Ace |
angiotensin I converting enzyme |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9259580 |
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NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
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IDA |
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RGD |
PMID:10966936 |
RGD:13831124 |
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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Adam10 |
ADAM metallopeptidase domain 10 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32715474 |
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NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889
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Agt |
angiotensinogen |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9259580 |
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NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
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Ambp |
alpha-1-microglobulin/bikunin precursor |
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ISO |
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RGD |
PMID:18046670 |
RGD:6904142 |
NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331
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Apoe |
apolipoprotein E |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20842518 |
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NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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Cd80 |
Cd80 molecule |
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IEP |
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RGD |
PMID:16893502 |
RGD:6902939 |
NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030
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Crp |
C-reactive protein |
severity |
ISO |
associated with Anemia, Sickle Cell; protein:increased expression:serum |
RGD |
PMID:20710104 |
RGD:6907441 |
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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Cyba |
cytochrome b-245 alpha chain |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23325087 |
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NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721
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Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8164439 |
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NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383
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Drd1 |
dopamine receptor D1 |
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ISO |
DNA:polymorphism:5' utr:g.-94G>A (human) |
RGD |
PMID:19675531 |
RGD:7248447 |
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
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Edn1 |
endothelin 1 |
onset |
IEP ISO |
protein:increased expression:kidney (rat) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:7967349 PMID:20888384 |
RGD:4144130 |
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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Epo |
erythropoietin |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:22013135 |
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NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
treatment |
ISO |
associated with Ovarian Neoplasms;DNA:SNPs: :8092C>A, 19007T>C (human) |
RGD |
PMID:19786980 |
RGD:5688741 |
NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963
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Gfer |
growth factor, augmenter of liver regeneration |
treatment |
ISO |
associated with liver transplant; |
RGD |
PMID:18929838 |
RGD:9685774 |
NCBI chr10:14,223,023...14,225,736
Ensembl chr10:13,718,489...13,720,869
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Grp |
gastrin releasing peptide |
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ISO |
protein:increased expression:serum (human) |
RGD |
PMID:30146822 |
RGD:401700396 |
NCBI chr18:61,658,655...61,672,037
Ensembl chr18:59,388,274...59,402,061
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Hif1a |
hypoxia inducible factor 1 subunit alpha |
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IEP |
associated with Hypertension;protein:increased expression:kidney |
RGD |
PMID:15583217 |
RGD:1626324 |
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27469509 |
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NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025
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Ifng |
interferon gamma |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:3091246 PMID:8289579 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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Il1b |
interleukin 1 beta |
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ISO IDA |
mRNA, protein:increased expression:kidney (mouse) |
RGD |
PMID:21907489 PMID:20722564 |
RGD:7175305, RGD:7175345 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Ins2 |
insulin 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8606734 PMID:9861226 |
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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Kl |
Klotho |
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IDA |
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RGD |
PMID:10892340 |
RGD:1581732 |
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
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Lepr |
leptin receptor |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29988851 |
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NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Mefv |
MEFV innate immunity regulator, pyrin |
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ISO |
ClinVar Annotator: match by term: Renal failure |
ClinVar |
PMID:9668175 PMID:10090880 PMID:10612841 PMID:10787450 PMID:10842288 PMID:11464238 PMID:11977178 PMID:15018633 PMID:15024744 PMID:16730661 PMID:17489852 PMID:19253030 PMID:19934083 PMID:20041150 PMID:20534143 PMID:21246368 PMID:21413889 PMID:21978701 PMID:22614345 PMID:22903357 PMID:23505242 PMID:23588594 PMID:23907647 PMID:23981758 PMID:24251727 PMID:24469716 PMID:24929125 PMID:25615955 PMID:25741868 PMID:26078663 PMID:28492532 PMID:29047407 PMID:29543225 PMID:29599418 PMID:31989427 PMID:32312770 PMID:33733382 PMID:34426522 PMID:35098403 More...
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NCBI chr10:12,288,514...12,303,337
Ensembl chr10:11,787,422...11,796,973
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Mme |
membrane metallo-endopeptidase |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:10485324 |
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NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
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Mt1 |
metallothionein 1 |
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IEP |
associated with Cadmium Poisoning;mRNA:increased expression:kidney |
RGD |
PMID:16226777 |
RGD:6483854 |
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mt2 |
metallothionein 2 |
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IEP |
associated with Cadmium Poisoning;mRNA:increased expression:kidney |
RGD |
PMID:16226777 |
RGD:6483854 |
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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Mthfr |
methylenetetrahydrofolate reductase |
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ISO |
DNA:transition:cds:g.677C>T (human) |
RGD |
PMID:20433440 |
RGD:6893515 |
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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Nampt |
nicotinamide phosphoribosyltransferase |
treatment |
IEP |
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RGD |
PMID:25594614 |
RGD:13781896 |
NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
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Notch2 |
notch receptor 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32715474 |
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NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
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Nox4 |
NADPH oxidase 4 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23325087 |
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NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
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Nphs1 |
NPHS1 adhesion molecule, nephrin |
severity |
IEP |
protein:decreased expression:kidney (rat) |
RGD |
PMID:18346151 |
RGD:38599007 |
NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078
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Parp1 |
poly (ADP-ribose) polymerase 1 |
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IEP |
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RGD |
PMID:19833176 |
RGD:10413912 |
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Phex |
phosphate regulating endopeptidase X-linked |
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IEP |
mRNA:increased expression:parathroid gland,tibia: |
RGD |
PMID:14693675 |
RGD:11556273 |
NCBI chr X:41,422,561...41,671,226
Ensembl chr X:37,610,760...37,854,469
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Pkd1 |
polycystin 1, transient receptor potential channel interacting |
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ISO |
ClinVar Annotator: match by term: Renal failure |
ClinVar |
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NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128
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Pparg |
peroxisome proliferator-activated receptor gamma |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28182703 |
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NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ppargc1a |
PPARG coactivator 1 alpha |
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IDA |
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RGD |
PMID:22076434 |
RGD:7242044 |
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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Ren |
renin |
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ISO |
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RGD |
PMID:28533331 |
RGD:39939034 |
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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Rhcg |
Rh family, C glycoprotein |
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IEP |
protein:altered localization |
RGD |
PMID:17652373 |
RGD:9850158 |
NCBI chr 1:133,531,704...133,555,902
Ensembl chr 1:133,531,716...133,555,876
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Serpinf1 |
serpin family F member 1 |
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ISO |
protein:increased expression:plasma (human) |
RGD |
PMID:16828495 |
RGD:36174008 |
NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646
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Slc22a2 |
solute carrier family 22 member 2 |
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IEP |
mRNA, protein:decreased expression:kidney cortex |
RGD |
PMID:21167265 |
RGD:7243878 |
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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Slco4c1 |
solute carrier organic anion transporter family, member 4C1 |
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IEP |
mRNA:decreased expression:kidney |
RGD |
PMID:14993604 |
RGD:1303977 |
NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:97,178,861...97,229,715
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Spp1 |
secreted phosphoprotein 1 |
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ISO |
In type 2 diabetic patients |
RGD |
PMID:21034455 |
RGD:6903271 |
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Tbxa2r |
thromboxane A2 receptor |
treatment |
IMP |
associated with Cholestasis; |
RGD |
PMID:9893136 |
RGD:11059601 |
NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176
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Tlr2 |
toll-like receptor 2 |
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IEP |
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RGD |
PMID:16177646 |
RGD:7241085 |
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
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Tlr4 |
toll-like receptor 4 |
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IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:27585667 PMID:16177646 |
RGD:7241085 |
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tnfrsf1b |
TNF receptor superfamily member 1B |
severity |
ISO |
associated with Neoplasms, Plasma Cell |
RGD |
PMID:9650354 |
RGD:7245537 |
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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Tsc1 |
TSC complex subunit 1 |
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ISO |
ClinVar Annotator: match by term: Renal failure |
ClinVar |
PMID:10227394 PMID:10570911 PMID:15798777 PMID:17304050 PMID:23341583 PMID:25741868 PMID:26467025 PMID:28492532 PMID:28968464 More...
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NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:11,979,729...12,015,674
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Xdh |
xanthine dehydrogenase |
treatment |
ISO |
associated with Hyperuricemia DNA:nonsense mutation:CDS |
RGD |
PMID:23137955 PMID:19667249 PMID:23024809 |
RGD:7247633, RGD:7247649, RGD:7247636 |
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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A2m |
alpha-2-macroglobulin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23052191 |
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NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786
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Ace |
angiotensin I converting enzyme |
treatment |
IMP |
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RGD |
PMID:24502693 |
RGD:11039053 |
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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Adrb2 |
adrenoceptor beta 2 |
treatment |
IEP IMP ISO |
associated with endotoxemia; protein:increased expression:kidney associated with Endotoxemia; associated with Bacteremia; |
RGD |
PMID:14747378 PMID:19020966 PMID:19887504 PMID:14747378 |
RGD:7175276, RGD:7175283, RGD:7175281, RGD:7175276 |
NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
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Afm |
afamin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,531,024...17,563,870
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Ager |
advanced glycosylation end product-specific receptor |
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ISO |
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RGD |
PMID:21811803 |
RGD:7243868 |
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078
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Ahsg |
alpha-2-HS-glycoprotein |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr11:91,625,975...91,632,583
Ensembl chr11:78,117,918...78,145,999
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Alad |
aminolevulinate dehydratase |
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IEP |
protein:decreased activity:kidney (rat) |
RGD |
PMID:19484701 |
RGD:4144146 |
NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474
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Alb |
albumin |
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ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD |
PMID:2048579 PMID:21259293 PMID:24361871 PMID:28885000 |
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NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Alox5 |
arachidonate 5-lipoxygenase |
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IMP |
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RGD |
PMID:19194548 |
RGD:2317536 |
NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743
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Ambp |
alpha-1-microglobulin/bikunin precursor |
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ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD RGD |
PMID:8963945 PMID:28885000 PMID:8963945 |
RGD:6904218 |
NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331
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Amn |
amnion associated transmembrane protein |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:20514524 |
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NCBI chr 6:136,132,567...136,140,008
Ensembl chr 6:130,311,372...130,318,815
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Anxa1 |
annexin A1 |
treatment |
IDA |
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RGD |
PMID:22101490 |
RGD:7421583 |
NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
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Ar |
androgen receptor |
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IEP |
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RGD |
PMID:24503548 |
RGD:11570523 |
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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Arg1 |
arginase 1 |
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IEP |
mRNA:decreased expression:renal tubule (rat) |
RGD |
PMID:12371970 |
RGD:631989 |
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
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Arg2 |
arginase 2 |
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IEP |
mRNA:decreased expression:renal tubule (rat) |
RGD |
PMID:12371970 |
RGD:631989 |
NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378
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Atp5f1b |
ATP synthase F1 subunit beta |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25666834 |
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NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273
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Avp |
arginine vasopressin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:2139164 |
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NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
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Avpr1a |
arginine vasopressin receptor 1A |
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IMP |
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RGD |
PMID:17347933 |
RGD:2300348 |
NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215
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Azgp1 |
alpha-2-glycoprotein 1, zinc-binding |
disease_progression |
ISO |
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RGD |
PMID:23849457 |
RGD:153350150 |
NCBI chr12:22,044,685...22,051,248
Ensembl chr12:16,931,024...16,939,091
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B2m |
beta-2 microglobulin |
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IEP ISO |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:2689182 PMID:22005293 PMID:28885000 PMID:19536607 |
RGD:6482685 |
NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766
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Bad |
BCL2-associated agonist of cell death |
treatment |
IEP |
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RGD |
PMID:20037173 |
RGD:10053672 |
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
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Bax |
BCL2 associated X, apoptosis regulator |
treatment |
IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20623750 PMID:20037173 |
RGD:10053672 |
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
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IEP |
protein:increased expression:kidney |
RGD |
PMID:20037173 |
RGD:10053672 |
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
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IEP |
protein:increased expression:kidney |
RGD |
PMID:20037173 |
RGD:10053672 |
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bdkrb2 |
bradykinin receptor B2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24975837 |
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NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:124,472,566...124,502,497
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G |
C3 |
complement C3 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429
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G |
Capn1 |
calpain 1 |
treatment |
IEP |
associated with Rhabdomyolysis; |
RGD |
PMID:24158126 |
RGD:13792553 |
NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:203,277,344...203,300,177
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G |
Casp1 |
caspase 1 |
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IMP |
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RGD |
PMID:16557226 |
RGD:2293624 |
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
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ISO |
protein:increased expression:kidney |
RGD |
PMID:22778179 |
RGD:7247739 |
NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
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ISO |
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RGD |
PMID:20482449 |
RGD:6906908 |
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
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ISO |
protein:increased secretion:serum (mouse) |
RGD |
PMID:19508392 |
RGD:4889990 |
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26055553 |
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NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
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G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:31825490 |
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NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580
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G |
Cd44 |
CD44 molecule |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23052191 |
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NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
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IEP |
protein:decreased expression:kidney |
RGD |
PMID:16557226 |
RGD:2293624 |
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G |
Clu |
clusterin |
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IEP ISO |
protein:increased expression:urine CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20118187 PMID:20623750 PMID:22005293 PMID:23052191 PMID:24361871 PMID:28885000 PMID:22581811 More...
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RGD:7245501 |
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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G |
Cp |
ceruloplasmin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075
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G |
Crp |
C-reactive protein |
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IEP ISO |
protein:increased expression:serum associated with Myocardial Infarction; |
RGD |
PMID:22551254 PMID:22694718 |
RGD:6903282, RGD:6906888 |
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Csf1 |
colony stimulating factor 1 |
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ISO |
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RGD |
PMID:23143303 |
RGD:7257565 |
NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704
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G |
Csf1r |
colony stimulating factor 1 receptor |
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ISO |
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RGD |
PMID:23143303 |
RGD:7257565 |
NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415
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G |
Cst3 |
cystatin C |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22005293 PMID:28885000 |
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NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
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ISO |
mRNA:increased expression:kidney, liver, spleen |
RGD |
PMID:21677145 |
RGD:7175314 |
NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
treatment |
ISO |
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RGD |
PMID:19890363 PMID:18495746 |
RGD:7257732, RGD:7257735 |
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
treatment |
ISO |
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RGD |
PMID:23981375 PMID:18495746 |
RGD:7257727, RGD:7257735 |
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
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IDA |
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RGD |
PMID:6223803 |
RGD:2307326 |
NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:62,871,297...62,876,241
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19814645 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19814645 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
treatment |
IEP |
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RGD |
PMID:24717297 PMID:24412858 |
RGD:14700914, RGD:14700920 |
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20623750 |
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NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
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IEP |
Protein:increased expression:renal tubule epithelium |
RGD |
PMID:15476864 |
RGD:1599736 |
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Dll4 |
delta like canonical Notch ligand 4 |
ameliorates |
ISO |
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RGD |
PMID:19828677 |
RGD:155663373 |
NCBI chr 3:126,770,945...126,780,769
Ensembl chr 3:106,316,986...106,326,931
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G |
Ece1 |
endothelin converting enzyme 1 |
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IMP IEP |
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RGD |
PMID:11043448 PMID:10073607 |
RGD:7244180, RGD:7244185 |
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Edn1 |
endothelin 1 |
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ISO |
mRNA, protein:increased expression:kidney (mouse) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:9788586 PMID:19967049 |
RGD:4144852 |
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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G |
Egf |
epidermal growth factor |
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ISO IEP |
mRNA:decreased expression:kidney |
RGD |
PMID:20482449 PMID:11340354 |
RGD:6906908, RGD:10395241 |
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
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IEP ISO |
mRNA:increased expression:kidney CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:14638913 PMID:11340354 |
RGD:10395241 |
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
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IEP |
mRNA, protein:decreased expression:kidney |
RGD |
PMID:19349364 |
RGD:11252083 |
NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
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IEP |
mRNA, protein:decreased expression:kidney |
RGD |
PMID:19349364 |
RGD:11252083 |
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766
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G |
Epas1 |
endothelial PAS domain protein 1 |
treatment |
IDA |
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RGD |
PMID:16762988 |
RGD:10395386 |
NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228
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G |
Ephx2 |
epoxide hydrolase 2 |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:26165641 |
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NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615
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G |
Epo |
erythropoietin |
treatment |
ISO |
CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:21847101 PMID:24561306 PMID:22209169 PMID:22235348 |
RGD:10400913, RGD:11041660 |
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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G |
Fas |
Fas cell surface death receptor |
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ISO |
protein:increased expression:renal tubule (rat) |
RGD |
PMID:21374789 |
RGD:8663469 |
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Fga |
fibrinogen alpha chain |
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IEP |
mRNA:increased expression:kidney (rat) |
RGD |
PMID:15805072 |
RGD:9685024 |
NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528
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G |
Fis1 |
fission, mitochondrial 1 |
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IEP |
protein:decreased expression:kidney (rat) |
RGD |
PMID:26480480 |
RGD:12910862 |
NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377
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G |
Fn1 |
fibronectin 1 |
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IEP |
protein:increased expression:kidney |
RGD |
PMID:12884040 PMID:11768240 |
RGD:7205684, RGD:729934 |
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G |
Fstl1 |
follistatin-like 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20861081 |
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NCBI chr11:76,400,870...76,454,053
Ensembl chr11:62,779,783...62,948,677
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:602954 PMID:734759 PMID:4794122 |
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NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
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G |
Gas6 |
growth arrest specific 6 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19564549 |
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NCBI chr16:82,747,676...82,778,090
Ensembl chr16:76,045,426...76,075,904
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G |
Gatm |
glycine amidinotransferase |
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IEP |
protein:decreased activity:kidney (rat) |
RGD |
PMID:2752493 |
RGD:1599823 |
NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:109,658,951...109,684,129
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G |
Gc |
GC, vitamin D binding protein |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,632,135...18,667,567
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G |
Gfer |
growth factor, augmenter of liver regeneration |
treatment |
IEP ISO IDA |
protein:increased expression:cortex of kidney,renal medulla: CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:20030531 PMID:20030531 PMID:20030531 |
RGD:9685736, RGD:9685736 |
NCBI chr10:14,223,023...14,225,736
Ensembl chr10:13,718,489...13,720,869
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
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ISO |
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RGD |
PMID:19625378 |
RGD:7242430 |
NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
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IEP |
protein:decreased activity:kidney (rat) |
RGD |
PMID:23924727 |
RGD:13506245 |
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpnmb |
glycoprotein nmb |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23052191 |
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NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpt |
glutamic--pyruvic transaminase |
treatment |
IEP |
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RGD |
PMID:22209169 |
RGD:10400913 |
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx3 |
glutathione peroxidase 3 |
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ISO |
protein:decreased expression:kidney |
RGD |
PMID:36583727 |
RGD:401827125 |
NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035
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G |
Gpx4 |
glutathione peroxidase 4 |
treatment |
IEP |
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RGD |
PMID:29548851 |
RGD:401827911 |
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
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ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD |
PMID:22785175 PMID:38014886 |
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
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IEP ISO |
glycerol-induced protein:decreased activity:kidney: |
RGD |
PMID:1870354 PMID:22286819 |
RGD:7257559, RGD:7257585 |
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstm2 |
glutathione S-transferase mu 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20623750 |
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NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20623750 PMID:20798258 |
RGD:6903954 |
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
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IEP ISO |
protein:increased expression:urine CTD Direct Evidence: marker/mechanism protein:increased expression:urine: associated with Pyelonephritis;protein:increased expression:urine: |
CTD RGD |
PMID:20118187 PMID:21259293 PMID:21835770 PMID:22005293 PMID:23052191 PMID:23845967 PMID:24189134 PMID:24361871 PMID:24958931 PMID:28885000 PMID:23683031 PMID:23019274 PMID:23319831 More...
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RGD:7244370, RGD:7245495, RGD:7245472 |
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G |
Hbegf |
heparin-binding EGF-like growth factor |
|
IEP ISO |
mRNA:increased expression:kidney CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:7635938 PMID:11340354 |
RGD:10395241 |
NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441
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G |
Hdac2 |
histone deacetylase 2 |
treatment |
ISO |
associated with sepsis; |
RGD |
PMID:22933299 |
RGD:9590257 |
NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
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G |
Hdac3 |
histone deacetylase 3 |
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IEP |
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RGD |
PMID:21416250 |
RGD:10047111 |
NCBI chr18:30,021,847...30,041,061
Ensembl chr18:29,770,636...29,793,856
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G |
Hdac5 |
histone deacetylase 5 |
treatment |
ISO IEP |
associated with sepsis; |
RGD |
PMID:22933299 PMID:21416250 |
RGD:9590257, RGD:10047111 |
NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,152,978...87,188,235
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G |
Hes1 |
hes family bHLH transcription factor 1 |
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IEP |
mRNA:increased expression:kidney collecting duct (rat) protein:increased expression:kidney tubule (rat) |
RGD |
PMID:24397211 PMID:24325066 |
RGD:9685383, RGD:9685389 |
NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192
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G |
Hexb |
hexosaminidase subunit beta |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22005293 |
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NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
treatment |
IEP IDA |
mRNA:increased expression:renal cortex (rat) |
RGD |
PMID:18593636 PMID:16762988 PMID:15673301 |
RGD:9068894, RGD:10395386, RGD:10395376 |
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Hipk1 |
homeodomain interacting protein kinase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36052886 |
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NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:191,248,817...191,298,902
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
|
ISO |
associated with Sepsis |
RGD |
PMID:16557230 |
RGD:5508471 |
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
treatment |
IMP ISO |
associated with Sepsis CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:21048024 PMID:23807243 |
RGD:10755583 |
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hp |
haptoglobin |
|
IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28885000 PMID:19270397 |
RGD:11041863 |
NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523
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G |
Hpx |
hemopexin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12690470 PMID:19546256 |
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NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
|
IEP |
protein:increased expression:kidney, lysosome (rat) |
RGD |
PMID:14966137 |
RGD:7242786 |
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
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G |
Icam1 |
intercellular adhesion molecule 1 |
treatment |
IEP |
|
RGD |
PMID:22659586 |
RGD:7175102 |
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G |
Igf1 |
insulin-like growth factor 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:7540432 |
|
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
|
IEP |
mRNA: decreased expression: kidney: both cortex and medulla |
RGD |
PMID:9767523 |
RGD:7242908 |
NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:7540432 |
|
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
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G |
Igg-2a |
gamma-2a immunoglobulin heavy chain |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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G |
Il10 |
interleukin 10 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18460982 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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G |
Il18 |
interleukin 18 |
|
ISO |
|
RGD |
PMID:11342578 |
RGD:6893450 |
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
|
ISO |
|
RGD |
PMID:21716595 |
RGD:6907069 |
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
|
IDA ISO IEP |
mRNA:increased expression:kidney, liver, spleen (mouse) protein:increased expression:kidney (rat) |
RGD |
PMID:22750969 PMID:21677145 PMID:22286667 PMID:22659586 |
RGD:7175094, RGD:7175314, RGD:7175258, RGD:7175102 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
|
ISO |
associated with Sepsis associated with Asphyxia; rat model treated with human protein |
RGD |
PMID:16763508 PMID:14610321 PMID:16259926 |
RGD:6907360, RGD:6907375, RGD:6907369 |
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
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G |
Il20 |
interleukin 20 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18496552 |
|
NCBI chr13:44,933,249...44,936,893
Ensembl chr13:42,380,981...42,384,625
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G |
Il6 |
interleukin 6 |
|
ISO |
associated with Acute Lung Injury;protein:increased expression:plasma CTD Direct Evidence: therapeutic |
CTD RGD |
PMID:21570986 PMID:18074478 |
RGD:5128661 |
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins2 |
insulin 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12243603 |
|
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G |
Jak2 |
Janus kinase 2 |
treatment |
ISO |
associated with Carcinoma, Lewis Lung, human cells in mouse model |
RGD |
PMID:31250048 |
RGD:149735351 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G |
Klk1 |
kallikrein 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:18227104 |
|
NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754
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G |
Kng1 |
kininogen 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:513486 PMID:3015452 |
|
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
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G |
Lcn2 |
lipocalin 2 |
|
IEP ISO |
protein:increased expression:urine associated with open cardiac surgeries;protein:increased expression:urine: CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20623750 PMID:22005293 PMID:23052191 PMID:27888128 PMID:28885000 PMID:23683031 PMID:23336369 PMID:28411423 More...
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RGD:7244370, RGD:126781714, RGD:125973912 |
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
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G |
Lgals3 |
galectin 3 |
|
IEP |
mRNA:increased expression:kidney |
RGD |
PMID:10980121 |
RGD:9685228 |
NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025
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G |
Lrg1 |
leucine-rich alpha-2-glycoprotein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34677723 |
|
NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:947,516...949,813
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G |
Lrp2 |
LDL receptor related protein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29286200 |
|
NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708
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|
G |
Mb |
myoglobin |
treatment |
ISO IEP IDA |
protein: increased expression: serum associated with Rhabdomyolysis; associated with Rhabdomyolysis;protein:increased expression:renal tubules |
RGD |
PMID:23497406 PMID:20133658 PMID:37175528 PMID:9822635 |
RGD:7244253, RGD:460967414, RGD:460967411, RGD:7244259 |
NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383
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G |
Mcoln1 |
mucolipin TRP cation channel 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:38097005 |
|
NCBI chr12:6,357,851...6,372,151
Ensembl chr12:1,560,359...1,574,252
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
|
IEP |
protein:increased expression:renal parenchyma (rat) |
RGD |
PMID:17940345 |
RGD:2317469 |
NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
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G |
Mfn1 |
mitofusin 1 |
|
IEP |
protein:decreased expression:kidney (rat) |
RGD |
PMID:26480480 |
RGD:12910862 |
NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640
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G |
Mir10a |
microRNA 10a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,283,171...81,283,280
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G |
Mir122 |
microRNA 122 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr18:61,028,817...61,028,901
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G |
Mir140 |
microRNA 140 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr19:52,375,293...52,375,391
Ensembl chr19:35,465,577...35,465,675
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G |
Mir143 |
microRNA 143 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr18:57,371,349...57,371,453
Ensembl chr18:55,101,006...55,101,110
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G |
Mir146b |
microRNA 146b |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:245,203,438...245,203,525
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G |
Mir148a |
microRNA 148a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr 4:81,664,431...81,664,527
Ensembl chr 4:80,333,762...80,333,858
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G |
Mir151 |
microRNA 151 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr 7:105,172,377...105,172,473
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G |
Mir152 |
microRNA 152 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32583487 |
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NCBI chr10:82,329,383...82,329,467
Ensembl chr10:81,832,936...81,833,020
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G |
Mir192 |
microRNA 192 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr 1:212,994,209...212,994,318
Ensembl chr 1:203,564,946...203,565,055
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G |
Mir23a |
microRNA 23a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr19:40,859,769...40,859,843
Ensembl chr19:23,954,997...23,955,071
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G |
Mir25 |
microRNA 25 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
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G |
Mir26a |
microRNA 26a |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:118,755,289...118,755,378
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G |
Mir30a |
microRNA 30a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:25,737,600...25,737,670
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G |
Mir30d |
microRNA 30d |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr 7:102,025,345...102,025,426
Ensembl chr 7:100,136,391...100,136,472
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G |
Mir3473 |
microRNA 3473 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr13:42,051,691...42,051,757
Ensembl chr13:39,499,246...39,499,312
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G |
Mir423 |
microRNA 423 |
disease_progression |
ISO |
miRNA:increased expression:serum, urine |
RGD |
PMID:32984995 |
RGD:158014895 |
NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
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G |
Mir486 |
microRNA 486 |
|
ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD |
PMID:30682439 PMID:35279909 |
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G |
Mir494 |
microRNA 494 |
|
ISO |
RNA:increased expression:urine |
RGD |
PMID:23160513 |
RGD:155883172 |
NCBI chr 6:134,550,115...134,550,197
Ensembl chr 6:128,728,709...128,728,793
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G |
Mir99a |
microRNA 99a |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
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NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
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G |
Mirlet7i |
microRNA let-7i |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30682439 |
|
NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
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G |
Mpo |
myeloperoxidase |
|
ISO IDA |
DNA:haplotye: : CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20623750 PMID:22739978 PMID:19793022 |
RGD:6909168, RGD:6909185 |
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Mthfr |
methylenetetrahydrofolate reductase |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17387702 |
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NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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G |
Mtor |
mechanistic target of rapamycin kinase |
|
IMP |
|
RGD |
PMID:23022334 |
RGD:7245507 |
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G |
Muc20 |
mucin 20, cell surface associated |
|
ISO |
|
RGD |
PMID:14565953 |
RGD:7364790 |
NCBI chr11:81,492,844...81,506,571
Ensembl chr11:67,987,800...68,001,495
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G |
Mug1 |
murinoglobulin 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
|
NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
susceptibility |
ISO |
protein:decreased phosphorylation:kidney (mouse) |
RGD |
PMID:23228991 |
RGD:7207407 |
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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G |
Ndufb8 |
NADH:ubiquinone oxidoreductase subunit B8 |
|
IEP |
|
RGD |
PMID:22160772 |
RGD:13801199 |
NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817
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G |
Nes |
nestin |
|
IEP |
|
RGD |
PMID:24503548 |
RGD:11570523 |
NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
treatment |
IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:24958931 PMID:24291173 |
RGD:10412697 |
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29286200 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos1 |
nitric oxide synthase 1 |
|
IEP |
|
RGD |
PMID:14531809 |
RGD:13825139 |
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9810145 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
|
ISO IEP |
CTD Direct Evidence: marker/mechanism in females;mRNA:increased expression:cortex of kidney (rat) |
CTD RGD |
PMID:9788586 PMID:28947737 |
RGD:13450947 |
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
|
IEP ISO |
mRNA:increased expression:kidney CTD Direct Evidence: marker/mechanism|therapeutic |
CTD RGD |
PMID:1825077 PMID:2948068 PMID:19298916 PMID:22209992 |
RGD:7247715 |
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
|
ISO IEP |
associated with lung diseases;protein:increased expression:serum: mRNA:increased expression:kidney associated with Myocardial Infarction;protein:increased expression:serum: associated with Pneumonia;protein:increased expression:serum: |
RGD |
PMID:23837838 PMID:22209992 PMID:23192919 PMID:23415693 |
RGD:7247620, RGD:7247715, RGD:7247624, RGD:7247622 |
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
treatment |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:26723870 PMID:28230744 |
RGD:13440091 |
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G |
Ocln |
occludin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19766176 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
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G |
Orm1 |
orosomucoid 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
|
NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:76,772,941...76,776,154
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
ISO |
|
RGD |
PMID:21884784 |
RGD:5510015 |
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Pkd2 |
polycystin 2, transient receptor potential cation channel |
|
IEP |
protein:altered localization |
RGD |
PMID:12089381 |
RGD:7175293 |
NCBI chr14:5,541,821...5,585,140
Ensembl chr14:5,237,135...5,280,825
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G |
Plat |
plasminogen activator, tissue type |
|
ISO |
protein:increased expression:plasma (human) |
RGD |
PMID:9767551 |
RGD:11541071 |
NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
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G |
Plg |
plasminogen |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
|
NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786
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G |
Pomc |
proopiomelanocortin |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:17216604 |
|
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
treatment |
IDA ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD RGD |
PMID:20623750 PMID:24011919 PMID:24433871 PMID:17494862 |
RGD:8553020 |
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
|
ISO |
associated with Endotoxemia; mRNA:decreased expression:kidney (mouse) |
RGD |
PMID:21881206 |
RGD:7242026 |
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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|
G |
Proc |
protein C, inactivator of coagulation factors Va and VIIIa |
treatment |
ISO |
|
RGD |
PMID:19092124 |
RGD:11250410 |
NCBI chr18:24,038,596...24,049,061
Ensembl chr18:23,764,368...23,775,133
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|
G |
Procr |
protein C receptor |
treatment |
IEP |
associated with Sepsis |
RGD |
PMID:23807243 |
RGD:10755583 |
NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:144,254,380...144,258,903
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|
G |
Ptafr |
platelet-activating factor receptor |
treatment |
IMP |
associated with Endotoxemia |
RGD |
PMID:2538527 |
RGD:10043182 |
NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251
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G |
Ptger4 |
prostaglandin E receptor 4 |
treatment |
IMP |
|
RGD |
PMID:16871242 |
RGD:10003092 |
NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
IMP |
|
RGD |
PMID:21893983 |
RGD:5508181 |
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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|
G |
Rapgef3 |
Rap guanine nucleotide exchange factor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21745194 |
|
NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:128,875,773...128,898,521
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|
G |
Rb1 |
RB transcriptional corepressor 1 |
|
IEP |
associated with Sepsis;protein:increased phosphorylation:kidney |
RGD |
PMID:19428114 |
RGD:8547990 |
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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G |
Ren |
renin |
exacerbates |
ISO |
Associated with toxic shock syndrome;protein:increased expression:blood plasma (human) |
RGD |
PMID:30407370 |
RGD:125097506 |
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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G |
Rup2 |
urinary protein 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 8:35,336,764...35,340,345
Ensembl chr 8:35,336,764...35,489,103
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G |
Scgb1a1 |
secretoglobin family 1A member 1 |
|
IEP |
associated with LPS induced endotoxemia |
RGD |
PMID:18824919 |
RGD:2313129 |
NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:205,977,060...205,980,610
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G |
Serpina1 |
serpin family A member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
|
NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339
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G |
Serpinc1 |
serpin family C member 1 |
|
ISO |
associated with heart failure; protein:decreased activity:plasma: |
RGD |
PMID:26108065 |
RGD:11354006 |
NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293
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G |
Sirt1 |
sirtuin 1 |
severity |
IEP ISO |
protein:increased expression:kidney (rat) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21416250 PMID:21416250 |
RGD:10047111 |
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G |
Slc11a1 |
solute carrier family 11 member 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20623750 |
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NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:75,957,316...75,968,101
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G |
Slc22a1 |
solute carrier family 22 member 1 |
treatment |
IDA |
|
RGD |
PMID:22414646 |
RGD:7243179 |
NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a12 |
solute carrier family 22 member 12 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14655203 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Slc22a19 |
solute carrier family 22, member 19 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23649842 PMID:26230185 |
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NCBI chr 1:214,339,594...214,394,681
Ensembl chr 1:204,910,455...204,965,538
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G |
Slc22a2 |
solute carrier family 22 member 2 |
treatment susceptibility |
IDA ISO IEP |
DNA:SNP: :808G>T (rs316019) human mRNA:decreased expression:kidney |
RGD |
PMID:22414646 PMID:19625999 PMID:18612803 |
RGD:7243179, RGD:7243884, RGD:7243880 |
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc34a1 |
solute carrier family 34 member 1 |
disease_progression |
ISO |
associated with Sepsis; protein:decreased expression:renal proximal tubule (mouse) |
RGD |
PMID:19729856 |
RGD:7242943 |
NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,218,876...9,233,852
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G |
Sod1 |
superoxide dismutase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Spp1 |
secreted phosphoprotein 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11274264 PMID:20623750 PMID:22863853 |
RGD:6903264 |
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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G |
Tbx1 |
T-box transcription factor 1 |
|
IEP |
mRNA:increased expression:kidney (rat) |
RGD |
PMID:24817956 |
RGD:155882498 |
NCBI chr11:95,913,610...95,923,392
Ensembl chr11:82,409,275...82,418,380
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G |
Tf |
transferrin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
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G |
Tff3 |
trefoil factor 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23052191 |
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NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054
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G |
Tgfa |
transforming growth factor alpha |
|
IEP |
mRNA:increased expression:kidney |
RGD |
PMID:11340354 |
RGD:10395241 |
NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:10469268 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34677723 |
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NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
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G |
Thbd |
thrombomodulin |
treatment |
IDA ISO |
|
RGD |
PMID:19176699 PMID:17804460 |
RGD:5684994, RGD:5685010 |
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
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G |
Tlr2 |
toll-like receptor 2 |
|
ISO |
associated with Sepsis CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:29286200 PMID:22655058 |
RGD:7207898 |
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
treatment |
ISO IDA |
associated with Sepsis CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:29286200 PMID:22655058 PMID:16638912 PMID:22266601 |
RGD:7207898, RGD:7241084, RGD:6892690 |
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tlr9 |
toll-like receptor 9 |
|
ISO |
associated with Sepsis |
RGD |
PMID:23548820 |
RGD:7245966 |
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
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G |
Tnf |
tumor necrosis factor |
susceptibility |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16595132 PMID:18460982 PMID:20623750 PMID:21150875 |
RGD:7245548 |
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf12a |
TNF receptor superfamily member 12A |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23052191 |
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NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
susceptibility |
ISO |
associated with Acute Lung Injury associated with Endotoxemia associated with Shock, Septic;protein:increased expression:serum |
RGD |
PMID:18074478 PMID:21150875 PMID:12023385 PMID:12500222 |
RGD:5128661, RGD:7245548, RGD:7245535, RGD:7245534 |
NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
|
ISO |
associated with Acute Lung Injury associated with Shock, Septic;protein:increased expression:serum |
RGD |
PMID:18074478 PMID:12500222 PMID:12865254 |
RGD:5128661, RGD:7245534, RGD:7245532 |
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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G |
Tp53 |
tumor protein p53 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20603111 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Ttr |
transthyretin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:28885000 |
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NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:3864191 |
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NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20623750 |
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NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G |
Uts2r |
urotensin 2 receptor |
|
IMP |
|
RGD |
PMID:15146030 |
RGD:2306847 |
NCBI chr10:106,936,398...106,937,558
Ensembl chr10:106,438,092...106,439,252
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G |
Vegfa |
vascular endothelial growth factor A |
|
ISO |
CTD Direct Evidence: marker/mechanism|therapeutic |
CTD |
PMID:20943766 PMID:22808199 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G |
Wnt4 |
Wnt family member 4 |
|
IDA |
|
RGD |
PMID:12707392 |
RGD:727218 |
NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859
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G |
Xdh |
xanthine dehydrogenase |
treatment |
IDA ISO |
associated with Reperfusion Injury |
RGD |
PMID:22571266 PMID:18539378 PMID:19628223 |
RGD:7247641, RGD:7247656, RGD:7247650 |
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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G |
Zfp644 |
zinc finger protein 644 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36052886 |
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NCBI chr14:3,248,350...3,324,820
Ensembl chr14:3,105,178...3,179,940
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G |
Ak4 |
adenylate kinase 4 |
|
IEP |
protein:decreased expression:kidney (rat) |
RGD |
PMID:21152904 |
RGD:5134352 |
NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:116,039,616...116,098,618
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G |
Bmp7 |
bone morphogenetic protein 7 |
|
IEP |
associated with Kidney Reperfusion Injury;protein:increased expression:kidney |
RGD |
PMID:16284088 |
RGD:1601494 |
NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788
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G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:31825490 |
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NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580
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G |
Ciita |
class II, major histocompatibility complex, transactivator |
|
ISO |
mRNA:increased expression:kidney |
RGD |
PMID:9422398 |
RGD:7242901 |
NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,140,178...5,187,440
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G |
Fabp1 |
fatty acid binding protein 1 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:18368030 |
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NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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G |
Gsr |
glutathione-disulfide reductase |
|
ISO IEP |
protein:decreased activity:renal cortex: |
RGD |
PMID:17078987 PMID:12885594 |
RGD:7257555, RGD:7257573 |
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
|
ISO |
protein:increased expression:kidney tubule, urine: |
RGD |
PMID:12081583 |
RGD:7245970 |
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G |
Nog |
noggin |
|
IEP |
associated with Kidney Reperfusion Injury |
RGD |
PMID:16284088 |
RGD:1601494 |
NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339
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G |
Pomc |
proopiomelanocortin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:4358912 PMID:6254450 |
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NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19834340 |
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NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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G |
Sod2 |
superoxide dismutase 2 |
|
ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:19917352 |
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G |
Tek |
TEK receptor tyrosine kinase |
|
IEP |
associated with Kidney Reperfusion Injury |
RGD |
PMID:16284088 |
RGD:1601494 |
NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804
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G |
Vipas39 |
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog |
|
ISO ISS |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Arthrogryposis with renal dysfunction and cholestasis syndrome |
CTD ClinVar MouseDO |
PMID:20190753 PMID:25741868 |
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NCBI chr 6:112,619,228...112,644,089
Ensembl chr 6:106,888,284...106,913,117
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G |
Vps33b |
VPS33B, late endosome and lysosome associated |
|
ISO ISS |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Arthrogryposis with renal dysfunction and cholestasis syndrome |
CTD MouseDO ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr 1:143,633,167...143,656,228
Ensembl chr 1:134,223,949...134,246,970
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G |
Fbn1 |
fibrillin 1 |
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ISO |
ClinVar Annotator: match by term: Arthrogryposis, renal dysfunction, and cholestasis 1 |
ClinVar |
PMID:25741868 |
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NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889
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G |
Vipas39 |
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog |
|
ISO |
ClinVar Annotator: match by term: Arthrogryposis, renal dysfunction, and cholestasis 1 |
ClinVar |
PMID:25741868 PMID:31319225 |
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NCBI chr 6:112,619,228...112,644,089
Ensembl chr 6:106,888,284...106,913,117
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G |
Vps33b |
VPS33B, late endosome and lysosome associated |
|
ISO |
ClinVar Annotator: match by term: Arthrogryposis, renal dysfunction, and cholestasis 1 |
OMIM ClinVar |
PMID:8151641 PMID:9536098 PMID:11668108 PMID:15052268 PMID:16896922 PMID:17576681 PMID:17994566 PMID:18853461 PMID:19274792 PMID:21851503 PMID:22753090 PMID:24782640 PMID:24917129 PMID:25239142 PMID:25741868 PMID:26505894 PMID:28492532 PMID:29907094 PMID:31343487 PMID:31479177 PMID:35126127 More...
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NCBI chr 1:143,633,167...143,656,228
Ensembl chr 1:134,223,949...134,246,970
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G |
Vipas39 |
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog |
|
ISO |
ClinVar Annotator: match by term: Arthrogryposis, renal dysfunction, and cholestasis 2 | ClinVar Annotator: match by term: VIPAS39-related condition |
OMIM ClinVar |
PMID:20190753 PMID:25741868 PMID:28492532 PMID:31479177 |
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NCBI chr 6:112,619,228...112,644,089
Ensembl chr 6:106,888,284...106,913,117
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G |
Adamts13 |
ADAM metallopeptidase with thrombospondin type 1 motif, 13 |
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ISO |
protein:decreased activity:serum (human) ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar RGD |
PMID:1787257 PMID:12753286 PMID:17187257 PMID:17627784 PMID:19847791 PMID:19880749 PMID:23715102 PMID:23878316 PMID:25741868 PMID:28492532 PMID:28748566 PMID:28866379 PMID:30046676 PMID:32183147 PMID:12640381 More...
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RGD:10449096 |
NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:10,300,028...10,346,687
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G |
Baat |
bile acid CoA:amino acid N-acyltransferase |
|
ISO |
ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 |
ClinVar |
PMID:17182750 PMID:20301541 |
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NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:63,850,705...63,860,685
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G |
C1galt1c1 |
C1GALT1-specific chaperone 1 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:36599939 |
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NCBI chr X:122,243,736...122,248,217
Ensembl chr X:117,375,525...117,382,787
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G |
C2 |
complement C2 |
|
ISO |
ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:1577763 PMID:2249879 PMID:6308626 PMID:8181962 PMID:9616367 PMID:16199547 PMID:16518403 PMID:16936732 PMID:18806293 PMID:20108004 PMID:20513133 PMID:21541267 PMID:22440158 PMID:24033266 PMID:24652797 PMID:25741868 PMID:28492532 PMID:35753512 More...
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NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505
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G |
C3 |
complement C3 |
|
ISO |
ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: CD46-related condition | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 DNA:missense mutations: :p.F603V, p.R1042L, p.I1157T (human) |
OMIM ClinVar CTD RGD |
PMID:1879662 PMID:1976733 PMID:9536098 PMID:12462331 PMID:14639503 PMID:16385454 PMID:17576681 PMID:17634448 PMID:18325906 PMID:18796626 PMID:19168221 PMID:19590060 PMID:20016463 PMID:20047980 PMID:20203157 PMID:20301500 PMID:20301541 PMID:20595690 PMID:21125405 PMID:21501302 PMID:21810760 PMID:22246034 PMID:22594991 PMID:22669319 PMID:22673887 PMID:23307876 PMID:23314101 PMID:23431077 PMID:23847193 PMID:24029428 PMID:24036949 PMID:24036950 PMID:24036952 PMID:24736606 PMID:24845532 PMID:25188723 PMID:25608561 PMID:25741868 PMID:25879158 PMID:25951460 PMID:26283675 PMID:26559391 PMID:26613027 PMID:26767664 PMID:26830967 PMID:27814381 PMID:28011711 PMID:28187980 PMID:28492532 PMID:28596415 PMID:28614243 PMID:28752844 PMID:28939980 PMID:29410599 PMID:29500241 PMID:29566171 PMID:29670616 PMID:29888403 PMID:30046676 PMID:30131807 PMID:30377230 PMID:30662780 PMID:30773290 PMID:30890598 PMID:31865800 PMID:32265146 PMID:32342491 PMID:32424742 PMID:32950058 PMID:33213850 PMID:33456446 PMID:33609329 PMID:34169201 PMID:34631043 PMID:34714369 PMID:34748552 PMID:34973142 PMID:35295324 PMID:35373096 PMID:17517971 PMID:20513133 More...
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RGD:7364995, RGD:11040768 |
NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429
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G |
C3ar1 |
complement C3a receptor 1 |
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ISO |
ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 |
ClinVar |
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NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:156,075,389...156,084,701
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G |
Cd46 |
CD46 molecule |
severity susceptibility |
ISO |
DNA:mutations:cds:multiple (human) ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: CD46-related condition | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: CD46-related condition | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome | ClinVar Annotator: match by term: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 CTD Direct Evidence: marker/mechanism protein:increased expression:peripheral blood mononuclear cell (human) DNA:snp:intron:c.IVS8+23T>G (rs2724374) (human) DNA:missense mutations:cds:p.R69W, p.A304V (human) |
ClinVar OMIM CTD RGD |
PMID:270646 PMID:2431077 PMID:3480783 PMID:9536098 PMID:9551389 PMID:10528197 PMID:11414356 PMID:14566051 PMID:14615110 PMID:16199547 PMID:16621965 PMID:16762990 PMID:16882452 PMID:17018561 PMID:17089378 PMID:17576681 PMID:19376828 PMID:20059470 PMID:20513133 PMID:21445332 PMID:21706448 PMID:21810760 PMID:23314101 PMID:23431077 PMID:23508668 PMID:23519521 PMID:23731345 PMID:23780777 PMID:24005975 PMID:24029428 PMID:24033266 PMID:24161037 PMID:24247905 PMID:24460647 PMID:24799305 PMID:24944786 PMID:25381125 PMID:25525159 PMID:25710174 PMID:25741868 PMID:25899302 PMID:25951460 PMID:26054645 PMID:26307634 PMID:26559391 PMID:26895476 PMID:27064621 PMID:27399110 PMID:28056875 PMID:28461395 PMID:28492532 PMID:28509134 PMID:28596415 PMID:28752844 PMID:29046944 PMID:29148534 PMID:29327071 PMID:29500241 PMID:29511899 PMID:29563339 PMID:29566171 PMID:29644059 PMID:30046676 PMID:30305631 PMID:30377230 PMID:30483272 PMID:30609409 PMID:30676336 PMID:30905589 PMID:31945341 PMID:32424742 PMID:33213850 PMID:33224962 PMID:34004375 PMID:34169200 PMID:34169201 PMID:35372954 PMID:37744338 PMID:20595690 PMID:16353080 PMID:20513133 PMID:17914026 More...
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RGD:11038684, RGD:11352810, RGD:11040768, RGD:11352768 |
NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445
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G |
Cep290 |
centrosomal protein 290 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25439097 PMID:25741868 PMID:28224992 PMID:28492532 PMID:29482223 PMID:31624253 PMID:33726816 PMID:34426522 PMID:34795310 More...
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NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:35,310,199...35,399,392
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G |
Cfb |
complement factor B |
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ISO |
DNA, protein:mutations:cds: c.858C>G, F286L, c.967A>G, K323E (human) ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome CTD Direct Evidence: marker/mechanism DNA:nonsense mutations: :multiple |
OMIM ClinVar CTD RGD |
PMID:1577763 PMID:2249879 PMID:6308626 PMID:7452889 PMID:8181962 PMID:9616367 PMID:15661753 PMID:16199547 PMID:16518403 PMID:16936732 PMID:17182750 PMID:18806293 PMID:20108004 PMID:20513133 PMID:21541267 PMID:22440158 PMID:23847193 PMID:24033266 PMID:24652797 PMID:24799305 PMID:24906628 PMID:25741868 PMID:26054779 PMID:26283675 PMID:26826462 PMID:27268256 PMID:27625572 PMID:27870017 PMID:28461395 PMID:28492532 PMID:28682564 PMID:29148534 PMID:29563339 PMID:34169201 PMID:34177949 PMID:34714369 PMID:35267578 PMID:35753512 PMID:36591303 PMID:17182750 PMID:20513133 More...
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RGD:7242707, RGD:11040768 |
NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
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G |
Cfh |
complement factor H |
susceptibility |
ISO ISS IMP |
DNA:missense mutation ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: CD46-related condition | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 2 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 1 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 CTD Direct Evidence: marker/mechanism DNA:nonsense mutations, missense mutations, splice-site mutation: :multiple DNA:deletion:Cds: DNA:SNPs,Haplotype:: |
OMIM ClinVar MouseDO CTD RGD |
PMID:646435 PMID:3418956 PMID:8072530 PMID:9536098 PMID:9551389 PMID:9811382 PMID:9848786 PMID:10577907 PMID:10762557 PMID:11158219 PMID:11170895 PMID:11170896 PMID:11851332 PMID:11978762 PMID:12424708 PMID:12697737 PMID:12960213 PMID:14583443 PMID:14978182 PMID:15661753 PMID:15761120 PMID:15870199 PMID:16299065 PMID:16338962 PMID:16470555 PMID:16601698 PMID:16619239 PMID:16621965 PMID:17018561 PMID:17076561 PMID:17089378 PMID:17576681 PMID:17599974 PMID:17947292 PMID:17973958 PMID:18235085 PMID:18252232 PMID:18252712 PMID:18268093 PMID:18557729 PMID:19190809 PMID:19259132 PMID:19297022 PMID:19454698 PMID:19633317 PMID:20016463 PMID:20059470 PMID:20203157 PMID:20301541 PMID:20513133 PMID:21317894 PMID:21415311 PMID:21909106 PMID:22019782 PMID:22171659 PMID:22223606 PMID:22389686 PMID:22403278 PMID:22410797 PMID:22456601 PMID:22594991 PMID:22669321 PMID:23235567 PMID:23307876 PMID:23431077 PMID:23685748 PMID:23852337 PMID:23870792 PMID:24036949 PMID:24036952 PMID:24333077 PMID:24498017 PMID:24799305 PMID:24847005 PMID:24906858 PMID:24933457 PMID:25006455 PMID:25037630 PMID:25087612 PMID:25188723 PMID:25525159 PMID:25741868 PMID:25814826 PMID:25880396 PMID:25951460 PMID:26215151 PMID:26283675 PMID:26376859 PMID:26501415 PMID:26559391 PMID:26613026 PMID:26691988 PMID:26826462 PMID:26915021 PMID:27064621 PMID:27572114 PMID:27718086 PMID:27939104 PMID:28011711 PMID:28176477 PMID:28492532 PMID:28596415 PMID:28859202 PMID:28941939 PMID:29218045 PMID:29410599 PMID:29500241 PMID:29511899 PMID:29686068 PMID:29888403 PMID:30046676 PMID:30295827 PMID:30560448 PMID:30674459 PMID:30930551 PMID:31447099 PMID:31575699 PMID:31589614 PMID:32185379 PMID:33048203 PMID:33369641 PMID:33519811 PMID:33873197 PMID:34169201 PMID:34189567 PMID:34260947 PMID:34508573 PMID:34714369 PMID:34748552 PMID:34912830 PMID:35925583 PMID:35930268 PMID:36246952 PMID:36445700 PMID:10577907 PMID:9811382 PMID:23243267 PMID:20513133 PMID:17517971 PMID:17517971 PMID:17517971 More...
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RGD:1599886, RGD:11041172, RGD:11041162, RGD:11040768, RGD:7364995, RGD:7364995, RGD:7364995 |
NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838
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G |
Cfhr1 |
complement factor H-related 1 |
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ISO |
DNA:deletion ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD RGD |
PMID:16998489 PMID:17367211 PMID:18006700 PMID:20843825 PMID:25741868 PMID:26284228 PMID:28339660 PMID:28911789 PMID:28993505 PMID:33651882 PMID:33732239 PMID:35545301 PMID:23243267 More...
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RGD:11041162 |
NCBI chr13:53,946,298...53,961,282
Ensembl chr13:51,369,211...51,410,592
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G |
Cfhr4 |
complement factor H-related 4 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr13:53,973,301...54,042,179
Ensembl chr13:51,422,592...51,491,502
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G |
Cfi |
complement factor I |
susceptibility |
ISO |
ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 4 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 3 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
OMIM ClinVar CTD RGD |
PMID:849647 PMID:8613545 PMID:9536098 PMID:15173250 PMID:15917334 PMID:16199547 PMID:16621965 PMID:17084897 PMID:17576681 PMID:17597211 PMID:17599974 PMID:18374984 PMID:18557729 PMID:18825487 PMID:19065647 PMID:19861685 PMID:19877009 PMID:20016463 PMID:20106822 PMID:20203157 PMID:20301541 PMID:20513133 PMID:20595690 PMID:21445332 PMID:22710145 PMID:23307876 PMID:23314101 PMID:23421077 PMID:23431077 PMID:23685748 PMID:23787556 PMID:24033266 PMID:24034049 PMID:24036952 PMID:24161037 PMID:25037630 PMID:25135378 PMID:25352734 PMID:25741868 PMID:25741909 PMID:25758434 PMID:25788521 PMID:25796589 PMID:25899302 PMID:26691988 PMID:26767664 PMID:26826462 PMID:27268256 PMID:27939104 PMID:28282489 PMID:28455885 PMID:28492532 PMID:28750931 PMID:29148534 PMID:29292855 PMID:29392637 PMID:29410599 PMID:29500241 PMID:29566171 PMID:29888403 PMID:29940891 PMID:30225434 PMID:30541482 PMID:30851964 PMID:30890598 PMID:30916388 PMID:30982675 PMID:31049720 PMID:31231365 PMID:31249236 PMID:31440263 PMID:31517156 PMID:31900968 PMID:32098865 PMID:32447592 PMID:32510551 PMID:32853637 PMID:32908800 PMID:33238263 PMID:33712733 PMID:33841858 PMID:34153144 PMID:34169201 PMID:34272986 PMID:34748552 PMID:35069568 PMID:35253925 PMID:35526386 PMID:35531992 PMID:35619721 PMID:35914225 PMID:36793547 PMID:36845135 PMID:37105825 PMID:37369098 PMID:37466676 PMID:15173250 More...
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RGD:6906889 |
NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561
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G |
Col4a3 |
collagen type IV alpha 3 chain |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:11134255 PMID:12028435 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 More...
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NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:83,875,561...84,001,895
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G |
Col4a4 |
collagen type IV alpha 4 chain |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:9792860 PMID:11134255 PMID:11685592 PMID:11961012 PMID:12028435 PMID:12631110 PMID:14871398 PMID:17216251 PMID:17396119 PMID:19129241 PMID:20029656 PMID:24033266 PMID:25741868 PMID:26467025 PMID:26809805 PMID:26934356 PMID:27884173 PMID:28059119 PMID:28492532 More...
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NCBI chr 9:91,281,324...91,323,577
Ensembl chr 9:83,755,515...83,875,876
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G |
Col4a5 |
collagen type IV alpha 5 chain |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:7599631 PMID:7695699 PMID:8218237 PMID:8651296 PMID:8940267 PMID:9848783 PMID:11462238 PMID:11572889 PMID:12028435 PMID:14514738 PMID:17396119 PMID:19344236 PMID:19965530 PMID:21505094 PMID:23144074 PMID:23720012 PMID:24033266 PMID:24046192 PMID:24304881 PMID:25741868 PMID:26467025 PMID:27627812 PMID:28492532 PMID:30577881 PMID:30773290 More...
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NCBI chr X:109,907,251...110,111,214
Ensembl chr X:105,118,820...105,322,692
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G |
Dgke |
diacylglycerol kinase epsilon |
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ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, susceptibility to, 1 |
CTD ClinVar |
PMID:23274426 PMID:23542698 PMID:24511134 PMID:24747643 PMID:25135762 PMID:25443527 PMID:25741868 PMID:25854283 PMID:28117080 PMID:28492532 PMID:28496993 PMID:28526779 PMID:29590070 PMID:29869118 More...
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NCBI chr10:74,348,931...74,374,509
Ensembl chr10:73,855,583...73,877,100
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G |
Hbb |
hemoglobin subunit beta |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:893142 PMID:1726094 PMID:7558877 PMID:25741868 |
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NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012
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G |
Lamb2 |
laminin subunit beta 2 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:109,178,409...109,190,549
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G |
Mmachc |
metabolism of cobalamin associated C |
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ISO |
ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:16311595 PMID:16714133 PMID:17768669 PMID:17853453 PMID:18164228 PMID:18245139 PMID:19370762 PMID:19760748 PMID:20549364 PMID:20610126 PMID:20631720 PMID:23757202 PMID:23837176 PMID:24033266 PMID:24126030 PMID:24599607 PMID:25687216 PMID:25741868 PMID:25894566 PMID:26467025 PMID:28492532 PMID:28835862 PMID:29294253 PMID:29302025 PMID:29396438 PMID:31137025 PMID:31279840 PMID:32164588 PMID:33562640 PMID:36338977 More...
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NCBI chr 5:135,403,094...135,409,285
Ensembl chr 5:130,166,451...130,172,601
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G |
Myh9 |
myosin, heavy chain 9 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 |
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NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Nphp3 |
nephrocystin 3 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:26184788 PMID:28492532 |
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NCBI chr 8:113,500,708...113,541,179
Ensembl chr 8:104,621,864...104,662,383
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G |
Nphp4 |
nephrocystin 4 |
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ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr 5:168,270,522...168,356,393
Ensembl chr 5:162,988,370...163,073,706
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G |
Pla2r1 |
phospholipase A2 receptor 1 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 |
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NCBI chr 3:65,292,629...65,422,462
Ensembl chr 3:44,883,943...45,013,660
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G |
Plg |
plasminogen |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:48,325,185...48,367,786
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G |
Smarcal1 |
SNF2 related chromatin remodeling annealing helicase 1 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:28492532 PMID:28844315 |
|
NCBI chr 9:81,689,446...81,735,406
Ensembl chr 9:74,240,241...74,286,146
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G |
Thbd |
thrombomodulin |
severity susceptibility no_association |
ISO |
ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: THBD-related condition ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 5 | ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome | ClinVar Annotator: match by term: Familial Atypical Hemolytic-Uremic Syndrome ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome CTD Direct Evidence: marker/mechanism DNA:SNPs:5' utr, 3' utr:multiple DNA:missense mutations:CDS:multiple |
OMIM ClinVar CTD RGD |
PMID:7811989 PMID:9157575 PMID:9198186 PMID:9236408 PMID:10102456 PMID:10460600 PMID:11245641 PMID:11552992 PMID:11986219 PMID:12139752 PMID:15574195 PMID:17677000 PMID:19625716 PMID:20595690 PMID:23314101 PMID:23332921 PMID:24029428 PMID:24799305 PMID:24933457 PMID:25135378 PMID:25741868 PMID:27904864 PMID:28492532 PMID:28939980 PMID:31064749 PMID:31118930 PMID:32890900 PMID:32935436 PMID:34355501 PMID:20595690 PMID:19625716 PMID:19625716 More...
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RGD:11038684, RGD:11038691, RGD:11038691 |
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
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G |
Tmem67 |
transmembrane protein 67 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:25,536,458...25,589,334
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:19380626 PMID:25741868 |
|
NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092
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G |
Wt1 |
WT1 transcription factor |
|
ISO |
ClinVar Annotator: match by term: Atypical hemolytic-uremic syndrome |
ClinVar |
PMID:18559874 PMID:18591546 PMID:19171881 PMID:19221039 PMID:19494353 PMID:19536888 PMID:20368469 PMID:20413658 PMID:20435628 PMID:25110071 PMID:25741868 PMID:25932436 PMID:26725263 PMID:28492532 More...
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|
NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643
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G |
Ren |
renin |
|
ISO |
ClinVar Annotator: match by term: EARLY-ONSET HYPERURICEMIA, ANEMIA, AND PROGRESSIVE KIDNEY FAILURE | ClinVar Annotator: match by term: REN-related condition | ClinVar Annotator: match by term: TUBULOINTERSTITIAL KIDNEY DISEASE, AUTOSOMAL DOMINANT, 4 CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD |
PMID:16116425 PMID:19664745 PMID:21084044 PMID:21473025 PMID:22095942 PMID:25741868 PMID:28492532 PMID:32750457 PMID:33532864 PMID:37283036 More...
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|
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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G |
Gh1 |
growth hormone 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:14728886 |
|
NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,228,103...91,230,078
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G |
Ren |
renin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:6338847 |
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NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
susceptibility |
ISO IEP |
protein:increased expression:kidney tubule: |
RGD |
PMID:23220287 PMID:22367506 |
RGD:7245477, RGD:7245950 |
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G |
Mir21 |
microRNA 21 |
ameliorates |
IMP |
|
RGD |
PMID:28760335 |
RGD:41410821 |
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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G |
Myocd |
myocardin |
ameliorates |
ISO IMP |
mRNA,protein:increased expression:left ventricle |
RGD |
PMID:30971740 PMID:30971740 |
RGD:401793740, RGD:401793740 |
NCBI chr10:50,332,356...50,426,819
Ensembl chr10:49,836,641...49,927,627
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G |
Aco1 |
aconitase 1 |
|
IEP |
|
RGD |
PMID:20176611 |
RGD:11541086 |
NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391
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G |
Alb |
albumin |
disease_progression |
ISO |
|
RGD |
PMID:24370342 |
RGD:11035281 |
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
|
ISO |
|
RGD |
PMID:17298994 |
RGD:7241819 |
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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|
G |
Ccn2 |
cellular communication network factor 2 |
disease_progression |
IEP |
mRNA, protein:increased expression:kidney (rat) |
RGD |
PMID:19921985 |
RGD:150517553 |
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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G |
Clu |
clusterin |
treatment |
IEP |
|
RGD |
PMID:22494435 |
RGD:9068431 |
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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|
G |
Cs |
citrate synthase |
treatment |
IDA |
|
RGD |
PMID:20005400 |
RGD:243048470 |
NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421
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|
G |
Mmp3 |
matrix metallopeptidase 3 |
|
ISO |
|
RGD |
PMID:22845765 |
RGD:7241226 |
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
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|
G |
Mmp7 |
matrix metallopeptidase 7 |
treatment |
IDA |
|
RGD |
PMID:18209025 |
RGD:9685339 |
NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
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G |
Pdgfa |
platelet derived growth factor subunit A |
|
IEP |
|
RGD |
PMID:11889420 |
RGD:11080974 |
NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497
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G |
Pdgfb |
platelet derived growth factor subunit B |
|
IEP |
mRNA:increased expression:kidney: |
RGD |
PMID:15785371 PMID:11889420 |
RGD:10449491, RGD:11080974 |
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdgfra |
platelet derived growth factor receptor alpha |
|
IEP |
|
RGD |
PMID:11889420 |
RGD:11080974 |
NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
|
IEP |
|
RGD |
PMID:11889420 |
RGD:11080974 |
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
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G |
Plau |
plasminogen activator, urokinase |
|
ISO |
protein:increased secretion:T lymphocyte (human) |
RGD |
PMID:16387096 |
RGD:7241259 |
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
|
ISO |
protein:increased expression:kidney: |
RGD |
PMID:16221712 |
RGD:13208600 |
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G |
Serpine1 |
serpin family E member 1 |
treatment |
ISO |
protein:increased expression:kidney: |
RGD |
PMID:16221712 PMID:18192922 |
RGD:13208600, RGD:13208601 |
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
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G |
Actn4 |
actinin alpha 4 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
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NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847
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G |
Ager |
advanced glycosylation end product-specific receptor |
disease_progression severity susceptibility |
ISO |
DNA:polymorphism:promoter:g.-374T>A (human) DNA:polymorphisms:promoter, intron:g.-429T>C, g.2184A>G (human) associated with Diabetes Mellitus, Type 2; DNA:polymorphism:promoter:g.-429T>C (human) protein:increased expression:serum (human) |
RGD |
PMID:23593165 PMID:20185929 PMID:20353610 PMID:21432860 PMID:21822023 |
RGD:7243185, RGD:7242570, RGD:7244142, RGD:7243958, RGD:7243867 |
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078
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G |
Agtr1a |
angiotensin II receptor, type 1a |
disease_progression |
IMP ISO |
DNA:polymorphism:3' utr:1166A>C (human) |
RGD |
PMID:12089373 PMID:12832734 |
RGD:6903863, RGD:8548869 |
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
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G |
Agtr2 |
angiotensin II receptor, type 2 |
|
IMP |
|
RGD |
PMID:12089373 |
RGD:6903863 |
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
|
ISO |
mRNA, protein:increased expression:heart (mouse) |
RGD |
PMID:31746392 |
RGD:401793746 |
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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|
G |
Akap12 |
A-kinase anchoring protein 12 |
susceptibility |
ISO |
DNA:polymorphism: :rs756009(human) |
RGD |
PMID:19724895 |
RGD:14349027 |
NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:40,730,123...40,819,886
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G |
Anln |
anillin, actin binding protein |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:20,858,228...20,921,538
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G |
Aoc3 |
amine oxidase, copper containing 3 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23154672 |
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NCBI chr10:86,773,018...86,780,961
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G |
Apoa1 |
apolipoprotein A1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoa4 |
apolipoprotein A4 |
disease_progression |
ISO |
protein:increased expression:blood plasma (human) |
RGD |
PMID:21569504 |
RGD:5685637 |
NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469
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G |
Apoc3 |
apolipoprotein C3 |
|
ISO |
protein:increased expression:plasma |
RGD |
PMID:21829457 PMID:21297177 |
RGD:7207207, RGD:7207209 |
NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583
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G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023
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G |
Atic |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 9:80,614,311...80,634,360
Ensembl chr 9:73,164,846...73,184,889
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G |
Axdnd1 |
axonemal dynein light chain domain containing 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:8589695 PMID:10742096 PMID:11805166 PMID:15253708 PMID:15327385 PMID:18823551 PMID:19406966 PMID:20947785 PMID:21355056 PMID:24509478 PMID:24742477 PMID:25741868 PMID:28492532 PMID:30655312 PMID:32581362 More...
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NCBI chr13:71,022,215...71,100,010
Ensembl chr13:68,458,411...68,544,172
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G |
Azgp1 |
alpha-2-glycoprotein 1, zinc-binding |
|
IEP ISO |
protein:increased expression:white adipose tissue: protein:increased expression:plasma,white adipose tissue: |
RGD |
PMID:23423258 PMID:23423258 |
RGD:153352319, RGD:153352319 |
NCBI chr12:22,044,685...22,051,248
Ensembl chr12:16,931,024...16,939,091
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G |
B2m |
beta-2 microglobulin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:37921072 |
|
NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766
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G |
Cbr1 |
carbonyl reductase 1 |
|
IEP |
mRNA, protein:decreased expression:liver |
RGD |
PMID:25332430 |
RGD:11565077 |
NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Cfh |
complement factor H |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838
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G |
Cfhr1 |
complement factor H-related 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr13:53,946,298...53,961,282
Ensembl chr13:51,369,211...51,410,592
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G |
Cfi |
complement factor I |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:17084897 PMID:20301541 PMID:25741868 PMID:28492532 |
|
NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561
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G |
Clu |
clusterin |
|
IEP |
associated with Obesity;protein:increased expression:urine |
RGD |
PMID:24325231 |
RGD:9068427 |
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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G |
Col4a1 |
collagen type IV alpha 1 chain |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a3 |
collagen type IV alpha 3 chain |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:14871398 PMID:17216251 PMID:24033266 PMID:24854265 PMID:25741868 PMID:26346198 PMID:26467025 PMID:27391953 PMID:28492532 PMID:29924831 PMID:30245029 PMID:32723786 More...
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|
NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:83,875,561...84,001,895
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G |
Col4a4 |
collagen type IV alpha 4 chain |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:12028435 PMID:12325029 PMID:12631110 PMID:16467446 PMID:17942953 PMID:21196518 PMID:24046192 PMID:24052634 PMID:24854265 PMID:25307543 PMID:25741868 PMID:26346198 PMID:28492532 PMID:28704582 PMID:32723786 More...
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|
NCBI chr 9:91,281,324...91,323,577
Ensembl chr 9:83,755,515...83,875,876
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G |
Col6a3 |
collagen type VI alpha 3 chain |
|
ISO |
DNA:SNP:CDS:E1386K (rs146092501) (human) |
RGD |
PMID:30226566 |
RGD:401851058 |
NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:91,361,583...91,439,471
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G |
Cpb2 |
carboxypeptidase B2 |
|
ISO |
DNA:polymorphism:cds :p.A147T(rs3742264)(human) |
RGD |
PMID:19056482 |
RGD:7243119 |
NCBI chr15:56,967,128...57,015,964
Ensembl chr15:50,557,717...50,606,556
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G |
Cst3 |
cystatin C |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32450046 |
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NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
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G |
Cubn |
cubilin |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:15024727 PMID:22929189 PMID:24033266 PMID:25349199 PMID:25741868 PMID:28492532 PMID:31613795 PMID:34979989 More...
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NCBI chr17:81,293,619...81,501,694
Ensembl chr17:76,385,060...76,593,231
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
|
ISO |
mRNA, protein:increased expression:heart (mouse) |
RGD |
PMID:31746392 |
RGD:401793746 |
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
|
IEP |
protein:decreased expression:liver: |
RGD |
PMID:23045433 |
RGD:10400847 |
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
|
IEP |
protein:decreased expression:liver: |
RGD |
PMID:23045433 |
RGD:10400847 |
NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:153,454,080...153,484,428
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G |
Dnm1l |
dynamin 1-like |
treatment |
IEP |
|
RGD |
PMID:27801955 |
RGD:12738369 |
NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
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G |
Dstyk |
dual serine/threonine and tyrosine protein kinase |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr13:46,409,412...46,457,426
Ensembl chr13:43,857,266...43,905,269
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr11:92,746,409...92,779,647
Ensembl chr11:79,241,938...79,275,188
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G |
Etfb |
electron transfer flavoprotein subunit beta |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:24215330 PMID:25741868 PMID:28492532 |
|
NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:93,851,858...93,866,068
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G |
Fgf21 |
fibroblast growth factor 21 |
|
ISO |
protein:increased expression:serum: |
RGD |
PMID:22494291 |
RGD:10401925 |
NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:96,083,441...96,090,454
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G |
Fgf23 |
fibroblast growth factor 23 |
|
IEP |
protein:increased expression:serum: |
RGD |
PMID:20016468 |
RGD:10044210 |
NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821
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|
G |
Fis1 |
fission, mitochondrial 1 |
treatment |
IEP |
|
RGD |
PMID:27801955 |
RGD:12738369 |
NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377
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|
G |
Fn1 |
fibronectin 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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|
G |
Frem1 |
Fras1 related extracellular matrix 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 5:97,321,266...97,469,523
Ensembl chr 5:97,322,538...97,469,543
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|
G |
Ganab |
glucosidase II alpha subunit |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 1:215,222,918...215,242,808
Ensembl chr 1:205,793,895...205,813,695
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|
G |
Gja1 |
gap junction protein, alpha 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:32045570 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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|
G |
Gp1ba |
glycoprotein Ib platelet subunit alpha |
exacerbates |
ISO |
|
RGD |
PMID:11314805 |
RGD:42722629 |
NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,352,899...55,356,774
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|
G |
Gpx1 |
glutathione peroxidase 1 |
treatment |
ISO |
DNA:SNP: :rs17080528 (human) |
RGD |
PMID:15954914 PMID:31924810 |
RGD:11352759, RGD:401827826 |
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
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|
G |
Grp |
gastrin releasing peptide |
|
IEP |
mRNA, protein:increased expression:aorta, plasma (human) |
RGD |
PMID:32192106 |
RGD:329961569 |
NCBI chr18:61,658,655...61,672,037
Ensembl chr18:59,388,274...59,402,061
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|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
|
IEP |
|
RGD |
PMID:22269876 |
RGD:7245952 |
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
|
IEP |
mRNA, protein:increased expression:liver |
RGD |
PMID:12841361 |
RGD:1300058 |
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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|
G |
Hp |
haptoglobin |
|
IEP |
protein:increased expression:serum |
RGD |
PMID:18569920 |
RGD:11041800 |
NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523
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|
G |
Il19 |
interleukin 19 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24714768 |
|
NCBI chr13:44,949,989...44,958,714
Ensembl chr13:42,399,138...42,405,473
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|
G |
Il1b |
interleukin 1 beta |
|
ISO IDA |
associated with Periodontitis; DNA:SNP:intron:g.3954C>T (human) mRNA:increased expression:kidney (mouse) protein:decreased expression:serum (human) |
RGD |
PMID:22795294 PMID:21975861 PMID:22398717 PMID:22613545 PMID:22728154 |
RGD:6906881, RGD:7175304, RGD:7175171, RGD:7175169, RGD:7175095 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il1rn |
interleukin 1 receptor antagonist |
susceptibility |
ISO |
protein:increased expression:plasma (human) DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human) |
RGD |
PMID:23024164 PMID:22795294 |
RGD:6906880, RGD:6906881 |
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
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|
G |
Inf2 |
inverted formin 2 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941
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|
G |
Insr |
insulin receptor |
|
IDA |
protein:decreased phosphorylation:aorta |
RGD |
PMID:22942179 |
RGD:7207055 |
NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
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|
G |
Kl |
Klotho |
disease_progression treatment |
IEP ISO |
mRNA,protein:decreased expression:renal tubule, epithelial cell: protein:decreased expression:urine: protein:decreased expression:urine,plasma,kidney: |
RGD |
PMID:11967236 PMID:21115613 PMID:21115613 PMID:11967236 |
RGD:70544, RGD:10403077, RGD:10403077, RGD:70544 |
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
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|
G |
Klk1 |
kallikrein 1 |
susceptibility |
ISO |
associated with Vesico-Ureteral Reflux |
RGD |
PMID:15086490 |
RGD:1581752 |
NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754
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|
G |
Lcn2 |
lipocalin 2 |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:24714768 PMID:20921623 |
RGD:126781837 |
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
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G |
Lepr |
leptin receptor |
|
IMP |
|
RGD |
PMID:27465994 PMID:32390513 |
RGD:12911217, RGD:34888223 |
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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|
G |
Leprem2Mcwi |
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin |
|
IMP |
|
RGD |
PMID:32390513 PMID:27465994 |
RGD:34888223, RGD:12911217 |
|
|
G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
|
IEP |
protein:increased expression:aorta (rat) |
RGD |
PMID:32581266 |
RGD:155804294 |
NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
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|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
treatment |
IEP |
|
RGD |
PMID:24614509 |
RGD:401793742 |
NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:47,880,309...47,911,709
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|
G |
Mfn1 |
mitofusin 1 |
treatment |
IEP |
|
RGD |
PMID:27801955 |
RGD:12738369 |
NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640
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|
G |
Mt2 |
metallothionein 2 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27122239 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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|
G |
Mthfr |
methylenetetrahydrofolate reductase |
susceptibility |
ISO |
DNA:polymorphism:cds:g.677C>T (human) |
RGD |
PMID:23595572 |
RGD:7244284 |
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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|
G |
Myh9 |
myosin, heavy chain 9 |
no_association |
ISO |
|
RGD |
PMID:22956460 |
RGD:12798515 |
NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
treatment |
IEP |
|
RGD |
PMID:23174956 |
RGD:10412711 |
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24244623 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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G |
Nherf1 |
NHERF family PDZ scaffold protein 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:18784102 PMID:25741868 PMID:28492532 |
|
NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,403,069...100,420,598
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G |
Nos3 |
nitric oxide synthase 3 |
susceptibility treatment |
IEP |
mRNA:decreased expression:cortex of kidney (rat) |
RGD |
PMID:29018182 PMID:29247650 |
RGD:13450920, RGD:13504713 |
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
severity treatment |
ISO |
mRNA:increased expression:urine (human) human cells in rat model |
RGD |
PMID:30133147 PMID:33298161 |
RGD:38549368, RGD:155631310 |
NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:8589695 PMID:10742096 PMID:11729243 PMID:11805166 PMID:11854170 PMID:12649741 PMID:14570703 PMID:14675423 PMID:14978175 PMID:15253708 PMID:15327385 PMID:17371932 PMID:17942957 PMID:18216321 PMID:18443213 PMID:18823551 PMID:19371226 PMID:19406966 PMID:20798252 PMID:20947785 PMID:21171529 PMID:21355056 PMID:21415313 PMID:23242530 PMID:24089165 PMID:24227627 PMID:24500309 PMID:24509478 PMID:24742477 PMID:24856380 PMID:25349199 PMID:25741868 PMID:25852895 PMID:26467025 PMID:28492532 PMID:28780565 PMID:29049388 PMID:29127259 PMID:29382718 PMID:29982877 PMID:30655312 PMID:32129207 PMID:32581362 More...
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NCBI chr13:70,993,622...71,011,585
Ensembl chr13:68,448,926...68,461,313
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|
G |
Nppa |
natriuretic peptide A |
disease_progression |
ISO |
protein:increased expression:plasma |
RGD |
PMID:19052536 |
RGD:7247723 |
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
disease_progression |
ISO |
|
RGD |
PMID:23725445 |
RGD:7246908 |
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
treatment |
IDA |
|
RGD |
PMID:22227174 |
RGD:10769366 |
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
disease_progression |
IMP |
|
RGD |
PMID:24722447 |
RGD:12910103 |
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a1m1Mcwi |
nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin |
disease_progression |
IMP |
|
RGD |
PMID:24722447 |
RGD:12910103 |
|
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
treatment |
IEP |
|
RGD |
PMID:27801955 |
RGD:12738369 |
NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109
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G |
Pask |
PAS domain containing serine/threonine kinase |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr 9:101,291,673...101,333,288
Ensembl chr 9:93,844,278...93,885,111
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G |
Pax2 |
paired box 2 |
treatment |
ISO |
human cells in rat model |
RGD |
PMID:33298161 |
RGD:155631310 |
NCBI chr 1:253,555,447...253,646,623
Ensembl chr 1:243,616,606...243,695,321
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G |
Pcsk2 |
proprotein convertase subtilisin/kexin type 2 |
|
IDA |
|
RGD |
PMID:18039782 |
RGD:6483556 |
NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127
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G |
Pkd1 |
polycystin 1, transient receptor potential channel interacting |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128
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G |
Postn |
periostin |
|
ISO |
protein:increased secretion:urine: protein:increased expression:kidney: |
RGD |
PMID:22167593 PMID:22403621 |
RGD:10040972, RGD:10041032 |
NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
|
ISO |
|
RGD |
PMID:22648295 |
RGD:7242023 |
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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G |
Pth |
parathyroid hormone |
severity treatment |
ISO IDA IEP |
associated with Diabetes Mellitus, Type 2; protein:increased expression:serum (human) protein:decreased expression:plasma (rat) |
RGD |
PMID:23528898 PMID:22517117 PMID:21826734 PMID:23345625 PMID:23467111 |
RGD:7242412, RGD:7242949, RGD:7242935, RGD:7242572, RGD:7242418 |
NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530
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G |
Rbp4 |
retinol binding protein 4 |
onset |
ISO |
associated with type 2 diabetes mellitus; protein:increased expression:blood serum (human) |
RGD |
PMID:21817822 |
RGD:329853323 |
NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399
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G |
Retn |
resistin |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22421264 |
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NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
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G |
Rnls |
renalase, FAD-dependent amine oxidase |
|
IEP |
protein, activity:decreased expression:plasma, heart, kidney: |
RGD |
PMID:18299506 |
RGD:7327164 |
NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:231,037,486...231,309,823
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G |
Rtn3 |
reticulon 3 |
|
ISS |
|
MouseDO |
|
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NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275
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G |
Sall1 |
spalt-like transcription factor 1 |
treatment |
ISO |
human cells in rat model |
RGD |
PMID:33298161 |
RGD:155631310 |
NCBI chr19:34,179,316...34,196,278
Ensembl chr19:18,007,503...18,022,705
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G |
Serpina3n |
serpin family A member 3N |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:35635602 |
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NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433
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G |
Shh |
sonic hedgehog signaling molecule |
|
IEP ISO |
mRNA, protein:increased expression:kidney |
RGD |
PMID:24744439 PMID:24744439 |
RGD:12859042, RGD:12859042 |
NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170
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G |
Six2 |
SIX homeobox 2 |
treatment |
ISO |
human cells in rat model |
RGD |
PMID:33298161 |
RGD:155631310 |
NCBI chr 6:14,727,756...14,734,219
Ensembl chr 6:8,967,157...8,981,193
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G |
Slc19a1 |
solute carrier family 19 member 1 |
|
IEP |
mRNA:decreased expression:multiple (rat) |
RGD |
PMID:21149507 |
RGD:7327184 |
NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972
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G |
Slc19a2 |
solute carrier family 19 member 2 |
|
IEP |
mRNA:decreased expression:liver, heart (rat) |
RGD |
PMID:21149507 |
RGD:7327184 |
NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
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G |
Slc19a3 |
solute carrier family 19 member 3 |
|
IEP |
mRNA:decreased expression:liver, heart, jejunum (rat) |
RGD |
PMID:21149507 |
RGD:7327184 |
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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G |
Slc34a1 |
solute carrier family 34 member 1 |
|
IEP ISO |
mRNA:decreased expression:kidney (rat) DNA:snp:intron:IVS9+122A>G rs6420094 (human) |
RGD |
PMID:21826734 PMID:20383146 |
RGD:7242935, RGD:7243100 |
NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,218,876...9,233,852
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G |
Slc46a1 |
solute carrier family 46 member 1 |
|
IEP |
mRNA:decreased expression:liver, heart, jejunum (rat) |
RGD |
PMID:21149507 |
RGD:7327184 |
NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,361,486...63,368,848
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G |
Synpo |
synaptopodin |
treatment |
ISO |
human cells in rat model |
RGD |
PMID:33298161 |
RGD:155631310 |
NCBI chr18:56,326,369...56,347,359
Ensembl chr18:54,026,152...54,102,126
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G |
Tbx18 |
T-box transcription factor 18 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
|
NCBI chr 8:97,531,960...97,559,988
Ensembl chr 8:88,652,054...88,680,058
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G |
Tert |
telomerase reverse transcriptase |
treatment |
IDA |
|
RGD |
PMID:23013219 |
RGD:11038770 |
NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561
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G |
Tfcp2l1 |
transcription factor CP2-like 1 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:33097957 |
|
NCBI chr13:32,286,643...32,346,671
Ensembl chr13:29,733,840...29,793,870
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G |
Tlr9 |
toll-like receptor 9 |
susceptibility |
ISS |
DNA:SNPs:promoter, exon:g.-1237T>C, g.1635G>A (rs5743836, rs352140) (human, Han Chinese) |
RGD |
PMID:21908957 |
RGD:7246887 |
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
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G |
Ttc21b |
tetratricopeptide repeat domain 21B |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:24033266 PMID:25741868 PMID:28492532 |
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NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903
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G |
Umod |
uromodulin |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 |
|
NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:173,816,339...173,830,302
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
|
IEP ISO |
protein:increased expression:kidney protein:increased expression:serum: |
RGD |
PMID:20820841 PMID:21111939 |
RGD:4145364, RGD:7241036 |
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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G |
Wnt9b |
Wnt family member 9B |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:34145744 |
|
NCBI chr10:88,635,330...88,657,035
Ensembl chr10:88,635,331...88,657,035
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G |
Wt1 |
WT1 transcription factor |
treatment |
ISO |
ClinVar Annotator: match by term: Chronic kidney disease human cells in rat model |
ClinVar RGD |
PMID:25741868 PMID:33298161 |
RGD:155631310 |
NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643
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G |
Xdh |
xanthine dehydrogenase |
treatment |
IDA ISO |
associated with Hypertension;DNA:SNP: :66292C>G (human) |
RGD |
PMID:22622455 PMID:18712049 |
RGD:7247640, RGD:7247654 |
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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G |
Zfp423 |
zinc finger protein 423 |
|
ISO |
ClinVar Annotator: match by term: Chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 PMID:32723786 |
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NCBI chr19:35,282,149...35,580,775
Ensembl chr19:19,110,238...19,407,373
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G |
Casp12 |
caspase 12 |
treatment |
IEP |
|
RGD |
PMID:27781957 |
RGD:13782262 |
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
treatment |
IDA |
|
RGD |
PMID:27781957 |
RGD:13782262 |
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Crp |
C-reactive protein |
|
ISO |
associated with coronary disease; |
RGD |
PMID:23102387 |
RGD:6909166 |
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
treatment |
IEP |
|
RGD |
PMID:27781957 |
RGD:13782262 |
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Ece1 |
endothelin converting enzyme 1 |
|
IEP |
mRNA,protein:increased expression:kidney medulla |
RGD |
PMID:18385664 |
RGD:7243946 |
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
|
IEP |
protein:increased expression:urine: |
RGD |
PMID:23335628 |
RGD:7245471 |
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
treatment |
IEP |
|
RGD |
PMID:27781957 |
RGD:13782262 |
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1b |
interleukin 1 beta |
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IDA |
associated with Diabetes Mellitus, Experimental |
RGD |
PMID:22094062 |
RGD:7175334 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Lcn2 |
lipocalin 2 |
|
IEP |
protein:increased expression:urine: associated with Diabetes Mellitus, Experimental; protein:increased expression:urine |
RGD |
PMID:23335628 PMID:23085980 |
RGD:7245471, RGD:7245484 |
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
treatment |
IDA |
|
RGD |
PMID:27781957 |
RGD:13782262 |
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G |
Mir188 |
microRNA 188 |
|
ISO IEP |
RNA:increased expression:plasma RNA:increased expression:plasma, kidney |
RGD |
PMID:27528406 PMID:27528406 |
RGD:35673289, RGD:35673289 |
NCBI chr X:15,247,715...15,247,794
Ensembl chr X:15,247,715...15,247,794
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G |
Mir30a |
microRNA 30a |
|
ISO IEP |
RNA:increased expression:plasma |
RGD |
PMID:27528406 PMID:27528406 |
RGD:35673289, RGD:35673289 |
NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:25,737,600...25,737,670
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G |
Mir30e |
microRNA 30e |
|
ISO IEP |
RNA:increased expression:plasma |
RGD |
PMID:27528406 PMID:27528406 |
RGD:35673289, RGD:35673289 |
NCBI chr 5:139,637,450...139,637,541
Ensembl chr 5:134,352,232...134,352,323
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G |
Mpo |
myeloperoxidase |
|
IDA |
|
RGD |
PMID:20722568 |
RGD:6909183 |
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Nppa |
natriuretic peptide A |
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ISO |
|
RGD |
PMID:19298916 |
RGD:7247719 |
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
|
ISO |
associated with Heart Failure |
RGD |
PMID:20438292 |
RGD:7248591 |
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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G |
Gp1ba |
glycoprotein Ib platelet subunit alpha |
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ISO |
associated with Escherichia Coli Infections;DNA:SNP:exon: (rs121908064) (human) |
RGD |
PMID:29216383 |
RGD:42722620 |
NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,352,899...55,356,774
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
ameliorates |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
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IEP |
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RGD |
PMID:17135344 |
RGD:2301067 |
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
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IDA |
|
RGD |
PMID:17135344 |
RGD:2301067 |
NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
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IDA |
|
RGD |
PMID:17135344 |
RGD:2301067 |
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
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IEP |
protein:decreased expression:intestine |
RGD |
PMID:17135344 |
RGD:2301067 |
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
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ISO IEP |
CTD Direct Evidence: marker/mechanism protein:increased expression:kidney (rat) |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
|
IEP ISO |
protein:increased expression:kidney (rat) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:53,979,813...54,008,855
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G |
Ace |
angiotensin I converting enzyme |
treatment susceptibility |
ISO IMP |
CTD Direct Evidence: marker/mechanism associated with Diabetes Mellitus, Type 2;DNA:deletion:intron:IVS16+1464-1751del (human) associated with Vesico-Ureteral Reflux;DNA:deletion |
CTD RGD |
PMID:7593601 PMID:10099885 PMID:15118671 PMID:14586729 PMID:16385653 PMID:20149750 More...
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RGD:1331525, RGD:12879398, RGD:8142355, RGD:6903283 |
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
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IEP ISO |
protein:increased expression:serum, urine CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19539174 PMID:24028144 |
RGD:8695941 |
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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G |
Adipor1 |
adiponectin receptor 1 |
|
IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19539174 PMID:24028144 |
RGD:8695941 |
NCBI chr13:48,411,438...48,431,251
Ensembl chr13:45,859,533...45,879,241
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G |
Adipor2 |
adiponectin receptor 2 |
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IEP |
|
RGD |
PMID:24028144 |
RGD:8695941 |
NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355
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G |
Adrb2 |
adrenoceptor beta 2 |
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ISO |
|
RGD |
PMID:9730702 |
RGD:7175286 |
NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
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G |
Ager |
advanced glycosylation end product-specific receptor |
|
ISO |
protein:increased expression:serum (human) |
RGD |
PMID:21822023 |
RGD:7243867 |
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078
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G |
Agt |
angiotensinogen |
|
ISO |
|
GAD |
PMID:15118671 |
RGD:1331525 |
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
|
ISO |
associated with Vesico-Ureteral Reflux;DNA:SNP: :-1332A>G (human) |
RGD |
PMID:20149750 PMID:19212419 |
RGD:6903283, RGD:6903843 |
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057
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G |
Alb |
albumin |
disease_progression |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11938814 PMID:11849406 |
RGD:11036089 |
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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G |
Alms1 |
ALMS1, centrosome and basal body associated protein |
|
ISO |
ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
ClinVar |
PMID:17594715 PMID:24462884 PMID:25296579 PMID:25741868 PMID:26066530 PMID:26104972 PMID:27178444 PMID:28492532 PMID:32581362 More...
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NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005
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G |
Apoa1 |
apolipoprotein A1 |
treatment |
ISO |
protein:decreased expression:blood protein:increased expression, increased glycation:plasma associated with Hyperlipidemias |
RGD |
PMID:22515595 PMID:18079481 PMID:20488818 |
RGD:7241208, RGD:7241576, RGD:7241571 |
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoc2 |
apolipoprotein C2 |
|
ISO |
associated with Diabetes Mellitus, Insulin-Dependent |
RGD |
PMID:8139482 |
RGD:2313968 |
NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:79,329,428...79,334,476
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G |
Apoc3 |
apolipoprotein C3 |
|
ISO |
associated with Diabetes Mellitus, Insulin-Dependent protein:increased expression: : |
RGD |
PMID:8139482 PMID:10822722 |
RGD:2313968, RGD:7207212 |
NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:46,531,478...46,533,583
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G |
Apoe |
apolipoprotein E |
|
ISO |
protein:increased expression:serum (human) |
RGD |
PMID:21705678 PMID:21332332 |
RGD:6903287, RGD:6904217 |
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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G |
Arg2 |
arginase 2 |
|
IEP |
protein:decreased activity:kidney (rat) |
RGD |
PMID:16809898 |
RGD:4110828 |
NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378
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G |
Bcl2 |
BCL2, apoptosis regulator |
treatment |
IDA |
|
RGD |
PMID:20424483 |
RGD:11522730 |
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdkrb1 |
bradykinin receptor B1 |
resistance no_association |
ISO |
DNA: SNP: G-699-->C DNA: SNP: G(-699)C |
RGD |
PMID:9555662 PMID:10604543 PMID:10809796 |
RGD:7241560, RGD:7241582, RGD:7241561 |
NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747
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G |
Becn1 |
beclin 1 |
|
IEP |
protein:increased expression:kidney |
RGD |
PMID:24090408 |
RGD:11561926 |
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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G |
Bglap |
bone gamma-carboxyglutamate protein |
|
ISO IEP |
protein:increased expression:serum |
RGD |
PMID:20845051 PMID:17365904 |
RGD:7207235, RGD:7207409 |
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
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G |
Bnip3 |
BCL2 interacting protein 3 |
|
IEP |
protein:increased expression:kidney |
RGD |
PMID:24090408 |
RGD:11561926 |
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
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G |
C6 |
complement C6 |
severity |
IAGP |
|
RGD |
PMID:11912252 |
RGD:1600675 |
NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275
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G |
Casr |
calcium-sensing receptor |
|
ISO |
protein:decreased expression:epigastric artery (human) |
RGD |
PMID:17537980 |
RGD:7205455 |
NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811
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G |
Cat |
catalase |
|
IEP ISO |
protein: decreased expression :kidney CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16518626 PMID:19420110 PMID:20007347 |
RGD:6892947 |
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26282591 |
|
NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
susceptibility treatment |
ISO IDA IEP |
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-2518A>G (human) CTD Direct Evidence: marker/mechanism protein:increased expression:renal proximal tubule (rat) |
CTD RGD |
PMID:19420110 PMID:19539174 PMID:17982227 PMID:18797164 PMID:12080327 |
RGD:2306990, RGD:2307007, RGD:8549739 |
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
|
ISO |
|
RGD |
PMID:22613545 |
RGD:7175169 |
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
|
IEP |
mRNA:increased expression:kidney cortex (rat) |
RGD |
PMID:19535570 |
RGD:4889989 |
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
|
ISO |
associated with Candidiasis, Invasive; |
RGD |
PMID:22916017 |
RGD:7241817 |
NCBI chr 8:132,433,711...132,439,266
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
|
IEP |
mRNA:increased expression:kidney cortex (rat) |
RGD |
PMID:19535570 |
RGD:4889989 |
NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
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G |
Cd2ap |
CD2-associated protein |
|
ISS |
|
MouseDO |
|
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NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:18,086,984...18,182,199
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G |
Cd40 |
CD40 molecule |
treatment severity |
ISO |
protein:increased expression:plasma |
RGD |
PMID:12941150 PMID:20846521 |
RGD:7248709, RGD:7248723 |
NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
|
ISO |
protein:increased expression:plasma |
RGD |
PMID:19019166 |
RGD:7248427 |
NCBI chr X:140,164,341...140,176,057
Ensembl chr X:135,126,969...135,138,306
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G |
Cd68 |
Cd68 molecule |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19539174 |
|
NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697
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G |
Cfb |
complement factor B |
severity |
ISO |
|
RGD |
PMID:17522263 PMID:1837062 |
RGD:7242704, RGD:7242753 |
NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
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G |
Chga |
chromogranin A |
|
ISO |
protein:increased expression:serum associated with Hypertension;DNA:polymorphisms, haplotypes:promoter, 3' utr:multiple |
RGD |
PMID:20730520 PMID:18235090 |
RGD:6906898, RGD:6906903 |
NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398
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G |
Col1a1 |
collagen type I alpha 1 chain |
|
ISO |
|
RGD |
PMID:25782334 |
RGD:11041185 |
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
|
ISO |
DNA:polymorphism: :p.I1205V (human) |
RGD |
PMID:19424605 |
RGD:7257553 |
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a3 |
collagen type IV alpha 3 chain |
|
ISO |
|
RGD |
PMID:19357112 |
RGD:7242047 |
NCBI chr 9:91,323,990...91,453,088
Ensembl chr 9:83,875,561...84,001,895
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G |
Col4a4 |
collagen type IV alpha 4 chain |
|
ISO |
ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
ClinVar RGD |
PMID:24033266 PMID:25741868 PMID:28492532 PMID:19357112 |
RGD:7242047 |
NCBI chr 9:91,281,324...91,323,577
Ensembl chr 9:83,755,515...83,875,876
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
|
ISO IEP |
CTD Direct Evidence: marker/mechanism protein:decreased expression:kidney (rat) |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
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G |
Crp |
C-reactive protein |
disease_progression |
ISO |
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19539174 PMID:22865783 |
RGD:6906886 |
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Csf1 |
colony stimulating factor 1 |
|
ISO |
protein:increased expression:plasma |
RGD |
PMID:11340249 |
RGD:7257586 |
NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704
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G |
Ctla4 |
cytotoxic T-lymphocyte-associated protein 4 |
|
ISO |
associated with Wegener Granulomatosis;DNA:polymorphisms:promoter,exon::-318C>T, (AT)repeats (human) |
RGD |
PMID:15708894 |
RGD:7204725 |
NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
|
ISO |
|
RGD |
PMID:20649681 |
RGD:7207863 |
NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:75,766,770...75,771,084
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
|
ISO |
DNA:polymorphism: :1208C>T (human) |
RGD |
PMID:23615182 |
RGD:7257672 |
NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425
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G |
Cyba |
cytochrome b-245 alpha chain |
|
IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19420110 PMID:19420110 |
RGD:2306994 |
NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
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IEP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19420110 PMID:15550752 |
RGD:1599682 |
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
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ISO IEP |
DNA:polymorphisms:exon, 3' utr:3801T>C (rs4646903), p.I462V (rs1048943) (human) mRNA, protein:decreased expression:intestine |
RGD |
PMID:23619522 PMID:12039987 |
RGD:7257728, RGD:7296923 |
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15248218 |
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NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
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IEP |
|
RGD |
PMID:11158222 PMID:8531418 |
RGD:6903939, RGD:6903940 |
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15248218 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
|
ISO |
DNA:polymorphisms: : |
RGD |
PMID:18769365 |
RGD:7243146 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
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IEP |
mRNA, protein:decreased expression:intestine |
RGD |
PMID:12039987 |
RGD:7296923 |
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Ddc |
dopa decarboxylase |
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IEP |
protein:altered activity:renal cortex (rat) |
RGD |
PMID:19167406 |
RGD:5128880 |
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208
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G |
Drd1 |
dopamine receptor D1 |
treatment |
IDA |
|
RGD |
PMID:18402547 |
RGD:7248448 |
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
|
ISO |
associated with Diabetes Mellitus, Non-Insulin Dependent; DNA:polymorphisms:5'utr, intron: -141delC, G>A (human) |
RGD |
PMID:18366720 |
RGD:2311602 |
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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G |
Edn1 |
endothelin 1 |
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IEP |
mRNA:increased expression:kidney (rat) |
RGD |
PMID:8441230 |
RGD:4144849 |
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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G |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
|
ISO |
Associated with Type 2 diabetes |
RGD |
PMID:18184924 |
RGD:6906927 |
NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:20,698,764...20,763,715
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G |
Ephx2 |
epoxide hydrolase 2 |
disease_progression |
ISO |
|
RGD |
PMID:20694143 |
RGD:5688726 |
NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615
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G |
Epo |
erythropoietin |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:16707910 |
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NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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G |
Epor |
erythropoietin receptor |
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IEP |
protein:decreased expression:heart |
RGD |
PMID:27468524 |
RGD:11532749 |
NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257
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G |
F2 |
coagulation factor II, thrombin |
treatment |
IDA |
|
RGD |
PMID:22473220 |
RGD:7387323 |
NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
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G |
F5 |
coagulation factor V |
|
ISO |
DNA:mutation: :1691G>A(human) |
RGD |
PMID:19520684 |
RGD:6893522 |
NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317
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G |
Fabp1 |
fatty acid binding protein 1 |
ameliorates |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp2 |
fatty acid binding protein 2 |
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ISO |
DNA:polymorphism:CDS:amino acid A54T, associated with Diabetes Mellitus, Type 2 (MeSH:D003924) |
RGD |
PMID:16249461 |
RGD:1578457 |
NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fasn |
fatty acid synthase |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19878707 |
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NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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G |
Fcgr2b |
Fc gamma receptor 2B |
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ISO |
|
RGD |
PMID:15266033 |
RGD:7240530 |
NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778
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G |
Fgb |
fibrinogen beta chain |
treatment |
ISO |
associated with hypertension;DNA:polymorphism: :-455G>A (human) |
RGD |
PMID:19352213 |
RGD:7175505 |
NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979
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G |
Fn1 |
fibronectin 1 |
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ISO |
protein:decreased expression:plasma |
RGD |
PMID:6665521 |
RGD:7205701 |
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G |
Gata3 |
GATA binding protein 3 |
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ISO |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
CTD ClinVar |
PMID:25741868 PMID:26970513 |
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NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
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G |
Gckr |
glucokinase regulator |
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ISO |
DNA: snp: rs1260326 |
RGD |
PMID:21980298 |
RGD:7242279 |
NCBI chr 6:30,765,071...30,795,627
Ensembl chr 6:25,045,100...25,075,654
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
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ISO |
|
RGD |
PMID:18809976 |
RGD:7242553 |
NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621
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G |
Glo1 |
glyoxalase 1 |
severity |
ISO |
DNA:SNP: :419C>A (human) |
RGD |
PMID:20185929 |
RGD:7242570 |
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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G |
Gsr |
glutathione-disulfide reductase |
|
ISO |
protein:increased activity:blood: protein:increased activity:lymphocyte: |
RGD |
PMID:20181004 PMID:6463365 |
RGD:7257547, RGD:7257560 |
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm1 |
glutathione S-transferase mu 1 |
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ISO |
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RGD |
PMID:24339523 |
RGD:14700960 |
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstt1 |
glutathione S-transferase theta 1 |
susceptibility |
ISO |
associated with Diabetes Mellitus;DNA:deletion |
RGD |
PMID:15492856 |
RGD:2306631 |
NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585
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G |
Gtpbp4 |
GTP binding protein 4 |
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IDA |
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RGD |
PMID:11316846 |
RGD:632611 |
NCBI chr17:65,997,472...66,019,530
Ensembl chr17:61,308,014...61,418,009
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G |
Guca2b |
guanylate cyclase activator 2B |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15780094 |
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NCBI chr 5:138,532,160...138,534,210
Ensembl chr 5:133,246,909...133,248,966
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G |
Hamp |
hepcidin antimicrobial peptide |
|
IEP ISO |
mRNA:increased expression:liver CTD Direct Evidence: marker/mechanism protein:increased expression:plasma |
CTD RGD |
PMID:16929540 PMID:20631677 PMID:19212416 |
RGD:11041611, RGD:11041622 |
NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891
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G |
Hbegf |
heparin-binding EGF-like growth factor |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21937979 |
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NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
|
IMP IEP ISO |
associated with Hypertension protein:decreased expression:kidney (rat) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:21119529 PMID:19878707 |
RGD:5508686, RGD:2326081 |
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:22622455 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
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IEP |
protein:increased expression:kidney (rat) |
RGD |
PMID:20820841 |
RGD:4145364 |
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G |
Igf1 |
insulin-like growth factor 1 |
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ISO |
CTD Direct Evidence: therapeutic |
CTD |
PMID:10198369 |
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NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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G |
Il1a |
interleukin 1 alpha |
no_association |
ISO |
DNA:SNP DNA:SNPs, deletion, haplotypes:3' utr:multiple (human) DNA:SNP, insertion/deletion:intron, 3' utr:rs1516792-3, rs16347-2 (human) |
RGD |
PMID:20551628 PMID:12631337 PMID:12837270 |
RGD:6907070, RGD:6907106, RGD:6907105 |
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
no_association |
ISO IEP IDA |
DNA:SNP protein:increased expression:plasma (rat) |
RGD |
PMID:20551628 PMID:20199183 PMID:22031851 |
RGD:6907070, RGD:7175346, RGD:7175302 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
disease_progression susceptibility |
ISO |
DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human) DNA:repeats:intron:IVS2+914_1000dup IL1RN*1 (human) protein:increased expression:serum (human) DNA:polymorphism:exon:g.14709C>T rs315952 (human) DNA:polymorphism:intron:IVS6+327A>G rs452204 (human) |
RGD |
PMID:17224277 PMID:16766392 PMID:16556139 PMID:12837270 PMID:20551628 |
RGD:6907131, RGD:6907370, RGD:6907368, RGD:6907105, RGD:6907070 |
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
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G |
Il20 |
interleukin 20 |
|
IEP |
protein:increased expression:multiple organs |
RGD |
PMID:18639518 |
RGD:5147394 |
NCBI chr13:44,933,249...44,936,893
Ensembl chr13:42,380,981...42,384,625
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G |
Il6 |
interleukin 6 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19539174 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Insig2 |
insulin induced gene 2 |
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IEP |
protein:decreased expression:kidney (rat) |
RGD |
PMID:19878707 |
RGD:2326081 |
NCBI chr13:35,025,160...35,052,937
Ensembl chr13:32,473,742...32,494,923
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G |
Irs1 |
insulin receptor substrate 1 |
|
IDA |
protein:decreased tyrosine phosphorylation:aorta |
RGD |
PMID:22942179 |
RGD:7207055 |
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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G |
Itga8 |
integrin subunit alpha 8 |
|
ISO |
associated with Polycystic Kidney, Autosomal Dominant;DNA:polymorphism: :-414T>C(human) |
RGD |
PMID:18277079 |
RGD:7257723 |
NCBI chr17:80,213,139...80,410,633
Ensembl chr17:75,304,008...75,501,510
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G |
Itgb3 |
integrin subunit beta 3 |
|
ISO |
associated with Hypertension;DNA:polymorphism |
RGD |
PMID:19368146 |
RGD:6907396 |
NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
|
IEP |
protein:increased expression:renal cortex, cytosol (rat) |
RGD |
PMID:20007347 |
RGD:6892947 |
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
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G |
Kl |
Klotho |
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ISO IEP |
mRNA,protein:decreased expression:kidney: mRNA:decreased expression:kidney: |
RGD |
PMID:11162628 PMID:9731228 |
RGD:10403042, RGD:10403067 |
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
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G |
Klk1 |
kallikrein 1 |
|
ISO |
|
RGD |
PMID:11849458 |
RGD:1581753 |
NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754
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G |
Lcat |
lecithin cholesterol acyltransferase |
|
IDA |
|
RGD |
PMID:15280162 |
RGD:1581769 |
NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
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G |
Lcn2 |
lipocalin 2 |
onset |
ISO |
protein:increased expression:urine: |
RGD |
PMID:22542304 |
RGD:7245503 |
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
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G |
Lep |
leptin |
|
ISO |
protein:increased expression:serum (human) |
RGD |
PMID:9294834 |
RGD:10053636 |
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Lipc |
lipase C, hepatic type |
|
IDA |
protein, mRNA:decreased expression:hepatocytes, liver (rat) |
RGD |
PMID:8636395 |
RGD:2308788 |
NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:71,509,635...71,635,464
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G |
Lipj |
lipase family member J |
|
ISO |
ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr 1:240,776,650...240,789,997
Ensembl chr 1:231,363,646...231,376,784
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G |
Lpin1 |
lipin 1 |
|
IEP |
mRNA:increased expression:skeletal muscle |
RGD |
PMID:14718385 |
RGD:1641826 |
NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:39,312,748...39,417,097
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G |
Lpl |
lipoprotein lipase |
|
IEP |
|
RGD |
PMID:22009636 |
RGD:6909179 |
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
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G |
Lrp2 |
LDL receptor related protein 2 |
|
IEP |
mRNA:decreased expression:kidney |
RGD |
PMID:15266031 |
RGD:1641836 |
NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708
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|
G |
Mbl2 |
mannose binding lectin 2 |
|
ISO |
associated with Lupus Erythematosus, Systemic;DNA:polymorphisms |
RGD |
PMID:16801331 |
RGD:6903261 |
NCBI chr 1:237,429,873...237,465,567
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G |
Mlxipl |
MLX interacting protein-like |
ameliorates |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr12:27,178,158...27,213,675
Ensembl chr12:21,543,576...21,577,112
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|
G |
Mmp1 |
matrix metallopeptidase 1 |
severity no_association |
ISO |
DNA:insertion, haplotype:promoter:g.-1607insG (human) DNA:insertion:promoter:g.-1607insG (human) |
RGD |
PMID:19221176 PMID:22401717 |
RGD:7207064, RGD:7206856 |
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
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|
G |
Mmp10 |
matrix metallopeptidase 10 |
|
ISO |
associated with Hypertension; protein:increased expression:plasma (human) |
RGD |
PMID:19886850 |
RGD:7207051 |
NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:4,689,840...4,697,748
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|
G |
Mmp2 |
matrix metallopeptidase 2 |
|
ISO |
associated with Hypertension; protein:increased expression:plasma (human) |
RGD |
PMID:19886850 |
RGD:7207051 |
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp3 |
matrix metallopeptidase 3 |
severity |
ISO |
DNA:insertion, haplotype:promoter:g.-1613insA (human) |
RGD |
PMID:19221176 |
RGD:7207064 |
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
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|
G |
Mpo |
myeloperoxidase |
disease_progression |
ISO |
|
RGD |
PMID:20638167 |
RGD:6909184 |
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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|
G |
Msc |
musculin |
susceptibility |
ISO |
associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs9298190(human) |
RGD |
PMID:19929986 |
RGD:596936222 |
NCBI chr 5:9,330,522...9,336,391
Ensembl chr 5:4,547,405...4,553,203
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|
G |
Msr1 |
macrophage scavenger receptor 1 |
|
ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19878707 |
|
NCBI chr16:59,421,250...59,507,070
Ensembl chr16:52,717,732...52,799,676
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|
G |
Mthfr |
methylenetetrahydrofolate reductase |
susceptibility severity no_association |
ISO |
DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human) DNA:SNP: :677C>T(human) DNA:transitions, transversion, haplotype:cds:g.677C>T, g.1298A>C, g.1793G>A (human) associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human) |
RGD |
PMID:19520684 PMID:25664255 PMID:17899317 PMID:14737040 PMID:19520069 |
RGD:6893522, RGD:14696732, RGD:6893579, RGD:6893524, RGD:6893523 |
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
treatment |
IMP |
|
RGD |
PMID:22427849 |
RGD:10040968 |
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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|
G |
Myh9 |
myosin, heavy chain 9 |
|
ISO |
associated with hypertension, glomerulosclerosis, focal segmental;DNA:SNPs: :rs4821480, rs2032487, rs4821481(human) CTD Direct Evidence: marker/mechanism associated with diabetes mellitus, type 2;DNA:SNPs: : DNA:SNPs:multiple: associated with hypertension;DNA:polymorphisms:multiple: associated with diabetes mellitus,type 2;DNA:SNPs: : |
CTD RGD |
PMID:18794854 PMID:18794856 PMID:18794854 PMID:21968013 PMID:20144966 PMID:19177153 PMID:19567477 More...
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RGD:6903237, RGD:6903256, RGD:6903243, RGD:6903239, RGD:6903238 |
NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457
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Nat2 |
N-acetyltransferase 2 |
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IEP |
mRNA,protein:decreased expression:liver: |
RGD |
PMID:20007296 |
RGD:11533637 |
NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520
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Ncf1 |
neutrophil cytosolic factor 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19420110 |
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NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
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Nfkb1 |
nuclear factor kappa B subunit 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19420110 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Ngf |
nerve growth factor |
treatment |
ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:24244623 PMID:19169037 |
RGD:7242783 |
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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Nos1 |
nitric oxide synthase 1 |
treatment |
IEP IDA |
protein:decreased expression:kidney cortex |
RGD |
PMID:17200156 PMID:23185775 |
RGD:1642147, RGD:7257669 |
NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945
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Nos3 |
nitric oxide synthase 3 |
susceptibility |
IEP ISO |
protein:decreased expression:glomerulus DNA:duplication, snp:intron, cds:g.IVS4?-?+27, p.E298D (human) |
RGD |
PMID:18089446 PMID:12701818 |
RGD:2292109, RGD:7777097 |
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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Nox4 |
NADPH oxidase 4 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19420110 |
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NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
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Nphs1 |
NPHS1 adhesion molecule, nephrin |
disease_progression |
IEP |
mRNA;increased expression:urine (rat) |
RGD |
PMID:19389856 |
RGD:38599006 |
NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078
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Nppb |
natriuretic peptide B |
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ISO |
protein:increased expression:plasma: |
RGD |
PMID:7606877 |
RGD:7246912 |
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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Nppc |
natriuretic peptide C |
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ISO |
protein:increased expression:plasma protein:increased expression:plasma (human) |
RGD |
PMID:8117275 PMID:8743538 |
RGD:1642297, RGD:1580770 |
NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:87,320,051...87,324,251
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Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
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IEP |
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RGD |
PMID:18591458 |
RGD:7174716 |
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
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Olr1 |
oxidized low density lipoprotein receptor 1 |
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IEP |
mRNA, protein:increased expression:kidney (rat) |
RGD |
PMID:12661921 |
RGD:1580992 |
NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:162,926,439...162,948,523
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Pax2 |
paired box 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16631587 |
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NCBI chr 1:253,555,447...253,646,623
Ensembl chr 1:243,616,606...243,695,321
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Pgf |
placental growth factor |
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IEP |
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RGD |
PMID:16543713 |
RGD:1642390 |
NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685
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Pkd1 |
polycystin 1, transient receptor potential channel interacting |
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ISO |
ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
ClinVar |
PMID:25741868 |
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NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128
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Pla2g7 |
phospholipase A2 group VII |
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ISO |
plasma:increased expression:plasma |
RGD |
PMID:16421163 |
RGD:7248787 |
NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476
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Plau |
plasminogen activator, urokinase |
treatment severity |
ISO IEP |
protein:increased expression, increased activity:kidney (rat) protein:increased expression:plasma (human) |
RGD |
PMID:19926968 PMID:15506291 PMID:17869326 PMID:22683425 |
RGD:6483806, RGD:7241279, RGD:7241218, RGD:7241081 |
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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Plaur |
plasminogen activator, urokinase receptor |
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ISO |
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RGD |
PMID:19926968 |
RGD:6483806 |
NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
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Postn |
periostin |
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IEP |
mRNA,protein:increased expression,increased secretion:kidney,urine: |
RGD |
PMID:22167593 |
RGD:10040972 |
NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099
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Ppara |
peroxisome proliferator activated receptor alpha |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19878707 |
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NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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Pparg |
peroxisome proliferator-activated receptor gamma |
disease_progression |
ISO |
associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.P12A (human) |
RGD |
PMID:18467141 |
RGD:2301857 |
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ptger4 |
prostaglandin E receptor 4 |
treatment |
IMP |
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RGD |
PMID:16871242 |
RGD:10003092 |
NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670
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Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19420110 |
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NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19420110 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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Pth |
parathyroid hormone |
severity |
IEP ISO |
protein:increased expression:serum (rat) protein:increased expression:serum (human) |
RGD |
PMID:23548814 PMID:23243213 |
RGD:7242564, RGD:7242692 |
NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:167,508,598...167,511,530
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Rela |
RELA proto-oncogene, NF-kB subunit |
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IEP ISO |
protein:increased expression:kidney CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19420110 PMID:18077597 |
RGD:2298859 |
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Retn |
resistin |
severity |
ISO |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19539174 PMID:22421264 |
RGD:7207074 |
NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
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Rnls |
renalase, FAD-dependent amine oxidase |
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ISO |
protein:decreased expression:plasma: ClinVar Annotator: match by term: Stage 5 chronic kidney disease |
ClinVar RGD |
PMID:25741868 PMID:28492532 PMID:15841207 |
RGD:7327153 |
NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:231,037,486...231,309,823
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Scaf1 |
SR-related CTD-associated factor 1 |
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IEP |
protein:increased expression:kidney (rat) |
RGD |
PMID:19878707 |
RGD:2326081 |
NCBI chr 1:95,485,448...95,499,389
Ensembl chr 1:95,485,448...95,496,029
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Scap |
SREBF chaperone |
multiple interactions |
IEP |
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RGD |
PMID:19878707 |
RGD:2326081 |
NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666
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Scarb1 |
scavenger receptor class B, member 1 |
ameliorates |
ISO IEP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:19878707 |
RGD:2326081 |
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
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Sell |
selectin L |
no_association |
ISO |
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RGD |
PMID:22119815 |
RGD:7175303 |
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456
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Serpine1 |
serpin family E member 1 |
treatment |
IDA ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19420110 PMID:26903149 |
RGD:11073683 |
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
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Slc22a2 |
solute carrier family 22 member 2 |
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IEP |
protein:decreased expression:kidney, plasma membrane |
RGD |
PMID:23280877 PMID:12110012 |
RGD:7243177, RGD:7243883 |
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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Slc34a1 |
solute carrier family 34 member 1 |
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IEP |
mRNA:decreased expression:renal cortex (rat) |
RGD |
PMID:15452708 |
RGD:7242930 |
NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,218,876...9,233,852
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Slc9a5 |
solute carrier family 9 member A5 |
resistance |
ISO |
DNA:polymorphism |
RGD |
PMID:10642288 |
RGD:1643221 |
NCBI chr19:33,225,481...33,246,913
Ensembl chr19:33,226,816...33,246,903
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Soat2 |
sterol O-acyltransferase 2 |
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IDA |
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RGD |
PMID:12217884 |
RGD:625687 |
NCBI chr 7:135,160,424...135,173,521
Ensembl chr 7:133,281,818...133,294,915
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Srebf1 |
sterol regulatory element binding transcription factor 1 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19878707 |
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NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
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IEP ISO |
mRNA, protein:increased expression:liver CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19878707 PMID:16814791 |
RGD:2308825 |
NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848
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Tbx21 |
T-box transcription factor 21 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:26970513 |
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NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831
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Tgfb1 |
transforming growth factor, beta 1 |
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IEP ISO |
mRNA, protein:increased expression:kidney CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19420110 PMID:10919844 |
RGD:7394838 |
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Thbd |
thrombomodulin |
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ISO |
protein:increased expression:plasma |
RGD |
PMID:22129968 PMID:21873362 |
RGD:5684979, RGD:5684981 |
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
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Tlr2 |
toll-like receptor 2 |
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ISO |
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RGD |
PMID:20729266 |
RGD:7240546 |
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
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Tlr4 |
toll-like receptor 4 |
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ISO |
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RGD |
PMID:20729266 |
RGD:7240546 |
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tnf |
tumor necrosis factor |
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ISO |
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:19539174 PMID:22266663 |
RGD:7245510 |
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf11b |
TNF receptor superfamily member 11B |
severity |
ISO |
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RGD |
PMID:21479768 |
RGD:7205485 |
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
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Tnfrsf1a |
TNF receptor superfamily member 1A |
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ISO |
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma |
RGD |
PMID:22266663 |
RGD:7245510 |
NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
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Tnfrsf1b |
TNF receptor superfamily member 1B |
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ISO |
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma |
RGD |
PMID:22266663 |
RGD:7245510 |
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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Ucp2 |
uncoupling protein 2 |
susceptibility |
ISO |
DNA:polymorphism: :-866G>A (human) DNA:deletion |
RGD |
PMID:19406964 PMID:18242170 |
RGD:7175298, RGD:7175299 |
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
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Vwf |
von Willebrand factor |
disease_progression treatment |
ISO |
protein:increased oxidation:plasma |
RGD |
PMID:22189209 PMID:21378155 PMID:22091998 |
RGD:7205641, RGD:7205649, RGD:7205646 |
NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
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Zmiz1 |
zinc finger, MIZ-type containing 1 |
susceptibility |
ISO |
associated with type 1 diabetes mellitus;DNA:SNP:5'UTR:rs1749824(human) |
RGD |
PMID:19929986 |
RGD:596936222 |
NCBI chr16:1,033,983...1,239,425
Ensembl chr16:1,027,325...1,232,597
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Wt1 |
WT1 transcription factor |
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ISO |
ClinVar Annotator: match by term: Frasier syndrome CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD |
PMID:1302008 PMID:1327525 PMID:1338906 PMID:1655284 PMID:1658787 PMID:6307071 PMID:7795587 PMID:8295405 PMID:8388765 PMID:8621495 PMID:9090524 PMID:9108089 PMID:9398852 PMID:9475094 PMID:9499425 PMID:9529364 PMID:9531607 PMID:9536098 PMID:9607189 PMID:9745866 PMID:9817285 PMID:10094551 PMID:10470095 PMID:10505699 PMID:10505700 PMID:10561752 PMID:10571943 PMID:10670748 PMID:10762296 PMID:10792605 PMID:11007843 PMID:11182928 PMID:11241055 PMID:11738793 PMID:12050205 PMID:12471221 PMID:12640141 PMID:12970737 PMID:15150775 PMID:15266301 PMID:15483024 PMID:15509792 PMID:16439601 PMID:16717397 PMID:16987884 PMID:17496156 PMID:17541636 PMID:17576681 PMID:17694336 PMID:17853480 PMID:18559874 PMID:18591546 PMID:18618575 PMID:19048299 PMID:19171881 PMID:19205749 PMID:19221039 PMID:19484379 PMID:19494353 PMID:19536888 PMID:20368469 PMID:20413658 PMID:20435628 PMID:20442690 PMID:20595692 PMID:21499692 PMID:21504297 PMID:21508141 PMID:21851196 PMID:22099579 PMID:22703879 PMID:22815844 PMID:22908070 PMID:23117548 PMID:23295293 PMID:23302619 PMID:23497137 PMID:23515051 PMID:23715653 PMID:23935527 PMID:24033266 PMID:24161391 PMID:24728327 PMID:24856380 PMID:25110071 PMID:25349199 PMID:25451826 PMID:25501161 PMID:25623218 PMID:25741868 PMID:25813279 PMID:25818337 PMID:25932436 PMID:26069768 PMID:26248470 PMID:26358501 PMID:26467025 PMID:26725263 PMID:27013732 PMID:27719739 PMID:27854218 PMID:27899157 PMID:28204945 PMID:28492532 PMID:28780565 PMID:28811308 PMID:29474669 PMID:29668062 PMID:30406062 PMID:30655312 PMID:30963316 PMID:31970404 PMID:32352694 PMID:32581362 PMID:32604935 PMID:32891756 PMID:34490048 PMID:34622098 PMID:35211794 PMID:35904974 PMID:36349777 PMID:36980135 More...
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NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643
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C1galt1c1 |
C1GALT1-specific chaperone 1 |
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ISO |
ClinVar Annotator: match by term: Hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature |
ClinVar OMIM |
PMID:25741868 PMID:36599939 PMID:37216524 |
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NCBI chr X:122,243,736...122,248,217
Ensembl chr X:117,375,525...117,382,787
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Alb |
albumin |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:6734075 |
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NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Ccl2 |
C-C motif chemokine ligand 2 |
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IEP |
protein:increased expression:plasma (rat) |
RGD |
PMID:10201001 |
RGD:11528527 |
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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Ccl3 |
C-C motif chemokine ligand 3 |
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ISO |
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RGD |
PMID:17220320 |
RGD:7241820 |
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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Cd36 |
CD36 molecule |
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ISO |
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RGD |
PMID:16197457 |
RGD:6893534 |
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
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Cd46 |
CD46 molecule |
susceptibility |
ISO |
DNA:frameshift mutation:cds:p.N233X3 (human) DNA:mutations:multiple (human) DNA:deletion, missense mutation:cds:p.D237_S238del, p.S206P (human) |
RGD |
PMID:14615110 PMID:16189652 PMID:14566051 |
RGD:11352767, RGD:11531138, RGD:11352770 |
NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106 | |