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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:interstitial nephritis
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Accession:DOID:1063 term browser browse the term
Definition:Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Synonyms:exact_synonym: interstitial nephritides;   renal tubulo-interstitial disease;   tubulointerstitial nephritides;   tubulointerstitial nephritis
 primary_id: MESH:D009395
 xref: ICD10CM:N12;   NCI:C26834
For additional species annotation, visit the Alliance of Genome Resources.



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interstitial nephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10916085 PMID:12217854 PMID:18176075 PMID:23994741 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10385480 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO RGD PMID:21952467 RGD:7247743 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10385480 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10385480 PMID:10385480 RGD:6483768 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Crp C-reactive protein onset ISO associated with ureteral obstruction
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17014549 PMID:21383672 PMID:21383672 RGD:6907431, RGD:6907431 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19814645 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dcn decorin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16005714 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16889433 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase IEP RGD PMID:24022426 RGD:7327155 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16005714 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Xdh xanthine dehydrogenase IMP RGD PMID:15933230 RGD:13209024 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
acute pyelonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr2 C-X-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism: :1208C>T (human) RGD PMID:22325052 RGD:7207860 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Rbp4 retinol binding protein 4 ISO protein:decreased expression:blood plasma (human) RGD PMID:20163326 RGD:329853301 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
Acute Tubulointerstitial Nephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 ISO RGD PMID:22659101 RGD:7241207 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:22194975 RGD:7207900 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:22194975 RGD:7207900 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
Balkan nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22071594 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
Chronic Tubulointerstitial Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:kidney (rat) RGD PMID:10844611 PMID:11135063 RGD:8549481, RGD:10755562 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Edn1 endothelin 1 IEP mRNA:increased expression:renal cortex (rat) RGD PMID:9893116 RGD:8662387 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:11135063 RGD:10755562 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 IEP protein:decreased localization:nucleus RGD PMID:23512109 RGD:10412728 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
Granulomatous Interstitial Nephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA, protein:increased expression:kidney, serum (rat) RGD PMID:20231821 RGD:11526149 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
karyomegalic interstitial nephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fan1 FANCD2 and FANCI associated nuclease 1 ISO
ISS
ClinVar Annotator: match by term: FAN1-related condition | ClinVar Annotator: match by term: Karyomegalic interstitial nephritis
OMIM:614817
OMIM
ClinVar
MouseDO
PMID:7847351 PMID:8546134 PMID:16678356 PMID:17304531 PMID:20621605 More... NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
JBrowse link
G Mtmr10 myotubularin related protein 10 ISO ClinVar Annotator: match by term: FAN1-related condition | ClinVar Annotator: match by term: Karyomegalic interstitial nephritis ClinVar PMID:7847351 PMID:16678356 PMID:17304531 PMID:20621605 PMID:20670886 More... NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
JBrowse link
Megalocytic Interstitial Nephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fan1 FANCD2 and FANCI associated nuclease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22772369 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
JBrowse link
pyelonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO protein:decreased expression:kidney, brush border epithelial cell (human) RGD PMID:10504496 RGD:8158033 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO RGD PMID:19205372 RGD:6904156 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G B2m beta-2 microglobulin IEP protein:increased expression:urine RGD PMID:21797109 RGD:6482315 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bmp7 bone morphogenetic protein 7 IEP protein:decreased expression:kidney RGD PMID:16034630 RGD:2289039 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO RGD PMID:15286264 RGD:7205498 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Cfb complement factor B ISO associated with pregnancy complications;protein:increased activity:plasma RGD PMID:20218820 RGD:7242756 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Crp C-reactive protein IEP RGD PMID:21797109 RGD:6482315 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 ISO DNA:SNP: :2608G>C (human)
DNA:mutations, polymorphisms: :multiple
RGD PMID:22325052 PMID:17786197 RGD:7207860, RGD:7207864 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:21814172 RGD:7257675 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyb5a cytochrome b5 type A IEP RGD PMID:9848217 RGD:1599663 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:urine (human) RGD PMID:8640042 RGD:6907372 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il3 interleukin 3 IEP mRNA:increased expression:kidney RGD PMID:18214547 RGD:2317665 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Pgf placental growth factor ISO protein:decreased expression:plasma RGD PMID:20213923 RGD:6483586 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23565217 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Retn resistin ISO protein:increased expression:plasma RGD PMID:20178460 RGD:7207160 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Tlr1 toll-like receptor 1 susceptibility ISO DNA:snp:cds:p.S602I (human) RGD PMID:19543401 RGD:7246906 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
Tubulointerstitial Nephritis and Uveitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein disease_progression ISO RGD PMID:20813859 RGD:6907435 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:kidney tubule, serum: RGD PMID:17162148 RGD:7246892 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:polymorphism (human) RGD PMID:12556395 RGD:5147802 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-Bb RT1 class II, locus Bb ISO DNA:polymorphisms:cds:HLA-DQB1*05, HLA-DQB1*0501 (human) RGD PMID:12556395 RGD:5147802 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO DNA:polymorphism (human) RGD PMID:12556395 RGD:5147802 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      Immune & Inflammatory Diseases 5752
        Inflammation 2843
          nephritis 496
            interstitial nephritis 42
              Acute Tubulointerstitial Nephritis 3
              Balkan nephropathy 1
              Chronic Tubulointerstitial Nephropathy 5
              Granulomatous Interstitial Nephritis 1
              Megalocytic Interstitial Nephritis 1
              Progressive Tubulointerstitial Nephropathy with Cholestatic Liver Disease 0
              Tubulointerstitial Nephritis and Uveitis 5
              karyomegalic interstitial nephritis 2
              pyelonephritis + 17
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      Urogenital Diseases 5391
        urinary system disease 2832
          kidney disease 2580
            nephritis 496
              interstitial nephritis 42
                Acute Tubulointerstitial Nephritis 3
                Balkan nephropathy 1
                Chronic Tubulointerstitial Nephropathy 5
                Granulomatous Interstitial Nephritis 1
                Megalocytic Interstitial Nephritis 1
                Progressive Tubulointerstitial Nephropathy with Cholestatic Liver Disease 0
                Tubulointerstitial Nephritis and Uveitis 5
                karyomegalic interstitial nephritis 2
                pyelonephritis + 17
paths to the root