RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: interstitial nephritis
Accession: DOID:1063
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Definition: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Synonyms: exact_synonym: interstitial nephritides; renal tubulo-interstitial disease; tubulointerstitial nephritides; tubulointerstitial nephritis
primary_id: MESH:D009395
xref: ICD10CM:N12 ; NCI:C26834
For additional species annotation, visit the
Alliance of Genome Resources .
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10916085 PMID:12217854 PMID:18176075 PMID:23994741
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Ccl1
C-C motif chemokine ligand 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10385480
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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Ccl11
C-C motif chemokine ligand 11
ISO
RGD
PMID:21952467
RGD:7247743
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10385480
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl7
C-C motif chemokine ligand 7
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10385480 PMID:10385480
RGD:6483768
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Crp
C-reactive protein
onset
ISO
associated with ureteral obstruction CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17014549 PMID:21383672 PMID:21383672
RGD:6907431 , RGD:6907431
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19814645
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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Dcn
decorin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16005714
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ngf
nerve growth factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16889433
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Rnls
renalase, FAD-dependent amine oxidase
IEP
RGD
PMID:24022426
RGD:7327155
NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
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Thbs1
thrombospondin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16005714
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Xdh
xanthine dehydrogenase
IMP
RGD
PMID:15933230
RGD:13209024
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Cxcr2
C-X-C motif chemokine receptor 2
susceptibility
ISO
DNA:polymorphism: :1208C>T (human)
RGD
PMID:22325052
RGD:7207860
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Rbp4
retinol binding protein 4
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:20163326
RGD:329853301
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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Apoa1
apolipoprotein A1
ISO
RGD
PMID:22659101
RGD:7241207
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Tlr2
toll-like receptor 2
ISO
RGD
PMID:22194975
RGD:7207900
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
RGD
PMID:22194975
RGD:7207900
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tp53
tumor protein p53
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22071594
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA:increased expression:kidney (rat)
RGD
PMID:10844611 PMID:11135063
RGD:8549481 , RGD:10755562
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Edn1
endothelin 1
IEP
mRNA:increased expression:renal cortex (rat)
RGD
PMID:9893116
RGD:8662387
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:11135063
RGD:10755562
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Nfe2l2
NFE2 like bZIP transcription factor 2
IEP
protein:decreased localization:nucleus
RGD
PMID:23512109
RGD:10412728
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Ccl2
C-C motif chemokine ligand 2
IEP
mRNA, protein:increased expression:kidney, serum (rat)
RGD
PMID:20231821
RGD:11526149
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Fan1
FANCD2 and FANCI associated nuclease 1
ISO ISS
ClinVar Annotator: match by term: FAN1-related condition | ClinVar Annotator: match by term: Karyomegalic interstitial nephritis OMIM:614817
OMIM ClinVar MouseDO
PMID:7847351 PMID:8546134 PMID:16678356 PMID:17304531 PMID:20621605 PMID:20670886 PMID:22772369 PMID:25741868 PMID:27196444 PMID:28492532 PMID:29590070 PMID:30773290 PMID:32111193 PMID:32220227 PMID:34386670 More...
NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
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Mtmr10
myotubularin related protein 10
ISO
ClinVar Annotator: match by term: FAN1-related condition | ClinVar Annotator: match by term: Karyomegalic interstitial nephritis
ClinVar
PMID:7847351 PMID:16678356 PMID:17304531 PMID:20621605 PMID:20670886 PMID:22772369 PMID:25741868 PMID:27196444 PMID:28492532 PMID:30773290 PMID:32111193 PMID:32220227 PMID:34386670 More...
NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
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Fan1
FANCD2 and FANCI associated nuclease 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22772369
NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
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Ace
angiotensin I converting enzyme
ISO
protein:decreased expression:kidney, brush border epithelial cell (human)
RGD
PMID:10504496
RGD:8158033
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ambp
alpha-1-microglobulin/bikunin precursor
ISO
RGD
PMID:19205372
RGD:6904156
NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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B2m
beta-2 microglobulin
IEP
protein:increased expression:urine
RGD
PMID:21797109
RGD:6482315
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bmp7
bone morphogenetic protein 7
IEP
protein:decreased expression:kidney
RGD
PMID:16034630
RGD:2289039
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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Calca
calcitonin-related polypeptide alpha
ISO
RGD
PMID:15286264
RGD:7205498
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Cfb
complement factor B
ISO
associated with pregnancy complications;protein:increased activity:plasma
RGD
PMID:20218820
RGD:7242756
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Crp
C-reactive protein
IEP
RGD
PMID:21797109
RGD:6482315
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cxcr1
C-X-C motif chemokine receptor 1
ISO
DNA:SNP: :2608G>C (human) DNA:mutations, polymorphisms: :multiple
RGD
PMID:22325052 PMID:17786197
RGD:7207860 , RGD:7207864
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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Cxcr2
C-X-C motif chemokine receptor 2
ISO
RGD
PMID:21814172
RGD:7257675
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cyb5a
cytochrome b5 type A
IEP
RGD
PMID:9848217
RGD:1599663
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Il1rn
interleukin 1 receptor antagonist
ISO
protein:increased expression:urine (human)
RGD
PMID:8640042
RGD:6907372
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il3
interleukin 3
IEP
mRNA:increased expression:kidney
RGD
PMID:18214547
RGD:2317665
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Pgf
placental growth factor
ISO
protein:decreased expression:plasma
RGD
PMID:20213923
RGD:6483586
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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Pim1
Pim-1 proto-oncogene, serine/threonine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23565217
NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
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Retn
resistin
ISO
protein:increased expression:plasma
RGD
PMID:20178460
RGD:7207160
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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Tlr1
toll-like receptor 1
susceptibility
ISO
DNA:snp:cds:p.S602I (human)
RGD
PMID:19543401
RGD:7246906
NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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Crp
C-reactive protein
disease_progression
ISO
RGD
PMID:20813859
RGD:6907435
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:kidney tubule, serum:
RGD
PMID:17162148
RGD:7246892
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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RT1-Ba
RT1 class II, locus Ba
ISO
DNA:polymorphism (human)
RGD
PMID:12556395
RGD:5147802
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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RT1-Bb
RT1 class II, locus Bb
ISO
DNA:polymorphisms:cds:HLA-DQB1*05, HLA-DQB1*0501 (human)
RGD
PMID:12556395
RGD:5147802
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1
RT1 class II, locus Db1
ISO
DNA:polymorphism (human)
RGD
PMID:12556395
RGD:5147802
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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