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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:common cold
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Accession:DOID:10459 term browser browse the term
Definition:An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus. (DO)
Synonyms:exact_synonym: Acute viral rhinopharyngitis;   Catarrh;   Catarrhs;   Common Colds;   acute coryza;   acute nasopharyngitis;   acute rhinitis;   rhino-sinusitis
 related_synonym: Rhinovirus Infection
 xref: EFO:0007214;   ICD9CM:460;   MESH:D003139;   MONDO:0005709;   NCI:C34500;   NCI:C78599
For additional species annotation, visit the Alliance of Genome Resources.



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common cold term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase IEP protein:increased expression:bronchus RGD PMID:11865407 RGD:4890421 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein IEP protein:increased expression:bronchus RGD PMID:11865407 RGD:4890421 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 IDA RGD PMID:20696083 RGD:4140458 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 IEP associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell RGD PMID:20395558 RGD:4145446 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 IEP protein:increased expression:respiratory system fluid/secretion RGD PMID:15764644 RGD:5135489 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 IEP associated with Asthma RGD PMID:12751040 RGD:5135264 NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment IEP RGD PMID:28343401 RGD:150521550 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19864593 RGD:5131210 NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G DEFB4A defensin beta 4A IEP mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus RGD PMID:15034083 RGD:4892264 NCBI chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
JBrowse link
G IFNA2 interferon alpha 2 treatment IDA RGD PMID:6381610 RGD:40886344 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398
JBrowse link
G IL10 interleukin 10 IDA RGD PMID:20696083 RGD:4140458 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha IEP protein:increased expression:nasal mucus RGD PMID:10358201 RGD:4143183 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta IEP protein:increased expression:nasal mucus RGD PMID:7734976 RGD:7401200 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist IEP
IDA
protein:increased expression:nasal mucus RGD PMID:10358201 PMID:18279051 RGD:4143183, RGD:4143207 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
JBrowse link
G IL33 interleukin 33 IEP protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G IL4 interleukin 4 ISO associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion RGD PMID:20644177 RGD:4140459 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G PRDX5 peroxiredoxin 5 IEP associated with asthma;protein:increased expression:sputum (human) RGD PMID:18219526 RGD:41404684 NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
JBrowse link
G TSLP thymic stromal lymphopoietin IEP protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 146647
    disease of anatomical entity 133718
      respiratory system disease 22193
        Respiratory Tract Infections 1781
          common cold 18
Path 2
Term Annotations click to browse term
  disease 146647
    disease by infectious agent 8205
      viral infectious disease 6774
        RNA Virus Infections 6111
          Picornaviridae Infections 70
            common cold 18
paths to the root