RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: common cold
Accession: DOID:10459
browse the term
Definition: An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus. (DO)
Synonyms: exact_synonym: Acute viral rhinopharyngitis; Catarrh; Catarrhs; Common Colds; acute coryza; acute nasopharyngitis; acute rhinitis; rhino-sinusitis
related_synonym: Rhinovirus Infection
xref: EFO:0007214 ; ICD9CM:460 ; MESH:D003139 ; MONDO:0005709 ; NCI:C34500 ; NCI:C78599
For additional species annotation, visit the
Alliance of Genome Resources .
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ALOX5
arachidonate 5-lipoxygenase
IEP
protein:increased expression:bronchus
RGD
PMID:11865407
RGD:4890421
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
IEP
protein:increased expression:bronchus
RGD
PMID:11865407
RGD:4890421
NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426
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CX3CL1
C-X3-C motif chemokine ligand 1
IDA
RGD
PMID:20696083
RGD:4140458
NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
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CXCL1
C-X-C motif chemokine ligand 1
IEP
associated with Pulmonary Disease, Chronic Obstructive;protein:increased expression:respiratory epithelial cell
RGD
PMID:20395558
RGD:4145446
NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
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CXCL10
C-X-C motif chemokine ligand 10
IEP
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:15764644
RGD:5135489
NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
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CXCL5
C-X-C motif chemokine ligand 5
IEP
associated with Asthma
RGD
PMID:12751040
RGD:5135264
NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677
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CXCL8
C-X-C motif chemokine ligand 8
treatment
IEP
RGD
PMID:28343401
RGD:150521550
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CXCR2
C-X-C motif chemokine receptor 2
ISO
RGD
PMID:19864593
RGD:5131210
NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251
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DEFB4A
defensin beta 4A
IEP
mRNA, protein:increased expression:nasal cavity epithelium, nasal mucus
RGD
PMID:15034083
RGD:4892264
NCBI chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716 Ensembl chr 8:7,894,677...7,896,716
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IFNA2
interferon alpha 2
treatment
IDA
RGD
PMID:6381610
RGD:40886344
NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398
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IL10
interleukin 10
IDA
RGD
PMID:20696083
RGD:4140458
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL1A
interleukin 1 alpha
IEP
protein:increased expression:nasal mucus
RGD
PMID:10358201
RGD:4143183
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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IL1B
interleukin 1 beta
IEP
protein:increased expression:nasal mucus
RGD
PMID:7734976
RGD:7401200
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1RN
interleukin 1 receptor antagonist
IEP IDA
protein:increased expression:nasal mucus
RGD
PMID:10358201 PMID:18279051
RGD:4143183 , RGD:4143207
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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IL33
interleukin 33
IEP
protein:increased expression:nasal mucus
RGD
PMID:28471975
RGD:38596342
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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IL4
interleukin 4
ISO
associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion
RGD
PMID:20644177
RGD:4140459
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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PRDX5
peroxiredoxin 5
IEP
associated with asthma;protein:increased expression:sputum (human)
RGD
PMID:18219526
RGD:41404684
NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811
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TSLP
thymic stromal lymphopoietin
IEP
protein:increased expression:nasal mucus (human)
RGD
PMID:28471975
RGD:38596342
NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
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