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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:prostate carcinoma
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Accession:DOID:10286 term browser browse the term
Definition:A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (DO)
Synonyms:exact_synonym: carcinoma of prostate
 narrow_synonym: metastatic prostate carcinoma
 xref: EFO:0001663;   NCI:C128122;   NCI:C4863
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
prostate carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 treatment ISO RGD PMID:24838891 RGD:13504674 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Angpt1 angiopoietin 1 ISO protein:increased expression:prostate gland RGD PMID:11326698 RGD:1643336 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Atf4 activating transcription factor 4 treatment ISO RGD PMID:25680860 RGD:13504680 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding exacerbates ISO RGD PMID:11309332 RGD:153350158 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO protein:increased expression:prostate gland RGD PMID:11781193 RGD:2292676 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator disease_progression ISO protein:increased expression:prostate gland epithelium RGD PMID:17454944 RGD:1643355 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO RGD PMID:17653717 RGD:1643474 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l14 Bcl2-like 14 ISO mRNA:decreased expression:prostate gland RGD PMID:14999772 RGD:2315712 NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086 		JBrowse link
G Bmp2 bone morphogenetic protein 2 disease_progression ISO protein:increased expression:prostate gland RGD PMID:16519147 RGD:1643592 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 disease_progression ISO protein:increased expression:prostate RGD PMID:16519147 RGD:1643592 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Casp6 caspase 6 IEP mRNA:increased expression:prostate gland RGD PMID:11406539 RGD:1582381 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Cdk13 cyclin-dependent kinase 13 ameliorates ISO RGD PMID:33390186 RGD:155641232 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide ISO mRNA:increased expression:prostate gland RGD PMID:12180238 RGD:2293634 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Chi3l1 chitinase 3 like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:16372331 RGD:4892641 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO protein:decreased tyrosine phosphorylation:prostate gland RGD PMID:16391854 RGD:7488899 NCBI chr11:97,033,033...97,067,457
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G E2f5 E2F transcription factor 5 ameliorates ISO RGD PMID:33390186 RGD:155641232 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H ISO DNA:amplification RGD PMID:14997205 RGD:2289900 NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451 		JBrowse link
G Ghrh growth hormone releasing hormone ISO mRNA:increased expression:prostate RGD PMID:12364462 RGD:2289976 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Hdac2 histone deacetylase 2 disease_progression ISO protein:increased expression:prostate gland RGD PMID:18212746 RGD:2306214 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:increased expression:prostate gland RGD PMID:18212746 RGD:2306214 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hmbs hydroxymethylbilane synthase ISO mRNA:decreased expression:tumor:in matched malignant and non-malignant sample pairs (p = 0.009) (human) RGD PMID:16211407 RGD:2301682 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP RGD PMID:18079205 RGD:13504770 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Inha inhibin subunit alpha ISO RGD PMID:11818495 RGD:2290381 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:16413376 RGD:2290480 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase disease_progression ISO protein:increased expression:primary tumor, metastatic carcinoma (human) RGD PMID:7639332 RGD:2317554 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgp matrix Gla protein ISO RGD PMID:1399132 RGD:2293578 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mki67 marker of proliferation Ki-67 IDA RGD PMID:22268182 RGD:6483545 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp7 matrix metallopeptidase 7 IDA RGD PMID:11406539 RGD:1582381 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO RGD PMID:8618340 RGD:2299063 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:23297038 RGD:13506769 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfd platelet derived growth factor D disease_progression ISO RGD PMID:21098708 RGD:13506773 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Plk1 polo-like kinase 1 ISO mRNA, protein:increased expression:prostate gland RGD PMID:15948124 RGD:2299939 NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Prkca protein kinase C, alpha ISO RGD PMID:9474241 RGD:2292463 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 ISO mRNA:decreased expression:prostate gland (human) RGD PMID:26317032 RGD:41410436 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO RGD PMID:12670908 RGD:2315046 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 disease_progression ISO protein:decreased expression:prostate gland (human) RGD PMID:16492908 RGD:1581314 NCBI chr 3:126,685,017...126,697,957
Ensembl chr 3:106,231,444...106,244,119 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:16331611 RGD:1581362 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO protein:increased activity:prostate gland RGD PMID:11987152 PMID:18210874 RGD:2298538, RGD:2291910 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO RGD PMID:11912448 RGD:2298560 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 ISO mRNA:increased expression:prostate gland RGD PMID:12875974 RGD:2291960 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Tp73 tumor protein p73 disease_progression ISO mRNA, protein:increased expression:prostate gland RGD PMID:16254107 RGD:2290587 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
castration-resistant prostate carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO mRNA,protein:increased expression:epithelial cell:
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:25555457 PMID:23196782 RGD:10053626 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ar androgen receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18985049 PMID:24740322 PMID:28500234 PMID:28757136 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr19:41,085,786...41,100,352
Ensembl chr19:24,181,028...24,195,549 		JBrowse link
G Ccne2 cyclin E2 treatment ISO RGD PMID:27431942 RGD:13504681 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd46 CD46 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:30185663 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cenpk centromere protein K ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706 		JBrowse link
G Chd1 chromodomain helicase DNA binding protein 1 ISO DNA:mutations: : RGD PMID:22722839 RGD:9587749 NCBI chr 1:56,661,743...56,729,119
Ensembl chr 1:56,664,054...56,728,125 		JBrowse link
G Kdm1a lysine demethylase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex treatment ISO RGD PMID:28498618 RGD:28867238 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A disease_progression
treatment 		ISO DNA:CNV: :prostate (human) RGD PMID:23660011 PMID:23660011 RGD:151667415, RGD:151667415 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Trim24 tripartite motif-containing 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27238081 NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241 		JBrowse link
G Zfp217 zinc finger protein 217 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 3:158,890,464...158,931,148
Ensembl chr 3:158,892,265...158,913,040 		JBrowse link
G Zfp367 zinc finger protein 367 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr17:970,896...990,025
Ensembl chr17:965,161...984,287 		JBrowse link
prostate adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing susceptibility ISO DNA:SNPs, haplotypes:5' utr, introns, exon:multiple RGD PMID:21397927 RGD:8694410 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor1 adiponectin receptor 1 susceptibility ISO DNA:SNPs, haplotype:intron, exon: (rs12733285, rs7539452) (human) RGD PMID:21397927 RGD:8694410 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ar androgen receptor treatment IDA RGD PMID:18439064 RGD:10043341 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bin1 bridging integrator 1 ISO RGD PMID:12532338 RGD:1580047 NCBI chr18:24,282,840...24,341,461
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 ameliorates ISO mRNA:increased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 exacerbates ISO mRNALincreased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:19079609 RGD:2315868 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 treatment ISO RGD PMID:25003983 RGD:18337280 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Ccnb1 cyclin B1 severity ISO RGD PMID:10193948 RGD:2315940 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne2 cyclin E2 ISO RGD PMID:25315431 RGD:13504706 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd9 CD9 molecule disease_progression ISO DNA, mRNA:deletion, point mutation, decreased expression:prostate gland RGD PMID:17406028 RGD:2326197 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ISO mRNA:decreased expression:prostate gland (human) RGD PMID:28486105 RGD:153323299 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex treatment ISO RGD PMID:26379052 RGD:13504774 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Clu clusterin treatment IEP RGD PMID:24118288 RGD:9068419 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 ISO RGD PMID:17270658 PMID:11830526 RGD:13504714, RGD:13504715 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:10192393 PMID:25741868 PMID:26619011 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO mRNA:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:14522896 RGD:2290290 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:23576558 PMID:18068632 RGD:13504748, RGD:2298702 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO RGD PMID:26103942 RGD:11056009 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:16155195 PMID:16170316 More... NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor treatment
disease_progression 		ISO
IMP 		RGD PMID:26452103 PMID:8692980 PMID:25442907 PMID:25862373 RGD:13504753, RGD:13504771, RGD:13504768, RGD:13504767 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:27196761 RGD:13504772 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ilk integrin-linked kinase disease_progression ISO protein:increased expression:tumor: high-grade tumors versus adjacent BHP (P<0.001), BHP from cancer-free patients (P<0.002), or low-grade tumors (P=0.003), also associated with proliferative index (P=0.001), but inversely related to 5-year survival (p=0.004) (human) RGD PMID:11448915 RGD:2301734 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Insr insulin receptor treatment ISO RGD PMID:26452103 RGD:13504753 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:9748134 RGD:2290484 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor ISO
IEP 		protein:increased expression:prostate gland RGD PMID:17491265 PMID:20808233 RGD:2291925, RGD:5684541 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 disease_progression IDA metastasis; inhibition reduced invasiveness of prostate tumor cells RGD PMID:12688676 RGD:2292631 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO RGD PMID:28492138 PMID:22139534 RGD:13504818, RGD:13504820 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO human gene in mouse model RGD PMID:14522256 PMID:20195545 RGD:7207413, RGD:7207781 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO human cells in mouse model RGD PMID:25664849 RGD:153002575 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfkbia NFKB inhibitor alpha severity ISO protein:increased serine phosphorylation RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO mRNA:increased expression:prostate gland (human) RGD PMID:11221851 RGD:6483769 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 treatment ISO RGD PMID:17562488 RGD:13506808 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate ClinVar PMID:15016963 PMID:15254419 PMID:15647370 PMID:15805248 PMID:18676830 More... NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment ISO RGD PMID:18755892 RGD:13217420 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Prkcq protein kinase C, theta IEP mRNA:increased expression:prostate RGD PMID:8180127 RGD:1625625 NCBI chr17:72,156,215...72,288,508
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase treatment ISO RGD PMID:15754006 RGD:13506897 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit disease_progression ISO protein:increased expression:prostate gland RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 disease_progression ISO protein:increased activity:prostate RGD PMID:9748134 RGD:2290484 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tmprss2 transmembrane serine protease 2 disease_progression ISO protein:increased expression, altered localization:prostate gland RGD PMID:18338334 RGD:2324904 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate
ClinVar Annotator: match by term: Prostate adenocarcinoma 		ClinVar PMID:1565143 PMID:1565144 PMID:11370630 PMID:12826609 PMID:19468865 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
prostate carcinoma in situ term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amacr alpha-methylacyl-CoA racemase disease_progression ISO RGD PMID:18343427 RGD:2315630 NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:59,946,153...59,958,255 		JBrowse link
G Ang angiogenin ISO RGD PMID:19276260 RGD:2325697 NCBI chr15:26,786,233...26,796,883 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO protein:increased expression, altered localization:prostate, cytoplasm RGD PMID:11309329 RGD:2315666 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Ar androgen receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20601956 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin ISO protein:increased expression:prostate gland RGD PMID:14716741 RGD:2292659 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atm ATM serine/threonine kinase ISO protein:increased serine phosphorylation:prostate gland RGD PMID:16997395 RGD:2293869 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Aurka aurora kinase A ISO protein:increased expression:prostate gland RGD PMID:15754349 PMID:16707419 RGD:2293883, RGD:2293877 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Aurkb aurora kinase B ISO RGD PMID:16707419 RGD:2293877 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 ISO protein:decreased expression:prostate gland RGD PMID:11470758 RGD:2289070 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 ISO protein:increased expression:prostate gland RGD PMID:15221992 RGD:2293206 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA, protein:decreased expression:prostate gland RGD PMID:14968434 RGD:2289283 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 ISO mRNA, protein:increased expression:prostate gland RGD PMID:14968434 RGD:2289283 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22581815 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:20932324 PMID:18691549 RGD:2299085 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 severity ISO RGD PMID:17270658 RGD:13504714 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO protein:increased expression:prostate gland RGD PMID:12381783 RGD:2293712 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO RGD PMID:19700748 RGD:7257711 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22581815 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Esr1 estrogen receptor 1 IDA
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16220300 PMID:22025007 RGD:8553211 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 treatment IDA
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16220300 PMID:22025007 RGD:8553211 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fgf6 fibroblast growth factor 6 ISO protein:increased expression:prostate gland RGD PMID:2289066 RGD:2301089 NCBI chr 4:161,541,089...161,549,624
Ensembl chr 4:159,854,913...159,863,447 		JBrowse link
G Fgf8 fibroblast growth factor 8 ISO RGD PMID:12208767 RGD:2301097 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:18068632 RGD:2298702 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO RGD PMID:14695195 RGD:2301192 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO protein:decreased expression:prostate gland RGD PMID:10893635 RGD:2301255 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fzd4 frizzled class receptor 4 ISO protein:increased expression:prostate gland RGD PMID:18068632 RGD:2298702 NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22581815 PMID:24312188 RGD:10401940 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac1 histone deacetylase 1 ISO protein:increased expression:prostate gland RGD PMID:15042618 RGD:2306219 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP protein:increased expression:prostate gland RGD PMID:19171036 RGD:2306713 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:19117991 RGD:2314913 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 ISO RGD PMID:27067790 RGD:11531513 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lrp1 LDL receptor related protein 1 IEP protein:increased expression:prostate gland RGD PMID:14623925 RGD:1625030 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 disease_progression ISO RGD PMID:17577251 RGD:2293334 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 disease_progression ISO RGD PMID:17577251 RGD:2293334 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 disease_progression ISO RGD PMID:17577251 RGD:2293334 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Mt2 metallothionein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16574721 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO RGD PMID:10861747 RGD:10059615 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Phb1 prohibitin 1 ISO mRNA, protein:increased expression:prostate gland RGD PMID:18384941 RGD:2292382 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23565217 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Prss8 serine protease 8 disease_progression ISO mRNA, protein:increased expression:prostate gland RGD PMID:12518323 RGD:2292484 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815 		JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19081794 PMID:22581815 PMID:18268330 RGD:2292497 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:altered localization RGD PMID:18468781 RGD:2300123 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:prostate gland RGD PMID:16278667 PMID:15570007 RGD:2298767, RGD:2298769 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rxra retinoid X receptor alpha IEP protein:decreased expression:prostate RGD PMID:15318950 RGD:1643115 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Slc30a4 solute carrier family 30 member 4 ISO protein:decreased expression:prostate gland RGD PMID:12955079 RGD:2299948 NCBI chr 3:130,206,852...130,228,888
Ensembl chr 3:109,753,273...109,775,306 		JBrowse link
G Smad4 SMAD family member 4 ISO protein:increased expression:prostate gland RGD PMID:15017584 RGD:2300005 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G St14 ST14 transmembrane serine protease matriptase ISO protein:increased expression:prostate gland RGD PMID:18813126 RGD:2315088 NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO RGD PMID:18381428 RGD:2291943 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 ISO RGD PMID:16940965 RGD:2290433 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Top2b DNA topoisomerase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20601956 NCBI chr15:11,482,089...11,542,464
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp63 tumor protein p63 ISO protein:decreased expression:prostate gland
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:22581815 PMID:17189982 PMID:17982114 RGD:2315434, RGD:2315433 NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
prostate small cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated ISO ClinVar Annotator: match by term: Metastatic Prostate Small Cell Carcinoma ClinVar PMID:10550133 PMID:10660329 PMID:11597388 PMID:11802209 PMID:15024741 More... NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19143
    disease of cellular proliferation 7895
      cancer 5723
        cell type cancer 3784
          carcinoma 3272
            prostate carcinoma 146
              adenosquamous prostate carcinoma 0
              castration-resistant prostate carcinoma 13
              prostate adenocarcinoma + 51
              prostate adenoid cystic carcinoma 0
              prostate carcinoma in situ 51
              prostate small cell carcinoma 1
              prostate squamous cell carcinoma 0
              prostate transitional cell carcinoma 0
Path 2
Term Annotations click to browse term
  disease 19143
    disease of anatomical entity 18456
      Urogenital Diseases 5402
        Urogenital Neoplasms 2347
          reproductive system neoplasm 1442
            reproductive organ cancer 1427
              male reproductive organ cancer 832
                prostate cancer 828
                  prostate carcinoma 146
                    adenosquamous prostate carcinoma 0
                    castration-resistant prostate carcinoma 13
                    prostate adenocarcinoma + 51
                    prostate adenoid cystic carcinoma 0
                    prostate carcinoma in situ 51
                    prostate small cell carcinoma 1
                    prostate squamous cell carcinoma 0
                    prostate transitional cell carcinoma 0
paths to the root