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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   preterm PROM (pregnancy);   preterm premature rupture of fetal membranes
 broad_synonym: SERPINH1-RELATED CONDITION
 primary_id: MESH:C563032
 alt_id: MIM:610504
 xref: MONDO:0012511

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preterm premature rupture of the membranes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr20:38,726,690...38,738,457
Ensembl chr20:38,726,798...38,739,408 		JBrowse link
G MMP1 matrix metallopeptidase 1 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767 		JBrowse link
G MMP8 matrix metallopeptidase 8 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr 1:94,097,620...94,110,114
Ensembl chr 1:94,097,896...94,109,432 		JBrowse link
G SERPINH1 serpin family H member 1 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes | ClinVar Annotator: match by term: SERPINH1-related condition ClinVar
OMIM		 PMID:16938879 PMID:25741868 PMID:28492532 PMID:32161841 PMID:37270749 NCBI chr 1:66,787,978...66,798,930
Ensembl chr 1:66,788,240...66,799,072 		JBrowse link
G TFPI tissue factor pathway inhibitor ISO protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr10:73,004,762...73,105,772
Ensembl chr10:73,002,522...73,105,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      reproductive system disease 3072
        female reproductive system disease 2096
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      Urogenital Diseases 4835
        Female Urogenital Diseases and Pregnancy Complications 2538
          Pregnancy Complications 751
            Obstetric Labor Complications 42
              Fetal Membranes, Premature Rupture 14
                preterm premature rupture of the membranes 5
paths to the root