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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   preterm PROM (pregnancy);   preterm premature rupture of fetal membranes
 broad_synonym: SERPINH1-RELATED CONDITION
 primary_id: MESH:C563032
 alt_id: MIM:610504
 xref: MONDO:0012511

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preterm premature rupture of the membranes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chrNW_004955423:254,060...264,448
Ensembl chrNW_004955423:254,189...264,159 		JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chrNW_004955412:5,928,997...5,939,012
Ensembl chrNW_004955412:5,928,997...5,939,012 		JBrowse link
G Serpinh1 serpin family H member 1 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes | ClinVar Annotator: match by term: SERPINH1-related condition ClinVar
OMIM		 PMID:16938879 PMID:25741868 PMID:28492532 PMID:32161841 PMID:37270749 NCBI chrNW_004955414:16,284,845...16,292,828
Ensembl chrNW_004955414:16,284,845...16,292,963 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chrNW_004955403:10,925,155...11,004,229
Ensembl chrNW_004955403:10,924,893...11,004,284 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14337
    disease of anatomical entity 14030
      reproductive system disease 2909
        female reproductive system disease 2000
          preterm premature rupture of the membranes 4
Path 2
Term Annotations click to browse term
  disease 14337
    disease of anatomical entity 14030
      Urogenital Diseases 4572
        Female Urogenital Diseases and Pregnancy Complications 2415
          Pregnancy Complications 712
            Obstetric Labor Complications 39
              Fetal Membranes, Premature Rupture 13
                preterm premature rupture of the membranes 4
paths to the root