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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:urinary tract infection
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Accession:DOID:0080784 term browser browse the term
Definition:An urinary system disease that is characterized by an infection in any part of the urinary system, including the kidneys, ureters, bladder or urethra. (DO)
Synonyms:exact_synonym: UTI;   urinary tract infections
 primary_id: MESH:D014552
 alt_id: MIM:603806
 xref: EFO:0003103;   ICD10CM:N39.0


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urinary tract infection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 treatment ISO human recombinant protein in a mouse model RGD PMID:28011398 RGD:150520199 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:18401338 RGD:7257688 NCBI chr15:120,219,657...120,230,203 JBrowse link
G IL18 interleukin 18 ISO protein:increased expression:urine RGD PMID:19171043 RGD:2311084 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:urine RGD PMID:19171043 PMID:21690238 RGD:2311084 RGD:6907113 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121 		JBrowse link
G LCN2 lipocalin 2 disease_progression
treatment
ameliorates		 ISO protein:increased expression:urine: RGD PMID:24937428 PMID:25398327 RGD:126779559 RGD:126779579 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO protein:increased expression:urine RGD PMID:19171043 PMID:20886104 RGD:2311084 RGD:7175340
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9011564 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6254450 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO DNA:polymorphism: :p.R753Q (human) RGD PMID:18001294 RGD:7240561 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:snp:cds:p.D299G (human) RGD PMID:19543401 RGD:7246906 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
urinary schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule ISO protein:increased expression:B cell (human) RGD PMID:22347409 RGD:127345101 NCBI chr 4:92,096,670...92,101,177
Ensembl chr 4:92,094,700...92,101,095 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO DNA:SNPs:multiple:Gabonese(human) RGD PMID:22288822 RGD:7204674 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G IL5 interleukin 5 resistance ISO RGD PMID:9697734 RGD:7241010 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 severity ISO DNA:SNP:enhancer: (rs324013) RGD PMID:18273035 RGD:7243977 NCBI chr 5:22,406,356...22,422,412
Ensembl chr 5:22,406,368...22,421,989 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15436
    disease of anatomical entity 15105
      Urogenital Diseases 4867
        urinary system disease 2389
          urinary tract infection 14
            acute gonococcal cystitis 0
            bacteriuria 0
            pyuria 0
            sparganosis 0
            urinary schistosomiasis 4
paths to the root