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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:urinary tract infection
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Accession:DOID:0080784 term browser browse the term
Definition:An urinary system disease that is characterized by an infection in any part of the urinary system, including the kidneys, ureters, bladder or urethra. (DO)
Synonyms:exact_synonym: UTI;   urinary tract infections
 primary_id: MESH:D014552
 alt_id: MIM:603806
 xref: EFO:0003103;   ICD10CM:N39.0


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urinary tract infection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 treatment ISO human recombinant protein in a mouse model RGD PMID:28011398 RGD:150520199 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 ISO RGD PMID:21151974 RGD:7207862 NCBI chr2B:105,429,576...105,433,243
Ensembl chr2B:224,028,838...224,029,890 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:18401338 RGD:7257688 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B ISO DNA: SNP: :g.1267A>G RGD PMID:20379347 RGD:7242733 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G IL18 interleukin 18 ISO protein:increased expression:urine RGD PMID:19171043 RGD:2311084 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:urine RGD PMID:19171043 PMID:21690238 RGD:2311084 RGD:6907113 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:urine RGD PMID:19171043 PMID:20886104 RGD:2311084 RGD:7175340 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G LCN2 lipocalin 2 ameliorates
treatment
disease_progression		 ISO protein:increased expression:urine: RGD PMID:24937428 PMID:25398327 RGD:126779559 RGD:126779579 NCBI chr 9:99,259,278...99,274,494
Ensembl chr 9:127,940,799...127,944,798 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9011564 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6254450 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO DNA:polymorphism: :p.R753Q (human) RGD PMID:18001294 RGD:7240561 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO DNA:snp:cds:p.D299G (human) RGD PMID:19543401 RGD:7246906 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
bacteriuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100978434 C-type lectin domain family 4 member M ISO associated with Escherichia Coli Infections RGD PMID:31998663 RGD:41410804 NCBI chr19:7,062,961...7,069,381 JBrowse link
urinary schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule ISO protein:increased expression:B cell (human) RGD PMID:22347409 RGD:127345101 NCBI chr 1:133,549,258...133,557,752
Ensembl chr 1:137,341,690...137,348,173 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility ISO DNA:SNPs:multiple:Gabonese(human) RGD PMID:22288822 RGD:7204674 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G IL5 interleukin 5 resistance ISO RGD PMID:9697734 RGD:7241010 NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 severity ISO DNA:SNP:enhancer: (rs324013) RGD PMID:18273035 RGD:7243977 Ensembl chr12:32,068,679...32,085,099 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15835
    disease of anatomical entity 15491
      Urogenital Diseases 4921
        urinary system disease 2408
          urinary tract infection 17
            acute gonococcal cystitis 0
            bacteriuria 1
            pyuria 0
            sparganosis 0
            urinary schistosomiasis 4
paths to the root