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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:colorectal carcinoma
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Accession:DOID:0080199 term browser browse the term
Definition:A colorectal cancer that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. (DO)
Synonyms:exact_synonym: colorectal carcinomas
 xref: EFO:0000755;   EFO:1001951;   NCI:C2955


show annotations for term's descendants           Sort by:
colorectal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 severity ISO protein:increased expression:colonic mucosa (human) RGD PMID:14990971 RGD:11570560 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 severity ISO protein:increased expression:colonic mucosa (human) RGD PMID:14990971 RGD:11570560 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IEP RGD PMID:22467055 RGD:7245559 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akap12 A-kinase anchoring protein 12 treatment ISO RGD PMID:21918680 RGD:14348959 NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:40,730,123...40,819,886 		JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 treatment ISO RGD PMID:19528090 RGD:9684940 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232 		JBrowse link
G Arid1a AT-rich interaction domain 1A onset ISO protein:decreased expression:colorectum (human) RGD PMID:24925223 RGD:126790632 NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Axin2 axin 2 ISO protein,RNA:increased expression:colorectum:
ClinVar Annotator: match by term: Colorectal carcinoma 		ClinVar
RGD		 PMID:15042511 PMID:16199547 PMID:21416598 PMID:25741868 PMID:28492532 More... RGD:151356501 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ameliorates ISO human cell line in a mouse model RGD PMID:30630498 RGD:152999008 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO RGD PMID:14732230 RGD:1580058 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:11497291 RGD:126925969 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated ISO RGD PMID:11497291 RGD:126925969 NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567 		JBrowse link
G Brd7 bromodomain containing 7 severity ISO mRNA,protein:decreased expression:colon: RGD PMID:23215825 RGD:9586444 NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494 		JBrowse link
G Calu calumenin ISO mRNA:increased expression:colon (human) RGD PMID:18776587 RGD:2316232 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Car12 carbonic anhydrase 12 disease_progression ISO RGD PMID:27688658 RGD:155226860 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Car2 carbonic anhydrase 2 disease_progression ISO RGD PMID:27688658 RGD:155226860 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Cat catalase treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbx7 chromobox 7 disease_progression ISO mRNA:decreased expression::colorectum: RGD PMID:22041561 RGD:9587355 NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Cd59b CD59b molecule IMP RGD PMID:12909127 RGD:1600485 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Chi3l1 chitinase 3 like 1 severity ISO protein:increased secretion:serum (human) RGD PMID:12124825 RGD:4892637 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO mRNA:decreased expression:colorectal mucosa (human) RGD PMID:28675510 RGD:150524297 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 disease_progression ISO mRNA,protein:increased expression:colorectum (human) RGD PMID:18803056 RGD:151893518 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Efnb2 ephrin B2 ameliorates ISO human cells in mouse model RGD PMID:26494468 RGD:153300950 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Ep300 E1A binding protein p300 ISO ClinVar Annotator: match by term: Colorectal carcinoma ClinVar PMID:15706485 PMID:24476420 PMID:25741868 PMID:28492532 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor treatment ISO human cell line in a mouse model RGD PMID:28665687 RGD:155260341 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO protein:increased expression:large intestine RGD PMID:30214616 RGD:126779593 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fubp1 far upstream element binding protein 1 ISO mRNA, protein:increased expression:colorectum (human) RGD PMID:25030436 RGD:151361190 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gpx2 glutathione peroxidase 2 ISO mRNA:increased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO mRNA:decreased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO RGD PMID:26909940 PMID:16886896 RGD:11564625, RGD:14700936 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO RGD PMID:16886896 RGD:14700936 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M disease_progression ISO protein:increased expression:colonic epithelium (human) RGD PMID:24381081 RGD:10054273 NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762 		JBrowse link
G Ifng interferon gamma ISO RGD PMID:16717119 RGD:150573704 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb3 integrin subunit beta 3 severity ISO RGD PMID:11299820 RGD:5112894 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Jak2 Janus kinase 2 treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 treatment
ameliorates 		ISO human cell line in a mouse model RGD PMID:23624232 PMID:25548290 PMID:27286263 RGD:151665352, RGD:151665508, RGD:151665507 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase ISO DNA:insertion, deletion:exon:c.939_940insA, c.939delA (human) RGD PMID:10637515 RGD:9588975 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mir152 microRNA 152 ISO DNA:hypermethylation RGD PMID:21327300 RGD:21066329 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020 		JBrowse link
G Msh3 mutS homolog 3 ISO RGD PMID:9401011 RGD:1625103 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 ISO RGD PMID:9401011 RGD:1625103 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor exacerbates
ameliorates 		ISO mRNA:increased expression:colon (human)
human cell line in a mouse model 		RGD PMID:30221070 PMID:31746347 RGD:150519917, RGD:150520167 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates
disease_progression 		ISO human gene and cell line in a mouse model
protein:increased expression:colorectum, myofibroblast cell, cytoplasm (human) 		RGD PMID:25823027 PMID:19277704 RGD:11085507, RGD:153002577 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nf1 neurofibromin 1 severity ISO protein:increased expression:colorectum (human) RGD PMID:27798892 RGD:150429697 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Phf6 PHD finger protein 6 ISO mRNA:increased expression:colorectal mucosa (human) RGD PMID:28675510 RGD:150524297 NCBI chr  X:132,656,658...132,699,720
Ensembl chr  X:132,656,672...132,699,127 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha severity ISO DNA:mutations:exons: RGD PMID:17546593 RGD:14402406 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit exacerbates ISO protein:decreased expression:colorectum (human) RGD PMID:32567205 RGD:151347643 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO protein: decreased expression RGD PMID:14750179 RGD:6483362 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B ISO associated with metastasis; human cells in mouse model RGD PMID:31040266 RGD:151361283 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748 		JBrowse link
G Rac1 Rac family small GTPase 1 exacerbates
ameliorates 		ISO protein:increased expression:colorectum (human)
protein:increased activity:colorectal mucosa (human)
human cell line in a mouse model 		RGD PMID:30064309 PMID:25529012 PMID:23559092 RGD:153298972, RGD:153350139, RGD:153350124 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rad21 RAD21 cohesin complex component exacerbates ISO mRNA, protein:increased expression:colorectum (human) RGD PMID:30546056 RGD:150520034 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Selenoh selenoprotein H ISO mRNA:increased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 3:69,751,850...69,753,417
Ensembl chr 3:69,752,757...69,753,417 		JBrowse link
G Selenop selenoprotein P ISO mRNA:decreased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852 		JBrowse link
G Selenos selenoprotein S ISO mRNA:decreased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Sephs2 selenophosphate synthetase 2 ISO mRNA:decreased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 exacerbates ISO protein:decreased expression:colorectum (human) RGD PMID:31706103 RGD:153297781 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Smad4 SMAD family member 4 disease_progression ISO RGD PMID:26861460 RGD:21066335 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smarcc1 SWI/SNF related BAF chromatin remodeling complex subunit C1 exacerbates ISO protein:increased expression:colorectum (human) RGD PMID:30144500 RGD:151347859 NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO RGD PMID:16717119 RGD:150573704 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase severity ISO RGD PMID:11443610 RGD:150521545 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IEP RGD PMID:29229353 RGD:127284843 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO RGD PMID:16778189 RGD:1581429 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:missense mutation::p.R72P (human) RGD PMID:29560751 RGD:14995498 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd3 thioredoxin reductase 3 ISO mRNA:increased expression:colorectum (human) RGD PMID:30469315 RGD:151665806 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491 		JBrowse link
G Xpo1 exportin 1 disease_progression ISO protein:increased expression:colorectum (human) RGD PMID:31870117 RGD:151665794 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNPs:exon 6, exon 10: p.R194W, p.R399Q (human) RGD PMID:28638257 RGD:150539031 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
colon adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd5 abhydrolase domain containing 5, lysophosphatidic acid acyltransferase disease_progression ISO human cells in mouse model
mRNA:decreased expression:colon (human) 		RGD PMID:30842415 PMID:30842415 RGD:153002829, RGD:153002829 NCBI chr 8:130,877,834...130,903,947
Ensembl chr 8:122,000,389...122,026,447 		JBrowse link
G Anxa7 annexin A7 ISO protein:decreased expression:colon RGD PMID:17708571 RGD:2292654 NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385 		JBrowse link
G Apc APC regulator of WNT signaling pathway IMP
ISO 		associated with Adenomatous Polyposis Coli;DNA:point mutation:CDS:p.K1137X (3409A>T) (rat)
ClinVar Annotator: match by term: Colon adenocarcinoma 		ClinVar
RGD		 PMID:24033266 PMID:24728327 PMID:25741868 PMID:27978560 PMID:28492532 More... RGD:1601201 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G ApcPirc APC, WNT signaling pathway regulator; polyposis in the rat colon IMP associated with Adenomatous Polyposis Coli RGD PMID:17360473 RGD:1601201
G Arid1a AT-rich interaction domain 1A disease_progression ISO protein:decreased expression:colorectum (human) RGD PMID:26980037 RGD:126790569 NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator susceptibility ISO DNA:frameshift mutation: ; RGD PMID:9020077 RGD:734633 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment ISO human cells in mouse model RGD PMID:32504672 RGD:125097526 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Btk Bruton tyrosine kinase ISO mRNA:decreased expression:colon (human) RGD PMID:31402962 RGD:151347853 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D disease_progression ISO protein:increased expression:colon (human) RGD PMID:29079724 RGD:152177516 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Calr calreticulin ISO RGD PMID:18812201 RGD:150521683 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Car12 carbonic anhydrase 12 disease_progression ISO RGD PMID:35847888 RGD:153352327 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ameliorates ISO human cells in a mouse model RGD PMID:28486105 RGD:153323299 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ameliorates ISO mouse cell line in a mouse model
human cells in a mouse model 		RGD PMID:29436396 PMID:24898549 PMID:32304779 RGD:150524289, RGD:150524303, RGD:150524290 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO RGD PMID:10830715 RGD:10450245 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 IAGP DNA:mutation RGD PMID:16886601 RGD:1599637 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 ISO mRNA:increased expression:colonic mucosa (human) RGD PMID:27793774 RGD:151665173 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Daxx death-domain associated protein ISO protein:decreased expression:colon: RGD PMID:16569639 RGD:9587838 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO protein:increased expression:colon(human) RGD PMID:19360331 RGD:153298969 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Fech ferrochelatase ISO mRNA:decreased expression:colon RGD PMID:28075030 RGD:14700888 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit ISO protein:increased expression:colon (human) RGD PMID:22419013 RGD:153344572 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO protein:increased expression:colon (human) RGD PMID:22419013 RGD:153344572 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Foxa1 forkhead box A1 ISO mRNA:decreased expression:colon RGD PMID:32839292 RGD:151665753 NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Gata1 GATA binding protein 1 ISO RGD PMID:31069596 RGD:149735196 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:20616616 RGD:10402080 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Il21 interleukin 21 treatment ISO RGD PMID:17695518 RGD:127285540 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Jak2 Janus kinase 2 treatment
ameliorates 		ISO Human cell in mouse model
human cells in mouse model 		RGD PMID:32504672 PMID:22050790 RGD:125097526, RGD:127285665 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdm6a lysine demethylase 6A ISO DNA:hypermethylation RGD PMID:33174323 RGD:150429730 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Lox lysyl oxidase ameliorates ISO RGD PMID:21282564 RGD:150520218 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO human cell line and gene in a mouse model RGD PMID:18436711 RGD:155630593 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO RGD PMID:24691442 RGD:13210775 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO RGD PMID:24691442 RGD:13210775 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase IEP mRNA:decreased expression:colon (rat) RGD PMID:16886601 RGD:1599637 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir155 microRNA 155 treatment ISO RGD PMID:29535520 RGD:21409754 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:colon (human) RGD PMID:22419013 RGD:153344572 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:colon (human) RGD PMID:22419013 RGD:153344572 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msh6 mutS homolog 6 ISO ClinVar Annotator: match by term: Colon adenocarcinoma ClinVar PMID:25741868 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor exacerbates ISO human cell line in a mouse model RGD PMID:18538140 RGD:150521533 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 exacerbates ISO mRNA:increased expression:colon (human) RGD PMID:31964418 RGD:153344516 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:colon (human) RGD PMID:22419013 RGD:153344572 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO mRNA:decreased expression:colon: RGD PMID:19737405 RGD:11556207 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase ISO RGD PMID:6722784 RGD:5135276 NCBI chr10:53,690,301...53,711,811
Ensembl chr10:53,691,626...53,708,420 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO DNA:mutation RGD PMID:17575153 RGD:5685670 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 treatment ISO RGD PMID:24632606 RGD:13432053 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Rac1 Rac family small GTPase 1 treatment ISO mRNA:alternative form RGD PMID:10597294 PMID:19561401 RGD:13432049, RGD:13432051 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rad54l RAD54 like ISO ClinVar Annotator: match by term: Colon adenocarcinoma ClinVar PMID:10362365 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Rnasel ribonuclease L severity ISO RGD PMID:23567782 RGD:40902808 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Rnaset2 ribonuclease T2 ISO human cells in mouse model RGD PMID:30842415 RGD:153002829 NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147 		JBrowse link
G Slc22a18 solute carrier family 22, member 18 ameliorates ISO mRNA:decreased expression:colorectum (human) RGD PMID:26196590 RGD:11522474 NCBI chr 1:198,670,626...198,694,977
Ensembl chr 1:198,671,731...198,694,975 		JBrowse link
G Smc2 structural maintenance of chromosomes 2 severity ISO human cell line in a mouse model RGD PMID:23095742 RGD:151356955 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ameliorates ISO RGD PMID:21282564 RGD:150520218 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229 		JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO mRNA:decreased expression:colon mucosa (human) RGD PMID:9865741 RGD:11039405 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO DNA:SNPs:introns: (rs2280232, rs4327257) (human) RGD PMID:22121102 RGD:153323313 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment ISO human cells in mouse model
DNA:SNPs:introns: (rs12949918, rs6503695) (human) 		RGD PMID:32504672 PMID:22121102 RGD:125097526, RGD:153323313 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO DNA:SNP:intron: (rs7217728) (human) RGD PMID:22121102 RGD:153323313 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO DNA:SNPs:introns: (rs6503691, rs7218653) (human) RGD PMID:22121102 RGD:153323313 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO DNA:SNP:3' utr: (rs324015) (human) RGD PMID:22121102 RGD:153323313 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 ISO mRNA:increased expression:colorectum, Cancer Stem-like Cells (human) RGD PMID:31057717 RGD:150429686 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:9019169 RGD:13432089 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tp73 tumor protein p73 ISO mRNA:increased expression:colon (human) RGD PMID:30420492 RGD:151347580 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 ameliorates
severity 		ISO human cell line in a mouse model RGD PMID:29296225 PMID:28856538 RGD:151665195, RGD:151665199 NCBI chr 7:71,000,197...71,109,841
Ensembl chr 7:69,116,761...69,224,903 		JBrowse link
G Vegfc vascular endothelial growth factor C IEP mRNA:increased expression:colon RGD PMID:18424890 RGD:2315488 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
colon signet ring adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Runx1 RUNX family transcription factor 1 ISO mRNA:increased expression:colon RGD PMID:29747153 RGD:126779566 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
colorectal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A susceptibility ISO DNA:polymorphism: :3435C>T (human) RGD PMID:16107775 RGD:2312343 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B IDA RGD PMID:16619498 RGD:1598563 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 ISO mRNA:decreased expression:colonic mucosa (human) RGD PMID:25107436 RGD:11049173 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO protein:increased expression:colonic mucosa (human) RGD PMID:8625322 RGD:11353854 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l2 Bcl2-like 2 disease_progression ISO RGD PMID:10638987 RGD:14394422 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 ISO RGD PMID:21122381 RGD:13217408 NCBI chr 3:188,425,392...188,430,174
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Borcs5 BLOC-1 related complex subunit 5 susceptibility ISO DNA:SNP:3'utr: (rs3803098) A>G (human) RGD PMID:27354594 RGD:152177496 NCBI chr 4:167,458,640...167,543,556
Ensembl chr 4:167,473,177...167,540,993 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase disease_progression ISO RGD PMID:24500602 RGD:11567230 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Brd8 bromodomain containing 8 disease_progression IEP RGD PMID:19787264 RGD:9587763 NCBI chr18:26,204,892...26,229,999
Ensembl chr18:26,181,732...26,229,884 		JBrowse link
G Car12 carbonic anhydrase 12 severity ISO RGD PMID:10666387 RGD:155226866 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Ccdc17 coiled-coil domain containing 17 susceptibility ISO DNA:SNP:3'utr: (rs2275085) T>C (human) RGD PMID:27354594 RGD:152177496 NCBI chr 5:130,051,158...130,056,676
Ensembl chr 5:130,045,938...130,056,673 		JBrowse link
G Cd44 CD44 molecule disease_progression ISO mRNA, protein:splice variant, increased expression:large intestine RGD PMID:16425351 RGD:2289356 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 susceptibility ISO DNA:SNPs:enhancers: (rs6013897, rs158552, rs17217119) (human) RGD PMID:28009432 RGD:151665179 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 susceptibility ISO DNA:SNP:3'utr: (rs2283606) T>C (human) RGD PMID:27354594 RGD:152177496 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta susceptibility ISO DNA:SNP: : 39179G>T(human) RGD PMID:19626461 RGD:9589082 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dok3 docking protein 3 susceptibility ISO DNA:SNP:3'utr: (rs2279398) (human) RGD PMID:27354594 RGD:152177496 NCBI chr17:9,109,633...9,115,188
Ensembl chr17:9,109,597...9,115,188 		JBrowse link
G Emx2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:colorectal mucosa (human) RGD PMID:28830374 RGD:153323301 NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 severity ISO RGD PMID:16507107 RGD:126781766 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor ISO mRNA:decreased expression:colorectum (human) RGD PMID:22966016 RGD:155598682 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO DNA:SNP: rs3757441 (human) RGD PMID:21926398 RGD:126779594 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fam151a family with sequence similarity 151, member A susceptibility ISO DNA:SNP:3'utr: (rs11206394) G>C (human) RGD PMID:27354594 RGD:152177496 NCBI chr 5:121,514,804...121,527,555
Ensembl chr 5:121,514,804...121,527,555 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 treatment ISO human cell line in a mouse model RGD PMID:31255687 RGD:155663557 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 severity ISO DNA:polymorphisms:multiple RGD PMID:33075166 RGD:149735513 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:8264230 RGD:13210753 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gata6 GATA binding protein 6 severity ISO human cells in a mouse model RGD PMID:24452072 RGD:13208874 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gjb3 gap junction protein, beta 3 susceptibility ISO DNA:SNP:3'utr: (rs9118) C>G (human) RGD PMID:27354594 RGD:152177496 NCBI chr 5:139,649,227...139,654,970
Ensembl chr 5:139,649,195...139,654,980 		JBrowse link
G Gpx4 glutathione peroxidase 4 susceptibility ISO DNA:SNP:3' utr:c.718T>C (human) RGD PMID:18850177 RGD:152998895 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:21609933 RGD:13210767 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO RGD PMID:12421502 RGD:14700996 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 onset ISO RGD PMID:12421502 PMID:12682546 RGD:14700996, RGD:14701003 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hpca hippocalcin severity ISO mRNA, protein:increased expression:colon carcinoma (human) RGD PMID:22696308 RGD:9693683 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Ier2 immediate early response 2 disease_progression ISO protein:increased expression:colon (human) RGD PMID:22120713 RGD:153323322 NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211 		JBrowse link
G Il16 interleukin 16 susceptibility ISO DNA:SNP:3'utr: (rs1131445) T>C (human) RGD PMID:27354594 RGD:152177496 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO RGD PMID:8264230 RGD:13210753 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:colorectal mucosa (human) RGD PMID:10874008 RGD:151347670 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 severity ISO DNA:amplification: (human) RGD PMID:17289873 RGD:9693694 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Kdr kinase insert domain receptor treatment
severity 		ISO protein:altered phosphorylation:colon RGD PMID:26325365 PMID:25372416 RGD:11529678, RGD:126848811 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kmt2b lysine methyltransferase 2B ISO human gene in a mouse model RGD PMID:22713656 RGD:9588601 NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO RGD PMID:25405740 RGD:13210782 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO RGD PMID:25405740 RGD:13210782 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:21122381 RGD:13217408 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mir31 microRNA 31 ISO RNA:increased expression:blood serum (human) RGD PMID:21658006 RGD:152998938 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Msh2 mutS homolog 2 disease_progression ISO RGD PMID:11604476 RGD:126790556 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor exacerbates ISO RNA:decreased expression:colon (human) RGD PMID:28533893 RGD:150540307 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO protein:increased expression:colorectal mucosa (human) RGD PMID:19198856 RGD:153002579 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO DNA:SNP:3'utr: (rs3135499) C>A (human) RGD PMID:27354594 RGD:152177496 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 susceptibility ISO DNA:SNP:3'utr: (rs1047854) C>T (human) RGD PMID:27354594 RGD:152177496 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585 		JBrowse link
G Rab24 RAB24, member RAS oncogene family susceptibility ISO DNA:SNP:3'utr: (rs1128287) C>A (human) RGD PMID:27354594 RGD:152177496 NCBI chr17:9,308,471...9,310,553
Ensembl chr17:9,308,525...9,310,553 		JBrowse link
G Rac1 Rac family small GTPase 1 disease_progression ISO mRNA, protein:increased expression:colorectum (human) RGD PMID:30926638 RGD:155230818 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:21122381 RGD:13217408 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 susceptibility ISO DNA:SNP:3'utr: (rs15049) C>A (human) RGD PMID:27354594 RGD:152177496 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 disease_progression ISO protein:increased expression:colon (human) RGD PMID:27729429 RGD:152995521 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426 		JBrowse link
G Rnaset2 ribonuclease T2 ISO human cells in mouse model RGD PMID:27014725 RGD:153002831 NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147 		JBrowse link
G Rsph1 radial spoke head component 1 susceptibility ISO DNA:SNP:3'utr: (rs2839531) T>C (human) RGD PMID:27354594 RGD:152177496 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Runx1 RUNX family transcription factor 1 ISO mRNA:increased expression:colon RGD PMID:29747153 RGD:126779566 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:32359697 RGD:151361139 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 disease_progression ISO protein:decreased expression:colon, nucleus RGD PMID:27184481 RGD:127285648 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 no_association ISO RGD PMID:25339048 RGD:150573690 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B disease_progression
ameliorates 		ISO protein:increased expression:colorectum (human)
human cells in a mouse model 		RGD PMID:21826656 PMID:23733954 RGD:153298931, RGD:11076784 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 ISO mRNA:increased expression:colorectum (human) RGD PMID:11358845 RGD:155631271 NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:8264230 RGD:13210753 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp73 tumor protein p73 exacerbates ISO protein:increased expression:colon (human) RGD PMID:19956069 RGD:151347585 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tpst1 tyrosylprotein sulfotransferase 1 susceptibility ISO DNA:SNP:3'utr: (rs3757417) G>T (human) RGD PMID:27354594 RGD:152177496 NCBI chr12:26,544,536...26,605,706
Ensembl chr12:26,544,536...26,605,704 		JBrowse link
G Tyms thymidylate synthetase IEP protein:increased activity:colon (rat) RGD PMID:10226549 RGD:2317418 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Utp23 UTP23, small subunit processome component susceptibility ISO DNA:missense mutation:cds:p.P215Q (rs16888728) (human) RGD PMID:26553438 RGD:11041896 NCBI chr 7:83,185,187...83,196,652
Ensembl chr 7:83,189,656...83,196,655 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 treatment ISO associated with Neoplasm Metastasis; DNA:missense mutation:cds: p.R399Q, c.1196G>A (human) RGD PMID:19908066 RGD:150573820 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
rectum adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Rectum adenocarcinoma ClinVar PMID:24033266 PMID:25741868 PMID:26467025 PMID:26530882 PMID:28195569 More... NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 disease_progression ISO mRNA:increased expression:rectum (human) RGD PMID:31964418 RGD:153344516 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ameliorates ISO mRNA:increased expression:rectum (human) RGD PMID:31964418 RGD:153344516 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ISO mRNA:increased expression:rectum (human) RGD PMID:28486105 RGD:153323299 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO protein:increased expression:rectum (human) RGD PMID:19360331 RGD:153298969 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Kdm6a lysine demethylase 6A exacerbates ISO mRNA:decreased expression:rectum (human) RGD PMID:33174323 RGD:150429730 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 treatment ISO RGD PMID:21036745 RGD:151361202 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO DNA:missense mutation:CDS: (rs2293152) (human) RGD PMID:22121102 RGD:153323313 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO DNA:SNP:intron: (rs3024861) (human) RGD PMID:22121102 RGD:153323313 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO DNA:SNP:intron: (rs3024979) (human) RGD PMID:22121102 RGD:153323313 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19145
    disease of cellular proliferation 7895
      Neoplasms by Histologic Type 5348
        cell type cancer 3784
          carcinoma 3273
            colorectal carcinoma 172
              colorectal adenocarcinoma + 124
Path 2
Term Annotations click to browse term
  disease 19145
    disease of anatomical entity 18457
      gastrointestinal system disease 7198
        Digestive System Neoplasms 3854
          Gastrointestinal Neoplasms 3730
            gastrointestinal system cancer 2920
              intestinal cancer 1015
                large intestine cancer 1014
                  colorectal cancer 1014
                    colorectal carcinoma 172
                      colorectal adenocarcinoma + 124
paths to the root