Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:late onset Parkinson's disease
go back to main search page
Accession:DOID:0060892 term browser browse the term
Definition:A Parkinson's disease characterized by onset of motor symptoms typically after 60 years of age. (DO)
Synonyms:exact_synonym: PD;   late onset Parkinson disease;   late onset Parkinson disease, hereditary
 narrow_synonym: PARK;   PARK18;   PARK24
 broad_synonym: ATXN3-RELATED CONDITION
 related_synonym: EIF4G1-RELATED CONDITION;   Parkinson disease 18, autosomal dominant, susceptibility to;   Parkinson disease 24, autosomal dominant, susceptibility to;   Parkinson disease, late-onset, susceptibility to;   Parkinson's disease 18, autosomal dominant, susceptibility to;   Parkinson's disease, late-onset, susceptibility to
 xref: MIM:168600;   MIM:614251;   MIM:619491;   MONDO:0008199;   ORDO:411602


show annotations for term's descendants           Sort by:
late onset Parkinson's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide susceptibility ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:25741868 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:229,470,703...229,482,291 		JBrowse link
G Atxn2 ataxin 2 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:40,414,904...40,510,473 		JBrowse link
G Atxn3 ataxin 3 susceptibility ISO ClinVar Annotator: match by term: ATXN3-related condition ClinVar
OMIM		 PMID:24033266 PMID:25741868 PMID:37091313 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:126,839,327...126,872,781 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:6,128,070...6,232,005 		JBrowse link
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:24218364 PMID:25118025 PMID:27270108 NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:113,646,573...113,756,104 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 ISO ClinVar Annotator: match by term: EIF4G1-related condition | ClinVar Annotator: match by term: Parkinson disease 18, autosomal dominant, susceptibility to | ClinVar Annotator: match by term: Parkinson disease, late-onset OMIM
ClinVar		 PMID:21907011 PMID:23408866 PMID:25368108 PMID:25741868 PMID:28492532 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:93,726,322...93,746,367 		JBrowse link
G Fgf20 fibroblast growth factor 20 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:18252210 PMID:19133659 PMID:25741868 NCBI chr16:52,030,549...52,038,201
Ensembl chr16:58,734,003...58,741,627 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:19394250 PMID:25741868 NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:10,098,571...10,102,083 		JBrowse link
G Gba1 glucosylceramidase beta 1 ISO ClinVar Annotator: match by term: Hereditary late onset Parkinson disease | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:1333717 PMID:1348297 PMID:1415223 PMID:1487244 PMID:1558964 More... NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:176,907,154...176,916,985 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism:exon:A>G313 (human) RGD PMID:17250723 RGD:5148021 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:1940 PMID:15680455 PMID:15680456 PMID:15680457 PMID:15726496 More... NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Mapt microtubule-associated protein tau ISO ClinVar Annotator: match by term: Hereditary late onset Parkinson disease | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:2273997 PMID:8673924 PMID:9382467 PMID:9629852 PMID:9641683 More... NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:8104867 PMID:15972314 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:12496759 PMID:15079038 PMID:15184637 PMID:19429166 PMID:23066323 More... NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Pink1 PTEN induced kinase 1 ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Podxl podocalyxin-like ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:26864383 PMID:28492532 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:61,102,419...61,149,789 		JBrowse link
G Psap prosaposin ISO ClinVar Annotator: match by term: PARKINSON DISEASE 24, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO | ClinVar Annotator: match by term: Parkinson disease 24, autosomal dominant, susceptibility to | ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:1350885 PMID:1371116 PMID:2019586 PMID:2302219 PMID:2320574 More... NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,757,181...28,783,421 		JBrowse link
G RT1-Da RT1 class II, locus Da ISO DNA:SNP:intron: (rs3129882) (human) RGD PMID:21791235 RGD:5490156 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383 		JBrowse link
G Sncaip synuclein, alpha interacting protein ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar PMID:12761037 PMID:18366718 PMID:25741868 PMID:28492532 NCBI chr18:46,205,846...46,343,932
Ensembl chr18:48,404,531...48,574,002 		JBrowse link
G Tbp TATA box binding protein susceptibility ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar
OMIM		 PMID:24033266 PMID:25741868 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:65,136,448...65,190,899 		JBrowse link
G Vps35 VPS35 retromer complex component ISO ClinVar Annotator: match by term: Parkinson disease, late-onset ClinVar NCBI chr19:37,938,989...37,974,887
Ensembl chr19:37,938,720...37,974,886 		JBrowse link
Parkinson's disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmrn1 multimerin 1 ISO ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 1 ClinVar PMID:14593171 PMID:14755720 PMID:15451224 PMID:15451225 PMID:16358335 More... NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:91,233,240...91,280,861 		JBrowse link
G Snca synuclein alpha ISO
ISS 		ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 1
OMIM:168601 		OMIM
ClinVar
MouseDO		 PMID:9197268 PMID:9462735 PMID:9499430 PMID:9506559 PMID:9827625 More... NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
Parkinson's disease 14 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g6 phospholipase A2 group VI ISO
ISS 		OMIM:612953
ClinVar Annotator: match by term: Autosomal recessive Parkinson disease 14 | ClinVar Annotator: match by term: DYSTONIA-PARKINSONISM, ADULT-ONSET 		OMIM
MouseDO
ClinVar		 PMID:2668131 PMID:16783378 PMID:18359254 PMID:18414213 PMID:18443314 More... NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36152728 NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229 		JBrowse link
Parkinson's disease 17 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mylk3 myosin light chain kinase 3 ISO ClinVar Annotator: match by term: Parkinson disease 17 ClinVar PMID:28492532 NCBI chr19:37,858,298...37,916,805
Ensembl chr19:37,865,141...37,915,827 		JBrowse link
G Orc6 origin recognition complex, subunit 6 ISO ClinVar Annotator: match by term: Parkinson disease 17 ClinVar PMID:25741868 PMID:28492532 NCBI chr19:21,757,867...21,765,638
Ensembl chr19:37,931,090...37,938,856 		JBrowse link
G Vps35 VPS35 retromer complex component ISO
ISS 		ClinVar Annotator: match by term: Parkinson disease 17 | ClinVar Annotator: match by term: VPS35-related condition
OMIM:614203 		OMIM
ClinVar
MouseDO		 PMID:9536098 PMID:17576681 PMID:18342564 PMID:21763482 PMID:21763483 More... NCBI chr19:37,938,989...37,974,887
Ensembl chr19:37,938,720...37,974,886 		JBrowse link
Parkinson's disease 21 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 ISO ClinVar Annotator: match by term: Parkinson disease 21 ClinVar PMID:24218364 PMID:25118025 PMID:27270108 PMID:28492532 NCBI chr 8:104,767,785...104,877,317
Ensembl chr 8:113,646,573...113,756,104 		JBrowse link
Parkinson's disease 22 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 ISO ClinVar Annotator: match by term: CHCHD2-related condition | ClinVar Annotator: match by term: Parkinson disease 22, autosomal dominant OMIM
ClinVar		 PMID:25662902 PMID:25741868 PMID:26067110 PMID:26067113 PMID:26561290 More... NCBI chr12:26,828,738...26,834,762
Ensembl chr12:32,464,824...32,470,871 		JBrowse link
Parkinson's disease 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISO
ISS 		CTD Direct Evidence: marker/mechanism
OMIM:605543
ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 4 		OMIM
CTD
MouseDO
ClinVar		 PMID:9197268 PMID:9499430 PMID:9506559 PMID:9827625 PMID:10417297 More... NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
Parkinson's disease 8 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 ISO
ISS 		DNA:missense mutation:cds:p.G2385R (human)
ClinVar Annotator: match by term: Autosomal dominant Parkinson disease 8 | ClinVar Annotator: match by term: LRRK2-related condition
OMIM:607060 		ClinVar
MouseDO
OMIM
RGD		 PMID:1940 PMID:7898705 PMID:9276200 PMID:9536098 PMID:15541308 More... RGD:5508405 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Nutritional and Metabolic Diseases 8574
      disease of metabolism 8574
        Proteostasis Deficiencies 818
          synucleinopathy 417
            Parkinson's disease 376
              late onset Parkinson's disease 29
                Parkinson's disease 1 2
                Parkinson's disease 14 2
                Parkinson's disease 17 3
                Parkinson's disease 21 1
                Parkinson's disease 22 1
                Parkinson's disease 3 0
                Parkinson's disease 4 1
                Parkinson's disease 8 1
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            movement disease 2631
              Parkinsonism 459
                Parkinson's disease 376
                  late onset Parkinson's disease 29
                    Parkinson's disease 1 2
                    Parkinson's disease 14 2
                    Parkinson's disease 17 3
                    Parkinson's disease 21 1
                    Parkinson's disease 22 1
                    Parkinson's disease 3 0
                    Parkinson's disease 4 1
                    Parkinson's disease 8 1
paths to the root