lymphatic system cancer - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	lymphatic system cancer	go back to main search page
Accession:	DOID:0060073	browse the term
Definition:	An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. (DO)

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Rat (698) Mouse (1043) Human (5354) Chinchilla (588) Bonobo (623) Dog (638) Squirrel (594) Pig (626) Green Monkey (612) Naked Mole-rat (580) All
Genes (619) Cell Lines (7)

acute biphenotypic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DOT1 like histone lysine methyltransferase

treatment

NCBI chr 2:76,339,452...76,401,974
Ensembl chr 2:76,339,470...76,401,965

G

ring finger protein 20

disease_progression

NCBI chr 1:243,225,711...243,254,465
Ensembl chr 1:243,225,924...243,254,446

acute leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 2, TFIIH core complex helicase subunit

ClinVar Annotator: match by term: Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified

PMID:7585650 PMID:8571952 PMID:9195225 PMID:9238033 PMID:15982307 More...

NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553

acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:snps, haplotype:multiple (human)

NCBI chr 9:93,049,955...93,146,469

G

ATP binding cassette subfamily C member 2

treatment

DNA:SNPs: :rs717620(human)
DNA:SNP:5'UTR:rs717620(human)

PMID:24404132 PMID:25007187

RGD:11080959 RGD:11080979

NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,633...111,037,537

G

ATP binding cassette subfamily G member 2A

disease_progression

mRNA:increased expression:mononuclear cell:

PMID:12100141 PMID:15521915

RGD:11081076 RGD:11081143

NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,889,684...130,945,393

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:11984797 PMID:21898527

NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

NCBI chr 1:272,912,239...272,935,316

G

activation induced cytidine deaminase

treatment

NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,369

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

PMID:19684603 PMID:19684604

NCBI chr14:65,408,603...65,598,485
Ensembl chr14:65,408,598...65,598,485

G

aryl hydrocarbon receptor nuclear translocator

CTD Direct Evidence: marker/mechanism

NCBI chr 4:98,333,431...98,390,012
Ensembl chr 4:98,333,459...98,389,457

G

BCL2 associated X, apoptosis regulator

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

BCL2 apoptosis regulator

severity

mRNA:increased expression:bone marrow (human)

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 1

treatment

mRNA:increased expression:blood, mononuclear cell (human)

PMID:12469194 PMID:19020783

RGD:11353852 RGD:11353866

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

BCR activator of RhoGEF and GTPase

NCBI chr14:49,208,662...49,322,109
Ensembl chr14:49,208,762...49,322,103

G

caspase 8

CTD Direct Evidence: therapeutic

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

calpastatin

protein:increased expresssion:B cell

NCBI chr 2:103,255,738...103,378,623
Ensembl chr 2:103,255,750...103,378,623

G

cyclin D1

mRNA:increased expression:bone marrow (human)

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

CD40 ligand

NCBI chr X:111,778,666...111,788,901
Ensembl chr X:111,778,493...111,789,709

G

CD46 molecule, complement regulatory protein

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr 9:135,025,439...135,078,910

G

CD79b molecule

protein:decreased expression:bone marrow, mononuclear cell (human)

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

CD86 molecule

severity

protein:increased expression:peripheral blood, bone marrow, mononuclear cell (human)

NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310

G

cyclin dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129

G

cyclin dependent kinase inhibitor 2A

no_association
disease_progression
susceptibility

DNA:deletion: :
ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia
DNA:missense mutations:cds:

PMID:7566978 PMID:7647780 PMID:7718873 PMID:7987387 PMID:8573142 More...

RGD:11057958 RGD:11251764 RGD:11252081 RGD:11252082

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

cyclin dependent kinase inhibitor 2B

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr 1:200,666,250...200,770,880
Ensembl chr 1:200,761,004...200,766,056

G

CCAAT enhancer binding protein epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr 7:75,926,652...75,929,949
Ensembl chr 7:75,927,662...75,929,769

G

complement factor B

DNA:missense mutation:p.R32Q b(human)

NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179

G

CREB binding protein

disease_progression

DNA:mutations:multiple

NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224

G

colony stimulating factor 3

treatment

NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753

G

chondroitin sulfate proteoglycan 4

severity

NCBI chr 7:57,949,182...57,988,602
Ensembl chr 7:57,949,455...57,988,335

G

cytochrome b-245 alpha chain

mRNA:increased expression:peripheral blood mononuclear cell:

NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420

G

cytochrome P450 family 1 subfamily A member 1

susceptibility
no_association

DNA:polymorphism:3"UTR:rs4646903(human)
DNA:polymorphism:3'UTR:3801T>C(human)
DNA:polymorphism:cds:2452C>A(p.T461N)(human)

PMID:16676594 PMID:22964275 PMID:23725389

RGD:11352714 RGD:11352725 RGD:11352728

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

cytochrome P450 family 1 subfamily A member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100

G

cytochrome P450 family 1 subfamily B member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683

G

cytochrome P450 family 2 subfamily D member 6

susceptibility

DNA:polymorphisms: :
DNA:SNP,deletion:splice junction,exon:1934G>A(human)

PMID:11037802 PMID:19593802

RGD:11252111 RGD:11352820

NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642

G

cytochrome P450 family 2 subfamily E member 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 family 3 subfamily A member 22

susceptibility
disease_progression

DNA:polymorphism: :

PMID:19650988 PMID:22215203

RGD:11353796 RGD:11353805

NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817

G

dihydrofolate reductase

disease_progression

DNA:polymorphisms: :-317A>G, 829C>T (human)
DNA:polymorphisms, haplotype:promoter:

PMID:9226157 PMID:12972803 PMID:19861437 PMID:22969948

RGD:11039542 RGD:11039543 RGD:11039544 RGD:11039545

NCBI chr 2:89,230,660...89,255,830

G

DNA methyltransferase 3 alpha

treatment

DNA:mutations:exon, intron:p.R882(human)

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

DNA nucleotidylexotransferase

protein:increased activity:peripheral blood,bone marrow:

NCBI chr14:107,750,796...107,784,626
Ensembl chr14:107,750,796...107,784,617

G

dihydropyrimidine dehydrogenase

no_association
disease_progression

DNA:SNP: :85T>C (human)
DNA:SNPs: :2194G>A, 1156G>T (human)
DNA:splice-site mutation:intron:IVS14+1G>A (human)

NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459

G

euchromatic histone lysine methyltransferase 1

CTD Direct Evidence: marker/mechanism

G

euchromatic histone lysine methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:23,977,683...23,992,673
Ensembl chr 7:23,977,683...23,993,478

G

endoglin

disease_progression

NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,309,400...268,343,783

G

epoxide hydrolase 1

susceptibility
no_association

DNA:missense mutation, haplotype:exon:p.H139R (human)
DNA:polymorphisms:exon
DNA:SNPs:exon:rs1051740, rs2234922 (human)
DNA:missense mutation, haplotype:exon:p.Y113H (human)
CTD Direct Evidence: marker/mechanism

PMID:19593802 PMID:21983886 PMID:22200898 PMID:22930568

RGD:11252110 RGD:11252111 RGD:11252113 RGD:11252114

NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:SNPs: :8092C>A, 19007G>A (human)
DNA:SNPs, haplotypes: :p.R194W, p.R280H, p.R399Q (human)

PMID:16435384 PMID:16723154

RGD:11252160 RGD:11340204

NCBI chr 6:51,783,537...51,808,898
Ensembl chr 6:51,783,478...51,798,984

G

ERCC excision repair 2, TFIIH core complex helicase subunit

no_association

DNA:haplotype
DNA:missense mutations: :p.D312N, p.K751Q (human)

PMID:19101034 PMID:21987080

RGD:11252192 RGD:11340201

NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553

G

ETS transcription factor ERG

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr13:201,999,237...202,302,572
Ensembl chr13:202,000,995...202,301,368

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr 5:60,523,530...60,776,792
Ensembl chr 5:60,523,433...60,776,750

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941

G

coagulation factor III, tissue factor

NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666

G

Fas cell surface death receptor

disease_progression

protein:increased expression:CD34+ bone marrow cell

PMID:9711907 PMID:10500800

RGD:11049148 RGD:11049157

NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716

G

fibrinogen alpha chain

protein:increased expression:serum (human)

NCBI chr 8:74,574,870...74,584,202
Ensembl chr 8:74,574,882...74,584,202

G

fms related receptor tyrosine kinase 3

ClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:11290608 PMID:11442493 PMID:14604974 PMID:14670924 PMID:15256420 More...

NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358

G

folylpolyglutamate synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:268,281,298...268,309,397
Ensembl chr 1:268,287,765...268,309,398

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859

G

growth factor independent 1B transcriptional repressor

mRNA:increased expression:blood:

NCBI chr 1:272,701,386...272,715,551
Ensembl chr 1:272,702,184...272,715,539

G

G protein subunit beta 1

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:25485910 PMID:25741868 PMID:27108799 PMID:28492532 PMID:32134617 More...

NCBI chr 6:63,867,155...63,957,514
Ensembl chr 6:63,867,158...63,952,505

G

glucose-6-phosphate isomerase

NCBI chr 6:44,038,374...44,069,331
Ensembl chr 6:44,038,357...44,069,328

G

glutathione peroxidase 1

treatment

PMID:17317918 PMID:24698347

RGD:11352774 RGD:11352812

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione-disulfide reductase

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

H1.2 linker histone, cluster member

susceptibility

DNA:SNP, haplotype:enhancer: (rs807212) (human)

NCBI chr 7:20,743,716...20,744,356
Ensembl chr 7:20,743,716...20,744,356

G

HCK proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr17:35,708,549...35,751,590
Ensembl chr17:35,709,349...35,751,582

G

histone deacetylase 1

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411

G

histone deacetylase 2

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr 1:79,867,713...79,901,597
Ensembl chr 1:79,863,094...79,901,585

G

histone deacetylase 4

treatment

NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301

G

homeostatic iron regulator

no_association

DNA:missense mutation:cds:p.C282Y (human)
DNA:missense mutation: :p.H63D (human)
DNA:missense mutation:cds:p.H63D (human)

PMID:10627122 PMID:17107905

RGD:10755557 RGD:10755558

NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000

G

hexokinase 1

protein:decreased activity:platelet

NCBI chr14:72,383,328...72,460,927
Ensembl chr14:72,351,246...72,460,924

G

HLF transcription factor, PAR bZIP family member

CTD Direct Evidence: marker/mechanism

NCBI chr12:31,589,337...31,643,595
Ensembl chr12:31,589,337...31,643,594

G

isocitrate dehydrogenase (NADP(+)) 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,153...111,362,296

G

interferon gamma

susceptibility

DNA:SNP: :rs2069727(human)

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

IKAROS family zinc finger 1

ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphocytic, susceptibility to, 2

PMID:25741868 PMID:27993330 PMID:28492532

NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,725...136,464,940

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:115,512,160...115,677,503
Ensembl chr15:115,512,179...115,677,374

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:22,466,386...22,562,320
Ensembl chr12:22,466,414...22,562,312

G

interleukin 10

treatment

protein:decreased expression:blood

PMID:15860861 PMID:21653647

RGD:11049158 RGD:11049169

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interferon regulatory factor 4

DNA:SNP:intron:rs12203592 (human)

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

inosine triphosphatase

treatment
no_association

DNA:SNPs:exon:94C>A, 138G>A (human)
DNA:SNP:intron

NCBI chr17:32,458,351...32,474,827
Ensembl chr17:32,455,459...32,474,784

G

lysine demethylase 2B

mRNA:increased expression:bone marrow (human)

NCBI chr14:31,057,121...31,203,093
Ensembl chr14:31,165,950...31,203,091

G

lysine demethylase 3B

protein:increased expression:bone marrow, mononuclear cell (human)

NCBI chr 2:140,346,145...140,418,556
Ensembl chr 2:140,346,223...140,418,527

G

lysine demethylase 6A

severity

DNA:mutations:cds:multiple (human)

NCBI chr X:39,953,764...40,154,197
Ensembl chr X:39,953,814...40,154,029

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism
OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

PMID:24736461 PMID:25730765

NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884

G

KRAS proto-oncogene, GTPase

disease_progression

PMID:17910045 PMID:25917266

RGD:11060148 RGD:11060149

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

LIM domain only 2

OMIM:247640 | OMIM:613065

NCBI chr 2:27,033,924...27,055,457
Ensembl chr 2:27,044,763...27,055,453

G

glutathione S-transferase P-like

no_association
disease_progression
susceptibility

DNA:polymorphism: :1578 a>G(human)
DNA:haplotype:cds:
DNA:transition mutation:exon:

PMID:10666194 PMID:15738600 PMID:23979883

RGD:10450829 RGD:10755321 RGD:10755417

NCBI chr 2:5,005,498...5,009,247

G

cytokine receptor-like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr Y:4,965,886...4,992,529

G

MEFV innate immunity regulator, pyrin

susceptibility

DNA:polymorphisms:cds:p.E148Q,M680I(human)

NCBI chr 3:38,934,573...38,948,609

G

methylenetetrahydrofolate reductase

treatment
disease_progression

DNA:missense mutation:cds:677C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:677C>T (p.A222V) (rs1801133) (human)

PMID:16706930 PMID:19923983 PMID:21644011

RGD:10449398 RGD:10449407

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

5-methyltetrahydrofolate-homocysteine methyltransferase

disease_progression
no_association
susceptibility

DNA:polymorphism: :66A>G(human)
DNA:polymorphism: :2756A>G(human)
DNA:SNP::rs10925235(human)

PMID:15159311 PMID:21618417 PMID:22453148 PMID:26605150

RGD:11531136 RGD:11531137 RGD:11531140 RGD:11531141

NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:haplotype:cds:
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs3776455(human)

PMID:17136115 PMID:23940529

RGD:11531133 RGD:11531135

NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

nibrin

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:9590180 PMID:11325820 PMID:12353271 PMID:14559852 PMID:15338273 More...

NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603

G

nitric oxide synthase 3

susceptibility
disease_progression

DNA:SNP: :rs3918186(human)
DNA:polymorphism, haplotype:cds,intron:P.E298D,-786T>C(human)

PMID:20510681 PMID:23922896

RGD:11533639 RGD:11533646

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

notch receptor 3

OMIM:247640 | OMIM:613065

NCBI chr 2:62,364,507...62,402,348
Ensembl chr 2:62,364,501...62,402,344

G

NAD(P)H quinone dehydrogenase 1

CTD Direct Evidence: marker/mechanism
DNA:missense mutations: :p.R139W (465C>T), p.P187S (609C>T) (human)
DNA:mutation: :609C>T (human)

PMID:11774269 PMID:17332311 PMID:18444911

RGD:10769347 RGD:10769359

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

NRAS proto-oncogene, GTPase

disease_progression

DNA:missense mutation:cds:

NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227

G

nuclear receptor binding SET domain protein 2

CTD Direct Evidence: therapeutic

NCBI chr 8:938,832...1,018,032
Ensembl chr 8:964,893...1,018,028

G

5'-nucleotidase, cytosolic II

CTD Direct Evidence: marker/mechanism

NCBI chr14:114,062,451...114,167,460
Ensembl chr14:114,062,459...114,145,109

G

nucleoporin 214

susceptibility

CTD Direct Evidence: marker/mechanism

NCBI chr 1:271,103,838...271,210,292
Ensembl chr 1:271,104,033...271,210,288

G

P2Y receptor family member 8

CTD Direct Evidence: marker/mechanism

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:55,450,824...55,619,226
Ensembl chr 4:55,506,069...55,616,111

G

paired box 5

susceptibility

ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to, 3

PMID:24013638 PMID:24728327 PMID:25741868 PMID:27993330 PMID:28492532 More...

NCBI chr 1:237,574,938...237,785,454
Ensembl chr 1:237,575,061...237,785,413

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M (rs854560), p.Q192R (rs662) (human)

NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723

G

PRAME nuclear receptor transcriptional regulator

severity

mRNA:increased expression:blood (human)

NCBI chr14:48,901,097...48,906,855
Ensembl chr14:48,899,343...48,911,231

G

PR/SET domain 14

CTD Direct Evidence: marker/mechanism

NCBI chr 4:65,273,988...65,295,362
Ensembl chr 4:65,271,315...65,295,178

G

phosphatase and tensin homolog

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr14:99,929,590...100,021,619

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690

G

RUNX family transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189

G

solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675

G

small nuclear ribonucleoprotein polypeptide E

severity

mRNA:decreased expression:bone marrow, blood, mononuclear cell (human)

NCBI chr 9:64,560,544...64,567,007
Ensembl chr 9:64,560,523...64,567,007

G

TAL bHLH transcription factor 1, erythroid differentiation factor

NCBI chr 6:164,282,242...164,297,636
Ensembl chr 6:164,283,366...164,295,290

G

TAL bHLH transcription factor 2

NCBI chr 1:246,932,975...246,944,722
Ensembl chr 1:246,933,241...246,942,163

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:76,859,079...76,906,275
Ensembl chr 2:76,859,089...76,898,351

G

transcobalamin 2

protein:altered activity:plasma:

NCBI chr14:47,496,245...47,515,966
Ensembl chr14:47,502,715...47,515,965

G

telomerase reverse transcriptase

DNA:SNPs:promoter, introns:g.1296486C>T, g.12866516A>C, g.1279790G>A (rs2735940, rs2736100, rs10069690) (human)

PMID:15621763 PMID:23066086

RGD:11038654 RGD:11038667

NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421

G

transmembrane 9 superfamily member 2

mRNA:increased expression:bone marrow, mononuclear cells (human)

NCBI chr11:68,407,834...68,469,956
Ensembl chr11:68,404,975...68,469,953

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

thiopurine S-methyltransferase

no_association
treatment

DNA:SNPs:introns:12356C>T, 16638C>T, 26354G>T (rs4449636, rs2518463, rs2842949) (human)
DNA:SNPs:exon:374C>T, 719A>G (rs2842934, rs1142345) (human)
DNA:SNPs:multiple
DNA:SNPs: :multiple

PMID:17164697 PMID:22009189 PMID:24499706

RGD:10766474 RGD:11038720 RGD:11038723

NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012

G

tetratricopeptide repeat domain 12

DNA:hypermethylation:5'end:CpG dinucleotide

NCBI chr 9:40,988,881...41,032,928
Ensembl chr 9:40,988,920...41,046,900

G

thymidylate synthetase

treatment

DNA:repeats: : rs347430033(human)

NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578

G

V-set pre-B cell surrogate light chain 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:49,972,058...49,972,768
Ensembl chr14:49,970,340...49,972,741

G

X-ray repair cross complementing 1

no_association
susceptibility

DNA:missense mutation: :p.R399Q (human)
DNA:missense mutation: :p.R194W (human)
DNA:missense mutation, haplotype: :p.R399Q (human)
CTD Direct Evidence: marker/mechanism

PMID:19101034 PMID:21983886

RGD:11252110 RGD:11252192

NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729

Acute Lymphoblastic Leukemia, with Lymphomatous Features

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:10988075 PMID:11423618 PMID:11853795 PMID:11861307 PMID:11964322 More...

NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708

G

cytochrome P450 family 2 subfamily B member 6B

susceptibility

DNA:polymorphism:G15631T

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

fibroblast growth factor receptor 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156

NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724

G

interleukin 7 receptor

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:22897847 PMID:22955920

NCBI chr16:21,300,141...21,330,156
Ensembl chr16:21,300,111...21,329,585

G

insulin like 6

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:216,792,785...216,820,197
Ensembl chr 1:216,792,787...216,823,479

G

Janus kinase 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:16239216 PMID:19139102 PMID:19470474 PMID:19838194 PMID:20167706 More...

NCBI chr 6:147,320,288...147,567,188
Ensembl chr 6:147,429,056...147,567,182

G

Janus kinase 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148

G

Janus kinase 3

ClinVar Annotator: match by term: LYMPHOMATOUS ALL

PMID:10982185 PMID:16843266 PMID:18270328 PMID:20132407 PMID:20372971 More...

NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495

G

cytokine receptor-like factor 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:19907440 PMID:19965641 PMID:20018760 PMID:22368272

NCBI chr Y:4,965,886...4,992,529

adenoid cystic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 1 (Colton blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746

G

AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:84,049,729...84,124,302
Ensembl chr 6:84,049,087...84,123,349

G

AT-rich interaction domain 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 5:76,637,385...76,800,155
Ensembl chr 5:76,636,967...76,797,043

G

AT-rich interaction domain 4B

CTD Direct Evidence: marker/mechanism

NCBI chr14:55,924,333...56,082,209
Ensembl chr14:55,924,367...56,082,198

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

NCBI chr14:65,408,603...65,598,485
Ensembl chr14:65,408,598...65,598,485

G

assembly factor for spindle microtubules

CTD Direct Evidence: marker/mechanism

NCBI chr10:19,971,516...20,039,680
Ensembl chr10:19,975,192...20,039,623

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552

G

ATR serine/threonine kinase

treatment

NCBI chr13:83,175,515...83,289,986
Ensembl chr13:83,174,824...83,289,989

G

ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:61,584,028...61,872,341
Ensembl chr X:61,584,848...61,872,287

G

BRCA1 associated deubiquitinase 1

ClinVar Annotator: match by term: Adenocystic carcinoma | ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:21642991 PMID:24894717 PMID:26166446 PMID:26452128 PMID:28492532

NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483

G

BCL11 transcription factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 3:81,195,217...81,296,165
Ensembl chr 3:81,196,294...81,296,382

G

BCL6 corepressor

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr X:35,768,013...35,891,013
Ensembl chr X:35,768,017...35,814,833

G

BCL6 corepressor like 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:106,547,754...106,613,130
Ensembl chr X:106,549,139...106,612,894

G

BRCA1 DNA repair associated

CTD Direct Evidence: marker/mechanism

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

bromodomain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:774,307...808,016
Ensembl chr 5:770,654...808,006

G

cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986

G

cap methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:14,325,869...14,334,043
Ensembl chr 6:14,323,981...14,334,008

G

contactin 6

CTD Direct Evidence: marker/mechanism

NCBI chr13:57,754,233...58,014,830
Ensembl chr13:57,719,846...58,014,970

G

CREB binding protein

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224

G

death associated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:27,724,644...27,954,708
Ensembl chr10:27,724,648...27,954,350

G

denticleless E3 ubiquitin protein ligase homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 9:131,225,840...131,275,426
Ensembl chr 9:131,227,705...131,275,451

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:12,197,943...12,237,884
Ensembl chr 2:12,199,231...12,237,615

G

EF-hand domain family member D1

CTD Direct Evidence: marker/mechanism

NCBI chr15:133,120,092...133,169,430
Ensembl chr15:133,120,093...133,169,428

G

engrailed homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:24,402,605...24,408,377
Ensembl chr15:24,402,370...24,407,692

G

E1A binding protein p300

CTD Direct Evidence: marker/mechanism

NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760

G

erbb2 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr16:44,415,106...44,533,353
Ensembl chr16:44,415,189...44,533,349

G

extra spindle pole bodies like 1, separase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:18,486,969...18,509,913
Ensembl chr 5:18,487,052...18,509,913

G

FA complementation group A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:253,207...300,159
Ensembl chr 6:253,207...300,152

G

FAT atypical cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:8,466,099...8,580,715
Ensembl chr17:8,457,187...8,580,715

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Adenocystic carcinoma

NCBI chr 8:76,482,027...76,699,354
Ensembl chr 8:76,482,844...76,699,348

G

fibroblast growth factor 16

CTD Direct Evidence: marker/mechanism

NCBI chr X:61,551,487...61,561,807
Ensembl chr X:61,552,460...61,561,954

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425

G

fibroblast growth factor receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796

G

forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325

G

forkhead box P2

CTD Direct Evidence: marker/mechanism

NCBI chr18:31,335,102...31,890,523
Ensembl chr18:31,335,264...31,888,845

G

growth arrest specific 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:36,712,758...36,885,436
Ensembl chr 2:36,711,612...36,885,620

G

growth arrest specific 6

CTD Direct Evidence: marker/mechanism

NCBI chr11:78,848,797...78,880,733
Ensembl chr11:78,848,797...78,881,284

G

GINS complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:3,218,655...3,252,740
Ensembl chr 6:3,218,702...3,243,899

G

guanylate cyclase 1 soluble subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135

G

homer scaffold protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:58,913,949...58,922,474
Ensembl chr 2:58,913,992...58,922,474

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501

G

isocitrate dehydrogenase (NADP(+)) 1

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,153...111,362,296

G

insulin like growth factor binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976

G

interleukin 17 receptor D

CTD Direct Evidence: marker/mechanism

NCBI chr13:38,935,631...39,006,721
Ensembl chr13:38,939,316...39,006,690

G

insulin receptor related receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:93,239,678...93,258,075
Ensembl chr 4:93,239,969...93,258,075

G

iroquois homeobox 4

CTD Direct Evidence: marker/mechanism

NCBI chr16:78,940,033...78,944,855
Ensembl chr16:78,937,566...78,945,269

G

inositol-3-phosphate synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:59,363,672...59,367,003
Ensembl chr 2:59,363,716...59,367,002

G

integrin subunit beta 4

CTD Direct Evidence: marker/mechanism

NCBI chr12:5,651,292...5,685,601
Ensembl chr12:5,651,292...5,685,611

G

jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:19,591,248...19,629,659
Ensembl chr17:19,591,259...19,629,641

G

Janus kinase 3

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:14615376 PMID:28492532 PMID:33040328

NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495

G

jumonji domain containing 1C

CTD Direct Evidence: marker/mechanism

NCBI chr14:66,640,845...66,966,911
Ensembl chr14:66,640,849...66,920,324

G

KAT8 regulatory NSL complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:16,901,611...17,096,912
Ensembl chr12:16,903,450...17,096,916

G

lysine acetyltransferase 6A

CTD Direct Evidence: marker/mechanism

NCBI chr17:11,002,818...11,109,974

G

lysine demethylase 6A

exacerbates

CTD Direct Evidence: marker/mechanism
DNA:mutations:multiple: (human)
DNA:splice-site mutation, missense mutations:splice junction, CDS:multiple: (human)

PMID:23685749 PMID:31483290

RGD:150429732 RGD:150429736

NCBI chr X:39,953,764...40,154,197
Ensembl chr X:39,953,814...40,154,029

G

lysine demethylase 6B

CTD Direct Evidence: marker/mechanism

NCBI chr12:53,087,072...53,108,949
Ensembl chr12:53,098,964...53,108,214

G

lysine methyltransferase 2C

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:31483290

NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:6695174 PMID:12460918 PMID:15696205 PMID:16361624 PMID:16618717 More...

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

keratin 15

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,124,605...21,130,247
Ensembl chr12:21,124,705...21,130,241

G

keratin 5

CTD Direct Evidence: marker/mechanism

NCBI chr 5:17,862,047...17,868,397
Ensembl chr 5:17,862,051...17,868,402

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:46,896,515...47,568,140
Ensembl chr13:46,897,903...47,567,717

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:100,846,693...102,171,199
Ensembl chr 9:100,847,013...102,170,004

G

mastermind like transcriptional coactivator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:86,879,353...87,323,123
Ensembl chr 8:86,879,974...87,323,117

G

mitogen-activated protein kinase kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:74,626,739...74,651,352
Ensembl chr 2:74,626,783...74,651,348

G

myristoylated alanine rich protein kinase C substrate

CTD Direct Evidence: marker/mechanism

NCBI chr 1:79,789,796...79,795,895
Ensembl chr 1:79,789,815...79,795,760

G

microtubule affinity regulating kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:8,153,870...8,216,141
Ensembl chr 2:8,155,348...8,215,959

G

MDS1 and EVI1 complex locus

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr13:107,753,207...108,336,136
Ensembl chr13:107,754,482...108,335,702

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr 1:129,590,645...129,697,434
Ensembl chr 1:129,594,795...129,697,408

G

MIER family member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:77,912,766...77,938,855
Ensembl chr 2:77,912,761...77,938,855

G

modulator of VRAC current 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:571,921...593,531
Ensembl chr 5:571,963...591,822

G

mortality factor 4 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:48,050,050...48,075,799
Ensembl chr 7:48,050,045...48,075,795

G

MYB proto-oncogene, transcription factor

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:26829750

NCBI chr 1:28,819,500...28,856,222
Ensembl chr 1:28,819,503...28,856,999

G

MYB proto-oncogene like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:68,120,078...68,159,513
Ensembl chr 4:68,119,865...68,159,509

G

MYC binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 6:94,805,649...94,814,443
Ensembl chr 6:94,805,640...94,814,337

G

MYCN proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:121,543,201...121,549,678
Ensembl chr 3:121,543,109...121,549,046

G

neuropilin and tolloid like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:37,443,534...37,506,589
Ensembl chr 6:37,443,699...37,505,736

G

nuclear factor I B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:208,182,397...208,427,504
Ensembl chr 1:208,175,194...208,421,602

G

notch receptor 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

G

nuclear receptor binding SET domain protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:80,649,882...80,810,934
Ensembl chr 2:80,654,379...80,809,059

G

neurotrophic receptor tyrosine kinase 3

treatment

NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,301...191,925,327

G

proprotein convertase subtilisin/kexin type 1 inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr X:42,947,688...42,952,222
Ensembl chr X:42,947,692...42,949,024

G

PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:99,625,085...99,657,170
Ensembl chr 4:99,625,080...99,657,161

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:15930273 PMID:17376864 PMID:18074223 PMID:19366826 PMID:22120714 More...

NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587

G

protein kinase, DNA-activated, catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 4:79,687,375...79,850,146
Ensembl chr 4:79,687,375...79,846,656

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr14:99,929,590...100,021,619

G

glycogen phosphorylase B

CTD Direct Evidence: marker/mechanism

NCBI chr17:30,940,457...30,995,688
Ensembl chr17:30,940,452...30,995,691

G

RNA binding fox-1 homolog 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:11,633,523...11,905,325
Ensembl chr 5:11,633,541...11,903,094

G

serpin family F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:47,949,004...47,959,471
Ensembl chr12:47,948,510...47,959,470

G

SET domain containing 2, histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:25741868 PMID:26619011

NCBI chr15:101,274,968...101,338,018
Ensembl chr15:101,276,851...101,299,105

G

solute carrier family 24 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:27,270,232...27,780,535
Ensembl chr17:27,270,093...27,780,526

G

solute carrier family 3 member 2

disease_progression

NCBI chr 2:8,892,071...8,919,070
Ensembl chr 2:8,892,089...8,919,072

G

solute carrier family 7 member 5

disease_progression

NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 1:219,624,773...219,815,438
Ensembl chr 1:219,573,535...219,815,421

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr14:49,874,981...49,906,043
Ensembl chr14:49,874,984...49,906,048

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,784,410...21,807,170
Ensembl chr12:21,786,897...21,807,162

G

structural maintenance of chromosomes 1A

CTD Direct Evidence: marker/mechanism

NCBI chr X:46,143,738...46,202,187
Ensembl chr X:46,144,920...46,218,543

G

SON DNA and RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr13:197,162,075...197,193,417
Ensembl chr13:197,162,116...197,194,078

G

SRY-box transcription factor 11

CTD Direct Evidence: marker/mechanism

NCBI chr 3:129,797,438...129,800,568
Ensembl chr 3:129,798,854...129,800,197

G

SRY-box transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:16,886,834...16,895,488
Ensembl chr 7:16,891,319...16,892,752

G

Snf2 related CREBBP activator protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:17,662,374...17,702,862
Ensembl chr 3:17,664,349...17,700,219

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:53,442,795...53,491,847
Ensembl chr 9:53,445,591...53,486,010

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

tousled like kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:77,169,661...77,329,548
Ensembl chr15:77,170,086...77,329,402

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450

G

tumor protein p53

disease_progression

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:1673792 PMID:1686725 PMID:6736287 PMID:7707106 PMID:7881428 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

ubiquitin like with PHD and ring finger domains 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:73,898,061...73,937,727
Ensembl chr 2:73,898,071...73,931,769

G

versican

CTD Direct Evidence: marker/mechanism

NCBI chr 2:91,682,177...91,811,674
Ensembl chr 2:91,384,391...91,811,208

G

Wnt family member 5B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:68,627,158...68,731,938
Ensembl chr 5:68,627,185...68,732,265

G

5'-3' exoribonuclease 2

DNA:hypermethylation:3' utr: (human)

NCBI chr17:29,107,641...29,193,500
Ensembl chr17:29,107,667...29,193,479

G

zinc finger imprinted 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:61,157,781...61,193,706

adenoid squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HNF1 homeobox A

NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328

adult T-cell leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:5,058,817...5,208,868
Ensembl chr 7:5,058,817...5,210,270

G

caspase recruitment domain family member 11

CTD Direct Evidence: marker/mechanism

NCBI chr 3:2,145,178...2,266,377
Ensembl chr 3:2,145,178...2,266,355

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr13:18,860,596...18,865,987
Ensembl chr13:18,860,730...18,865,983

G

C-C motif chemokine receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475

G

CD163 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498

G

CD274 molecule

disease_progression

NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724

G

CD28 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr15:107,128,103...107,155,431
Ensembl chr15:107,128,203...107,162,935

G

CD68 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695

G

CD80 molecule

NCBI chr13:140,693,312...140,730,541
Ensembl chr13:140,693,382...140,728,976

G

CD86 molecule

NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310

G

casein kinase 1 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284

G

casein kinase 2 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:34,692,960...34,748,067

G

casein kinase 2 beta

CTD Direct Evidence: marker/mechanism

NCBI chr 7:23,781,194...23,787,914
Ensembl chr 7:23,780,362...23,788,678
Ensembl chr 7:23,780,362...23,788,678

G

cytotoxic T-lymphocyte associated protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103

G

Fas cell surface death receptor

susceptibility

DNA:polymorphism:promoter: -670 G>A(human)
protein:increased expression:peripheral blood mononuclear cell:

PMID:7513372 PMID:17962369

RGD:11049147 RGD:11049453

NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716

G

forkhead box P3

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23797717 PMID:23962110

NCBI chr X:43,303,777...43,328,164
Ensembl chr X:43,303,785...43,322,968

G

FYN proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859

G

G protein-coupled receptor 183

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,231,851...68,248,627
Ensembl chr11:68,231,224...68,245,751

G

heterogeneous nuclear ribonucleoprotein A2/B1

CTD Direct Evidence: marker/mechanism

NCBI chr18:46,205,164...46,215,861
Ensembl chr18:46,205,418...46,215,856

G

inducible T cell costimulator

CTD Direct Evidence: marker/mechanism

NCBI chr15:107,350,253...107,370,123
Ensembl chr15:107,350,203...107,370,119

G

interferon, alpha 1

CTD Direct Evidence: therapeutic

NCBI chr 1:201,515,835...201,516,477
Ensembl chr 1:201,515,809...201,516,488

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

PMID:8800741 PMID:23962110

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:115,512,160...115,677,503
Ensembl chr15:115,512,179...115,677,374

G

interleukin 10

CTD Direct Evidence: marker/mechanism

PMID:8704212 PMID:23962110

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609

G

interleukin 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

interleukin 5

disease_progression

protein:increased expression:serum

NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212

G

interleukin 6

protein:increased expression:serum (human)

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interferon regulatory factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

Janus kinase 3

DNA:missense mutations: :p.L156P, p.R172Q, p.E183G (human)

NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:CD4+ T cell:

NCBI chr 1:28,819,500...28,856,222
Ensembl chr 1:28,819,503...28,856,999

G

notch receptor 1

DNA:mutations:multiple (human)

G

NRAS proto-oncogene, GTPase

disease_progression

NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227

G

phospholipase C gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:43,810,003...43,844,553
Ensembl chr17:43,810,048...43,844,554

G

protein kinase C beta

CTD Direct Evidence: marker/mechanism

NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

TAL bHLH transcription factor 2

NCBI chr 1:246,932,975...246,944,722
Ensembl chr 1:246,933,241...246,942,163

G

telomeric repeat binding factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:17,605,748...17,631,795
Ensembl chr 6:17,605,763...17,631,721

G

T cell leukemia homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1683261 PMID:1717256

NCBI chr14:112,206,964...112,213,957
Ensembl chr14:112,207,360...112,213,955

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073

G

tumor protein p73

CTD Direct Evidence: marker/mechanism

NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,182,456...65,228,990

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:72,327,433...72,391,649
Ensembl chr 2:72,326,716...72,391,648

anaplastic large cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:16151469 PMID:19503098 PMID:21345110 PMID:22155737 PMID:22920921 More...

NCBI chr 3:109,411,146...110,105,755

G

heat shock protein 90 alpha family class A member 1

CTD Direct Evidence: marker/mechanism

G

interferon regulatory factor 4

DNA:translocation

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

JunB proto-oncogene, AP-1 transcription factor subunit

NCBI chr 2:66,214,086...66,219,435
Ensembl chr 2:66,214,138...66,217,002

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

TNF receptor superfamily member 8

CTD Direct Evidence: marker/mechanism

PMID:10908157 PMID:17261581

NCBI chr 6:72,103,309...72,174,882

G

twist family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:88,286,911...88,290,131
Ensembl chr 9:88,289,407...88,290,015

angioimmunoblastic T-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tet methylcytosine dioxygenase 2

ClinVar Annotator: match by term: Angioimmunoblastic T-cell lymphoma

PMID:19797729 PMID:27210295 PMID:27276561 PMID:28337768 PMID:28492532 More...

NCBI chr 8:116,413,253...116,546,976
Ensembl chr 8:116,415,267...116,545,299

B-cell acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:23623386 PMID:25741868

NCBI chr 3:29,266,234...29,306,109
Ensembl chr 3:29,269,989...29,306,151

G

neurofibromin 1

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:9536098 PMID:17576681 PMID:23656349 PMID:25741868 PMID:28492532

NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969

G

WT1 transcription factor

ClinVar Annotator: match by term: B Acute Lymphoblastic Leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997

B-Cell Chronic Lymphocytic Leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2A

susceptibility

DNA:SNPs,haplotype: :rs1481012,rs2231142(human)

NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,889,684...130,945,393

G

acyl-CoA oxidase like

CTD Direct Evidence: marker/mechanism

NCBI chr 3:45,202,875...45,563,062
Ensembl chr 3:45,203,195...45,538,220

G

activation induced cytidine deaminase

disease_progression

NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,369

G

apolipoprotein E

disease_progression

NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552

G

BCL11 transcription factor A

DNA:translocation:5' utr: (human)

NCBI chr 3:81,195,217...81,296,165
Ensembl chr 3:81,196,294...81,296,382

G

BCL2 apoptosis regulator

no_association
treatment
severity

CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:g.-938C>A (human)
protein:increased expression:B cell (human)

PMID:16960146 PMID:17296974 PMID:17959858 PMID:20001236 PMID:21750559 More...

RGD:11522735 RGD:11526104 RGD:11526105 RGD:11526110

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

Bcl2 modifying factor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:131,178,021...131,199,668
Ensembl chr 1:131,178,315...131,200,393

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12068308 PMID:12198537 PMID:12692057 PMID:12960123 PMID:14612909 More...

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

G

Bruton tyrosine kinase

treatment

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:23045577 PMID:24869598 PMID:25741868 PMID:28492532

NCBI chr X:82,981,512...83,014,475
Ensembl chr X:82,981,515...83,014,573

G

Cbl proto-oncogene

severity

mRNA,protein:increased expression:CD5+ B cell:
DNA:hypophosphorylation:CD5+ B cell:

NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,416,938...46,512,834

G

coiled-coil domain containing 50

NCBI chr13:128,619,223...128,690,964
Ensembl chr13:128,619,230...128,690,649

G

CD40 molecule

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

CD40 ligand

mouse-human chimeric gene in human

NCBI chr X:111,778,666...111,788,901
Ensembl chr X:111,778,493...111,789,709

G

CD5 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 2:10,648,973...10,673,479
Ensembl chr 2:10,648,974...10,673,919

G

CD79b molecule

protein:decreased expression:B lymphocyte, cell surface (human)
DNA:polymorphism:multiple (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)

PMID:9269755 PMID:10090943 PMID:10552962

RGD:11250403 RGD:151665190 RGD:151665202

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

CD86 molecule

severity

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310

G

cytoplasmic polyadenylation element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:52,329,054...52,382,408
Ensembl chr 7:52,304,472...52,383,732

G

cytotoxic T-lymphocyte associated protein 4

protein:increased expression:T cell

PMID:15914560 PMID:16094420

RGD:11344923 RGD:11352246

NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103

G

dyskerin pseudouridine synthase 1

NCBI chr X:125,218,928...125,228,881
Ensembl chr X:125,218,923...125,229,525

G

DNA methyltransferase 3 beta

mRNA:decreased expression: B cell

NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,345,816...36,386,072

G

ERCC excision repair 2, TFIIH core complex helicase subunit

severity

DNA:SNP: :p.K751Q (rs13181) (human)

PMID:19484764 PMID:22739018

RGD:11252203 RGD:11252204

NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553

G

FERM, ARH/RhoGEF and pleckstrin domain protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:140,060,304...140,144,059
Ensembl chr15:140,060,372...140,144,037

G

Fas cell surface death receptor

disease_progression

NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:25741868 PMID:26619011

NCBI chr 8:76,482,027...76,699,354
Ensembl chr 8:76,482,844...76,699,348

G

Fc fragment of IgG receptor IIIa

no_association

DNA:SNP:exon:p.F158V (rs396991) (human)

NCBI chr 4:88,948,357...88,956,513

G

GNAS complex locus

disease_progression

DNA:polymorphism:393T>C (human)

NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501

G

intercellular adhesion molecule 1

severity

NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205

G

interferon gamma

susceptibility

DNA:polymorphism: :847A>T(human)

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

disease_progression
no_association

DNA:SNPs: :rs1800890, rs4072227, rs17015865 (human)
protein:increased expression:serum
DNA:SNPs: :multiple

PMID:10638947 PMID:19573080 PMID:22945689

RGD:11041895 RGD:11049165 RGD:11049174

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 19

CTD Direct Evidence: marker/mechanism

NCBI chr 9:67,469,519...67,479,597
Ensembl chr 9:67,469,524...67,479,813

G

interleukin 1 alpha

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119

G

interleukin 1 receptor antagonist

protein:decreased expression:plasma:

G

interleukin 6

CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma:

PMID:10870116 PMID:18006695

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interferon regulatory factor 4

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:12079517 PMID:12393648 PMID:18758461

RGD:11526160 RGD:11530024

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

integrin subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:86,942,054...87,028,428
Ensembl chr15:86,947,240...87,030,364

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,825,161...113,944,070

G

tumor necrosis factor receptor superfamily member 10B-like

susceptibility

DNA:SNP: :1322A>G (human)
DNA:missense mutation:cds:p.E228A (c.683A>C) (human)

PMID:15531454 PMID:16217763

RGD:11038717 RGD:11038718

NCBI chr14:7,344,788...7,371,086

G

interleukin-1 beta-like

severity

DNA:SNP:promoter:-511C>T (human)
protein:decreased expression:plasma:

PMID:10870116 PMID:18271063

RGD:11051967 RGD:11522755

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699

G

microRNA mir-143

CTD Direct Evidence: marker/mechanism

NCBI chr 2:150,578,738...150,578,817
Ensembl chr 2:150,578,738...150,578,817

G

microRNA mir-145

CTD Direct Evidence: marker/mechanism

NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211

G

membrane spanning 4-domains A1

NCBI chr 2:11,216,238...11,229,060
Ensembl chr 2:11,215,901...11,222,914

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227

G

purinergic receptor P2X 7

CTD Direct Evidence: marker/mechanism

NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:B cell (human)

NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293

G

phospholipase C gamma 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:24869598 PMID:28492532

NCBI chr 6:6,433,146...6,603,092
Ensembl chr 6:6,433,153...6,603,060

G

phorbol-12-myristate-13-acetate-induced protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,887...161,188,164

G

DNA polymerase beta

CTD Direct Evidence: marker/mechanism

NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821

G

protein phosphatase 2 regulatory subunit B'gamma

CTD Direct Evidence: marker/mechanism

G

PRAME nuclear receptor transcriptional regulator

protein:increased expression:mononuclear cell (human)

NCBI chr14:48,901,097...48,906,855
Ensembl chr14:48,899,343...48,911,231

G

protein kinase D2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:52,559,066...52,599,174
Ensembl chr 6:52,559,393...52,599,132

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12161469 PMID:12717436 PMID:14644997 PMID:14982869 PMID:15385933 More...

NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003

G

glutaminyl-peptide cyclotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:102,795,199...102,823,090
Ensembl chr 3:102,792,720...102,823,026

G

RB transcriptional corepressor like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,757,718...31,802,047
Ensembl chr 6:31,748,739...31,802,022

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:23634996 PMID:25741868 PMID:26619011

NCBI chr15:101,274,968...101,338,018
Ensembl chr15:101,276,851...101,299,105

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr 2:6,279,039...6,295,550
Ensembl chr 2:6,279,049...6,294,639

G

SP140 nuclear body protein

CTD Direct Evidence: marker/mechanism

NCBI chr15:131,225,305...131,292,172
Ensembl chr15:131,226,626...131,292,170

G

telomerase reverse transcriptase

disease_progression

NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,985...134,000,276

G

thrombomodulin

NCBI chr17:30,219,870...30,223,499
Ensembl chr17:30,217,303...30,224,099

G

tumor necrosis factor

disease_progression

protein:increased expression:bone marrow, blood, lymphocyte

PMID:12010662 PMID:22945689

RGD:10449463 RGD:11041895

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

G

TNF receptor superfamily member 11a

CTD Direct Evidence: marker/mechanism

NCBI chr 1:159,128,039...159,187,476
Ensembl chr 1:159,128,038...159,187,481

G

TNF superfamily member 11

CTD Direct Evidence: marker/mechanism

NCBI chr11:24,468,011...24,505,421
Ensembl chr11:24,468,110...24,505,477

G

TNF superfamily member 13

protein:increased expression:serum

NCBI chr12:52,853,646...52,857,033
Ensembl chr12:52,853,904...52,857,029

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073

G

DNA topoisomerase II binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:74,768,251...74,846,377
Ensembl chr13:74,768,257...74,846,340

G

tumor protein p53

disease_progression

DNA:deletion: :
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1679237 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

vitamin D receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475

G

exportin 1

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr 3:80,255,016...80,300,260
Ensembl chr 3:80,255,146...80,300,327

G

X-ray repair cross complementing 1

severity
no_association

DNA:SNP: :p.R399Q (rs25487) (human)
DNA:SNP: :p.R194W (rs1799782), p.R280H (25489) (human)

NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729

B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2A

susceptibility

DNA:SNP: :rs6857600(human)

NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,889,684...130,945,393

G

activation induced cytidine deaminase

NCBI chr 5:62,777,236...62,787,342
Ensembl chr 5:62,777,352...62,787,369

G

BCL2 like 2

disease_progression

NCBI chr 7:75,765,603...75,770,743
Ensembl chr 7:75,763,078...75,769,763

G

BCL6 transcription repressor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330

G

bromodomain containing 2

NCBI chr 7:25,096,579...25,162,591
Ensembl chr 7:25,152,043...25,162,578

G

Bruton tyrosine kinase

treatment

human cell in a mouse model

PMID:25662332 PMID:28348046

RGD:11040764 RGD:124713554

NCBI chr X:82,981,512...83,014,475
Ensembl chr X:82,981,515...83,014,573

G

chromobox 7

NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634

G

CD40 molecule

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

colony stimulating factor 2

treatment

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753

G

ELL associated factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr13:138,632,541...138,681,607
Ensembl chr13:138,648,270...138,681,613

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

severity
treatment

PMID:23982173 PMID:29456795

RGD:10755356 RGD:126781726

NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr 3:19,447,488...19,489,201
Ensembl chr 3:19,443,359...19,489,152

G

Janus kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495

G

lysine acetyltransferase 5

severity

NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466

G

galectin 1

protein:increased expression:primary tumor (rat)

NCBI chr 5:10,149,069...10,152,514
Ensembl chr 5:10,149,068...10,156,023

G

microRNA mir-143

CTD Direct Evidence: marker/mechanism

NCBI chr 2:150,578,738...150,578,817
Ensembl chr 2:150,578,738...150,578,817

G

microRNA mir-145

CTD Direct Evidence: marker/mechanism

NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211

G

NRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

protein tyrosine phosphatase non-receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,130...52,086,736

G

signal transducer and activator of transcription 5A

NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073

G

TNF superfamily member 9

NCBI chr 2:72,578,811...72,582,834
Ensembl chr 2:72,578,821...72,582,745

B-lymphoblastic leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

treatment

NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943

G

aldo-keto reductase family 1, member C1

treatment

NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248

G

activating transcription factor 7 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 5:58,022,734...58,149,980
Ensembl chr 5:58,022,741...58,133,399

G

BCL2 like 1

severity

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

BCR activator of RhoGEF and GTPase

BCR/ABL fusion

NCBI chr14:49,208,662...49,322,109
Ensembl chr14:49,208,762...49,322,103

G

bromodomain containing 2

NCBI chr 7:25,096,579...25,162,591
Ensembl chr 7:25,152,043...25,162,578

G

cellular communication network factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691

G

cyclin D1

mRNA:increased expression:B cell (mouse)

NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296

G

cyclin dependent kinase inhibitor 2A

susceptibility
treatment

DNA:mutation:cds:c.442C>T,p.A148T,rs3731249 (human)

PMID:16618932 PMID:21622646 PMID:26104880

RGD:11057958 RGD:11251751 RGD:11251772

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

cytochrome P450 family 3 subfamily A member 22

treatment

DNA:polymorphisms: :

NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817

G

ETS variant transcription factor 6

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735 PMID:25807284

NCBI chr 5:60,523,530...60,776,792
Ensembl chr 5:60,523,433...60,776,750

G

coagulation factor XIII A chain

protein:increased expression:B lymphoblast:

NCBI chr 7:3,751,290...3,900,797
Ensembl chr 7:3,751,292...3,900,762

G

coagulation factor III, tissue factor

treatment

NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666

G

fumarate hydratase

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr10:12,404,143...12,431,843
Ensembl chr10:12,404,176...12,431,824

G

fms related receptor tyrosine kinase 3

mRNA,protein:increased expression:bone marrow:

NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859

G

indoleamine 2,3-dioxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,473

G

IKAROS family zinc finger 1

disease_progression

DNA:mutations: :
CTD Direct Evidence: marker/mechanism

PMID:22699455 PMID:24141364

NCBI chr 9:136,372,202...136,464,942
Ensembl chr 9:136,372,725...136,464,940

G

interleukin 5

NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212

G

interferon regulatory factor 4

PMID:20585039 PMID:21818355 PMID:25006123

RGD:11526159 RGD:11530020 RGD:11530030

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

interferon regulatory factor 8

NCBI chr 6:3,041,617...3,060,685
Ensembl chr 6:3,041,645...3,097,406

G

intestine specific homeobox

CTD Direct Evidence: marker/mechanism

G

cytokine receptor-like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr Y:4,965,886...4,992,529

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr 1:129,590,645...129,697,434
Ensembl chr 1:129,594,795...129,697,408

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:cds:

NCBI chr 1:28,819,500...28,856,222
Ensembl chr 1:28,819,503...28,856,999

G

MYC proto-oncogene, bHLH transcription factor

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

paired box 5

CTD Direct Evidence: marker/mechanism

PMID:24013638 PMID:30643249

NCBI chr 1:237,574,938...237,785,454
Ensembl chr 1:237,575,061...237,785,413

G

platelet derived growth factor receptor alpha

treatment

NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690

G

RUNX family transcription factor 1

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735

NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

signal transducer and activator of transcription 5A

protein:increased phosphorylation:bone marrow (human)

NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138

G

serine/threonine kinase 11

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:26080840 PMID:26295973 PMID:28492532

NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327

G

SUFU negative regulator of hedgehog signaling

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr14:113,500,001...113,628,064
Ensembl chr14:113,500,842...113,626,003

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:76,859,079...76,906,275
Ensembl chr 2:76,859,089...76,898,351

G

tryptophan 2,3-dioxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,962

G

tissue factor pathway inhibitor

treatment

NCBI chr15:92,345,083...92,409,962
Ensembl chr15:92,345,075...92,409,905

G

TNF superfamily member 13

NCBI chr12:52,853,646...52,857,033
Ensembl chr12:52,853,904...52,857,029

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 1:255,436,206...255,459,020
Ensembl chr 1:255,432,969...255,459,073

G

tumor protein p53

disease_progression

DNA:mutations: :

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

WT1 transcription factor

ClinVar Annotator: match by term: Pre-B-cell acute lymphoblastic leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997

B-lymphoblastic leukemia/lymphoma MLL rearranged

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

WT1 transcription factor

ClinVar Annotator: match by term: Mixed phenotype acute leukemia with t(v;11q23.3)

NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997

B-lymphoblastic leukemia/lymphoma with BCR-ABL1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mutS homolog 6

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1

PMID:22658618 PMID:25741868 PMID:28492532

NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,238

B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone morphogenetic protein receptor type 1A

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:30093976

NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,790

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:33471991

NCBI chr 3:22,586,881...22,612,837
Ensembl chr 3:22,586,856...22,612,834

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532

NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690

G

RecQ like helicase 4

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:10678659 PMID:12734318 PMID:12838562 PMID:12952869 PMID:15897384 More...

NCBI chr 4:287,206...293,629
Ensembl chr 4:287,214...293,913

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cbl proto-oncogene

ClinVar Annotator: match by term: B lymphoblastic leukemia lymphoma with hyperdiploidy

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,416,938...46,512,834

B-lymphoblastic leukemia/lymphoma with hypodiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

succinate dehydrogenase complex flavoprotein subunit A

ClinVar Annotator: match by term: B-lymphoblastic leukemia/lymphoma with hypodiploidy

PMID:25741868 PMID:28492532

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

Burkitt lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:6,083,793...6,105,921
Ensembl chr 5:6,083,444...6,105,924

G

AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 6:84,049,729...84,124,302
Ensembl chr 6:84,049,087...84,123,349

G

BCL2 binding component 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:53,037,103...53,046,902
Ensembl chr 6:53,037,104...53,046,887

G

BCL2 like 2

mRNA:increased expression:lymph node

NCBI chr 7:75,765,603...75,770,743
Ensembl chr 7:75,763,078...75,769,763

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:17262179 PMID:25741868 PMID:26467025 PMID:28492532 PMID:31911673 More...

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

Bruton tyrosine kinase

ameliorates
treatment

Human cell line in a mouse model
mRNA:increased expression:multiple (human)

PMID:28474336 PMID:30546948

RGD:124713565 RGD:124715474

NCBI chr X:82,981,512...83,014,475
Ensembl chr X:82,981,515...83,014,573

G

calreticulin

treatment

human cell line and recombinant protein in a mouse model
human cells and recombinant protein in a mouse model

PMID:9858521 PMID:10961892

RGD:150521687 RGD:150521702

NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132

G

chaperonin containing TCP1 subunit 6B

CTD Direct Evidence: marker/mechanism

NCBI chr12:40,205,122...40,230,130
Ensembl chr12:40,205,123...40,230,073

G

CD40 molecule

treatment

human cell line in a mouse model

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

formimidoyltransferase cyclodeaminase

CTD Direct Evidence: marker/mechanism

G

G protein subunit alpha 13

CTD Direct Evidence: marker/mechanism

NCBI chr12:11,922,630...11,966,913
Ensembl chr12:11,922,632...11,966,610

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

PMID:23143595 PMID:23143597

NCBI chr 6:81,422,541...81,424,169
Ensembl chr 6:81,422,546...81,424,075

G

microRNA mir-21

treatment

NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358

G

microRNA mir-23b

treatment

NCBI chr10:27,080,197...27,080,276
Ensembl chr10:27,080,197...27,080,276

G

MLLT11 transcription factor 7 cofactor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:98,165,990...98,171,674
Ensembl chr 4:98,164,676...98,171,674

G

MYC proto-oncogene, bHLH transcription factor

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:8220424 PMID:25157968 PMID:27993330

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

PBX homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

NCBI chr 4:85,824,590...86,170,328
Ensembl chr 4:85,824,666...86,170,191

G

pyruvate carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:5,566,608...5,587,797
Ensembl chr 2:5,518,517...5,587,797

G

phosphoinositide-3-kinase regulatory subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609

G

ret proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr14:61,305,818...61,361,416
Ensembl chr14:61,305,841...61,361,412

G

spalt like transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:146,251,591...146,273,778
Ensembl chr 1:146,252,155...146,273,906

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

CTD Direct Evidence: marker/mechanism

NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,295

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

NCBI chr 2:76,859,079...76,906,275
Ensembl chr 2:76,859,089...76,898,351

central nervous system lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bruton tyrosine kinase

ameliorates

NCBI chr X:82,981,512...83,014,475
Ensembl chr X:82,981,515...83,014,573

G

CD79b molecule

treatment

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

interleukin 10

DNA:SNP:promoter:-1082G>A (human)

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

MYD88 innate immune signal transduction adaptor

treatment

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

childhood acute lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CCCTC-binding factor

disease_progression

mRNA, protein:increased expression:bone marrow, blood (human)

NCBI chr 6:28,188,002...28,261,009
Ensembl chr 6:28,195,647...28,261,009

chronic lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate kinase 3

protein:increased expression:peripheral blood mononuclear cell

NCBI chr 1:217,236,561...217,263,144
Ensembl chr 1:217,236,482...217,261,367

G

Rho GTPase activating protein 44

mRNA:increased expression: (human)

NCBI chr12:57,049,900...57,206,706
Ensembl chr12:57,049,895...57,206,889

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12068308 PMID:12198537 PMID:12960123 PMID:14612909 PMID:14679157 More...

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

G

CD40 ligand

protein:increased expression:serum (human)

NCBI chr X:111,778,666...111,788,901
Ensembl chr X:111,778,493...111,789,709

G

CD79b molecule

protein:decreased expression:peripheral blood cells (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
protein:decreased expression:blood, B cell (human)
protein:decreased expression:blood cells (human)

PMID:10090943 PMID:10329919 PMID:10516749 PMID:10753858

RGD:11531139 RGD:151665125 RGD:151665152 RGD:151665190

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

CD86 molecule

DNA:hypermethylation (human)

NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:25741868 PMID:26619011

NCBI chr 8:76,482,027...76,699,354
Ensembl chr 8:76,482,844...76,699,348

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501

G

interleukin 5

protein:increased expression:serum

NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212

G

interferon regulatory factor 4

disease_progression

DNA:SNP: :rs872071 (human)
DNA:SNPs:3' utr:multiple
DNA:missense mutation:exon:p.L116R (human)

PMID:20090783 PMID:20123861 PMID:20731705 PMID:21791429 PMID:23897826 More...

RGD:11526156 RGD:11526158 RGD:11530021 RGD:11530026 RGD:11530029 RGD:11530031

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699

G

microRNA mir-155

miRNA:increased expression:peripheral blood mononuclear cell

NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902

G

microRNA mir-21

miRNA:increased expression:peripheral blood mononuclear cell

NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 4:105,845,913...105,853,769
Ensembl chr 4:105,845,872...105,858,227

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M, p.Q192R (human)

NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12717436 PMID:14644997 PMID:15385933 PMID:15710330 PMID:15928039 More...

NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003

G

protein tyrosine phosphatase non-receptor type 22

susceptibility

protein:increased expression:B cell (human)
DNA:snp:cds:p.R620W (rs2476601) (human)

PMID:22569400 PMID:23287625

RGD:11533998 RGD:11535006

NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr15:101,274,968...101,338,018
Ensembl chr15:101,276,851...101,299,105

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr 2:6,279,039...6,295,550
Ensembl chr 2:6,279,049...6,294,639

G

signal transducer and activator of transcription 3

protein:increased phosphorylation:peripheral blood mononuclear cell

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

tumor protein p53

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

exportin 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr 3:80,255,016...80,300,260
Ensembl chr 3:80,255,146...80,300,327

diffuse large B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:93,049,955...93,146,469

G

ATP binding cassette subfamily G member 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:130,853,414...130,945,388
Ensembl chr 8:130,889,684...130,945,393

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:109,411,146...110,105,755

G

beta-2-microglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr 1:126,837,721...126,844,043
Ensembl chr 1:126,835,143...126,981,582

G

BCAS2 pre-mRNA processing factor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:105,992,558...106,003,160
Ensembl chr 4:105,992,452...106,003,150

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 2

disease_progression

NCBI chr 7:75,765,603...75,770,743
Ensembl chr 7:75,763,078...75,769,763

G

BCL6 transcription repressor

disease_progression

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

PMID:11821949 PMID:15701085

RGD:11530023 RGD:1600111

NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9150172 PMID:18489799 PMID:20104584 PMID:21138478 PMID:22798144 More...

NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,953...8,858,418

G

Bruton tyrosine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24869598 PMID:25082755 PMID:25189416 PMID:25741868 PMID:27199251 More...

NCBI chr X:82,981,512...83,014,475
Ensembl chr X:82,981,515...83,014,573

G

caspase recruitment domain family member 11

DNA:missense mutations:exons:multiple (human)
CTD Direct Evidence: marker/mechanism

PMID:18323416 PMID:25049379 PMID:26192916

NCBI chr 3:2,145,178...2,266,377
Ensembl chr 3:2,145,178...2,266,355

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

coiled-coil domain containing 86

CTD Direct Evidence: marker/mechanism

NCBI chr 2:10,895,649...10,906,196
Ensembl chr 2:10,895,652...10,906,119

G

CD22 molecule

treatment

NCBI chr 6:44,820,593...44,834,392
Ensembl chr 6:44,820,689...44,834,389

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

CD79a molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 6:49,996,116...49,999,294
Ensembl chr 6:49,995,765...49,999,340

G

CD79b molecule

treatment
severity

ClinVar Annotator: match by term: Diffuse large B cell lymphoma
DNA:missense mutation:multiple, exon 5 (human)

PMID:11160144 PMID:25708834 PMID:31402495 PMID:31609782

RGD:151665133 RGD:151665203

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

cyclin dependent kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854

G

checkpoint kinase 2

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:16199547 PMID:21876083 PMID:24713400 PMID:28492532

NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290

G

clathrin heavy chain

CTD Direct Evidence: marker/mechanism

NCBI chr12:35,848,894...35,926,028
Ensembl chr12:35,848,540...35,926,015

G

CREB binding protein

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24755471 PMID:28481359 PMID:30239046 PMID:33323405

NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224

G

dicer 1, ribonuclease III

disease_progression

NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,365,802...116,411,224

G

DNA methyltransferase 3 alpha

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:25363760 PMID:25741868 PMID:29900417 PMID:30478443 PMID:32581362 More...

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr 5:60,523,530...60,776,792
Ensembl chr 5:60,523,433...60,776,750

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

CTD Direct Evidence: marker/mechanism

PMID:20081860 PMID:28438623

NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716

G

forkhead box O1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:26314988 PMID:29721381 PMID:35079069

NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473

G

GLI family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:22,736,325...22,747,421
Ensembl chr 5:22,739,900...22,747,421

G

intercellular adhesion molecule 1

disease_progression

proteion:increased expression:serum:

NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr 3:19,447,488...19,489,201
Ensembl chr 3:19,443,359...19,489,152

G

inner mitochondrial membrane peptidase subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:34,006,841...34,930,252
Ensembl chr18:34,006,900...34,907,287

G

interferon regulatory factor 4

disease_progression

NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609

G

lysine methyltransferase 2D

CTD Direct Evidence: marker/mechanism

NCBI chr 5:15,049,827...15,091,622

G

glutathione S-transferase P-like

susceptibility

DNA:SNP: :(rs1695)(human)

NCBI chr 2:5,005,498...5,009,247

G

MALT1 paracaspase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:162,076,933...162,144,915
Ensembl chr 1:162,076,955...162,144,880

G

marker of proliferation Ki-67

disease_progression

NCBI chr14:137,266,622...137,296,312

G

methylenetetrahydrofolate reductase

susceptibility

DNA:transition, transversion, haplotype:cds:g.677C>T, g.1298A>C (human)

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

MYD88 innate immune signal transduction adaptor

severity

DNA:missense mutation:L265P (human)
ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nibrin

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9590180 PMID:16415040 PMID:28492532

NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,691...46,874,603

G

nectin cell adhesion molecule 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:51,317,386...51,358,665

G

neurofibromin 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21390130 PMID:22158541 PMID:23292937

NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969

G

NFKB inhibitor alpha

no_association

SNA:polymorphism(s)

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

nucleolar protein with MIF4G domain 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:1,747,217...1,760,914
Ensembl chr18:1,747,223...1,761,859

G

3-phosphoinositide dependent protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,835...79,610,840

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,084,742

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,118,018...5,145,628

G

PR/SET domain 1

disease_progression

NCBI chr 1:72,309,096...72,335,474
Ensembl chr 1:72,311,880...72,335,466

G

peroxiredoxin 3

CTD Direct Evidence: marker/mechanism

NCBI chr14:129,079,050...129,090,790
Ensembl chr14:129,079,051...129,090,830

G

peroxiredoxin 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:19,800,153...19,819,575
Ensembl chr X:19,797,550...19,819,571

G

protein arginine methyltransferase 5

CTD Direct Evidence: marker/mechanism

NCBI chr 7:76,110,956...76,119,619
Ensembl chr 7:76,110,951...76,124,989

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:10468583 PMID:10555148 PMID:10698513 PMID:10866302 PMID:10866658 More...

NCBI chr14:99,929,590...100,021,619

G

Ran GTPase activating protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:7,210,974...7,240,965
Ensembl chr 5:7,211,010...7,241,003

G

ribosomal protein S6 kinase B1

CTD Direct Evidence: marker/mechanism

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

SEC31 homolog A, COPII coat complex component

CTD Direct Evidence: marker/mechanism

NCBI chr 8:135,431,965...135,495,124
Ensembl chr 8:135,426,403...135,495,121

G

splicing factor 3a subunit 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:22037554 PMID:26498691 PMID:33563892

NCBI chr14:47,312,460...47,335,448
Ensembl chr14:47,312,473...47,335,370

G

S-phase kinase associated protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:21,463,270...21,500,925
Ensembl chr16:21,463,012...21,509,310

G

SMAD specific E3 ubiquitin protein ligase 2

NCBI chr12:14,368,683...14,492,129
Ensembl chr12:14,368,701...14,492,108

G

suppressor of cytokine signaling 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:19734449 PMID:23296022 PMID:26336985 PMID:28302137 PMID:29625055

NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

superoxide dismutase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,637...18,802,152

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21690253 PMID:22591296 PMID:22859607 PMID:23926297 PMID:25873174 More...

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

spleen associated tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171

G

TBL1X/Y related 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9450851 PMID:16492805 PMID:21156281 PMID:21156282 PMID:25741868 More...

NCBI chr13:115,312,444...115,488,228
Ensembl chr13:115,312,452...115,487,284

G

tumor protein p53

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:1631137 PMID:1978757 PMID:8062826 PMID:8099841 PMID:8425176 More...

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

thioredoxin interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 4:99,348,589...99,351,760
Ensembl chr 4:99,348,490...99,352,755

Enteropathy-Associated T-Cell Lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

SET domain containing 2, histone lysine methyltransferase

DNA:mutations:multiple (human)

NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266

extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: MALT lymphoma

PMID:9989495 PMID:10380920 PMID:10408400

NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,216...130,657,995

G

baculoviral IAP repeat containing 3

treatment

DNA:gene fusion: (human)

NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,003,276...33,020,242

G

C-X-C motif chemokine receptor 4

protein:increased expression: mucosa-associated lymphoid tissue (human)

NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232

follicular lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase H+ transporting accessory protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:124,952,532...124,960,344
Ensembl chr X:124,952,500...124,960,343

G

ATPase H+ transporting V1 subunit B2

CTD Direct Evidence: marker/mechanism

NCBI chr14:4,289,257...4,318,587
Ensembl chr14:4,289,339...4,318,584

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: Follicular lymphoma

NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,216...130,657,995

G

BCL2 apoptosis regulator

susceptibility

DNA:translocation: ;t(14;18)(q32;q21)
CTD Direct Evidence: marker/mechanism

PMID:3287162 PMID:12855623 PMID:16671111

RGD:1599473 RGD:734639

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528

G

CD40 ligand

human gene in a mouse model

NCBI chr X:111,778,666...111,788,901
Ensembl chr X:111,778,493...111,789,709

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr12:15,052,966...15,056,441
Ensembl chr12:15,053,007...15,056,438

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224

G

EBF transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:64,357,999...64,753,188
Ensembl chr16:64,359,001...64,752,210

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941