lymphatic system cancer - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	lymphatic system cancer	go back to main search page
Accession:	DOID:0060073	browse the term
Definition:	An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. (DO)

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Rat (698) Mouse (1043) Human (5354) Chinchilla (588) Bonobo (623) Dog (638) Squirrel (594) Pig (626) Green Monkey (612) Naked Mole-rat (580) All
Genes (626) Cell Lines (12)

acute biphenotypic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DOT1 like histone lysine methyltransferase

treatment

NCBI chr20:56,805,030...56,868,771
Ensembl chr20:56,803,242...56,852,539

G

ring finger protein 20

disease_progression

NCBI chr11:58,239,245...58,266,637
Ensembl chr11:58,239,313...58,265,866

acute leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 2, TFIIH core complex helicase subunit

ClinVar Annotator: match by term: Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified

PMID:7585650 PMID:8571952 PMID:9195225 PMID:9238033 PMID:15982307 More...

NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125

acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:snps, haplotype:multiple (human)

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

ATP binding cassette subfamily C member 2

treatment

DNA:SNPs: :rs717620(human)
DNA:SNP:5'UTR:rs717620(human)

PMID:24404132 PMID:25007187

RGD:11080959 RGD:11080979

NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740

G

ATP binding cassette subfamily G member 2

disease_progression

mRNA:increased expression:mononuclear cell:

PMID:12100141 PMID:15521915

RGD:11081076 RGD:11081143

NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:11984797 PMID:21898527

NCBI chr 9:53,118,462...53,262,092
Ensembl chr 9:53,119,641...53,261,307

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

activation induced cytidine deaminase

treatment

NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

PMID:19684603 PMID:19684604

NCBI chr 4:13,926,759...14,105,069
Ensembl chr 4:13,927,217...14,101,364

G

aryl hydrocarbon receptor nuclear translocator

CTD Direct Evidence: marker/mechanism

Ensembl chr17:59,941,353...60,010,867
Ensembl chr17:59,941,353...60,010,867

G

BCL2 associated X, apoptosis regulator

NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464

G

BCL2 apoptosis regulator

severity

mRNA:increased expression:bone marrow (human)

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

BCL2 like 1

treatment

mRNA:increased expression:blood, mononuclear cell (human)

PMID:12469194 PMID:19020783

RGD:11353852 RGD:11353866

NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355

G

BCR activator of RhoGEF and GTPase

NCBI chr26:27,856,280...27,980,923
Ensembl chr26:27,856,082...27,978,318

G

caspase 8

CTD Direct Evidence: therapeutic

NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822

G

calpastatin

protein:increased expresssion:B cell

NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959

G

cyclin D1

mRNA:increased expression:bone marrow (human)

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

CD40 ligand

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

CD79b molecule

protein:decreased expression:bone marrow, mononuclear cell (human)

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

CD86 molecule

severity

protein:increased expression:peripheral blood, bone marrow, mononuclear cell (human)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

cyclin dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869

G

cyclin dependent kinase inhibitor 2A

disease_progression
no_association
susceptibility

DNA:deletion: :
DNA:missense mutations:cds:
ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:7566978 PMID:7647780 PMID:7718873 PMID:7987387 PMID:8573142 More...

RGD:11057958 RGD:11251764 RGD:11252081 RGD:11252082

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

cyclin dependent kinase inhibitor 2B

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr11:41,259,627...41,264,832

G

CCAAT enhancer binding protein epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr 8:3,423,046...3,425,595
Ensembl chr 8:3,423,040...3,425,217

G

complement factor B

DNA:missense mutation:p.R32Q b(human)

NCBI chr12:1,400,143...1,406,267

G

CREB binding protein

disease_progression

DNA:mutations:multiple

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

G

cytokine receptor like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:780,924...801,961
Ensembl chr X:780,711...802,836

G

colony stimulating factor 3

treatment

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

chondroitin sulfate proteoglycan 4

severity

NCBI chr30:38,465,486...38,498,365
Ensembl chr30:38,465,241...38,497,971

G

cytochrome b-245 alpha chain

mRNA:increased expression:peripheral blood mononuclear cell:

NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893

G

cytochrome P450 family 1 subfamily A member 1

no_association
susceptibility

DNA:polymorphism:3'UTR:3801T>C(human)
DNA:polymorphism:cds:2452C>A(p.T461N)(human)
DNA:polymorphism:3"UTR:rs4646903(human)

PMID:16676594 PMID:22964275 PMID:23725389

RGD:11352714 RGD:11352725 RGD:11352728

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

G

cytochrome P450 family 1 subfamily A member 2

CTD Direct Evidence: marker/mechanism

NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135

G

cytochrome P450 family 1 subfamily B member 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:30,273,281...30,278,554
Ensembl chr17:30,272,749...30,278,554

G

cytochrome P450 family 2 subfamily D member 15

susceptibility

DNA:polymorphisms: :
DNA:SNP,deletion:splice junction,exon:1934G>A(human)

PMID:11037802 PMID:19593802

RGD:11252111 RGD:11352820

NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298

G

cytochrome P450 family 2 subfamily E member 1

CTD Direct Evidence: marker/mechanism

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

G

dihydrofolate reductase

disease_progression

DNA:polymorphisms, haplotype:promoter:
DNA:polymorphisms: :-317A>G, 829C>T (human)

PMID:9226157 PMID:12972803 PMID:19861437 PMID:22969948

RGD:11039542 RGD:11039543 RGD:11039544 RGD:11039545

NCBI chr 3:26,521,214...26,556,065

G

major histocompatibility complex, class II, DQ beta 1

DNA:polymorphisms, haplotypes:cds:multiple
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0501 (human)

PMID:9744491 PMID:22434102

RGD:11041749 RGD:11041762

NCBI chr12:2,305,307...2,307,711

G

DNA methyltransferase 3 alpha

treatment

DNA:mutations:exon, intron:p.R882(human)

NCBI chr17:19,489,524...19,563,074
Ensembl chr17:19,492,193...19,563,902

G

DNA nucleotidylexotransferase

protein:increased activity:peripheral blood,bone marrow:

NCBI chr28:9,729,812...9,759,019
Ensembl chr28:9,729,814...9,759,008

G

dihydropyrimidine dehydrogenase

disease_progression
no_association

DNA:splice-site mutation:intron:IVS14+1G>A (human)
DNA:SNPs: :2194G>A, 1156G>T (human)
DNA:SNP: :85T>C (human)

NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923

G

euchromatic histone lysine methyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:48,031,593...48,110,954
Ensembl chr 9:48,032,709...48,175,828

G

euchromatic histone lysine methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584

G

endoglin

disease_progression

NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064

G

epoxide hydrolase 1

susceptibility
no_association

DNA:polymorphisms:exon
DNA:SNPs:exon:rs1051740, rs2234922 (human)
DNA:missense mutation, haplotype:exon:p.H139R (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation, haplotype:exon:p.Y113H (human)

PMID:19593802 PMID:21983886 PMID:22200898 PMID:22930568

RGD:11252110 RGD:11252111 RGD:11252113 RGD:11252114

NCBI chr 7:38,964,319...39,004,902
Ensembl chr 7:38,964,338...38,999,238

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:SNPs, haplotypes: :p.R194W, p.R280H, p.R399Q (human)
DNA:SNPs: :8092C>A, 19007G>A (human)

PMID:16435384 PMID:16723154

RGD:11252160 RGD:11340204

NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602

G

ERCC excision repair 2, TFIIH core complex helicase subunit

no_association

DNA:missense mutations: :p.D312N, p.K751Q (human)
DNA:haplotype

PMID:19101034 PMID:21987080

RGD:11252192 RGD:11340201

NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125

G

ETS transcription factor ERG

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr31:33,456,902...33,562,704
Ensembl chr31:33,497,209...33,515,272

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr27:34,351,206...34,587,060
Ensembl chr27:34,343,390...34,587,060

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838

G

coagulation factor III, tissue factor

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

Fas cell surface death receptor

disease_progression

protein:increased expression:CD34+ bone marrow cell

PMID:9711907 PMID:10500800

RGD:11049148 RGD:11049157

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

fibrinogen alpha chain

protein:increased expression:serum (human)

NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975

G

fms related receptor tyrosine kinase 3

ClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:11290608 PMID:11442493 PMID:14604974 PMID:14670924 PMID:15256420 More...

NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284

G

folylpolyglutamate synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:55,590,092...55,612,639
Ensembl chr 9:55,585,970...55,599,028

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760

G

growth factor independent 1B transcriptional repressor

mRNA:increased expression:blood:

NCBI chr 9:51,380,697...51,394,679
Ensembl chr 9:51,380,696...51,392,812

G

G protein subunit beta 1

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:25485910 PMID:25741868 PMID:27108799 PMID:28492532 PMID:32134617 More...

NCBI chr 5:56,777,854...56,879,619
Ensembl chr 5:56,779,354...56,817,295

G

glucose-6-phosphate isomerase

NCBI chr 1:117,922,380...117,948,325
Ensembl chr 1:117,922,635...117,948,316

G

glutathione peroxidase 1

treatment

PMID:17317918 PMID:24698347

RGD:11352774 RGD:11352812

NCBI chr20:39,889,165...39,890,253
Ensembl chr20:39,889,174...39,890,260

G

glutathione-disulfide reductase

NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752

G

glutathione S-transferase pi 1

disease_progression
susceptibility
no_association

DNA:haplotype:cds:
DNA:transition mutation:exon:
DNA:polymorphism: :1578 a>G(human)

PMID:10666194 PMID:15738600 PMID:23979883

RGD:10450829 RGD:10755321 RGD:10755417

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

H1.2 linker histone, cluster member

susceptibility

DNA:SNP, haplotype:enhancer: (rs807212) (human)

NCBI chr35:24,009,304...24,011,602

G

HCK proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr24:21,473,424...21,513,673
Ensembl chr24:21,473,305...21,513,564

G

histone deacetylase 1

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr 2:68,901,339...68,936,473
Ensembl chr 2:68,901,651...68,936,186

G

histone deacetylase 2

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr12:70,053,822...70,083,491
Ensembl chr12:70,053,297...70,103,578

G

histone deacetylase 4

treatment

NCBI chr25:49,318,621...49,545,314
Ensembl chr25:49,317,349...49,453,478

G

homeostatic iron regulator

no_association

DNA:missense mutation:cds:p.C282Y (human)
DNA:missense mutation:cds:p.H63D (human)
DNA:missense mutation: :p.H63D (human)

PMID:10627122 PMID:17107905

RGD:10755557 RGD:10755558

NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413

G

hexokinase 1

protein:decreased activity:platelet

NCBI chr 4:20,396,761...20,516,889
Ensembl chr 4:20,421,526...20,518,211

G

HLF transcription factor, PAR bZIP family member

CTD Direct Evidence: marker/mechanism

NCBI chr 9:30,321,090...30,380,480
Ensembl chr 9:30,327,495...30,377,175

G

homeobox D4

ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to

G

isocitrate dehydrogenase (NADP(+)) 1

CTD Direct Evidence: marker/mechanism

NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219

G

interferon gamma

susceptibility

DNA:SNP: :rs2069727(human)

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

IKAROS family zinc finger 1

ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphocytic, susceptibility to, 2

PMID:25741868 PMID:27993330 PMID:28492532

NCBI chr18:1,661,851...1,750,987
Ensembl chr18:1,661,690...1,770,768

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr37:20,508,647...20,662,549
Ensembl chr37:20,516,239...20,661,298

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,643,482...22,733,988
Ensembl chr 9:22,643,640...22,728,385

G

interleukin 10

treatment

protein:decreased expression:blood

PMID:15860861 PMID:21653647

RGD:11049158 RGD:11049169

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interferon regulatory factor 4

DNA:SNP:intron:rs12203592 (human)

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

inosine triphosphatase

treatment
no_association

DNA:SNPs:exon:94C>A, 138G>A (human)
DNA:SNP:intron

NCBI chr24:18,070,980...18,081,815
Ensembl chr24:18,064,983...18,082,163

G

lysine demethylase 2B

mRNA:increased expression:bone marrow (human)

NCBI chr26:7,625,857...7,746,049
Ensembl chr26:7,598,931...7,745,113

G

lysine demethylase 3B

protein:increased expression:bone marrow, mononuclear cell (human)

NCBI chr11:25,954,352...26,024,919
Ensembl chr11:25,943,864...26,023,866

G

lysine demethylase 6A

severity

DNA:mutations:cds:multiple (human)

NCBI chr X:38,745,854...38,964,029
Ensembl chr X:38,745,854...38,959,842

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism
OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

PMID:24736461 PMID:25730765

NCBI chr 5:15,212,559...15,302,825
Ensembl chr 5:15,217,348...15,270,971

G

KRAS proto-oncogene, GTPase

disease_progression

PMID:17910045 PMID:25917266

RGD:11060148 RGD:11060149

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

LIM domain only 2

OMIM:247640 | OMIM:613065

G

double homeobox protein 4C-like

CTD Direct Evidence: marker/mechanism

NCBI chr17:64,277,421...64,282,701

G

CD46 molecule, complement regulatory protein-like

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr 7:6,602,762...6,646,561

G

MEFV innate immunity regulator, pyrin

susceptibility

DNA:polymorphisms:cds:p.E148Q,M680I(human)

NCBI chr 6:37,964,776...37,984,830
Ensembl chr 6:37,970,608...37,983,737

G

methylenetetrahydrofolate reductase

disease_progression
treatment

CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:677C>T (p.A222V) (rs1801133) (human)
DNA:missense mutation:cds:677C>T (human)

PMID:16706930 PMID:19923983 PMID:21644011

RGD:10449398 RGD:10449407

NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818

G

5-methyltetrahydrofolate-homocysteine methyltransferase

no_association
disease_progression
susceptibility

DNA:polymorphism: :2756A>G(human)
DNA:polymorphism: :66A>G(human)
DNA:SNP::rs10925235(human)

PMID:15159311 PMID:21618417 PMID:22453148 PMID:26605150

RGD:11531136 RGD:11531137 RGD:11531140 RGD:11531141

NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:SNP: :rs3776455(human)
DNA:haplotype:cds:
CTD Direct Evidence: marker/mechanism

PMID:17136115 PMID:23940529

RGD:11531133 RGD:11531135

NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

nibrin

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:9590180 PMID:11325820 PMID:12353271 PMID:14559852 PMID:15338273 More...

NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563

G

nitric oxide synthase 3

susceptibility
disease_progression

DNA:SNP: :rs3918186(human)
DNA:polymorphism, haplotype:cds,intron:P.E298D,-786T>C(human)

PMID:20510681 PMID:23922896

RGD:11533639 RGD:11533646

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

notch receptor 3

OMIM:247640 | OMIM:613065

NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219

G

NAD(P)H quinone dehydrogenase 1

DNA:missense mutations: :p.R139W (465C>T), p.P187S (609C>T) (human)
DNA:mutation: :609C>T (human)
CTD Direct Evidence: marker/mechanism

PMID:11774269 PMID:17332311 PMID:18444911

RGD:10769347 RGD:10769359

NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860

G

NRAS proto-oncogene, GTPase

disease_progression

DNA:missense mutation:cds:

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

nuclear receptor binding SET domain protein 2

CTD Direct Evidence: therapeutic

NCBI chr 3:62,164,888...62,228,006
Ensembl chr 3:62,167,939...62,228,035

G

5'-nucleotidase, cytosolic II

CTD Direct Evidence: marker/mechanism

NCBI chr28:15,525,581...15,621,287
Ensembl chr28:15,526,790...15,621,235

G

nucleoporin 214

NCBI chr 9:52,840,300...52,943,785
Ensembl chr 9:52,841,096...52,947,770

G

P2Y receptor family member 8

CTD Direct Evidence: marker/mechanism

NCBI chr X:1,060,204...1,097,471

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

CTD Direct Evidence: marker/mechanism

NCBI chr29:28,207,445...28,340,812
Ensembl chr29:28,211,031...28,263,322

G

paired box 5

susceptibility

ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to, 3

PMID:24013638 PMID:24728327 PMID:25741868 PMID:27993330 PMID:28492532 More...

NCBI chr11:53,194,905...53,390,204
Ensembl chr11:53,201,344...53,390,974

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M (rs854560), p.Q192R (rs662) (human)

NCBI chr14:20,565,620...20,600,774
Ensembl chr14:20,565,641...20,642,985

G

PRAME nuclear receptor transcriptional regulator

severity

mRNA:increased expression:blood (human)

NCBI chr26:27,124,901...27,137,772
Ensembl chr26:27,124,902...27,136,112

G

PR/SET domain 14

CTD Direct Evidence: marker/mechanism

NCBI chr29:19,203,798...19,220,149
Ensembl chr29:19,203,807...19,220,518

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phosphatase and tensin homolog

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726

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RUNX family transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839

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solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr31:38,958,332...38,971,091
Ensembl chr31:38,967,013...38,971,094

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small nuclear ribonucleoprotein polypeptide E

severity

mRNA:decreased expression:bone marrow, blood, mononuclear cell (human)

NCBI chr38:515,808...521,536
Ensembl chr38:515,860...521,535

G

TAL bHLH transcription factor 1, erythroid differentiation factor

NCBI chr15:13,446,752...13,462,038
Ensembl chr15:13,449,481...13,462,047

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TAL bHLH transcription factor 2

NCBI chr11:61,425,927...61,484,525
Ensembl chr11:61,456,727...61,482,348

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transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981

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transcobalamin 2

protein:altered activity:plasma:

NCBI chr26:23,693,664...23,710,342
Ensembl chr26:23,693,773...23,709,832

G

telomerase reverse transcriptase

DNA:SNPs:promoter, introns:g.1296486C>T, g.12866516A>C, g.1279790G>A (rs2735940, rs2736100, rs10069690) (human)

PMID:15621763 PMID:23066086

RGD:11038654 RGD:11038667

NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951

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transmembrane 9 superfamily member 2

mRNA:increased expression:bone marrow, mononuclear cells (human)

NCBI chr22:49,515,350...49,578,519
Ensembl chr22:49,515,382...49,577,905

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

thiopurine S-methyltransferase

treatment
no_association

DNA:SNPs:multiple
DNA:SNPs:introns:12356C>T, 16638C>T, 26354G>T (rs4449636, rs2518463, rs2842949) (human)
DNA:SNPs: :multiple
DNA:SNPs:exon:374C>T, 719A>G (rs2842934, rs1142345) (human)

PMID:17164697 PMID:22009189 PMID:24499706

RGD:10766474 RGD:11038720 RGD:11038723

NCBI chr35:16,928,991...16,953,891
Ensembl chr35:16,929,240...16,953,229

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tetratricopeptide repeat domain 12

DNA:hypermethylation:5'end:CpG dinucleotide

NCBI chr 5:19,829,873...19,874,934
Ensembl chr 5:19,829,874...19,873,145

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thymidylate synthetase

treatment

DNA:repeats: : rs347430033(human)

NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747

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V-set pre-B cell surrogate light chain 1

CTD Direct Evidence: marker/mechanism

NCBI chr26:28,833,763...28,834,870
Ensembl chr26:28,833,136...28,834,679

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X-ray repair cross complementing 1

susceptibility
no_association

DNA:missense mutation: :p.R194W (human)
DNA:missense mutation, haplotype: :p.R399Q (human)
DNA:missense mutation: :p.R399Q (human)
CTD Direct Evidence: marker/mechanism

PMID:19101034 PMID:21983886

RGD:11252110 RGD:11252192

NCBI chr 1:111,548,719...111,571,816
Ensembl chr 1:111,548,719...111,571,816

Acute Lymphoblastic Leukemia, with Lymphomatous Features

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:10988075 PMID:11423618 PMID:11853795 PMID:11861307 PMID:11964322 More...

NCBI chr 9:53,118,462...53,262,092
Ensembl chr 9:53,119,641...53,261,307

G

cytokine receptor like factor 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:19907440 PMID:19965641 PMID:20018760 PMID:22368272

NCBI chr X:780,924...801,961
Ensembl chr X:780,711...802,836

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cytochrome P450 2B11

susceptibility

DNA:polymorphism:G15631T

NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293

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fibroblast growth factor receptor 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156

NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261

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interleukin 7 receptor

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:22897847 PMID:22955920

NCBI chr 4:72,633,528...72,668,242
Ensembl chr 4:72,636,325...72,668,300

G

insulin like 6

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:93,457,854...93,474,777
Ensembl chr 1:93,459,945...93,474,793

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Janus kinase 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:16239216 PMID:19139102 PMID:19470474 PMID:19838194 PMID:20167706 More...

NCBI chr 5:45,251,653...45,408,571
Ensembl chr 5:45,251,653...45,408,571

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Janus kinase 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

G

Janus kinase 3

ClinVar Annotator: match by term: LYMPHOMATOUS ALL

PMID:10982185 PMID:16843266 PMID:18270328 PMID:20132407 PMID:20372971 More...

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

adenoid cystic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:43,592,266...43,603,903
Ensembl chr14:43,578,721...43,605,720

G

AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102

G

AT-rich interaction domain 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr27:8,411,092...8,579,735
Ensembl chr27:8,412,377...8,579,882

G

AT-rich interaction domain 4B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:4,602,470...4,752,060
Ensembl chr 4:4,602,667...4,750,469

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

NCBI chr 4:13,926,759...14,105,069
Ensembl chr 4:13,927,217...14,101,364

G

assembly factor for spindle microtubules

CTD Direct Evidence: marker/mechanism

NCBI chr 7:5,591,530...5,663,673
Ensembl chr 7:5,590,957...5,660,919

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

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ATR serine/threonine kinase

treatment

NCBI chr23:38,131,956...38,223,888
Ensembl chr23:38,132,788...38,224,016

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ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:59,772,067...60,107,016
Ensembl chr X:59,774,585...60,106,980

G

BRCA1 associated deubiquitinase 1

ClinVar Annotator: match by term: Adenocystic carcinoma | ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:21642991 PMID:24894717 PMID:26166446 PMID:26452128 PMID:28492532

NCBI chr20:37,355,499...37,364,298
Ensembl chr20:37,355,494...37,511,125

G

BCL11 transcription factor A

CTD Direct Evidence: marker/mechanism

NCBI chr10:60,589,298...60,691,997
Ensembl chr10:60,589,708...60,689,073

G

BCL6 corepressor

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr X:34,621,314...34,735,502
Ensembl chr X:34,621,886...34,645,766

G

BCL6 corepressor like 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:101,153,952...101,215,365
Ensembl chr X:101,154,823...101,214,175

G

BRCA1 DNA repair associated

CTD Direct Evidence: marker/mechanism

NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494

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bromodomain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,361,043...17,396,725
Ensembl chr10:17,361,117...17,395,928

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cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

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cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878

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cap methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:77,117,795...77,124,995
Ensembl chr 5:77,118,964...77,121,264

G

contactin 6

CTD Direct Evidence: marker/mechanism

NCBI chr20:15,903,412...16,175,131
Ensembl chr20:15,903,591...16,175,319

G

CREB binding protein

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

G

death associated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:72,278,939...72,448,907
Ensembl chr 1:72,280,103...72,447,822

G

denticleless E3 ubiquitin protein ligase homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 7:10,323,842...10,368,529
Ensembl chr 7:10,323,559...10,369,560

G

deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr18:37,535,957...37,570,937
Ensembl chr18:37,538,342...37,591,589

G

EF-hand domain family member D1

CTD Direct Evidence: marker/mechanism

NCBI chr25:44,281,673...44,307,347
Ensembl chr25:44,281,710...44,306,220

G

engrailed homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:31,124,325...31,129,538

G

E1A binding protein p300

CTD Direct Evidence: marker/mechanism

NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396

G

erbb2 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:51,613,344...51,730,868
Ensembl chr 2:51,613,230...51,729,021

G

extra spindle pole bodies like 1, separase

CTD Direct Evidence: marker/mechanism

NCBI chr27:1,911,179...1,934,446
Ensembl chr27:1,911,193...1,933,807

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FA complementation group A

CTD Direct Evidence: marker/mechanism

NCBI chr 5:63,778,149...63,838,869
Ensembl chr 5:63,778,212...63,838,823

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FAT atypical cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:44,113,621...44,241,187
Ensembl chr16:44,128,386...44,241,192

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Adenocystic carcinoma

NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195

G

fibroblast growth factor 16

CTD Direct Evidence: marker/mechanism

NCBI chr X:59,738,512...59,748,188
Ensembl chr X:59,739,398...59,748,204

G

fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr28:31,303,882...31,411,015
Ensembl chr28:31,303,894...31,411,621

G

fibroblast growth factor receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 4:36,243,689...36,254,636
Ensembl chr 4:36,244,220...36,252,035

G

forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198

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forkhead box P2

CTD Direct Evidence: marker/mechanism

NCBI chr14:53,311,214...53,864,056
Ensembl chr14:53,312,045...53,862,655

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growth arrest specific 2

CTD Direct Evidence: marker/mechanism

NCBI chr21:44,277,996...44,406,210
Ensembl chr21:44,286,531...44,405,060

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growth arrest specific 6

CTD Direct Evidence: marker/mechanism

NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875

G

GINS complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:66,982,033...66,997,115
Ensembl chr 5:66,982,137...67,000,338

G

guanylate cyclase 1 soluble subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:53,172,914...53,236,200
Ensembl chr15:53,174,157...53,234,533

G

H1.4 linker histone, cluster member

CTD Direct Evidence: marker/mechanism

NCBI chr35:24,091,950...24,092,694

G

homer scaffold protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:44,179,145...44,186,814
Ensembl chr20:44,179,153...44,186,814

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717

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isocitrate dehydrogenase (NADP(+)) 1

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219

G

insulin like growth factor binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr37:23,553,227...23,569,321
Ensembl chr37:23,559,501...23,569,312

G

interleukin 17 receptor D

CTD Direct Evidence: marker/mechanism

NCBI chr20:33,240,728...33,306,727
Ensembl chr20:33,240,767...33,303,404

G

insulin receptor related receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:41,161,036...41,176,739
Ensembl chr 7:41,161,333...41,175,940

G

iroquois homeobox 4

CTD Direct Evidence: marker/mechanism

NCBI chr34:10,926,042...10,929,142
Ensembl chr34:10,923,097...10,929,164

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inositol-3-phosphate synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:44,594,816...44,598,495
Ensembl chr20:44,489,219...44,598,497

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integrin subunit beta 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:4,825,148...4,855,266
Ensembl chr 9:4,825,292...4,855,820

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jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199

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Janus kinase 3

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:14615376 PMID:28492532 PMID:33040328

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

G

jumonji domain containing 1C

CTD Direct Evidence: marker/mechanism

NCBI chr 4:15,006,670...15,261,139
Ensembl chr 4:15,007,508...15,261,691

G

KAT8 regulatory NSL complex subunit 1

CTD Direct Evidence: marker/mechanism

Ensembl chr 9:9,381,737...9,565,976
Ensembl chr 9:9,381,737...9,565,976

G

lysine acetyltransferase 6A

CTD Direct Evidence: marker/mechanism

NCBI chr16:23,604,629...23,717,047
Ensembl chr16:23,604,200...23,724,252

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lysine demethylase 6A

exacerbates

CTD Direct Evidence: marker/mechanism
DNA:splice-site mutation, missense mutations:splice junction, CDS:multiple: (human)
DNA:mutations:multiple: (human)

PMID:23685749 PMID:31483290

RGD:150429732 RGD:150429736

NCBI chr X:38,745,854...38,964,029
Ensembl chr X:38,745,854...38,959,842

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lysine demethylase 6B

CTD Direct Evidence: marker/mechanism

NCBI chr 5:32,689,000...32,711,026
Ensembl chr 5:32,696,211...32,710,666

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lysine methyltransferase 2C

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:31483290

NCBI chr16:15,962,045...16,117,601
Ensembl chr16:15,963,901...16,158,408

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:6695174 PMID:12460918 PMID:15696205 PMID:16361624 PMID:16618717 More...

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

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keratin 15

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,249,887...21,254,131

G

keratin 81

CTD Direct Evidence: marker/mechanism

NCBI chr27:2,776,693...2,782,016

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr18:25,647,024...25,662,646
Ensembl chr18:25,647,882...25,664,220

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:25,314,597...25,952,256
Ensembl chr20:25,314,923...25,949,921

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:17,973,058...19,098,785
Ensembl chr18:17,918,928...18,930,059

G

mastermind like transcriptional coactivator 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:2,461,784...3,061,878
Ensembl chr19:2,656,370...3,060,769

G

mitogen-activated protein kinase kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:55,465,460...55,487,629
Ensembl chr20:55,465,212...55,487,641

G

myristoylated alanine rich protein kinase C substrate

CTD Direct Evidence: marker/mechanism

NCBI chr12:69,980,003...69,987,150
Ensembl chr12:69,980,433...69,984,848

G

microtubule affinity regulating kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:53,101,635...53,125,636
Ensembl chr18:53,101,624...53,151,561

G

MDS1 and EVI1 complex locus

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr34:33,747,495...34,299,389
Ensembl chr34:33,748,843...34,299,276

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr30:8,633,122...8,805,822
Ensembl chr30:8,711,091...8,802,324

G

MIER family member 2

CTD Direct Evidence: marker/mechanism

NCBI chr20:58,063,976...58,083,041
Ensembl chr20:58,063,449...58,083,083

G

modulator of VRAC current 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:17,139,912...17,164,666
Ensembl chr10:17,139,448...17,163,056

G

mortality factor 4 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:58,127,152...58,149,709
Ensembl chr 3:58,127,669...58,193,005

G

MYB proto-oncogene, transcription factor

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:26829750

NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969

G

MYB proto-oncogene like 1

CTD Direct Evidence: marker/mechanism

NCBI chr29:16,155,867...16,192,814
Ensembl chr29:16,157,821...16,192,808

G

MYC binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr15:3,865,175...3,870,938
Ensembl chr15:3,865,175...3,870,984

G

MYCN proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr17:11,720,857...11,724,308

G

neuropilin and tolloid like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:67,781,264...67,835,859
Ensembl chr 2:67,789,035...67,835,436

G

nuclear factor I B

CTD Direct Evidence: marker/mechanism

NCBI chr11:34,573,136...35,010,319
Ensembl chr11:34,579,431...34,901,322

G

notch receptor 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277

G

nuclear receptor binding SET domain protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:36,058,351...36,214,254
Ensembl chr 4:36,063,134...36,210,999

G

neurotrophic receptor tyrosine kinase 3

treatment

NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024

G

proprotein convertase subtilisin/kexin type 1 inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr X:42,030,708...42,036,363
Ensembl chr X:41,962,524...42,036,586

G

PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:58,496,977...58,536,772

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:15930273 PMID:17376864 PMID:18074223 PMID:19366826 PMID:22120714 More...

NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910

G

protein kinase, DNA-activated, catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

glycogen phosphorylase B

CTD Direct Evidence: marker/mechanism

NCBI chr23:1,440,826...1,494,570
Ensembl chr23:1,420,052...1,496,245

G

RNA binding fox-1 homolog 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,284,836...28,494,618
Ensembl chr10:28,192,683...28,489,114

G

serpin family F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765

G

SET domain containing 2, histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr20:41,675,539...41,800,697
Ensembl chr20:41,675,599...41,800,612

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:25741868 PMID:26619011

NCBI chr37:6,922,150...6,962,474
Ensembl chr37:6,924,047...6,962,896

G

solute carrier family 24 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr24:3,593,562...4,014,366
Ensembl chr24:3,593,513...3,784,467

G

solute carrier family 3 member 2

disease_progression

NCBI chr18:53,810,468...53,819,021
Ensembl chr18:53,810,398...53,819,021

G

solute carrier family 7 member 5

disease_progression

NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 1:90,709,221...90,884,295
Ensembl chr 1:90,712,520...90,883,622

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr26:28,692,610...28,728,778
Ensembl chr26:28,692,899...28,728,783

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,015,402...22,036,424
Ensembl chr 9:22,015,600...22,035,442

G

structural maintenance of chromosomes 1A

CTD Direct Evidence: marker/mechanism

NCBI chr X:45,099,312...45,148,103
Ensembl chr X:45,109,653...45,148,001

G

SON DNA and RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr31:28,165,758...28,198,692

G

SRY-box transcription factor 11

CTD Direct Evidence: marker/mechanism

G

SRY-box transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr35:20,098,783...20,101,357
Ensembl chr35:20,099,773...20,101,154

G

Snf2 related CREBBP activator protein

CTD Direct Evidence: marker/mechanism

NCBI chr 6:17,437,097...17,470,724

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:8,132,663...8,160,008
Ensembl chr 5:8,133,085...8,141,254

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

tousled like kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr36:15,524,350...15,675,019
Ensembl chr36:15,526,564...15,675,678

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,207,501...22,237,497
Ensembl chr 9:22,207,638...22,237,496

G

tumor protein p53

disease_progression

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:1673792 PMID:1686725 PMID:6736287 PMID:7707106 PMID:7881428 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

ubiquitin like with PHD and ring finger domains 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:54,858,673...54,889,769
Ensembl chr20:54,859,947...54,889,907

G

versican

CTD Direct Evidence: marker/mechanism

NCBI chr 3:24,127,293...24,238,859
Ensembl chr 3:24,119,181...24,239,192

G

Wnt family member 5B

CTD Direct Evidence: marker/mechanism

NCBI chr27:43,662,482...43,679,713
Ensembl chr27:43,620,284...43,677,078

G

5'-3' exoribonuclease 2

DNA:hypermethylation:3' utr: (human)

NCBI chr24:2,042,521...2,128,942
Ensembl chr24:2,042,888...2,128,867

G

zinc finger imprinted 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:101,156,317...101,186,321

adenoid squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HNF1 homeobox A

NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790

adult T-cell leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr 9:2,930,308...2,959,307

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845

G

caspase recruitment domain family member 11

CTD Direct Evidence: marker/mechanism

NCBI chr 6:14,273,115...14,331,029
Ensembl chr 6:14,210,114...14,332,094

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr23:3,844,072...3,847,770
Ensembl chr23:3,844,173...3,845,255

G

C-C motif chemokine receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,077,976...22,092,818
Ensembl chr 9:22,068,775...22,090,656

G

CD163 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr27:37,669,757...37,700,746
Ensembl chr27:37,669,827...37,753,106

G

CD274 molecule

disease_progression

NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522

G

CD28 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854

G

CD68 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr 5:32,500,899...32,503,355
Ensembl chr 5:32,501,380...32,503,183

G

CD80 molecule

NCBI chr33:23,177,136...23,208,421
Ensembl chr33:23,177,138...23,201,380

G

CD86 molecule

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

casein kinase 1 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,435,530...59,485,591
Ensembl chr 4:59,435,764...59,483,475

G

casein kinase 2 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:20,333,593...20,390,341

G

casein kinase 2 beta

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,149,467...1,154,417
Ensembl chr12:1,149,548...1,154,418

G

cytotoxic T-lymphocyte associated protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874

G

Fas cell surface death receptor

susceptibility

protein:increased expression:peripheral blood mononuclear cell:
DNA:polymorphism:promoter: -670 G>A(human)

PMID:7513372 PMID:17962369

RGD:11049147 RGD:11049453

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

forkhead box P3

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23797717 PMID:23962110

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

FYN proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760

G

G protein-coupled receptor 183

CTD Direct Evidence: marker/mechanism

NCBI chr22:49,332,665...49,347,721
Ensembl chr22:49,333,188...49,347,593

G

heterogeneous nuclear ribonucleoprotein A2/B1

CTD Direct Evidence: marker/mechanism

NCBI chr14:39,498,805...39,509,034
Ensembl chr14:39,500,897...39,508,952

G

inducible T cell costimulator

CTD Direct Evidence: marker/mechanism

NCBI chr37:12,663,839...12,735,266
Ensembl chr37:12,670,999...12,733,458

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

PMID:8800741 PMID:23962110

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr37:20,508,647...20,662,549
Ensembl chr37:20,516,239...20,661,298

G

interleukin 10

CTD Direct Evidence: marker/mechanism

PMID:8704212 PMID:23962110

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394

G

interleukin 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 5

disease_progression

protein:increased expression:serum

NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269

G

interleukin 6

protein:increased expression:serum (human)

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interferon regulatory factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

Janus kinase 3

DNA:missense mutations: :p.L156P, p.R172Q, p.E183G (human)

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:CD4+ T cell:

NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969

G

notch receptor 1

DNA:mutations:multiple (human)

NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277

G

NRAS proto-oncogene, GTPase

disease_progression

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

phospholipase C gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714

G

protein kinase C beta

CTD Direct Evidence: marker/mechanism

NCBI chr 6:21,742,970...22,064,360
Ensembl chr 6:21,742,973...22,065,185

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

TAL bHLH transcription factor 2

NCBI chr11:61,425,927...61,484,525
Ensembl chr11:61,456,727...61,482,348

G

telomeric repeat binding factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:80,278,224...80,305,315
Ensembl chr 5:80,277,505...80,306,342

G

T cell leukemia homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1683261 PMID:1717256

NCBI chr28:13,807,428...13,813,875
Ensembl chr28:13,807,720...13,813,849

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355

G

tumor protein p73

CTD Direct Evidence: marker/mechanism

NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:53,482,239...53,532,399
Ensembl chr20:53,482,498...53,531,296

anaplastic large cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:16151469 PMID:19503098 PMID:21345110 PMID:22155737 PMID:22920921 More...

NCBI chr17:23,010,308...23,688,841
Ensembl chr17:23,010,308...23,688,841

G

heat shock protein 90 alpha family class A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243

G

interferon regulatory factor 4

DNA:translocation

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

JunB proto-oncogene, AP-1 transcription factor subunit

NCBI chr20:49,358,904...49,360,746
Ensembl chr20:49,359,399...49,360,442

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

TNF receptor superfamily member 8

CTD Direct Evidence: marker/mechanism

PMID:10908157 PMID:17261581

NCBI chr 2:84,185,445...84,225,986
Ensembl chr 2:84,186,961...84,232,675

G

twist family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

angioimmunoblastic T-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tet methylcytosine dioxygenase 2

ClinVar Annotator: match by term: Angioimmunoblastic T-cell lymphoma

PMID:19797729 PMID:27210295 PMID:27276561 PMID:28337768 PMID:28492532 More...

NCBI chr32:26,021,745...26,145,109
Ensembl chr32:26,059,693...26,143,536

B-cell acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:23623386 PMID:25741868

NCBI chr 6:29,193,192...29,226,935
Ensembl chr 6:29,196,421...29,226,887

G

neurofibromin 1

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:9536098 PMID:17576681 PMID:23656349 PMID:25741868 PMID:28492532

NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382

G

WT1 transcription factor

ClinVar Annotator: match by term: B Acute Lymphoblastic Leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

B-Cell Chronic Lymphocytic Leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

susceptibility

DNA:SNPs,haplotype: :rs1481012,rs2231142(human)

NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674

G

acyl-CoA oxidase like

CTD Direct Evidence: marker/mechanism

NCBI chr17:35,269,824...35,617,068
Ensembl chr17:35,269,501...35,617,335

G

activation induced cytidine deaminase

disease_progression

NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789

G

apolipoprotein E

disease_progression

NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

BCL11 transcription factor A

DNA:translocation:5' utr: (human)

NCBI chr10:60,589,298...60,691,997
Ensembl chr10:60,589,708...60,689,073

G

BCL2 apoptosis regulator

severity
no_association
treatment

protein:increased expression:B cell (human)
CTD Direct Evidence: marker/mechanism
DNA:snp:promoter:g.-938C>A (human)

PMID:16960146 PMID:17296974 PMID:17959858 PMID:20001236 PMID:21750559 More...

RGD:11522735 RGD:11526104 RGD:11526105 RGD:11526110

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

Bcl2 modifying factor

CTD Direct Evidence: marker/mechanism

NCBI chr30:7,301,000...7,321,949
Ensembl chr30:7,274,174...7,322,034

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12068308 PMID:12198537 PMID:12692057 PMID:12960123 PMID:14612909 More...

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

G

Bruton tyrosine kinase

treatment

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:23045577 PMID:24869598 PMID:25741868 PMID:28492532

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

Cbl proto-oncogene

severity

mRNA,protein:increased expression:CD5+ B cell:
DNA:hypophosphorylation:CD5+ B cell:

NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956

G

coiled-coil domain containing 50

NCBI chr34:23,168,594...23,243,221
Ensembl chr34:23,168,525...23,258,497

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

mouse-human chimeric gene in human

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

CD5 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,216,415...55,235,567
Ensembl chr18:55,217,276...55,235,405

G

CD79b molecule

protein:decreased expression:B lymphocyte, cell surface (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
DNA:polymorphism:multiple (human)

PMID:9269755 PMID:10090943 PMID:10552962

RGD:11250403 RGD:151665190 RGD:151665202

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

CD86 molecule

severity

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

cytoplasmic polyadenylation element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:54,405,140...54,499,614
Ensembl chr 3:54,405,717...54,500,221

G

cytotoxic T-lymphocyte associated protein 4

protein:increased expression:T cell

PMID:15914560 PMID:16094420

RGD:11344923 RGD:11352246

NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874

G

dyskerin pseudouridine synthase 1

NCBI chr X:122,838,787...122,850,870
Ensembl chr X:122,838,645...122,850,884

G

DNA methyltransferase 3 beta

mRNA:decreased expression: B cell

NCBI chr24:22,096,386...22,123,378
Ensembl chr24:22,096,349...22,122,900

G

ERCC excision repair 2, TFIIH core complex helicase subunit

severity

DNA:SNP: :p.K751Q (rs13181) (human)

PMID:19484764 PMID:22739018

RGD:11252203 RGD:11252204

NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125

G

FERM, ARH/RhoGEF and pleckstrin domain protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr25:51,331,876...51,425,754
Ensembl chr25:51,332,409...51,425,449

G

Fas cell surface death receptor

disease_progression

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:25741868 PMID:26619011

NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195

G

GNAS complex locus

disease_progression

DNA:polymorphism:393T>C (human)

NCBI chr24:43,643,409...43,658,641
Ensembl chr24:43,643,405...43,658,657

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717

G

intercellular adhesion molecule 1

severity

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interferon gamma

susceptibility

DNA:polymorphism: :847A>T(human)

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 10

disease_progression
no_association

protein:increased expression:serum
DNA:SNPs: :rs1800890, rs4072227, rs17015865 (human)
DNA:SNPs: :multiple

PMID:10638947 PMID:19573080 PMID:22945689

RGD:11041895 RGD:11049165 RGD:11049174

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 19

CTD Direct Evidence: marker/mechanism

NCBI chr 7:6,000,994...6,006,959
Ensembl chr 7:6,000,907...6,006,870

G

interleukin 1 alpha

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

severity

DNA:SNP:promoter:-511C>T (human)
protein:decreased expression:plasma:

PMID:10870116 PMID:18271063

RGD:11051967 RGD:11522755

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

protein:decreased expression:plasma:

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 6

CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma:

PMID:10870116 PMID:18006695

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interferon regulatory factor 4

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:12079517 PMID:12393648 PMID:18758461

RGD:11526160 RGD:11530024

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

integrin subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr36:24,670,464...24,686,719
Ensembl chr36:24,653,408...24,729,057

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019

G

NKG2-A/NKG2-B type II integral membrane protein-like

CTD Direct Evidence: marker/mechanism

NCBI chr27:35,307,892...35,374,397

G

low affinity immunoglobulin gamma Fc region receptor III

no_association

DNA:SNP:exon:p.F158V (rs396991) (human)

NCBI chr38:21,054,870...21,060,948

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr18:25,647,024...25,662,646
Ensembl chr18:25,647,882...25,664,220

G

microRNA mir-143

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594

G

microRNA mir-145

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,533,128...59,533,210
Ensembl chr 4:59,533,128...59,533,210

G

membrane spanning 4-domains A1

NCBI chr21:50,722,142...50,734,934
Ensembl chr21:50,722,041...50,733,704

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

purinergic receptor P2X 7

CTD Direct Evidence: marker/mechanism

NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:B cell (human)

NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778

G

phospholipase C gamma 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:24869598 PMID:28492532

NCBI chr 5:70,054,683...70,233,459
Ensembl chr 5:70,059,255...70,207,049

G

phorbol-12-myristate-13-acetate-induced protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910

G

DNA polymerase beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322

G

protein phosphatase 2 regulatory subunit B'gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 8:69,846,311...69,969,409
Ensembl chr 8:69,846,446...69,967,578

G

PRAME nuclear receptor transcriptional regulator

protein:increased expression:mononuclear cell (human)

NCBI chr26:27,124,901...27,137,772
Ensembl chr26:27,124,902...27,136,112

G

protein kinase D2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:109,206,400...109,241,529
Ensembl chr 1:109,207,067...109,330,007

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12161469 PMID:12717436 PMID:14644997 PMID:14982869 PMID:15385933 More...

NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481

G

glutaminyl-peptide cyclotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr17:29,700,422...29,741,652
Ensembl chr17:29,716,378...29,741,221

G

RB transcriptional corepressor like 2

CTD Direct Evidence: marker/mechanism

NCBI chr 2:62,263,974...62,315,371
Ensembl chr 2:62,265,293...62,315,425

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:23634996 PMID:25741868 PMID:26619011

NCBI chr37:6,922,150...6,962,474
Ensembl chr37:6,924,047...6,962,896

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr18:51,197,924...51,212,397
Ensembl chr18:51,197,939...51,212,354

G

SP140 nuclear body protein

CTD Direct Evidence: marker/mechanism

NCBI chr25:42,459,013...42,527,141
Ensembl chr25:42,459,084...42,527,093

G

telomerase reverse transcriptase

disease_progression

NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242

G

thrombomodulin

NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649

G

tumor necrosis factor

disease_progression

protein:increased expression:bone marrow, blood, lymphocyte

PMID:12010662 PMID:22945689

RGD:10449463 RGD:11041895

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

TNF receptor superfamily member 11a

CTD Direct Evidence: marker/mechanism

NCBI chr 1:14,504,595...14,555,956
Ensembl chr 1:14,503,033...14,556,041

G

TNF superfamily member 11

CTD Direct Evidence: marker/mechanism

NCBI chr22:8,226,931...8,257,926
Ensembl chr22:8,227,555...8,258,645

G

TNF superfamily member 13

protein:increased expression:serum

NCBI chr 5:32,482,723...32,484,790
Ensembl chr 5:32,482,723...32,484,789

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355

G

DNA topoisomerase II binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr23:30,517,172...30,578,664
Ensembl chr23:30,516,125...30,578,108

G

tumor protein p53

disease_progression

DNA:deletion: :
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1679237 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

vitamin D receptor

CTD Direct Evidence: marker/mechanism

NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470

G

exportin 1

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr10:61,541,647...61,588,397
Ensembl chr10:61,542,211...61,585,054

G

X-ray repair cross complementing 1

no_association
severity

DNA:SNP: :p.R194W (rs1799782), p.R280H (25489) (human)
DNA:SNP: :p.R399Q (rs25487) (human)

NCBI chr 1:111,548,719...111,571,816
Ensembl chr 1:111,548,719...111,571,816

B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

susceptibility

DNA:SNP: :rs6857600(human)

NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674

G

activation induced cytidine deaminase

NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789

G

BCL2 like 2

disease_progression

NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070

G

BCL6 transcription repressor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704

G

bromodomain containing 2

NCBI chr12:2,534,034...2,546,029
Ensembl chr12:2,534,034...2,546,029

G

Bruton tyrosine kinase

treatment

human cell in a mouse model

PMID:25662332 PMID:28348046

RGD:11040764 RGD:124713554

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

chromobox 7

NCBI chr10:25,876,022...25,896,284
Ensembl chr10:25,876,016...25,893,501

G

CD40 molecule

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

colony stimulating factor 2

treatment

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

ELL associated factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr33:25,113,348...25,147,064
Ensembl chr33:25,112,570...25,146,692

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

severity
treatment

PMID:23982173 PMID:29456795

RGD:10755356 RGD:126781726

NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr 6:19,181,846...19,217,915
Ensembl chr 6:19,182,071...19,217,931

G

Janus kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

G

lysine acetyltransferase 5

severity

NCBI chr18:51,499,615...51,507,434
Ensembl chr18:51,499,938...51,576,699

G

galectin 1

protein:increased expression:primary tumor (rat)

NCBI chr10:26,932,351...26,935,580
Ensembl chr10:26,932,301...26,935,646

G

microRNA mir-143

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594

G

microRNA mir-145

CTD Direct Evidence: marker/mechanism

NCBI chr 4:59,533,128...59,533,210
Ensembl chr 4:59,533,128...59,533,210

G

NRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

protein tyrosine phosphatase non-receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720

G

signal transducer and activator of transcription 5A

NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355

G

TNF superfamily member 9

NCBI chr20:53,680,882...53,682,521
Ensembl chr20:53,679,880...53,682,706

B-lymphoblastic leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

treatment

NCBI chr 9:53,118,462...53,262,092
Ensembl chr 9:53,119,641...53,261,307

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

treatment

NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043

G

activating transcription factor 7 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr27:32,082,615...32,194,954
Ensembl chr27:32,086,675...32,177,364

G

BCL2 like 1

severity

NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355

G

BCR activator of RhoGEF and GTPase

BCR/ABL fusion

NCBI chr26:27,856,280...27,980,923
Ensembl chr26:27,856,082...27,978,318

G

bromodomain containing 2

NCBI chr12:2,534,034...2,546,029
Ensembl chr12:2,534,034...2,546,029

G

cellular communication network factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:25,508,082...25,511,058
Ensembl chr 1:25,507,662...25,510,145

G

cyclin D1

mRNA:increased expression:B cell (mouse)

NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005

G

cyclin dependent kinase inhibitor 2A

treatment
susceptibility

DNA:mutation:cds:c.442C>T,p.A148T,rs3731249 (human)

PMID:16618932 PMID:21622646 PMID:26104880

RGD:11057958 RGD:11251751 RGD:11251772

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

cytokine receptor like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:780,924...801,961
Ensembl chr X:780,711...802,836

G

ETS variant transcription factor 6

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735 PMID:25807284

NCBI chr27:34,351,206...34,587,060
Ensembl chr27:34,343,390...34,587,060

G

coagulation factor XIII A chain

protein:increased expression:B lymphoblast:

NCBI chr35:6,186,750...6,347,522
Ensembl chr35:6,187,235...6,349,773

G

coagulation factor III, tissue factor

treatment

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

fumarate hydratase

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr 7:32,900,250...32,927,436
Ensembl chr 7:32,901,586...32,927,412

G

fms related receptor tyrosine kinase 3

mRNA,protein:increased expression:bone marrow:

NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760

G

indoleamine 2,3-dioxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048

G

IKAROS family zinc finger 1

disease_progression

DNA:mutations: :
CTD Direct Evidence: marker/mechanism

PMID:22699455 PMID:24141364

NCBI chr18:1,661,851...1,750,987
Ensembl chr18:1,661,690...1,770,768

G

interleukin 5

NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269

G

interferon regulatory factor 4

PMID:20585039 PMID:21818355 PMID:25006123

RGD:11526159 RGD:11530020 RGD:11530030

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

interferon regulatory factor 8

NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179

G

intestine specific homeobox

CTD Direct Evidence: marker/mechanism

NCBI chr10:28,993,515...29,011,736
Ensembl chr10:28,993,795...29,011,640

G

double homeobox protein 4C-like

CTD Direct Evidence: marker/mechanism

NCBI chr17:64,277,421...64,282,701

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr30:8,633,122...8,805,822
Ensembl chr30:8,711,091...8,802,324

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:cds:

NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969

G

MYC proto-oncogene, bHLH transcription factor

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

paired box 5

CTD Direct Evidence: marker/mechanism

PMID:24013638 PMID:30643249

NCBI chr11:53,194,905...53,390,204
Ensembl chr11:53,201,344...53,390,974

G

platelet derived growth factor receptor alpha

treatment

NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726

G

RUNX family transcription factor 1

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735

NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

signal transducer and activator of transcription 5A

protein:increased phosphorylation:bone marrow (human)

NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103

G

serine/threonine kinase 11

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:26080840 PMID:26295973 PMID:28492532

NCBI chr20:57,558,966...57,579,163
Ensembl chr20:57,559,424...57,579,118

G

SUFU negative regulator of hedgehog signaling

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981

G

tryptophan 2,3-dioxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr15:53,406,110...53,424,260
Ensembl chr15:53,405,957...53,423,958

G

tissue factor pathway inhibitor

treatment

NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310

G

TNF superfamily member 13

NCBI chr 5:32,482,723...32,484,790
Ensembl chr 5:32,482,723...32,484,789

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,979,498...69,006,898
Ensembl chr11:68,982,360...69,007,355

G

tumor protein p53

disease_progression

DNA:mutations: :

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

WT1 transcription factor

ClinVar Annotator: match by term: Pre-B-cell acute lymphoblastic leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

B-lymphoblastic leukemia/lymphoma MLL rearranged

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

WT1 transcription factor

ClinVar Annotator: match by term: Mixed phenotype acute leukemia with t(v;11q23.3)

NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000

B-lymphoblastic leukemia/lymphoma with BCR-ABL1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mutS homolog 6

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1

PMID:22658618 PMID:25741868 PMID:28492532

NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028

B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone morphogenetic protein receptor type 1A

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:30093976

NCBI chr 4:34,499,898...34,582,481
Ensembl chr 4:34,517,492...34,578,923

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:33471991

NCBI chr 6:22,209,711...22,237,798
Ensembl chr 6:22,209,384...22,237,745

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532

NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726

G

RecQ like helicase 4

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:10678659 PMID:12734318 PMID:12838562 PMID:12952869 PMID:15897384 More...

NCBI chr13:37,930,906...37,936,653
Ensembl chr13:37,930,621...37,936,753

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cbl proto-oncogene

ClinVar Annotator: match by term: B lymphoblastic leukemia lymphoma with hyperdiploidy

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956

B-lymphoblastic leukemia/lymphoma with hypodiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

succinate dehydrogenase complex flavoprotein subunit A

ClinVar Annotator: match by term: B-lymphoblastic leukemia/lymphoma with hypodiploidy

PMID:25741868 PMID:28492532

NCBI chr34:11,935,684...11,965,094
Ensembl chr34:11,935,941...11,965,189

Burkitt lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr10:22,752,657...22,776,858
Ensembl chr10:22,774,834...22,776,069

G

AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102

G

BCL2 binding component 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946

G

BCL2 like 2

mRNA:increased expression:lymph node

NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:17262179 PMID:25741868 PMID:26467025 PMID:28492532 PMID:31911673 More...

NCBI chr 9:19,958,941...20,025,494
Ensembl chr 9:19,958,391...20,025,494

G

Bruton tyrosine kinase

ameliorates
treatment

Human cell line in a mouse model
mRNA:increased expression:multiple (human)

PMID:28474336 PMID:30546948

RGD:124713565 RGD:124715474

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

calreticulin

treatment

human cells and recombinant protein in a mouse model
human cell line and recombinant protein in a mouse model

PMID:9858521 PMID:10961892

RGD:150521687 RGD:150521702

NCBI chr20:49,251,390...49,255,291
Ensembl chr20:49,251,777...49,255,245

G

chaperonin containing TCP1 subunit 6B

CTD Direct Evidence: marker/mechanism

NCBI chr 9:38,384,115...38,410,667
Ensembl chr 9:38,366,383...38,542,801

G

CD40 molecule

treatment

human cell line in a mouse model

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

formimidoyltransferase cyclodeaminase

CTD Direct Evidence: marker/mechanism

NCBI chr31:39,451,557...39,464,249
Ensembl chr31:39,275,159...39,464,715

G

G protein subunit alpha 13

CTD Direct Evidence: marker/mechanism

NCBI chr 9:14,932,341...14,972,857
Ensembl chr 9:14,932,335...14,967,881

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

PMID:23143595 PMID:23143597

NCBI chr 2:75,880,659...75,881,786
Ensembl chr 2:75,880,657...75,882,010

G

microRNA mir-21

treatment

NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624

G

microRNA mir-23b

treatment

NCBI chr 1:71,678,353...71,678,406
Ensembl chr 1:71,678,346...71,678,416

G

MLLT11 transcription factor 7 cofactor

CTD Direct Evidence: marker/mechanism

NCBI chr17:60,142,411...60,153,650
Ensembl chr17:60,152,378...60,152,650

G

MYC proto-oncogene, bHLH transcription factor

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:8220424 PMID:25157968 PMID:27993330

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

PBX homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

NCBI chr38:18,378,997...18,703,694
Ensembl chr38:18,418,093...18,703,497

G

pyruvate carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669

G

phosphoinositide-3-kinase regulatory subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970

G

ret proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr28:3,946,132...3,995,505
Ensembl chr28:3,947,232...3,994,210

G

spalt like transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:1,413,991...1,421,516
Ensembl chr 1:1,416,390...1,435,326

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

CTD Direct Evidence: marker/mechanism

NCBI chr20:50,175,489...50,268,865
Ensembl chr20:50,175,687...50,268,836

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981

central nervous system lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bruton tyrosine kinase

ameliorates

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

CD79b molecule

treatment

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

interleukin 10

DNA:SNP:promoter:-1082G>A (human)

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

MYD88 innate immune signal transduction adaptor

treatment

NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534

childhood acute lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CCCTC-binding factor

disease_progression

mRNA, protein:increased expression:bone marrow, blood (human)

NCBI chr 5:81,808,512...81,863,811
Ensembl chr 5:81,809,393...81,858,655

chronic lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Rho GTPase activating protein 44

mRNA:increased expression: (human)

NCBI chr 5:36,790,059...36,957,932
Ensembl chr 5:36,789,814...36,957,411

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12068308 PMID:12198537 PMID:12960123 PMID:14612909 PMID:14679157 More...

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

G

CD40 ligand

protein:increased expression:serum (human)

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

CD79b molecule

protein:decreased expression:blood cells (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
protein:decreased expression:blood, B cell (human)
protein:decreased expression:peripheral blood cells (human)

PMID:10090943 PMID:10329919 PMID:10516749 PMID:10753858

RGD:11531139 RGD:151665125 RGD:151665152 RGD:151665190

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

CD86 molecule

DNA:hypermethylation (human)

NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:25741868 PMID:26619011

NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717

G

interleukin 5

protein:increased expression:serum

NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269

G

interferon regulatory factor 4

disease_progression

DNA:SNP: :rs872071 (human)
DNA:SNPs:3' utr:multiple
DNA:missense mutation:exon:p.L116R (human)

PMID:20090783 PMID:20123861 PMID:20731705 PMID:21791429 PMID:23897826 More...

RGD:11526156 RGD:11526158 RGD:11530021 RGD:11530026 RGD:11530029 RGD:11530031

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369

G

GTP:AMP phosphotransferase AK3, mitochondrial

protein:increased expression:peripheral blood mononuclear cell

NCBI chr 9:10,282,452...10,283,479

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr18:25,647,024...25,662,646
Ensembl chr18:25,647,882...25,664,220

G

microRNA mir-155

miRNA:increased expression:peripheral blood mononuclear cell

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

microRNA mir-21

miRNA:increased expression:peripheral blood mononuclear cell

NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M, p.Q192R (human)

NCBI chr14:20,565,620...20,600,774
Ensembl chr14:20,565,641...20,642,985

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12717436 PMID:14644997 PMID:15385933 PMID:15710330 PMID:15928039 More...

NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481

G

protein tyrosine phosphatase non-receptor type 22

susceptibility

DNA:snp:cds:p.R620W (rs2476601) (human)
protein:increased expression:B cell (human)

PMID:22569400 PMID:23287625

RGD:11533998 RGD:11535006

NCBI chr17:51,623,628...51,683,039
Ensembl chr17:51,623,623...51,682,858

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr37:6,922,150...6,962,474
Ensembl chr37:6,924,047...6,962,896

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr18:51,197,924...51,212,397
Ensembl chr18:51,197,939...51,212,354

G

signal transducer and activator of transcription 3

protein:increased phosphorylation:peripheral blood mononuclear cell

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

tumor protein p53

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

exportin 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr10:61,541,647...61,588,397
Ensembl chr10:61,542,211...61,585,054

diffuse large B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

ATP binding cassette subfamily G member 2

CTD Direct Evidence: marker/mechanism

NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr17:23,010,308...23,688,841
Ensembl chr17:23,010,308...23,688,841

G

beta-2-microglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997

G

BCAS2 pre-mRNA processing factor

CTD Direct Evidence: marker/mechanism

NCBI chr17:52,277,677...52,291,150
Ensembl chr17:52,277,804...52,291,022

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

BCL2 like 2

disease_progression

NCBI chr 8:3,569,335...3,573,922
Ensembl chr 8:3,569,399...3,586,070

G

BCL6 transcription repressor

disease_progression

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

PMID:11821949 PMID:15701085

RGD:11530023 RGD:1600111

NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr16:8,222,909...8,318,179
Ensembl chr16:8,222,907...8,317,906

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9150172 PMID:18489799 PMID:20104584 PMID:21138478 PMID:22798144 More...

NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815

G

Bruton tyrosine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24869598 PMID:25082755 PMID:25189416 PMID:25741868 PMID:27199251 More...

NCBI chr X:75,270,952...75,302,663
Ensembl chr X:75,270,979...75,302,562

G

caspase recruitment domain family member 11

DNA:missense mutations:exons:multiple (human)
CTD Direct Evidence: marker/mechanism

PMID:18323416 PMID:25049379 PMID:26192916

NCBI chr 6:14,273,115...14,331,029
Ensembl chr 6:14,210,114...14,332,094

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

coiled-coil domain containing 86

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,431,768...55,437,612
Ensembl chr18:55,432,310...55,438,286

G

CD22 molecule

treatment

NCBI chr 1:117,261,730...117,285,775
Ensembl chr 1:117,261,740...117,284,818

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD79a molecule

CTD Direct Evidence: marker/mechanism

NCBI chr 1:112,411,281...112,414,827
Ensembl chr 1:112,411,281...112,427,381

G

CD79b molecule

treatment
severity

ClinVar Annotator: match by term: Diffuse large B cell lymphoma
DNA:missense mutation:multiple, exon 5 (human)

PMID:11160144 PMID:25708834 PMID:31402495 PMID:31609782

RGD:151665133 RGD:151665203

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

cyclin dependent kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:12,884,106...12,899,203
Ensembl chr 4:12,883,385...12,899,197

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379

G

checkpoint kinase 2

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:16199547 PMID:21876083 PMID:24713400 PMID:28492532

NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624

G

clathrin heavy chain

CTD Direct Evidence: marker/mechanism

NCBI chr 9:34,116,344...34,183,023
Ensembl chr 9:34,116,634...34,182,719

G

CREB binding protein

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24755471 PMID:28481359 PMID:30239046 PMID:33323405

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

G

dicer 1, ribonuclease III

disease_progression

NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879

G

DNA methyltransferase 3 alpha

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:25363760 PMID:25741868 PMID:29900417 PMID:30478443 PMID:32581362 More...

NCBI chr17:19,489,524...19,563,074
Ensembl chr17:19,492,193...19,563,902

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr27:34,351,206...34,587,060
Ensembl chr27:34,343,390...34,587,060

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

CTD Direct Evidence: marker/mechanism

PMID:20081860 PMID:28438623

NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

forkhead box O1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:26314988 PMID:29721381 PMID:35079069

NCBI chr25:603,433...706,961
Ensembl chr25:603,543...702,825

G

GLI family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:1,565,306...1,575,971
Ensembl chr10:1,565,244...1,575,982

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP: :(rs1695)(human)

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

intercellular adhesion molecule 1

disease_progression

proteion:increased expression:serum:

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr 6:19,181,846...19,217,915
Ensembl chr 6:19,182,071...19,217,931

G

inner mitochondrial membrane peptidase subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr14:50,487,679...51,336,906

G

interferon regulatory factor 4

disease_progression

NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339

G

lysine methyltransferase 2D

CTD Direct Evidence: marker/mechanism

NCBI chr27:5,516,866...5,556,303
Ensembl chr27:5,521,804...5,553,490

G

MALT1 paracaspase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:17,351,458...17,412,591
Ensembl chr 1:17,354,926...17,403,927

G

marker of proliferation Ki-67

disease_progression

NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486

G

methylenetetrahydrofolate reductase

susceptibility

DNA:transition, transversion, haplotype:cds:g.677C>T, g.1298A>C (human)

NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309

G

MYD88 innate immune signal transduction adaptor

severity

DNA:missense mutation:L265P (human)
ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534

G

nibrin

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9590180 PMID:16415040 PMID:28492532

NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563

G

nectin cell adhesion molecule 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:110,543,140...110,569,168
Ensembl chr 1:110,543,247...110,569,143

G

neurofibromin 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21390130 PMID:22158541 PMID:23292937

NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382

G

NFKB inhibitor alpha

no_association

SNA:polymorphism(s)

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

nucleolar protein with MIF4G domain 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:19,477,187...19,491,714
Ensembl chr16:19,476,227...19,490,441

G

3-phosphoinositide dependent protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

CTD Direct Evidence: marker/mechanism

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940

G

PR/SET domain 1

disease_progression

NCBI chr12:63,454,242...63,495,278
Ensembl chr12:63,470,974...63,495,579

G

peroxiredoxin 3

CTD Direct Evidence: marker/mechanism

NCBI chr28:29,395,593...29,403,745
Ensembl chr28:29,395,581...29,403,745

G

peroxiredoxin 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:19,361,658...19,383,718
Ensembl chr X:19,361,731...19,383,719

G

protein arginine methyltransferase 5

CTD Direct Evidence: marker/mechanism

NCBI chr 8:3,248,349...3,257,567
Ensembl chr 8:3,248,404...3,257,456

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:10468583 PMID:10555148 PMID:10698513 PMID:10866302 PMID:10866658 More...

NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176

G

Ran GTPase activating protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:23,953,877...23,985,622
Ensembl chr10:23,953,912...24,003,162

G

ribosomal protein S6 kinase B1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292

G

SEC31 homolog A, COPII coat complex component

CTD Direct Evidence: marker/mechanism

NCBI chr32:6,761,018...6,840,802
Ensembl chr32:6,761,289...6,840,709

G

splicing factor 3a subunit 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:22037554 PMID:26498691 PMID:33563892

NCBI chr26:23,485,551...23,504,242
Ensembl chr26:23,485,797...23,504,346

G

S-phase kinase associated protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:72,352,966...72,386,469
Ensembl chr 4:72,352,986...72,386,307

G

SMAD specific E3 ubiquitin protein ligase 2

NCBI chr 9:12,348,777...12,472,636
Ensembl chr 9:12,351,627...12,471,467

G

suppressor of cytokine signaling 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:19734449 PMID:23296022 PMID:26336985 PMID:28302137 PMID:29625055

NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

superoxide dismutase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 3:85,382,698...85,387,144
Ensembl chr 3:85,382,484...85,387,455

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21690253 PMID:22591296 PMID:22859607 PMID:23926297 PMID:25873174 More...

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

spleen associated tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:95,903,501...95,955,577
Ensembl chr 1:95,903,566...95,955,583

G

TBL1X/Y related 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9450851 PMID:16492805 PMID:21156281 PMID:21156282 PMID:25741868 More...

NCBI chr34:40,573,631...40,690,975
Ensembl chr34:40,578,507...40,739,352

G

tumor protein p53

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:1631137 PMID:1978757 PMID:8062826 PMID:8099841 PMID:8425176 More...

NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109

G

thioredoxin interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr17:58,775,588...58,779,730
Ensembl chr17:58,776,871...58,779,531

Enteropathy-Associated T-Cell Lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

SET domain containing 2, histone lysine methyltransferase

DNA:mutations:multiple (human)

NCBI chr20:41,675,539...41,800,697
Ensembl chr20:41,675,599...41,800,612

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

NCBI chr 9:20,647,712...20,718,453
Ensembl chr 9:20,691,483...20,716,485

extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: MALT lymphoma

PMID:9989495 PMID:10380920 PMID:10408400

NCBI chr 6:62,712,937...62,723,852
Ensembl chr 6:62,712,971...62,722,368

G

baculoviral IAP repeat containing 3

treatment

DNA:gene fusion: (human)

NCBI chr 5:29,324,893...29,343,322
Ensembl chr 5:29,325,331...29,337,240

G

C-X-C motif chemokine receptor 4

protein:increased expression: mucosa-associated lymphoid tissue (human)

NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740

follicular lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase H+ transporting accessory protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:122,133,314...122,140,949
Ensembl chr X:122,133,325...122,140,447

G

ATPase H+ transporting V1 subunit B2

CTD Direct Evidence: marker/mechanism

NCBI chr25:36,833,246...36,858,846
Ensembl chr25:36,834,196...36,858,819

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: Follicular lymphoma

NCBI chr 6:62,712,937...62,723,852
Ensembl chr 6:62,712,971...62,722,368

G

BCL2 apoptosis regulator

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:translocation: ;t(14;18)(q32;q21)

PMID:3287162 PMID:12855623 PMID:16671111

RGD:1599473 RGD:734639

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

human gene in a mouse model

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr 9:11,834,230...11,844,946
Ensembl chr 9:11,842,190...11,844,843

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 6:37,410,201...37,536,688
Ensembl chr 6:37,409,930...37,534,176

G

EBF transcription factor 1