lymphatic system cancer - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	lymphatic system cancer	go back to main search page
Accession:	DOID:0060073	browse the term
Definition:	An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. (DO)

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Rat (698) Mouse (1043) Human (5354) Chinchilla (588) Bonobo (623) Dog (638) Squirrel (594) Pig (626) Green Monkey (612) Naked Mole-rat (580) All
Genes (623)

acute biphenotypic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DOT1 like histone lysine methyltransferase

treatment

NCBI chr19:1,173,915...1,243,633
Ensembl chr19:2,147,031...2,210,039

G

ring finger protein 20

disease_progression

NCBI chr 9:72,738,132...72,767,868
Ensembl chr 9:100,732,342...100,761,258

acute leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 2, TFIIH core complex helicase subunit

ClinVar Annotator: match by term: Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified

PMID:7585650 PMID:8571952 PMID:9195225 PMID:9238033 PMID:15982307 More...

NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819

acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

susceptibility

DNA:snps, haplotype:multiple (human)
CTD Direct Evidence: marker/mechanism

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

ATP binding cassette subfamily C member 2

treatment

DNA:SNPs: :rs717620(human)
DNA:SNP:5'UTR:rs717620(human)

PMID:24404132 PMID:25007187

RGD:11080959 RGD:11080979

NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270

G

ATP binding cassette subfamily G member 2 (JR blood group)

disease_progression

mRNA:increased expression:mononuclear cell:

PMID:12100141 PMID:15521915

RGD:11081076 RGD:11081143

NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:11984797 PMID:21898527

NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

NCBI chr 9:104,354,115...104,399,057
Ensembl chr 9:132,989,574...133,010,324

G

activation induced cytidine deaminase

treatment

NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917

G

AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

PMID:19684603 PMID:19684604

NCBI chr10:58,426,519...58,621,986
Ensembl chr10:60,756,484...60,952,174

G

aryl hydrocarbon receptor nuclear translocator

CTD Direct Evidence: marker/mechanism

NCBI chr 1:126,160,017...126,226,222
Ensembl chr 1:129,809,431...129,875,629

G

BCL2 associated X, apoptosis regulator

NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468

G

BCL2 apoptosis regulator

severity

mRNA:increased expression:bone marrow (human)

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

BCL2 like 1

treatment

mRNA:increased expression:blood, mononuclear cell (human)

PMID:12469194 PMID:19020783

RGD:11353852 RGD:11353866

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

BCR activator of RhoGEF and GTPase

G

caspase 8

CTD Direct Evidence: therapeutic

NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468

G

calpastatin

protein:increased expresssion:B cell

NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650

G

cyclin D1

mRNA:increased expression:bone marrow (human)

NCBI chr11:64,737,006...64,750,353

G

CD40 ligand

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD46 molecule

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr 1:183,330,423...183,373,916
Ensembl chr 1:188,031,758...188,182,046

G

CD79b molecule

protein:decreased expression:bone marrow, mononuclear cell (human)

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

CD86 molecule

severity

protein:increased expression:peripheral blood, bone marrow, mononuclear cell (human)

NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339

G

cyclin dependent kinase 6

CTD Direct Evidence: marker/mechanism

NCBI chr 7:84,603,419...84,835,082

G

cyclin dependent kinase inhibitor 2A

susceptibility
disease_progression
no_association

DNA:missense mutations:cds:
ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia
DNA:deletion: :

PMID:7566978 PMID:7647780 PMID:7718873 PMID:7987387 PMID:8573142 More...

RGD:11057958 RGD:11251764 RGD:11252081 RGD:11252082

NCBI chr 9:21,803,862...21,831,322

G

cyclin dependent kinase inhibitor 2B

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156

G

CCAAT enhancer binding protein epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr14:3,937,200...3,939,112
Ensembl chr14:22,033,654...22,035,219

G

complement factor B

DNA:missense mutation:p.R32Q b(human)

NCBI chr 6:31,606,716...31,612,782

G

CREB binding protein

disease_progression

DNA:mutations:multiple

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

G

colony stimulating factor 3

treatment

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

chondroitin sulfate proteoglycan 4

severity

NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498

G

cytochrome P450 family 1 subfamily A member 1

susceptibility
no_association

DNA:polymorphism:3"UTR:rs4646903(human)
DNA:polymorphism:cds:2452C>A(p.T461N)(human)
DNA:polymorphism:3'UTR:3801T>C(human)

PMID:16676594 PMID:22964275 PMID:23725389

RGD:11352714 RGD:11352725 RGD:11352728

NCBI chr15:53,664,968...53,672,277
Ensembl chr15:73,284,566...73,290,636

G

cytochrome P450 family 1 subfamily A member 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447

G

cytochrome P450 family 1 subfamily B member 1

CTD Direct Evidence: marker/mechanism

NCBI chr2A:38,087,863...38,096,529
Ensembl chr2A:38,851,000...38,859,824

G

cytochrome P450 family 2 subfamily C member 8

CTD Direct Evidence: marker/mechanism

NCBI chr10:91,646,387...91,679,998
Ensembl chr10:95,157,661...95,186,620

G

cytochrome P450 family 2 subfamily E member 1

CTD Direct Evidence: marker/mechanism

Ensembl chr10:134,839,025...134,852,719

G

cytochrome P450 family 3 subfamily A member 5

susceptibility
disease_progression

DNA:polymorphism: :

PMID:19650988 PMID:22215203

RGD:11353796 RGD:11353805

NCBI chr 7:91,621,561...91,654,164
Ensembl chr 7:105,123,437...105,155,322

G

dihydrofolate reductase

disease_progression

DNA:polymorphisms, haplotype:promoter:
DNA:polymorphisms: :-317A>G, 829C>T (human)

PMID:9226157 PMID:12972803 PMID:19861437 PMID:22969948

RGD:11039542 RGD:11039543 RGD:11039544 RGD:11039545

NCBI chr 5:34,663,210...34,689,467
Ensembl chr 5:34,938,548...34,967,003

G

DNA methyltransferase 3 alpha

treatment

DNA:mutations:exon, intron:p.R882(human)

NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605

G

DNA nucleotidylexotransferase

protein:increased activity:peripheral blood,bone marrow:

NCBI chr10:92,916,783...92,958,216
Ensembl chr10:96,423,819...96,457,742

G

dihydropyrimidine dehydrogenase

disease_progression
no_association

DNA:splice-site mutation:intron:IVS14+1G>A (human)
DNA:SNPs: :2194G>A, 1156G>T (human)
DNA:SNP: :85T>C (human)

NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100

G

euchromatic histone lysine methyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:108,724,568...108,951,077
Ensembl chr 9:137,764,950...137,895,564

G

euchromatic histone lysine methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,542,946...31,560,894
Ensembl chr 6:32,429,271...32,451,844

G

endoglin

disease_progression

NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641

G

epoxide hydrolase 1

susceptibility
no_association

CTD Direct Evidence: marker/mechanism
DNA:SNPs:exon:rs1051740, rs2234922 (human)
DNA:missense mutation, haplotype:exon:p.Y113H (human)
DNA:polymorphisms:exon
DNA:missense mutation, haplotype:exon:p.H139R (human)

PMID:19593802 PMID:21983886 PMID:22200898 PMID:22930568

RGD:11252110 RGD:11252111 RGD:11252113 RGD:11252114

NCBI chr 1:201,271,366...201,306,635
Ensembl chr 1:206,272,866...206,307,581

G

ERCC excision repair 1, endonuclease non-catalytic subunit

susceptibility

DNA:SNPs: :8092C>A, 19007G>A (human)
DNA:SNPs, haplotypes: :p.R194W, p.R280H, p.R399Q (human)

PMID:16435384 PMID:16723154

RGD:11252160 RGD:11340204

NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430

G

ERCC excision repair 2, TFIIH core complex helicase subunit

no_association

DNA:haplotype
DNA:missense mutations: :p.D312N, p.K751Q (human)

PMID:19101034 PMID:21987080

RGD:11252192 RGD:11340201

NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819

G

ETS transcription factor ERG

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr21:24,737,829...25,016,378
Ensembl chr21:38,087,339...38,281,403

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Acute lymphoid leukemia

NCBI chr12:11,675,955...11,920,913
Ensembl chr12:11,844,939...12,179,537

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726

G

coagulation factor III, tissue factor

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

Fas cell surface death receptor

disease_progression

protein:increased expression:CD34+ bone marrow cell

PMID:9711907 PMID:10500800

RGD:11049148 RGD:11049157

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

fibrinogen alpha chain

protein:increased expression:serum (human)

NCBI chr 4:146,949,680...146,957,291

G

fms related receptor tyrosine kinase 3

ClinVar Annotator: match by term: Acute lymphoid leukemia

PMID:11290608 PMID:11442493 PMID:14604974 PMID:14670924 PMID:15256420 More...

NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940

G

folylpolyglutamate synthase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:98,921,986...98,933,542
Ensembl chr 9:127,593,592...127,604,200

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272

G

growth factor independent 1B transcriptional repressor

mRNA:increased expression:blood:

NCBI chr 9:104,061,236...104,113,208
Ensembl chr 9:132,692,343...132,742,326

G

G protein subunit beta 1

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:25485910 PMID:25741868 PMID:27108799 PMID:28492532 PMID:32134617 More...

NCBI chr 1:490,415...596,826
Ensembl chr 1:1,647,340...1,701,614

G

glucose-6-phosphate isomerase

NCBI chr19:31,301,469...31,355,362
Ensembl chr19:40,024,584...40,080,598

G

glutathione peroxidase 1

treatment

PMID:17317918 PMID:24698347

RGD:11352774 RGD:11352812

NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826

G

glutathione-disulfide reductase

NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557

G

glutathione S-transferase mu 1

disease_progression
susceptibility
no_association

PMID:10666194 PMID:12827651 PMID:14607752 PMID:15738600

RGD:10450829 RGD:10755321 RGD:10755409 RGD:10755410

Ensembl chr 1:127,979,238...128,010,411

G

glutathione S-transferase pi 1

disease_progression
no_association
susceptibility

DNA:haplotype:cds:
DNA:polymorphism: :1578 a>G(human)
DNA:transition mutation:exon:

PMID:10666194 PMID:15738600 PMID:23979883

RGD:10450829 RGD:10755321 RGD:10755417

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

H1.2 linker histone, cluster member

susceptibility

DNA:SNP, haplotype:enhancer: (rs807212) (human)

NCBI chr 6:25,891,079...25,891,859
Ensembl chr 6:26,549,016...26,549,657

G

HCK proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr20:28,346,244...28,395,370
Ensembl chr20:29,474,737...29,523,399

G

histone deacetylase 1

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr 1:31,578,373...31,619,970
Ensembl chr 1:32,585,791...32,626,410

G

histone deacetylase 2

disease_progression

mRNA:increased expression:bone marrow,blood:

NCBI chr 6:111,731,139...111,761,826
Ensembl chr 6:115,802,367...115,833,004

G

histone deacetylase 4

treatment

NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054

G

homeostatic iron regulator

no_association

DNA:missense mutation:cds:p.C282Y (human)
DNA:missense mutation: :p.H63D (human)
DNA:missense mutation:cds:p.H63D (human)

PMID:10627122 PMID:17107905

RGD:10755557 RGD:10755558

NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591

G

hexokinase 1

protein:decreased activity:platelet

NCBI chr10:65,786,940...65,870,204
Ensembl chr10:68,289,288...68,401,045

G

HLF transcription factor, PAR bZIP family member

CTD Direct Evidence: marker/mechanism

NCBI chr17:49,353,790...49,413,676
Ensembl chr17:54,218,399...54,278,044

G

homeobox D4

ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to

NCBI chr2B:63,429,084...63,432,972
Ensembl chr2B:181,140,175...181,141,484

G

isocitrate dehydrogenase (NADP(+)) 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:95,475,320...95,494,286
Ensembl chr2B:213,599,036...213,617,175

G

interferon gamma

susceptibility

DNA:SNP: :rs2069727(human)

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

IKAROS family zinc finger 1

ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphocytic, susceptibility to, 2

PMID:25741868 PMID:27993330 PMID:28492532

NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:100,255,430...100,407,395
Ensembl chr2B:218,737,506...218,882,087

G

IKAROS family zinc finger 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:17,459,438...17,498,452
Ensembl chr17:17,643,750...17,741,479

G

interleukin 10

treatment

protein:decreased expression:blood

PMID:15860861 PMID:21653647

RGD:11049158 RGD:11049169

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interferon regulatory factor 4

DNA:SNP:intron:rs12203592 (human)

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

inosine triphosphatase

no_association
treatment

DNA:SNP:intron
DNA:SNPs:exon:94C>A, 138G>A (human)

NCBI chr20:3,295,075...3,309,546
Ensembl chr20:3,056,395...3,070,924

G

lysine demethylase 2B

mRNA:increased expression:bone marrow (human)

NCBI chr12:119,027,633...119,183,779
Ensembl chr12:122,401,296...122,555,246

G

lysine demethylase 3B

protein:increased expression:bone marrow, mononuclear cell (human)

NCBI chr 5:133,732,400...133,816,988
Ensembl chr 5:139,863,922...139,947,895

G

lysine demethylase 6A

severity

DNA:mutations:cds:multiple (human)

NCBI chr X:37,313,000...37,548,630
Ensembl chr X:45,127,382...45,362,029

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism
OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

PMID:24736461 PMID:25730765

NCBI chr11:113,273,198...113,364,404
Ensembl chr11:117,204,820...117,290,100

G

KRAS proto-oncogene, GTPase

disease_progression

PMID:17910045 PMID:25917266

RGD:11060148 RGD:11060149

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

LIM domain only 2

OMIM:247640 | OMIM:613065

NCBI chr11:33,830,370...33,863,960

G

somatotropin

treatment

NCBI chr17:58,010,848...58,013,421
Ensembl chr17:63,103,332...63,105,067

G

HLA class II histocompatibility antigen, DQ beta 1 chain

DNA:polymorphisms, haplotypes:cds:multiple
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0501 (human)

PMID:9744491 PMID:22434102

RGD:11041749 RGD:11041762

NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272

G

cytokine receptor like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:933,459...957,950

G

cytochrome b-245 light chain

mRNA:increased expression:peripheral blood mononuclear cell:

NCBI chr16:69,356,396...69,364,225
Ensembl chr16:89,016,349...89,024,719

G

cytochrome P450 2D6-like

susceptibility

DNA:SNP,deletion:splice junction,exon:1934G>A(human)
DNA:polymorphisms: :

PMID:11037802 PMID:19593802

RGD:11252111 RGD:11352820

NCBI chr22:23,022,449...23,031,627

G

MEFV innate immunity regulator, pyrin

susceptibility

DNA:polymorphisms:cds:p.E148Q,M680I(human)

NCBI chr16:2,175,858...2,191,056
Ensembl chr16:3,353,666...3,368,970

G

methylenetetrahydrofolate reductase

treatment
disease_progression

DNA:missense mutation:cds:677C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:677C>T (p.A222V) (rs1801133) (human)

PMID:16706930 PMID:19923983 PMID:21644011

RGD:10449398 RGD:10449407

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

5-methyltetrahydrofolate-homocysteine methyltransferase

susceptibility
disease_progression
no_association

DNA:polymorphism: :2756A>G(human)
DNA:SNP::rs10925235(human)
DNA:polymorphism: :66A>G(human)

PMID:15159311 PMID:21618417 PMID:22453148 PMID:26605150

RGD:11531136 RGD:11531137 RGD:11531140 RGD:11531141

NCBI chr 1:212,353,195...212,463,304
Ensembl chr 1:217,358,050...217,460,946

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs3776455(human)
DNA:haplotype:cds:

PMID:17136115 PMID:23940529

RGD:11531133 RGD:11531135

NCBI chr 5:8,195,868...8,228,071
Ensembl chr 5:8,017,403...8,049,322

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

N-acetyltransferase 2

susceptibility
no_association

DNA:polymorphisms: :
DNA:polymorphisms,haplotype: :
CTD Direct Evidence: marker/mechanism

PMID:21888617 PMID:22200898 PMID:22215203 PMID:25804798

RGD:11353805 RGD:11532767 RGD:11532769

NCBI chr 8:17,606,445...17,623,397
Ensembl chr 8:14,575,455...14,576,327

G

nibrin

ClinVar Annotator: match by term: Acute lymphoblastic leukemia | ClinVar Annotator: match by term: Acute lymphocytic leukemia | ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Lymphoblastic leukemia

PMID:9590180 PMID:11325820 PMID:12353271 PMID:14559852 PMID:15338273 More...

NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307

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nitric oxide synthase 3

disease_progression
susceptibility

DNA:polymorphism, haplotype:cds,intron:P.E298D,-786T>C(human)
DNA:SNP: :rs3918186(human)

PMID:20510681 PMID:23922896

RGD:11533639 RGD:11533646

NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233

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notch receptor 3

OMIM:247640 | OMIM:613065

NCBI chr19:14,692,571...14,733,758
Ensembl chr19:15,678,674...15,715,080

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NAD(P)H quinone dehydrogenase 1

DNA:mutation: :609C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutations: :p.R139W (465C>T), p.P187S (609C>T) (human)

PMID:11774269 PMID:17332311 PMID:18444911

RGD:10769347 RGD:10769359

NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731

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NRAS proto-oncogene, GTPase

disease_progression

DNA:missense mutation:cds:

NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585

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nuclear receptor binding SET domain protein 2

CTD Direct Evidence: therapeutic

NCBI chr 4:2,009,276...2,119,182
Ensembl chr 4:1,945,307...2,027,425

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5'-nucleotidase, cytosolic II

CTD Direct Evidence: marker/mechanism

NCBI chr10:99,687,366...99,790,744
Ensembl chr10:103,148,578...103,251,513

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nucleoporin 214

susceptibility

CTD Direct Evidence: marker/mechanism

NCBI chr 9:102,246,575...102,355,291
Ensembl chr 9:130,893,110...131,001,305

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P2Y receptor family member 8

CTD Direct Evidence: marker/mechanism

Ensembl chr X:1,599,411...1,600,490

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phosphoprotein membrane anchor with glycosphingolipid microdomains 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:77,492,087...77,635,854
Ensembl chr 8:79,123,503...79,218,100

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paired box 5

susceptibility

ClinVar Annotator: match by term: Acute lymphoid leukemia | ClinVar Annotator: match by term: Leukemia, acute lymphoblastic, susceptibility to, 3

PMID:24013638 PMID:24728327 PMID:25741868 PMID:27993330 PMID:28492532 More...

NCBI chr 9:36,677,369...36,876,678
Ensembl chr 9:37,474,267...37,673,684

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paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M (rs854560), p.Q192R (rs662) (human)

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

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PR/SET domain 14

CTD Direct Evidence: marker/mechanism

NCBI chr 8:66,578,674...66,599,360
Ensembl chr 8:68,240,741...68,260,263

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phosphatase and tensin homolog

OMIM:247640 | OMIM:613065 | OMIM:613067 | OMIM:615545

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

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RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575

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solute carrier family 19 member 1

CTD Direct Evidence: marker/mechanism

NCBI chr21:31,836,774...31,883,829
Ensembl chr21:45,090,595...45,134,752

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small nuclear ribonucleoprotein polypeptide E

severity

mRNA:decreased expression:bone marrow, blood, mononuclear cell (human)

NCBI chr 1:179,466,263...179,474,779
Ensembl chr 1:183,755,392...183,764,937

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TAL bHLH transcription factor 1, erythroid differentiation factor

NCBI chr 1:46,524,484...46,540,595
Ensembl chr 1:48,042,594...48,048,622

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TAL bHLH transcription factor 2

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transcription factor 3

CTD Direct Evidence: marker/mechanism

Ensembl chr19:1,582,297...1,622,025

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transcobalamin 2

protein:altered activity:plasma:

NCBI chr22:11,635,107...11,655,137
Ensembl chr22:29,435,517...29,455,494

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telomerase reverse transcriptase

DNA:SNPs:promoter, introns:g.1296486C>T, g.12866516A>C, g.1279790G>A (rs2735940, rs2736100, rs10069690) (human)

PMID:15621763 PMID:23066086

RGD:11038654 RGD:11038667

Ensembl chr 5:1,300,960...1,338,872

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transmembrane 9 superfamily member 2

mRNA:increased expression:bone marrow, mononuclear cells (human)

NCBI chr13:80,669,277...80,731,340
Ensembl chr13:99,807,555...99,869,456

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tumor protein p53

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

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thiopurine S-methyltransferase

no_association
treatment

DNA:SNPs:introns:12356C>T, 16638C>T, 26354G>T (rs4449636, rs2518463, rs2842949) (human)
DNA:SNPs:exon:374C>T, 719A>G (rs2842934, rs1142345) (human)
DNA:SNPs: :multiple
DNA:SNPs:multiple

PMID:17164697 PMID:22009189 PMID:24499706

RGD:10766474 RGD:11038720 RGD:11038723

NCBI chr 6:17,977,544...18,002,839
Ensembl chr 6:18,330,000...18,355,157

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tetratricopeptide repeat domain 12

DNA:hypermethylation:5'end:CpG dinucleotide

NCBI chr11:108,194,610...108,253,161
Ensembl chr11:112,037,620...112,106,537

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thymidylate synthetase

treatment

DNA:repeats: : rs347430033(human)

NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320

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X-ray repair cross complementing 1

susceptibility
no_association

DNA:missense mutation, haplotype: :p.R399Q (human)
DNA:missense mutation: :p.R399Q (human)
DNA:missense mutation: :p.R194W (human)
CTD Direct Evidence: marker/mechanism

PMID:19101034 PMID:21983886

RGD:11252110 RGD:11252192

NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520

Acute Lymphoblastic Leukemia, with Lymphomatous Features

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

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ABL proto-oncogene 1, non-receptor tyrosine kinase

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:10988075 PMID:11423618 PMID:11853795 PMID:11861307 PMID:11964322 More...

NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941

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cytochrome P450 family 2 subfamily B member 6

susceptibility

DNA:polymorphism:G15631T

NCBI chr19:38,003,083...38,028,980
Ensembl chr19:46,509,370...46,534,672

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fibroblast growth factor receptor 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156

NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904

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interleukin 7 receptor

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:22897847 PMID:22955920

NCBI chr 5:74,489,188...74,516,330
Ensembl chr 5:79,769,859...79,792,612

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insulin like 6

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 9:5,007,158...5,029,056
Ensembl chr 9:5,192,023...5,213,827

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Janus kinase 1

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:16239216 PMID:19139102 PMID:19470474 PMID:19838194 PMID:20167706 More...

NCBI chr 1:64,083,562...64,315,909
Ensembl chr 1:65,973,904...66,024,991

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Janus kinase 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:18805579 PMID:19470474 PMID:20585391 PMID:22368270 PMID:22955920

NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626

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Janus kinase 3

ClinVar Annotator: match by term: LYMPHOMATOUS ALL

PMID:10982185 PMID:16843266 PMID:18270328 PMID:20132407 PMID:20372971 More...

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

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cytokine receptor like factor 2

ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features

PMID:19907440 PMID:19965641 PMID:20018760 PMID:22368272

NCBI chr X:933,459...957,950

adenoid cystic carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

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aquaporin 1 (Colton blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 7:31,524,933...31,538,602
Ensembl chr 7:31,644,331...31,658,141

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AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:25,960,868...26,047,057
Ensembl chr 1:27,018,616...27,103,239

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AT-rich interaction domain 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr12:42,823,236...43,004,465
Ensembl chr12:43,692,914...43,871,564

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AT-rich interaction domain 4B

CTD Direct Evidence: marker/mechanism

NCBI chr 1:210,711,946...210,874,034
Ensembl chr 1:215,729,783...215,888,412

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AT-rich interaction domain 5B

CTD Direct Evidence: marker/mechanism

NCBI chr10:58,426,519...58,621,986
Ensembl chr10:60,756,484...60,952,174

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assembly factor for spindle microtubules

CTD Direct Evidence: marker/mechanism

NCBI chr 1:172,674,890...172,737,426
Ensembl chr 1:176,988,297...177,050,810

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ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

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ATR serine/threonine kinase

treatment

NCBI chr 3:139,482,606...139,612,274
Ensembl chr 3:147,075,185...147,196,261

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ATRX chromatin remodeler

CTD Direct Evidence: marker/mechanism

NCBI chr X:66,682,968...66,969,421
Ensembl chr X:76,795,574...77,083,486

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BRCA1 associated deubiquitinase 1

ClinVar Annotator: match by term: Adenocystic carcinoma | ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:21642991 PMID:24894717 PMID:26166446 PMID:26452128 PMID:28492532

NCBI chr 3:52,344,067...52,352,187
Ensembl chr 3:53,573,785...53,581,943

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BCL11 transcription factor A

CTD Direct Evidence: marker/mechanism

NCBI chr2A:60,552,908...60,655,437
Ensembl chr2A:61,695,613...61,795,800

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BCL6 corepressor

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr X:32,497,931...32,624,307
Ensembl chr X:40,202,235...40,249,986

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BCL6 corepressor like 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:119,108,049...119,185,165
Ensembl chr X:129,403,888...129,479,297

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BRCA1 DNA repair associated

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815

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bromodomain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:29,993,902...30,048,349
Ensembl chr22:48,998,037...49,048,101

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cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chr11:64,737,006...64,750,353

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cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488

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cap methyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:53,727,087...53,734,555

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CREB binding protein

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

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death associated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:58,628,872...58,836,205
Ensembl chr 9:86,681,953...86,887,958

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denticleless E3 ubiquitin protein ligase homolog

CTD Direct Evidence: marker/mechanism

NCBI chr 1:187,603,600...187,672,006
Ensembl chr 1:192,466,408...192,535,071

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deltex E3 ubiquitin ligase 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:54,389,228...54,425,655
Ensembl chr11:57,839,228...57,874,337

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EF-hand domain family member D1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:119,865,065...119,914,446

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engrailed homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:5,798,557...5,804,368

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E1A binding protein p300

CTD Direct Evidence: marker/mechanism

NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604

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erbb2 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 5:47,929,305...48,081,381
Ensembl chr 5:49,589,418...49,676,689

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extra spindle pole bodies like 1, separase

CTD Direct Evidence: marker/mechanism

NCBI chr12:35,460,500...35,486,794
Ensembl chr12:36,241,533...36,266,101

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FA complementation group A

CTD Direct Evidence: marker/mechanism

NCBI chr16:70,495,310...70,579,275
Ensembl chr16:90,163,950...90,245,147

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FAT atypical cadherin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:178,752,261...178,895,038
Ensembl chr 4:190,952,737...191,093,357

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F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Adenocystic carcinoma

NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351

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fibroblast growth factor 16

CTD Direct Evidence: marker/mechanism

NCBI chr X:66,623,050...66,634,325
Ensembl chr X:76,737,733...76,749,731

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fibroblast growth factor receptor 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr10:118,055,854...118,175,440
Ensembl chr10:121,469,735...121,588,815

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fibroblast growth factor receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:172,386,443...172,400,271
Ensembl chr 5:179,454,995...179,467,605

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forkhead box O3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272

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forkhead box P2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:106,040,118...106,648,741
Ensembl chr 7:119,077,332...119,343,893

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growth arrest specific 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:22,639,677...22,822,208
Ensembl chr11:22,583,367...22,729,243

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growth arrest specific 6

CTD Direct Evidence: marker/mechanism

Ensembl chr13:113,968,843...114,009,562

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GINS complex subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:66,344,706...66,356,079
Ensembl chr16:85,681,716...85,691,626

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guanylate cyclase 1 soluble subunit alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,032,167...148,102,757
Ensembl chr 4:159,850,107...159,913,338

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H1.4 linker histone, cluster member

CTD Direct Evidence: marker/mechanism

NCBI chr 6:25,992,845...26,006,585
Ensembl chr 6:26,652,151...26,652,810
Ensembl chr 6:26,652,151...26,652,810

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homer scaffold protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:18,367,191...18,379,454
Ensembl chr19:19,374,442...19,385,392

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HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078

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isocitrate dehydrogenase (NADP(+)) 1

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

NCBI chr2B:95,475,320...95,494,286
Ensembl chr2B:213,599,036...213,617,175

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insulin like growth factor binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:103,893,724...103,925,318

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interleukin 17 receptor D

CTD Direct Evidence: marker/mechanism

NCBI chr 3:57,023,622...57,098,869
Ensembl chr 3:58,240,835...58,309,409

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insulin receptor related receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:132,183,963...132,195,267
Ensembl chr 1:136,005,458...136,024,374

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iroquois homeobox 4

CTD Direct Evidence: marker/mechanism

Ensembl chr 5:1,929,977...1,939,622

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inositol-3-phosphate synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:17,913,400...17,916,789
Ensembl chr19:18,884,412...18,887,931

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integrin subunit beta 4

CTD Direct Evidence: marker/mechanism

NCBI chr17:69,671,252...69,708,520
Ensembl chr17:75,222,376...75,259,401

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jagged canonical Notch ligand 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:10,582,234...10,618,507
Ensembl chr20:10,582,094...10,618,383

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Janus kinase 3

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:14615376 PMID:28492532 PMID:33040328

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

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jumonji domain containing 1C

CTD Direct Evidence: marker/mechanism

NCBI chr10:59,674,227...60,028,763
Ensembl chr10:61,999,571...62,295,332

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KAT8 regulatory NSL complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:11,508,245...11,705,023
Ensembl chr17:11,296,318...11,456,593

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lysine acetyltransferase 6A

CTD Direct Evidence: marker/mechanism

NCBI chr 8:41,173,833...41,296,547
Ensembl chr 8:38,625,156...38,741,538

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lysine demethylase 6A

exacerbates

CTD Direct Evidence: marker/mechanism
DNA:splice-site mutation, missense mutations:splice junction, CDS:multiple: (human)
DNA:mutations:multiple: (human)

PMID:23685749 PMID:31483290

RGD:150429732 RGD:150429736

NCBI chr X:37,313,000...37,548,630
Ensembl chr X:45,127,382...45,362,029

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lysine demethylase 6B

CTD Direct Evidence: marker/mechanism

NCBI chr17:7,878,783...7,889,372
Ensembl chr17:7,866,973...7,874,937

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lysine methyltransferase 2C

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:31483290

NCBI chr 7:143,714,716...144,016,188
Ensembl chr 7:155,862,610...156,081,043

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KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:6695174 PMID:12460918 PMID:15696205 PMID:16361624 PMID:16618717 More...

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

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keratin 15

CTD Direct Evidence: marker/mechanism

NCBI chr17:15,794,336...15,802,977
Ensembl chr17:16,011,990...16,020,629

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keratin 5

CTD Direct Evidence: marker/mechanism

NCBI chr12:36,243,221...36,249,573
Ensembl chr12:37,021,432...37,025,105

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X antigen family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:44,700,391...44,705,731

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histone H2A type 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:27,695,226...27,696,385
Ensembl chr 6:28,342,376...28,342,768

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contactin-6

CTD Direct Evidence: marker/mechanism

NCBI chr 3:1,021,854...1,339,952
Ensembl chr 3:1,133,190...1,442,622

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leucine rich repeat containing 56

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:11150980 PMID:16155195 PMID:16170316 PMID:16329078 PMID:16372351 More...

NCBI chr11:514,227...559,838
Ensembl chr11:575,495...588,750

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membrane associated guanylate kinase, WW and PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:65,257,763...65,932,527
Ensembl chr 3:66,635,580...66,757,358

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membrane associated guanylate kinase, WW and PDZ domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:69,943,704...71,395,176
Ensembl chr 7:83,758,512...84,760,872

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mastermind like transcriptional coactivator 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:132,082,120...132,518,928
Ensembl chr 4:143,391,606...143,562,699

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mitogen-activated protein kinase kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933

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myristoylated alanine rich protein kinase C substrate

CTD Direct Evidence: marker/mechanism

NCBI chr 6:111,647,847...111,653,821

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microtubule affinity regulating kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chr11:59,195,852...59,268,391
Ensembl chr11:62,546,455...62,618,772

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MDS1 and EVI1 complex locus

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 3:166,099,530...166,677,739
Ensembl chr 3:174,154,814...174,731,252

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MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr15:20,560,842...20,710,269
Ensembl chr15:38,839,708...38,948,847

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MIER family member 2

CTD Direct Evidence: marker/mechanism

Ensembl chr19:259,565...288,920

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modulator of VRAC current 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:30,287,928...30,316,094
Ensembl chr22:49,289,366...49,315,112

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mortality factor 4 like 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:57,844,220...57,869,139
Ensembl chr15:76,772,007...76,829,259

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MYB proto-oncogene, transcription factor

CTD Direct Evidence: marker/mechanism

PMID:23685749 PMID:26829750

NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194

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MYB proto-oncogene like 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:63,105,379...63,156,421
Ensembl chr 8:64,771,278...64,811,960

G

MYC binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr 1:38,135,375...38,145,640

G

MYCN proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr2A:15,925,130...15,931,605

G

neuropilin and tolloid like 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:27,343,333...27,405,173
Ensembl chr16:46,235,165...46,284,344

G

nuclear factor I B

CTD Direct Evidence: marker/mechanism

NCBI chr 9:13,923,516...14,376,264

G

notch receptor 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

G

nuclear receptor binding SET domain protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:172,431,968...172,602,174
Ensembl chr 5:179,499,865...179,666,351

G

neurotrophic receptor tyrosine kinase 3

treatment

NCBI chr15:66,566,219...66,953,279
Ensembl chr15:85,776,832...86,157,204

G

proprotein convertase subtilisin/kexin type 1 inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chr X:41,128,785...41,133,284
Ensembl chr X:48,988,948...48,990,028

G

PDZ domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:122,034,097...122,091,823
Ensembl chr 1:113,579,273...113,615,390

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:15930273 PMID:17376864 PMID:18074223 PMID:19366826 PMID:22120714 More...

NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977

G

protein kinase, DNA-activated, catalytic subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

glycogen phosphorylase B

CTD Direct Evidence: marker/mechanism

NCBI chr20:25,191,066...25,242,955
Ensembl chr20:25,593,589...25,648,066

G

RNA binding fox-1 homolog 2

CTD Direct Evidence: marker/mechanism

NCBI chr22:16,740,707...17,031,415
Ensembl chr22:34,586,044...34,870,257

G

serpin family F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:1,745,597...1,761,399
Ensembl chr17:1,638,556...1,653,568

G

SET domain containing 2, histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:46,916,615...47,064,046
Ensembl chr 3:48,018,517...48,163,999

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

PMID:25741868 PMID:26619011

NCBI chr2B:84,633,272...84,678,602
Ensembl chr2B:202,530,200...202,573,346

G

solute carrier family 24 member 3

CTD Direct Evidence: marker/mechanism

NCBI chr20:19,168,820...19,680,706
Ensembl chr20:19,137,938...19,646,475

G

solute carrier family 3 member 2

disease_progression

NCBI chr11:58,212,395...58,241,686
Ensembl chr11:61,565,680...61,594,579

G

solute carrier family 7 member 5

disease_progression

NCBI chr16:68,512,407...68,552,763

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr 9:1,818,004...1,997,652
Ensembl chr 9:2,013,237...2,189,409

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr22:4,542,764...4,589,461
Ensembl chr22:22,627,982...22,673,921

G

SWI/SNF related BAF chromatin remodeling complex subunit E1

CTD Direct Evidence: marker/mechanism

NCBI chr17:16,633,982...16,660,502
Ensembl chr17:16,860,400...16,884,946

G

structural maintenance of chromosomes 1A

CTD Direct Evidence: marker/mechanism

NCBI chr X:45,576,100...45,637,314
Ensembl chr X:53,697,154...53,745,636

G

SON DNA and RNA binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr21:19,910,024...19,944,511
Ensembl chr21:33,282,910...33,316,007

G

SRY-box transcription factor 11

CTD Direct Evidence: marker/mechanism

NCBI chr2A:5,699,738...5,711,210

G

SRY-box transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 6:21,422,846...21,427,779

G

Snf2 related CREBBP activator protein

CTD Direct Evidence: marker/mechanism

NCBI chr16:24,229,869...24,271,427
Ensembl chr16:31,065,964...31,106,312

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

CTD Direct Evidence: marker/mechanism

NCBI chr11:121,169,213...121,228,287
Ensembl chr11:125,079,260...125,141,737

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Adenoid cystic carcinoma

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

tousled like kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr2B:58,277,362...58,445,321
Ensembl chr2B:175,735,054...175,903,322

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207

G

tumor protein p53

disease_progression

ClinVar Annotator: match by term: Adenocystic carcinoma

PMID:1673792 PMID:1686725 PMID:6736287 PMID:7707106 PMID:7881428 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

ubiquitin like with PHD and ring finger domains 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:3,926,583...3,979,163
Ensembl chr19:4,872,753...4,925,330

G

versican

CTD Direct Evidence: marker/mechanism

NCBI chr 5:31,699,278...31,810,169
Ensembl chr 5:32,019,709...32,130,351

G

Wnt family member 5B

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,633,987...1,757,431
Ensembl chr12:1,691,097...1,708,351

G

5'-3' exoribonuclease 2

DNA:hypermethylation:3' utr: (human)

NCBI chr20:21,260,871...21,347,430
Ensembl chr20:21,222,138...21,308,561

adenoid squamous cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HNF1 homeobox A

NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911

adult T-cell leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat containing 5

CTD Direct Evidence: marker/mechanism

NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159

G

bone morphogenetic protein 6

CTD Direct Evidence: marker/mechanism

NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649

G

caspase recruitment domain family member 11

CTD Direct Evidence: marker/mechanism

NCBI chr 7:3,166,788...3,304,729
Ensembl chr 7:3,258,736...3,332,999

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 3:32,882,419...32,887,442
Ensembl chr 3:33,188,482...33,189,564

G

C-C motif chemokine receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chr17:16,720,236...16,731,955
Ensembl chr17:16,949,119...16,956,370

G

CD163 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr12:7,616,714...7,649,768
Ensembl chr12:7,775,343...7,810,023

G

CD274 molecule

disease_progression

NCBI chr 9:5,269,270...5,289,629
Ensembl chr 9:5,454,391...5,474,402

G

CD28 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213

G

CD68 molecule

disease_progression

protein:increased expression:lymph node tumor (human)

NCBI chr17:7,610,725...7,613,696
Ensembl chr17:7,596,947...7,599,981

G

CD80 molecule

NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870

G

CD86 molecule

NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339

G

casein kinase 1 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:144,919,775...144,977,105
Ensembl chr 5:150,929,420...150,985,912

G

casein kinase 2 alpha 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126

G

casein kinase 2 beta

CTD Direct Evidence: marker/mechanism

NCBI chr 6:31,327,250...31,331,250

G

cytotoxic T-lymphocyte associated protein 4

CTD Direct Evidence: marker/mechanism

NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498

G

Fas cell surface death receptor

susceptibility

protein:increased expression:peripheral blood mononuclear cell:
DNA:polymorphism:promoter: -670 G>A(human)

PMID:7513372 PMID:17962369

RGD:11049147 RGD:11049453

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

forkhead box P3

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:23797717 PMID:23962110

NCBI chr X:41,550,462...41,567,492
Ensembl chr X:49,402,652...49,417,029

G

FYN proto-oncogene, Src family tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272

G

G protein-coupled receptor 183

CTD Direct Evidence: marker/mechanism

NCBI chr13:80,461,908...80,475,046
Ensembl chr13:99,601,220...99,602,305

G

heterogeneous nuclear ribonucleoprotein A2/B1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:26,835,881...26,846,578
Ensembl chr 7:26,439,443...26,449,985

G

inducible T cell costimulator

CTD Direct Evidence: marker/mechanism

NCBI chr2B:91,168,998...91,193,808
Ensembl chr2B:209,307,938...209,332,734

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

PMID:8800741 PMID:23962110

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

IKAROS family zinc finger 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:100,255,430...100,407,395
Ensembl chr2B:218,737,506...218,882,087

G

interleukin 10

CTD Direct Evidence: marker/mechanism

PMID:8704212 PMID:23962110

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984

G

interleukin 4

CTD Direct Evidence: marker/mechanism

NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581

G

interleukin 5

disease_progression

protein:increased expression:serum

NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675

G

interleukin 6

protein:increased expression:serum (human)

NCBI chr 7:23,415,922...23,420,767

G

interferon regulatory factor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

Janus kinase 3

DNA:missense mutations: :p.L156P, p.R172Q, p.E183G (human)

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

G

interferon alpha-2

CTD Direct Evidence: therapeutic

PMID:12560223 PMID:17077332

NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:CD4+ T cell:

NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194

G

notch receptor 1

DNA:mutations:multiple (human)

NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740

G

NRAS proto-oncogene, GTPase

disease_progression

NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585

G

phospholipase C gamma 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145

G

protein kinase C beta

CTD Direct Evidence: marker/mechanism

NCBI chr16:13,888,936...14,268,759
Ensembl chr16:24,091,289...24,466,203

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

TAL bHLH transcription factor 2

G

telomeric repeat binding factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:49,729,906...49,763,002
Ensembl chr16:69,116,539...69,148,423

G

T cell leukemia homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1683261 PMID:1717256

NCBI chr10:97,731,715...97,738,978
Ensembl chr10:101,207,374...101,214,625

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822

G

tumor protein p73

CTD Direct Evidence: marker/mechanism

NCBI chr 1:2,323,399...2,405,295
Ensembl chr 1:3,476,064...3,529,206

G

vav guanine nucleotide exchange factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:5,805,121...5,888,203
Ensembl chr19:6,726,578...6,806,112

anaplastic large cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

PMID:16151469 PMID:19503098 PMID:21345110 PMID:22155737 PMID:22920921 More...

NCBI chr2A:29,196,195...29,930,062
Ensembl chr2A:29,276,041...30,006,735

G

heat shock protein 90 alpha family class A member 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:82,700,881...82,707,020
Ensembl chr14:102,519,699...102,576,723

G

interferon regulatory factor 4

DNA:translocation

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

JunB proto-oncogene, AP-1 transcription factor subunit

NCBI chr19:12,353,760...12,355,598
Ensembl chr19:13,097,931...13,098,974

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

TNF receptor superfamily member 8

CTD Direct Evidence: marker/mechanism

PMID:10908157 PMID:17261581

NCBI chr 1:10,813,111...10,893,005
Ensembl chr 1:12,029,038...12,108,495

G

twist family bHLH transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:19,761,041...19,765,665

angioimmunoblastic T-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tet methylcytosine dioxygenase 2

ClinVar Annotator: match by term: Angioimmunoblastic T-cell lymphoma

PMID:19797729 PMID:27210295 PMID:27276561 PMID:28337768 PMID:28492532 More...

NCBI chr 4:97,612,439...97,745,544
Ensembl chr 4:108,269,082...108,358,400

B-cell acute lymphoblastic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ERCC excision repair 4, endonuclease catalytic subunit

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:23623386 PMID:25741868

NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496

G

neurofibromin 1

ClinVar Annotator: match by term: Precursor B-cell acute lymphoblastic leukemia

PMID:9536098 PMID:17576681 PMID:23656349 PMID:25741868 PMID:28492532

NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295

G

WT1 transcription factor

ClinVar Annotator: match by term: B Acute Lymphoblastic Leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249

B-Cell Chronic Lymphocytic Leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (JR blood group)

susceptibility

DNA:SNPs,haplotype: :rs1481012,rs2231142(human)

NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157

G

acyl-CoA oxidase like

CTD Direct Evidence: marker/mechanism

NCBI chr2A:90,912,247...91,300,770
Ensembl chr2A:111,985,358...112,335,160

G

activation induced cytidine deaminase

disease_progression

NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917

G

apolipoprotein E

disease_progression

NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490

G

ATM serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041

G

BCL11 transcription factor A

DNA:translocation:5' utr: (human)

NCBI chr2A:60,552,908...60,655,437
Ensembl chr2A:61,695,613...61,795,800

G

BCL2 apoptosis regulator

severity
no_association
treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:B cell (human)
DNA:snp:promoter:g.-938C>A (human)

PMID:16960146 PMID:17296974 PMID:17959858 PMID:20001236 PMID:21750559 More...

RGD:11522735 RGD:11526104 RGD:11526105 RGD:11526110

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

Bcl2 modifying factor

CTD Direct Evidence: marker/mechanism

NCBI chr15:19,026,053...19,047,008
Ensembl chr15:37,281,655...37,302,075

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12068308 PMID:12198537 PMID:12692057 PMID:12960123 PMID:14612909 More...

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

G

Bruton tyrosine kinase

treatment

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:23045577 PMID:24869598 PMID:25741868 PMID:28492532

NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187

G

chromosome 9 C11orf21 homolog

CTD Direct Evidence: marker/mechanism

NCBI chr11:2,332,841...2,348,227
Ensembl chr11:2,361,217...2,367,568

G

Cbl proto-oncogene

severity

mRNA,protein:increased expression:CD5+ B cell:
DNA:hypophosphorylation:CD5+ B cell:

NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671

G

coiled-coil domain containing 50

NCBI chr 3:188,621,004...188,686,831
Ensembl chr 3:196,968,817...197,031,790

G

CD40 molecule

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

mouse-human chimeric gene in human

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD5 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr11:56,362,415...56,388,469
Ensembl chr11:59,801,808...59,826,448

G

CD79b molecule

protein:decreased expression:B lymphocyte, cell surface (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
DNA:polymorphism:multiple (human)

PMID:9269755 PMID:10090943 PMID:10552962

RGD:11250403 RGD:151665190 RGD:151665202

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

CD86 molecule

severity

protein:increased expression:peripheral blood mononuclear cell (human)

NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339

G

cytoplasmic polyadenylation element binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr15:62,949,264...63,053,994
Ensembl chr15:80,443,096...80,526,948

G

cytotoxic T-lymphocyte associated protein 4

protein:increased expression:T cell

PMID:15914560 PMID:16094420

RGD:11344923 RGD:11352246

NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498

G

dyskerin pseudouridine synthase 1

NCBI chr X:144,243,493...144,257,419
Ensembl chr X:154,084,412...154,098,475

G

DNA methyltransferase 3 beta

mRNA:decreased expression: B cell

NCBI chr20:29,049,993...29,096,957
Ensembl chr20:30,186,069...30,215,487

G

ERCC excision repair 2, TFIIH core complex helicase subunit

severity

DNA:SNP: :p.K751Q (rs13181) (human)

PMID:19484764 PMID:22739018

RGD:11252203 RGD:11252204

NCBI chr19:42,298,927...42,319,816
Ensembl chr19:50,897,004...50,915,819

G

FERM, ARH/RhoGEF and pleckstrin domain protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr2B:128,627,208...128,766,233
Ensembl chr2B:247,438,265...247,559,735

G

Fas cell surface death receptor

disease_progression

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:25741868 PMID:26619011

NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351

G

Fc gamma receptor IIIa

no_association

DNA:SNP:exon:p.F158V (rs396991) (human)

NCBI chr 1:137,027,943...137,036,738

G

GNAS complex locus

disease_progression

DNA:polymorphism:393T>C (human)

NCBI chr20:55,190,607...55,262,245

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078

G

intercellular adhesion molecule 1

severity

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interferon gamma

susceptibility

DNA:polymorphism: :847A>T(human)

NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829

G

interleukin 10

disease_progression
no_association

protein:increased expression:serum
DNA:SNPs: :rs1800890, rs4072227, rs17015865 (human)
DNA:SNPs: :multiple

PMID:10638947 PMID:19573080 PMID:22945689

RGD:11041895 RGD:11049165 RGD:11049174

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

interleukin 19

CTD Direct Evidence: marker/mechanism

NCBI chr 1:182,372,339...182,446,147
Ensembl chr 1:186,651,640...186,724,748

G

interleukin 1 alpha

NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801

G

interleukin 1 beta

severity

DNA:SNP:promoter:-511C>T (human)
protein:decreased expression:plasma:

PMID:10870116 PMID:18271063

RGD:11051967 RGD:11522755

NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424

G

interleukin 1 receptor antagonist

protein:decreased expression:plasma:

NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839

G

interleukin 6

protein:increased expression:plasma:
CTD Direct Evidence: marker/mechanism

PMID:10870116 PMID:18006695

NCBI chr 7:23,415,922...23,420,767

G

interferon regulatory factor 4

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:12079517 PMID:12393648 PMID:18758461

RGD:11526160 RGD:11530024

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

integrin subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203

G

killer cell lectin like receptor C4

CTD Direct Evidence: marker/mechanism

NCBI chr12:10,418,672...10,449,250
Ensembl chr12:10,697,454...10,699,818

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

lymphoid enhancer binding factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:100,552,959...100,674,156
Ensembl chr 4:111,125,312...111,245,980

G

phorbol-12-myristate-13-acetate-induced protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr18:53,286,590...53,290,913
Ensembl chr18:56,611,098...56,615,449

G

leukocyte immunoglobulin-like receptor subfamily A member 4

CTD Direct Evidence: marker/mechanism

NCBI chr19:51,287,944...51,294,118
Ensembl chr19:60,128,447...60,134,248

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr11:514,227...559,838
Ensembl chr11:575,495...588,750

G

membrane spanning 4-domains A1

NCBI chr11:55,691,750...55,706,697
Ensembl chr11:59,134,617...59,149,521

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585

G

purinergic receptor P2X 7

CTD Direct Evidence: marker/mechanism

NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068

G

platelet and endothelial cell adhesion molecule 1

severity

protein:increased expression:B cell (human)

NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067

G

phospholipase C gamma 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia

PMID:24869598 PMID:28492532

NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064

G

DNA polymerase beta

CTD Direct Evidence: marker/mechanism

NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464

G

protein phosphatase 2 regulatory subunit B'gamma

CTD Direct Evidence: marker/mechanism

NCBI chr14:82,383,086...82,549,822
Ensembl chr14:102,206,396...102,372,978

G

protein kinase D2

CTD Direct Evidence: marker/mechanism

NCBI chr19:43,666,591...43,710,858
Ensembl chr19:52,195,303...52,237,731

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:12161469 PMID:12717436 PMID:14644997 PMID:14982869 PMID:15385933 More...

NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762

G

glutaminyl-peptide cyclotransferase

CTD Direct Evidence: marker/mechanism

NCBI chr2A:37,371,848...37,400,820
Ensembl chr2A:38,136,532...38,165,254

G

RB transcriptional corepressor like 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:33,674,751...33,731,308
Ensembl chr16:52,759,290...52,816,175

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:23634996 PMID:25741868 PMID:26619011

NCBI chr2B:84,633,272...84,678,602
Ensembl chr2B:202,530,200...202,573,346

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr11:61,416,764...61,433,334
Ensembl chr11:64,743,629...64,759,772

G

SP140 nuclear body protein

CTD Direct Evidence: marker/mechanism

NCBI chr2B:117,477,923...117,565,367
Ensembl chr2B:236,279,460...236,366,314

G

telomerase reverse transcriptase

disease_progression

Ensembl chr 5:1,300,960...1,338,872

G

transferrin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998

G

thrombomodulin

NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812

G

tumor necrosis factor

disease_progression

protein:increased expression:bone marrow, blood, lymphocyte

PMID:12010662 PMID:22945689

RGD:10449463 RGD:11041895

NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381

G

TNF receptor superfamily member 10a

susceptibility

DNA:SNP: :1322A>G (human)
DNA:missense mutation:cds:p.E228A (c.683A>C) (human)

PMID:15531454 PMID:16217763

RGD:11038717 RGD:11038718

NCBI chr 8:22,440,502...22,476,790
Ensembl chr 8:19,378,547...19,414,724

G

TNF receptor superfamily member 11a

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,695,394...55,761,307
Ensembl chr18:59,034,770...59,075,044

G

TNF superfamily member 11

CTD Direct Evidence: marker/mechanism

NCBI chr13:23,750,835...23,784,740

G

TNF superfamily member 13

protein:increased expression:serum

NCBI chr17:7,589,931...7,593,527
Ensembl chr17:7,576,465...7,579,834

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822

G

DNA topoisomerase II binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363

G

tumor protein p53

disease_progression

DNA:deletion: :
ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia | ClinVar Annotator: match by term: Leukemia, B-cell, chronic

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1679237 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

vitamin D receptor

CTD Direct Evidence: marker/mechanism

NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192

G

exportin 1

ClinVar Annotator: match by term: Leukemia, B-cell, chronic

NCBI chr2A:61,562,372...61,622,841
Ensembl chr2A:62,698,935...62,757,793

G

X-ray repair cross complementing 1

severity
no_association

DNA:SNP: :p.R399Q (rs25487) (human)
DNA:SNP: :p.R194W (rs1799782), p.R280H (25489) (human)

NCBI chr19:40,485,052...40,522,188
Ensembl chr19:49,094,014...49,125,520

B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2 (JR blood group)

susceptibility

DNA:SNP: :rs6857600(human)

NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157

G

activation induced cytidine deaminase

NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917

G

BCL6 transcription repressor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124

G

bromodomain containing 2

NCBI chr 6:32,538,130...32,550,823
Ensembl chr 6:33,657,648...33,666,031

G

Bruton tyrosine kinase

treatment

human cell in a mouse model

PMID:25662332 PMID:28348046

RGD:11040764 RGD:124713554

NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187

G

chromobox 7

NCBI chr22:20,037,529...20,059,459
Ensembl chr22:37,854,056...37,876,084

G

CD40 molecule

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

colony stimulating factor 2

treatment

NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729

G

ELL associated factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:118,936,685...118,996,051
Ensembl chr 3:125,844,338...125,895,416

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

severity
treatment

PMID:23982173 PMID:29456795

RGD:10755356 RGD:126781726

NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

Ensembl chr16:27,774,864...27,821,769

G

Janus kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964

G

lysine acetyltransferase 5

severity

NCBI chr11:61,071,118...61,078,667
Ensembl chr11:64,404,572...64,412,667

G

galectin 1

protein:increased expression:primary tumor (rat)

NCBI chr22:18,593,154...18,597,432
Ensembl chr22:36,426,228...36,430,356

G

signal transducer and activator of transcription 5A

NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783

G

NRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519

G

protein tyrosine phosphatase non-receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:46,854,918...46,929,509
Ensembl chr20:47,983,098...48,057,421

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822

G

TNF superfamily member 9

NCBI chr19:5,558,021...5,562,901
Ensembl chr19:6,476,941...6,483,352

B-lymphoblastic leukemia/lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

treatment

NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171

G

aldo-keto reductase family 1 member C3

treatment

NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812

G

activating transcription factor 7 interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr12:14,373,084...14,504,286
Ensembl chr12:14,789,794...14,900,411

G

BCL2 like 1

severity

NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585

G

BCR activator of RhoGEF and GTPase

BCR/ABL fusion

G

bromodomain containing 2

NCBI chr 6:32,538,130...32,550,823
Ensembl chr 6:33,657,648...33,666,031

G

cellular communication network factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:129,729,572...129,733,113
Ensembl chr 6:133,836,319...133,842,077

G

cyclin D1

mRNA:increased expression:B cell (mouse)

NCBI chr11:64,737,006...64,750,353

G

cyclin dependent kinase inhibitor 2A

susceptibility
treatment

DNA:mutation:cds:c.442C>T,p.A148T,rs3731249 (human)

PMID:16618932 PMID:21622646 PMID:26104880

RGD:11057958 RGD:11251751 RGD:11251772

NCBI chr 9:21,803,862...21,831,322

G

cytochrome P450 family 3 subfamily A member 5

treatment

DNA:polymorphisms: :

NCBI chr 7:91,621,561...91,654,164
Ensembl chr 7:105,123,437...105,155,322

G

ETS variant transcription factor 6

CTD Direct Evidence: marker/mechanism

PMID:15217836 PMID:24413735 PMID:25807284

NCBI chr12:11,675,955...11,920,913
Ensembl chr12:11,844,939...12,179,537

G

coagulation factor XIII A chain

protein:increased expression:B lymphoblast:

NCBI chr 6:5,978,505...6,156,705
Ensembl chr 6:6,157,926...6,513,961

G

coagulation factor III, tissue factor

treatment

NCBI chr 1:97,190,381...97,203,076
Ensembl chr 1:95,918,502...95,931,050

G

fumarate hydratase

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr 1:217,059,847...217,081,795
Ensembl chr 1:222,041,142...222,064,212

G

fms related receptor tyrosine kinase 3

mRNA,protein:increased expression:bone marrow:

NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940

G

GATA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272

G

indoleamine 2,3-dioxygenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352

G

IKAROS family zinc finger 1

disease_progression

CTD Direct Evidence: marker/mechanism
DNA:mutations: :

PMID:22699455 PMID:24141364

NCBI chr 7:50,946,817...51,047,168
Ensembl chr 7:51,191,685...51,291,245

G

interleukin 5

NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675

G

interferon regulatory factor 4

PMID:20585039 PMID:21818355 PMID:25006123

RGD:11526159 RGD:11530020 RGD:11530030

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

interferon regulatory factor 8

NCBI chr16:66,568,370...66,591,949
Ensembl chr16:85,905,334...85,929,073

G

intestine specific homeobox

CTD Direct Evidence: marker/mechanism

NCBI chr22:16,071,117...16,095,029
Ensembl chr22:33,917,642...33,938,908

G

cytokine receptor like factor 2

CTD Direct Evidence: marker/mechanism

NCBI chr X:933,459...957,950

G

signal transducer and activator of transcription 5A

protein:increased phosphorylation:bone marrow (human)

NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783

G

MAX dimerization protein MGA

CTD Direct Evidence: marker/mechanism

NCBI chr15:20,560,842...20,710,269
Ensembl chr15:38,839,708...38,948,847

G

MYB proto-oncogene, transcription factor

disease_progression

mRNA:splice variants:cds:

NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194

G

MYC proto-oncogene, bHLH transcription factor

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

paired box 5

CTD Direct Evidence: marker/mechanism

PMID:24013638 PMID:30643249

NCBI chr 9:36,677,369...36,876,678
Ensembl chr 9:37,474,267...37,673,684

G

platelet derived growth factor receptor alpha

treatment

NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575

G

RUNX family transcription factor 1

onset

DNA:amplification

NCBI chr21:21,159,586...21,423,946
Ensembl chr21:34,530,956...34,788,544

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

serine/threonine kinase 11

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:26080840 PMID:26295973 PMID:28492532

Ensembl chr19:1,188,537...1,210,677

G

SUFU negative regulator of hedgehog signaling

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

PMID:25741868 PMID:28492532

NCBI chr10:99,107,516...99,231,761
Ensembl chr10:102,571,886...102,696,472

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

Ensembl chr19:1,582,297...1,622,025

G

tryptophan 2,3-dioxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266

G

tissue factor pathway inhibitor

treatment

NCBI chr2B:74,744,154...74,834,338
Ensembl chr2B:192,541,881...192,581,384

G

TNF superfamily member 13

NCBI chr17:7,589,931...7,593,527
Ensembl chr17:7,576,465...7,579,834

G

TNF superfamily member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822

G

tumor protein p53

disease_progression

DNA:mutations: :

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

WT1 transcription factor

ClinVar Annotator: match by term: Pre-B-cell acute lymphoblastic leukemia

PMID:8621495 PMID:12640141 PMID:16987884 PMID:25741868 PMID:28492532 More...

NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249

B-lymphoblastic leukemia/lymphoma MLL rearranged

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

WT1 transcription factor

ClinVar Annotator: match by term: Mixed phenotype acute leukemia with t(v;11q23.3)

NCBI chr11:32,349,807...32,398,494
Ensembl chr11:32,238,720...32,287,249

B-lymphoblastic leukemia/lymphoma with BCR-ABL1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mutS homolog 6

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1

PMID:22658618 PMID:25741868 PMID:28492532

NCBI chr2A:47,901,591...47,926,662
Ensembl chr2A:48,824,350...48,849,779

B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone morphogenetic protein receptor type 1A

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:30093976

NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912

G

partner and localizer of BRCA2

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532 PMID:33471991

NCBI chr16:14,470,367...14,507,841
Ensembl chr16:23,855,535...23,892,117

G

RB transcriptional corepressor 1

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:25741868 PMID:28492532

NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575

G

RecQ like helicase 4

ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

PMID:10678659 PMID:12734318 PMID:12838562 PMID:12952869 PMID:15897384 More...

Ensembl chr 8:144,267,101...144,276,985

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Cbl proto-oncogene

ClinVar Annotator: match by term: B lymphoblastic leukemia lymphoma with hyperdiploidy

PMID:24033266 PMID:25741868 PMID:28492532

NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671

B-lymphoblastic leukemia/lymphoma with hypodiploidy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

succinate dehydrogenase complex flavoprotein subunit A

ClinVar Annotator: match by term: B-lymphoblastic leukemia/lymphoma with hypodiploidy

PMID:25741868 PMID:28492532

Burkitt lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase (P1PK blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr22:23,587,378...23,615,467
Ensembl chr22:41,739,062...41,740,123

G

AT-rich interaction domain 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:25,960,868...26,047,057
Ensembl chr 1:27,018,616...27,103,239

G

BCL2 binding component 3

CTD Direct Evidence: marker/mechanism

NCBI chr19:44,203,517...44,215,860

G

BRCA1 DNA repair associated

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:17262179 PMID:25741868 PMID:26467025 PMID:28492532 PMID:31911673 More...

NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815

G

Bruton tyrosine kinase

ameliorates
treatment

Human cell line in a mouse model
mRNA:increased expression:multiple (human)

PMID:28474336 PMID:30546948

RGD:124713565 RGD:124715474

NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187

G

calreticulin

treatment

human cells and recombinant protein in a mouse model
human cell line and recombinant protein in a mouse model

PMID:9858521 PMID:10961892

RGD:150521687 RGD:150521702

NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416

G

chaperonin containing TCP1 subunit 6B

CTD Direct Evidence: marker/mechanism

NCBI chr17:21,825,636...21,875,619
Ensembl chr17:22,117,492...22,152,205

G

CD40 molecule

treatment

human cell line in a mouse model

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

formimidoyltransferase cyclodeaminase

CTD Direct Evidence: marker/mechanism

NCBI chr21:32,481,042...32,501,932
Ensembl chr21:45,734,825...45,753,400

G

G protein subunit alpha 13

CTD Direct Evidence: marker/mechanism

NCBI chr17:58,957,682...59,005,182

G

inhibitor of DNA binding 3

CTD Direct Evidence: marker/mechanism

PMID:23143595 PMID:23143597

NCBI chr 1:22,748,714...22,750,582
Ensembl chr 1:23,734,263...23,736,175

G

MLLT11 transcription factor 7 cofactor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:126,408,533...126,417,624

G

MYC proto-oncogene, bHLH transcription factor

ClinVar Annotator: match by term: Burkitt lymphoma

PMID:8220424 PMID:25157968 PMID:27993330

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

PBX homeobox 1

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

NCBI chr 1:139,985,392...140,311,845
Ensembl chr 1:143,778,701...144,104,797

G

pyruvate carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr11:62,205,644...62,317,917
Ensembl chr11:65,527,662...65,551,396

G

phosphoinositide-3-kinase regulatory subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960

G

ret proto-oncogene

CTD Direct Evidence: marker/mechanism

NCBI chr10:40,050,396...40,103,629
Ensembl chr10:43,249,468...43,284,331

G

spalt like transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr18:72,381,249...72,403,789

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

CTD Direct Evidence: marker/mechanism

NCBI chr19:10,515,216...10,616,155
Ensembl chr19:11,250,006...11,334,952

G

transcription factor 3

CTD Direct Evidence: marker/mechanism

PMID:1967982 PMID:17244677

Ensembl chr19:1,582,297...1,622,025

central nervous system lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bruton tyrosine kinase

ameliorates

NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187

G

CD79b molecule

treatment

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

interleukin 10

DNA:SNP:promoter:-1082G>A (human)

NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371

G

MYD88 innate immune signal transduction adaptor

treatment

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

childhood acute lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CCCTC-binding factor

disease_progression

mRNA, protein:increased expression:bone marrow, blood (human)

NCBI chr16:47,906,503...47,983,271
Ensembl chr16:67,302,952...67,372,041

chronic lymphocytic leukemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate kinase 3

protein:increased expression:peripheral blood mononuclear cell

NCBI chr 9:4,541,984...4,576,341
Ensembl chr 9:4,732,847...4,762,900

G

Rho GTPase activating protein 44

mRNA:increased expression: (human)

NCBI chr17:38,657,824...38,859,591
Ensembl chr17:43,357,438...43,453,457

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12068308 PMID:12198537 PMID:12960123 PMID:14612909 PMID:14679157 More...

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

G

CD40 ligand

protein:increased expression:serum (human)

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD79b molecule

protein:decreased expression:blood cells (human)
mRNA, protein:splice variants, alternative forms:exon 3 (human)
protein:decreased expression:blood, B cell (human)
protein:decreased expression:peripheral blood cells (human)

PMID:10090943 PMID:10329919 PMID:10516749 PMID:10753858

RGD:11531139 RGD:151665125 RGD:151665152 RGD:151665190

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

CD86 molecule

DNA:hypermethylation (human)

NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339

G

F-box and WD repeat domain containing 7

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:25741868 PMID:26619011

NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351

G

HRas proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078

G

interleukin 5

protein:increased expression:serum

NCBI chr 5:127,955,377...127,961,726
Ensembl chr 5:134,119,608...134,121,675

G

interferon regulatory factor 4

disease_progression

DNA:SNPs:3' utr:multiple
DNA:SNP: :rs872071 (human)
DNA:missense mutation:exon:p.L116R (human)

PMID:20090783 PMID:20123861 PMID:20731705 PMID:21791429 PMID:23897826 More...

RGD:11526156 RGD:11526158 RGD:11530021 RGD:11530026 RGD:11530029 RGD:11530031

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

KRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More...

NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12835555 PMID:16329078 PMID:16372351 PMID:16835863 PMID:17211612 More...

NCBI chr11:514,227...559,838
Ensembl chr11:575,495...588,750

G

MYC proto-oncogene, bHLH transcription factor

disease_progression

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

MYD88 innate immune signal transduction adaptor

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

G

NRAS proto-oncogene, GTPase

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

NCBI chr 1:87,837,146...87,850,013
Ensembl chr 1:122,890,505...122,903,585

G

paraoxonase 1

susceptibility

DNA:missense mutations:cds:p.L55M, p.Q192R (human)

NCBI chr 7:87,253,476...87,279,650
Ensembl chr 7:100,841,286...100,867,493

G

protein tyrosine phosphatase non-receptor type 11

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:12717436 PMID:14644997 PMID:15385933 PMID:15710330 PMID:15928039 More...

NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762

G

protein tyrosine phosphatase non-receptor type 22

susceptibility

protein:increased expression:B cell (human)
DNA:snp:cds:p.R620W (rs2476601) (human)

PMID:22569400 PMID:23287625

RGD:11533998 RGD:11535006

NCBI chr 1:88,685,736...88,743,164
Ensembl chr 1:123,734,511...123,790,830

G

splicing factor 3b subunit 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr2B:84,633,272...84,678,602
Ensembl chr2B:202,530,200...202,573,346

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr11:61,416,764...61,433,334
Ensembl chr11:64,743,629...64,759,772

G

signal transducer and activator of transcription 3

protein:increased phosphorylation:peripheral blood mononuclear cell

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

tumor protein p53

ClinVar Annotator: match by term: Chronic lymphatic leukemia

PMID:253702 PMID:1565143 PMID:1565144 PMID:1631137 PMID:1683921 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

exportin 1

ClinVar Annotator: match by term: Chronic lymphatic leukemia

NCBI chr2A:61,562,372...61,622,841
Ensembl chr2A:62,698,935...62,757,793

diffuse large B-cell lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238

G

ATP binding cassette subfamily G member 2 (JR blood group)

CTD Direct Evidence: marker/mechanism

NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157

G

ALK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr2A:29,196,195...29,930,062
Ensembl chr2A:29,276,041...30,006,735

G

beta-2-microglobulin

CTD Direct Evidence: marker/mechanism

NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991

G

BCAS2 pre-mRNA processing factor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:87,972,721...87,986,819
Ensembl chr 1:123,024,910...123,039,068

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

BCL6 transcription repressor

disease_progression

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

PMID:11821949 PMID:15701085

RGD:11530023 RGD:1600111

NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124

G

B-Raf proto-oncogene, serine/threonine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr 7:132,651,908...132,855,422
Ensembl chr 7:145,138,510...145,327,115

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9150172 PMID:18489799 PMID:20104584 PMID:21138478 PMID:22798144 More...

NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332

G

Bruton tyrosine kinase

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24869598 PMID:25082755 PMID:25189416 PMID:25741868 PMID:27199251 More...

NCBI chr X:90,551,874...90,588,786
Ensembl chr X:100,684,017...100,725,187

G

caspase recruitment domain family member 11

CTD Direct Evidence: marker/mechanism
DNA:missense mutations:exons:multiple (human)

PMID:18323416 PMID:25049379 PMID:26192916

NCBI chr 7:3,166,788...3,304,729
Ensembl chr 7:3,258,736...3,332,999

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160

G

coiled-coil domain containing 86

CTD Direct Evidence: marker/mechanism

NCBI chr11:56,105,239...56,114,322
Ensembl chr11:59,546,050...59,555,028

G

CD22 molecule

treatment

NCBI chr19:32,265,278...32,294,122
Ensembl chr19:41,012,222...41,030,713

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD79a molecule

CTD Direct Evidence: marker/mechanism

NCBI chr19:38,765,067...38,769,556
Ensembl chr19:47,270,377...47,274,711

G

CD79b molecule

treatment
severity

ClinVar Annotator: match by term: Diffuse large B cell lymphoma
DNA:missense mutation:multiple, exon 5 (human)

PMID:11160144 PMID:25708834 PMID:31402495 PMID:31609782

RGD:151665133 RGD:151665203

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

cyclin dependent kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:57,314,692...57,331,261
Ensembl chr10:59,647,993...59,664,434

G

cyclin dependent kinase inhibitor 2A

CTD Direct Evidence: marker/mechanism

NCBI chr 9:21,803,862...21,831,322

G

checkpoint kinase 2

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:16199547 PMID:21876083 PMID:24713400 PMID:28492532

NCBI chr22:9,757,038...9,811,171

G

clathrin heavy chain

CTD Direct Evidence: marker/mechanism

NCBI chr17:53,685,865...53,761,008
Ensembl chr17:58,529,750...58,603,636

G

CREB binding protein

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:24755471 PMID:28481359 PMID:30239046 PMID:33323405

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

G

dicer 1, ribonuclease III

disease_progression

NCBI chr14:75,709,029...75,780,779
Ensembl chr14:95,036,385...95,107,940

G

DNA methyltransferase 3 alpha

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:25363760 PMID:25741868 PMID:29900417 PMID:30478443 PMID:32581362 More...

NCBI chr2A:25,229,593...25,344,733
Ensembl chr2A:25,331,095...25,412,605

G

ETS variant transcription factor 6

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr12:11,675,955...11,920,913
Ensembl chr12:11,844,939...12,179,537

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

CTD Direct Evidence: marker/mechanism

PMID:20081860 PMID:28438623

NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612

G

forkhead box O1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:26314988 PMID:29721381 PMID:35079069

NCBI chr13:21,763,729...21,874,279

G

GLI family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chr12:31,453,759...31,466,194
Ensembl chr12:31,710,057...31,722,473

G

glutathione S-transferase mu 1

treatment

Ensembl chr 1:127,979,238...128,010,411

G

glutathione S-transferase pi 1

susceptibility

DNA:SNP: :(rs1695)(human)

NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472

G

intercellular adhesion molecule 1

disease_progression

proteion:increased expression:serum:

NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605

G

interleukin 21 receptor

diffuse large B-cell lymphoma DNA:translocation:promoter,CDS:t(3;16)(q27;p11) results in IL21R promoter fused to BCL6 coding region

Ensembl chr16:27,774,864...27,821,769

G

inner mitochondrial membrane peptidase subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chr 7:102,647,212...103,536,293

G

interferon regulatory factor 4

disease_progression

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

lysine methyltransferase 2D

CTD Direct Evidence: marker/mechanism

NCBI chr12:39,689,463...39,731,904
Ensembl chr12:40,575,083...40,608,661

G

low affinity immunoglobulin gamma Fc region receptor II-a

disease_progression

DNA:SNP: :rs1801274 (human)

NCBI chr 1:136,892,311...136,906,450

G

MALT1 paracaspase

CTD Direct Evidence: marker/mechanism

NCBI chr18:52,060,878...52,141,985
Ensembl chr18:55,395,462...55,473,574

G

marker of proliferation Ki-67

disease_progression

NCBI chr10:124,684,336...124,714,143
Ensembl chr10:128,936,037...128,962,555

G

methylenetetrahydrofolate reductase

susceptibility

DNA:transition, transversion, haplotype:cds:g.677C>T, g.1298A>C (human)

NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863

G

MYD88 innate immune signal transduction adaptor

severity

DNA:missense mutation:L265P (human)
ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21179087 PMID:22931316 PMID:23215570 PMID:23355535 PMID:26619011 More...

NCBI chr 3:38,036,565...38,041,014
Ensembl chr 3:38,319,024...38,323,572

G

nibrin

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9590180 PMID:16415040 PMID:28492532

NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307

G

nectin cell adhesion molecule 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:41,794,037...41,837,047
Ensembl chr19:50,399,668...50,443,024

G

neurofibromin 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21390130 PMID:22158541 PMID:23292937

NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295

G

NFKB inhibitor alpha

no_association

SNA:polymorphism(s)

NCBI chr14:16,155,331...16,158,588

G

nucleolar protein with MIF4G domain 1

CTD Direct Evidence: marker/mechanism

NCBI chr 7:148,568,075...148,588,155
Ensembl chr 7:160,262,174...160,282,110

G

3-phosphoinositide dependent protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:1,394,447...1,463,735

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

CTD Direct Evidence: marker/mechanism

NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984

G

PR/SET domain 1

disease_progression

NCBI chr 6:103,899,410...103,923,389
Ensembl chr 6:107,773,229...107,796,815

G

peroxiredoxin 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:115,738,346...115,749,482
Ensembl chr10:119,162,714...119,173,845

G

peroxiredoxin 4

CTD Direct Evidence: marker/mechanism

NCBI chr X:16,266,501...16,285,458
Ensembl chr X:23,641,701...23,660,267

G

protein arginine methyltransferase 5

CTD Direct Evidence: marker/mechanism

NCBI chr14:3,737,741...3,746,646
Ensembl chr14:21,836,984...21,846,018

G

phosphatase and tensin homolog

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:10468583 PMID:10555148 PMID:10698513 PMID:10866302 PMID:10866658 More...

NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605

G

Ran GTPase activating protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr22:22,142,644...22,199,268
Ensembl chr22:40,233,357...40,272,671

G

ribosomal protein S6 kinase B1

CTD Direct Evidence: marker/mechanism

NCBI chr17:53,958,807...54,014,752
Ensembl chr17:58,799,069...58,853,653

G

SEC31 homolog A, COPII coat complex component

CTD Direct Evidence: marker/mechanism

NCBI chr 4:41,312,389...41,384,924
Ensembl chr 4:47,173,348...47,235,812

G

splicing factor 3a subunit 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:22037554 PMID:26498691 PMID:33563892

NCBI chr22:11,369,772...11,392,998
Ensembl chr22:29,172,536...29,194,735

G

S-phase kinase associated protein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:74,179,608...74,211,563
Ensembl chr 5:79,461,018...79,492,311

G

SMAD specific E3 ubiquitin protein ligase 2

NCBI chr17:58,638,995...58,759,443
Ensembl chr17:63,731,386...63,809,298

G

suppressor of cytokine signaling 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:19734449 PMID:23296022 PMID:26336985 PMID:28302137 PMID:29625055

NCBI chr16:10,196,432...10,198,205

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960

G

superoxide dismutase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781

G

signal transducer and activator of transcription 3

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:21690253 PMID:22591296 PMID:22859607 PMID:23926297 PMID:25873174 More...

NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067

G

spleen associated tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chr 9:61,859,767...61,956,619
Ensembl chr 9:89,959,599...90,056,101

G

TBL1X/Y related 1

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:9450851 PMID:16492805 PMID:21156281 PMID:21156282 PMID:25741868 More...

NCBI chr 3:174,067,964...174,251,913
Ensembl chr 3:182,247,335...182,429,619

G

tumor protein p53

ClinVar Annotator: match by term: Diffuse large B cell lymphoma

PMID:1631137 PMID:1978757 PMID:8062826 PMID:8099841 PMID:8425176 More...

NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120

G

thioredoxin interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 1:121,763,312...121,767,468

Enteropathy-Associated T-Cell Lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

signal transducer and activator of transcription 5B

CTD Direct Evidence: marker/mechanism

NCBI chr17:15,040,303...15,116,682
Ensembl chr17:15,306,418...15,336,463

G

SET domain containing 2, histone lysine methyltransferase

DNA:mutations:multiple (human)

NCBI chr 3:46,916,615...47,064,046
Ensembl chr 3:48,018,517...48,163,999

extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: MALT lymphoma

PMID:9989495 PMID:10380920 PMID:10408400

NCBI chr 1:117,823,388...117,834,314

G

baculoviral IAP repeat containing 3

treatment

DNA:gene fusion: (human)

NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194

G

C-X-C motif chemokine receptor 4

protein:increased expression: mucosa-associated lymphoid tissue (human)

NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647

follicular lymphoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase H+ transporting accessory protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:143,870,421...143,878,288
Ensembl chr X:153,740,751...153,748,621

G

ATPase H+ transporting V1 subunit B2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,422,423...19,446,799
Ensembl chr 8:16,369,937...16,394,284

G

BCL10 immune signaling adaptor

ClinVar Annotator: match by term: Follicular lymphoma

NCBI chr 1:117,823,388...117,834,314

G

BCL2 apoptosis regulator

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:translocation: ;t(14;18)(q32;q21)

PMID:3287162 PMID:12855623 PMID:16671111

RGD:1599473 RGD:734639

NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100

G

CD40 molecule

susceptibility

DNA:SNP:5' utr:c.-1C>T (rs1883832) (human)

NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994

G

CD40 ligand

human gene in a mouse model

NCBI chr X:125,776,138...125,788,820
Ensembl chr X:136,042,849...136,058,202

G

CD79b molecule

treatment

human cells in mouse model

NCBI chr17:58,022,375...58,026,359
Ensembl chr17:63,116,722...63,120,335

G

CREB binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr16:2,645,445...2,800,975
Ensembl chr16:3,820,519...3,974,206

G

EBF transcription factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:154,091,337...154,492,474
Ensembl chr 5:160,708,235...161,108,568

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726

G

interferon regulatory factor 4

severity

NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654

G

3-ketodihydrosphingosine reductase

CTD Direct Evidence: marker/mechanism

PMID:8417785 PMID:25526675

NCBI chr18:56,686,914...56,727,681
Ensembl chr18:60,001,637...60,036,292

G

lysine methyltransferase 2D

CTD Direct Evidence: marker/mechanism

NCBI chr12:39,689,463...39,731,904
Ensembl chr12:40,575,083...40,608,661