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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sexual health disorder
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Accession:DOID:0060043 term browser browse the term
Definition:A disease of mental health that involves the impairment in normal sexual functioning. (DO)
Synonyms:exact_synonym: Frigidity;   Orgasmic Disorder;   Sexual Arousal Disorder;   Sexual Arousal Disorders;   Sexual Aversion Disorder;   orgasmic disorders;   sexual aversion disorders;   sexual disorder
 primary_id: MESH:D020018


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sexual health disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15890676 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12378847 PMID:17541852 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19295509 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9334596 PMID:15829128 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
premature ejaculation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IEP protein:decreased expression:raphe nuclei RGD PMID:34384732 RGD:597830150 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Tph2 tryptophan hydroxylase 2 treatment IEP mRNA, protein:decreased expression:raphe nuclei RGD PMID:34874128 PMID:34384732 RGD:597830146, RGD:597830150 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19134
    disease of anatomical entity 18447
      nervous system disease 14354
        central nervous system disease 12627
          brain disease 11847
            disease of mental health 8447
              sexual health disorder 8
                Gender Dysphoria 0
                Sexual and Gender Disorders 0
                ego-dystonic sexual orientation 0
                gender incongruence 0
                paraphilia disorder + 0
                premature ejaculation 2
                psychosexual disorder + 2
                sexual masochism 0
                sexual sadism 0
paths to the root