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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:mantle cell lymphoma
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Accession:DOID:0050746 term browser browse the term
Definition:A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. (DO)
Synonyms:exact_synonym: Centrocytic Small-Cell Lymphoma;   Diffuse Lymphocytic Lymphoma, Poorly Differentiated;   Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated;   Lymphoma, Lymphocytic, Intermediate;   Mantle Cell Lymphoma, Somatic;   Mantle Zone Lymphoma;   Mantle-Cell Lymphomas;   centrocytic small-cell lymphomas;   mantle-zone lymphomas
 narrow_synonym: Gastric Mantle Cell Lymphoma;   Splenic Mantle Cell Lymphoma
 primary_id: MESH:D020522
 xref: EFO:1000272;   EFO:1000549;   EFO:1001469;   GARD:6969;   ICDO:9673/3;   NCI:C187985;   NCI:C4337


show annotations for term's descendants           Sort by:
mantle cell lymphoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4930550C14Rik RIKEN cDNA 4930550C14 gene ISO ClinVar Annotator: match by term: Mantle cell lymphoma ClinVar PMID:10706620 PMID:28492532 NCBI chr 9:53,313,814...53,345,726
Ensembl chr 9:53,313,625...53,345,702 		JBrowse link
G Ak1 adenylate kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23676220 NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17488656 NCBI chr 3:121,746,752...121,810,326
Ensembl chr 3:121,746,190...121,810,402 		JBrowse link
G Atm ataxia telangiectasia mutated ISO ClinVar Annotator: match by term: Mantle cell lymphoma ClinVar PMID:10706620 PMID:23807571 PMID:25614872 PMID:28492532 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase treatment ISO RGD PMID:23045577 RGD:11040699 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Ccdc50 coiled-coil domain containing 50 ISO RGD PMID:19641524 RGD:9685139 NCBI chr16:27,205,815...27,270,968
Ensembl chr16:27,207,619...27,270,968 		JBrowse link
G Ccnd1 cyclin D1 ISO mRNA:increased expression:bone marrow, peripheral blood (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22383795 PMID:26174628 PMID:24060591 RGD:11352827 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd79b CD79B antigen treatment ISO protein:decreased expression:blood, B cell (human)
human cells in mouse model		 RGD PMID:10329919 PMID:17374736 RGD:11531139, RGD:151665154 NCBI chr11:106,202,167...106,205,388
Ensembl chr11:106,202,167...106,205,588 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18787224 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17148679 NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17148679 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18787224 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17148679 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:23676220 NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028 		JBrowse link
G Pramex1 PRAME like, X-linked 1 ISO protein:increased expression:mononuclear cell (human) RGD PMID:16620968 RGD:11535021 NCBI chr  X:134,513,662...134,528,437
Ensembl chr  X:134,513,751...134,528,454 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b susceptibility ISO DNA:missense mutation:cds:p.E228A (c.683A>C) (human)
DNA:SNP:exon:626C>G, 1322A>G (human)		 RGD PMID:16217763 PMID:15531454 RGD:11038717, RGD:11038718 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Wnt10a wingless-type MMTV integration site family, member 10A ISO CTD Direct Evidence: marker/mechanism CTD PMID:18787224 NCBI chr 1:74,831,178...74,843,335
Ensembl chr 1:74,830,675...74,843,338 		JBrowse link
G Wnt3 wingless-type MMTV integration site family, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18787224 NCBI chr11:103,665,000...103,708,854
Ensembl chr11:103,664,976...103,708,783 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16180
    disease of anatomical entity 15794
      hematopoietic system disease 3467
        leukocyte disease 1323
          B-cell lymphoma 349
            mantle cell lymphoma 18
Path 2
Term Annotations click to browse term
  disease 16180
    disease of cellular proliferation 7619
      cancer 5585
        organ system cancer 5352
          immune system cancer 643
            lymphatic system cancer 643
              lymphoma 555
                non-Hodgkin lymphoma 469
                  B-cell lymphoma 349
                    mantle cell lymphoma 18
paths to the root