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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:CD4-CD25+ splenocyte count
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Accession:CMO:0003542 term browser browse the term
Definition:The number of splenocytes expressing CD25 molecules, but not CD4 molecules on their surface in a specified sample of spleen tissue. The CD4 molecule acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD25 molecule (IL2RA) is normally an integral-membrane protein, but soluble IL2RA has been isolated and determined to result from extracellular proteolysis.


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Related Phenotype Data for Term "CD4-CD25+ splenocyte count" (CMO:0003542)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Term paths to the root
Path 1
Term Annotations click to browse term
  clinical measurement 2369
    cell measurement 24
      mononuclear cell measurement 7
        mononuclear cell count 7
          spleen mononuclear cell count 3
            CD4-CD25+ splenocyte count 0
Path 2
Term Annotations click to browse term
  clinical measurement 2369
    cell measurement 24
      immune cell measurement 16
        white blood cell measurement 15
          white blood cell count 15
            mononuclear cell count 7
              spleen mononuclear cell count 3
                CD4-CD25+ splenocyte count 0
paths to the root