concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) - Ontology Report

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CLINICAL MEASUREMENT - ANNOTATIONS

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Term:	concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)	go back to main search page
Accession:	CMO:0003413	browse the term
Definition:	A calculated value for the concentration of BAY 60-4552, a small molecule stimulator of soluble guanylate cyclase, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of BAY 60-4552 is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during BAY 60-4552-induced relaxation of the vessel wall (i.e. the maximum effect of BAY 60-4552 which is the minimum contractile energy).
Synonyms:	exact_synonym:	concentration of Nelociguat at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
	xref:	PMID:22783192

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Related Phenotype Data for Term "concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)" (CMO:0003413)

Rat Strains:

SHRSP/A3NCrl

Clinical Measurements:

concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

Experimental Conditions:

Measurement Methods:

tissue force analysis utilizing a force transducer

Term paths to the root

Path 1
Term	Annotations
clinical measurement	2369
chemical response/sensitivity measurement	0
BAY60-4552 response/sensitivity measurement	0
concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)	0
Path 2
Term	Annotations
clinical measurement	2369
cardiovascular measurement	610
blood vessel measurement	44
blood vessel dilation measurement	0
blood vessel dilation force reduction measurement	0
calculated blood vessel dilation force reduction measurement	0
concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)	0

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CLINICAL MEASUREMENT - ANNOTATIONS

Related Phenotype Data for Term "concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)" (CMO:0003413)