logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50) - Ontology Report

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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)	go back to main search page
Accession:	CMO:0001658	browse the term
Definition:	A calculated value for logarithm of the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
Synonyms:	related_synonym:	Ang2 Log half maximal effective concentration; AngII Log half maximal effective concentration; angiotensin 2 Log half maximal effective concentration; angiotensin II Log half maximal effective concentration (EC50)
	xref:	CHEBI:48432

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Related Phenotype Data for Term "logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)" (CMO:0001658)

Rat Strains:

Clinical Measurements:

logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)

Experimental Conditions:

Measurement Methods:

tissue force analysis utilizing a force transducer

Term paths to the root

Path 1
Term	Annotations
clinical measurement	2369
chemical response/sensitivity measurement	0
angiotensin II response/sensitivity measurement	0
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)	0
Path 2
Term	Annotations
clinical measurement	2369
cardiovascular measurement	610
blood vessel measurement	44
blood vessel constriction measurement	0
blood vessel contractile force measurement	0
calculated blood vessel contractile force measurement	0
logarithm of the concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (Log EC50)	0
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)	0

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CLINICAL MEASUREMENT - ANNOTATIONS

Related Phenotype Data for Term "logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)" (CMO:0001658)