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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50)
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Accession:CMO:0001657 term browser browse the term
Definition:A calculated value for the concentration of angiotensin II (AngII), the octapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, that is derived from angiotensinogen and acts as a powerful vasopressor and stimulator of aldosterone secretion, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of AngII is halfway between the baseline value and the highest achievable value of such AngII-induced contractile energy.
Synonyms:related_synonym: Ang2 half maximal effective concentration;   AngII half maximal effective concentration;   angiotensin 2 half maximal effective concentration;   angiotensin II half maximal effective concentration (EC50)
 xref: CHEBI:48432



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Path 1
Term Annotations click to browse term
  clinical measurement 0
    chemical response/sensitivity measurement 0
      angiotensin II response/sensitivity measurement 0
        concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50) 0
Path 2
Term Annotations click to browse term
  clinical measurement 0
    cardiovascular measurement 0
      blood vessel measurement 0
        blood vessel constriction measurement 0
          blood vessel contractile force measurement 0
            calculated blood vessel contractile force measurement 0
              concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50) 0
                concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (EC50) 0
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