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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
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Accession:CMO:0000722 term browser browse the term
Definition:A calculated value for logarithm of the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
Synonyms:exact_synonym: phenylephrine Log half maximal effective concentration (Log EC50)
 xref: CHEBI:8093


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Related Phenotype Data for Term "logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)" (CMO:0000722)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Term paths to the root
Path 1
Term Annotations click to browse term
  clinical measurement 2369
    chemical response/sensitivity measurement 0
      phenylephrine response/sensitivity measurement 0
        concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) 0
          logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) 0
Path 2
Term Annotations click to browse term
  clinical measurement 2369
    cardiovascular measurement 610
      blood vessel measurement 44
        blood vessel constriction measurement 0
          blood vessel contractile force measurement 0
            calculated blood vessel contractile force measurement 0
              concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50) 0
                concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) 0
                  logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) 0
paths to the root