concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) - Ontology Report

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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:	concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)	go back to main search page
Accession:	CMO:0000721	browse the term
Definition:	A calculated value for the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy.
Synonyms:	exact_synonym:	phenylephrine half maximal effective concentration (EC50)
	xref:	CHEBI:8093

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Related Phenotype Data for Term "concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)" (CMO:0000721)

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Clinical Measurements:

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

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Term paths to the root

Path 1
Term	Annotations
clinical measurement	2369
chemical response/sensitivity measurement	0
phenylephrine response/sensitivity measurement	0
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)	0
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)	0
Path 2
Term	Annotations
clinical measurement	2369
cardiovascular measurement	610
blood vessel measurement	44
blood vessel constriction measurement	0
blood vessel contractile force measurement	0
calculated blood vessel contractile force measurement	0
concentration of vasoconstrictor at which the force of blood vessel contraction is half the maximum value (EC50)	0
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)	0
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)	0

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CLINICAL MEASUREMENT - ANNOTATIONS

Related Phenotype Data for Term "concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)" (CMO:0000721)