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CLINICAL MEASUREMENT - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:dose of methacholine at which pulmonary conductance is half its pretreatment value
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Accession:CMO:0000713 term browser browse the term
Definition:The administered quantity of methacholine, a quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group and which acts as a parasympathomimetic bronchoconstrictor, at which the ability of the repiratory tract to allow airflow during breathing (inspration and expiration) is half its value in an untreated subject, or at which the resistance of the respiratory tract to airflow is doubled.
Synonyms:broad_synonym: methacholine median effective dose (ED50)
 xref: CHEBI:50142;   CHEBI:6804


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Related Phenotype Data for Term "dose of methacholine at which pulmonary conductance is half its pretreatment value" (CMO:0000713)

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Clinical Measurements:
Experimental Conditions:
Measurement Methods:
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  clinical measurement 2369
    chemical response/sensitivity measurement 0
      methacholine response/sensitivity measurement 0
        dose of methacholine at which pulmonary conductance is half its pretreatment value 0
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