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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Tylophorine
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Accession:CHEBI:9786 term browser browse the term
Definition:An organic heteropentacyclic compound that has formula C24H27NO4.
Synonyms:related_synonym: Formula=C24H27NO4;   InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1;   InChIKey=SSEUDFYBEOIWGF-AWEZNQCLSA-N;   SMILES=COc1cc2c3C[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2cc1OC
 xref: CAS:482-20-2;   KEGG:C10623;   KNApSAcK:C00002367
 xref_mesh: MESH:C004218


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Tylophorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog results in decreased phosphorylation of and results in decreased expression of AKT1 CTD PMID:19284764 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO tylophorine analog results in increased expression of BCL2L1 mRNA CTD PMID:19284764 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO tylophorine analog results in decreased expression of CCNA2 CTD PMID:19284764 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO tylophorine analog results in increased expression of CCNB1 protein CTD PMID:19284764 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO tylophorine analog results in increased expression of CCND1 protein CTD PMID:19284764 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO tylophorine analog results in increased expression of CDC25A CTD PMID:19284764 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tylophorine analog results in increased expression of CFLAR mRNA CTD PMID:19284764 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex increases activity ISO tylophorine analog results in increased activity of CHUK protein CTD PMID:19284764 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO tylophorine analog results in increased expression of IRAK1 mRNA CTD PMID:19284764 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO tylophorine analog results in increased expression of MAP3K14 mRNA CTD PMID:19284764 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO tylophorine analog results in increased expression of NFKBIA mRNA CTD PMID:19284764 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression ISO tylophorine analog results in increased expression of PIK3CD mRNA CTD PMID:19284764 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PPP3CA mRNA CTD PMID:19284764 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO tylophorine analog results in increased expression of PRKACA mRNA CTD PMID:19284764 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein CTD PMID:19284764 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein; tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein]; tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] CTD PMID:19284764 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          nitrogen atom 18974
            nitrogen molecular entity 18974
              organonitrogen compound 18827
                organonitrogen heterocyclic compound 18148
                  Tylophorine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heteropentacyclic compound 13566
                                      Tylophorine 17
paths to the root