Triptolide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Triptolide	go back to main search page
Accession:	CHEBI:9747	browse the term
Definition:	An oxacycle that has formula C20H24O6.
Synonyms:	related_synonym:	Formula=C20H24O6; InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1; InChIKey=DFBIRQPKNDILPW-CIVMWXNOSA-N; SMILES=CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O
	xref:	CAS:38748-32-2; KEGG:C09204; KNApSAcK:C00003494; LINCS:LSM-5518
	xref_mesh:	MESH:C001899
	xref:	Wikipedia:Triptolide

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Genes (1125)

Triptolide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aladin WD repeat nucleoporin

increases expression

triptolide results in increased expression of AAAS mRNA

NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961

G

arylacetamide deacetylase

decreases expression

triptolide results in decreased expression of AADAC mRNA

NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734

G

ATP binding cassette subfamily A member 4

increases expression

triptolide results in increased expression of ABCA4 mRNA

NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069

G

ATP binding cassette subfamily B member 11

increases expression
decreases expression
multiple interactions

triptolide results in increased expression of ABCB11 protein
triptolide results in decreased expression of ABCB11 mRNA
triptolide results in decreased expression of ABCB11 protein
[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein]

PMID:32519852 PMID:32987112 PMID:36328986 PMID:36990132

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases response to substance
increases expression
decreases expression

[ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde; ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]
ABCB1A protein results in decreased susceptibility to triptolide
triptolide results in increased expression of ABCB1A protein
triptolide results in decreased expression of ABCB1A protein

PMID:26134275 PMID:32519852 PMID:33600922

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

decreases expression
increases expression

triptolide results in decreased expression of ABCB1B mRNA
triptolide results in increased expression of ABCB1B mRNA

PMID:32835833 PMID:33600922

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

affects expression
decreases expression
multiple interactions

triptolide affects the expression of ABCC2 protein
triptolide results in decreased expression of ABCC2 protein
[triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 protein

PMID:36328986 PMID:36990132

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

increases expression
decreases expression

triptolide results in increased expression of ABCC4 mRNA
triptolide results in decreased expression of ABCC4 protein

PMID:32835833 PMID:36990132

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily D member 2

decreases expression

triptolide results in decreased expression of ABCD2 mRNA

NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642

G

ATP binding cassette subfamily G member 2

increases expression

triptolide results in increased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

triptolide results in increased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

increases expression

triptolide results in increased expression of ABHD5 mRNA

NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447

G

ankyrin repeat and BTB domain containing 2

increases expression

triptolide results in increased expression of ABTB2 mRNA

NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548

G

acetyl-Coenzyme A acyltransferase 1B

decreases expression

triptolide results in decreased expression of ACAA1B protein

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

acetyl-CoA carboxylase alpha

increases phosphorylation

triptolide results in increased phosphorylation of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA carboxylase beta

decreases expression

triptolide results in decreased expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

ATP citrate lyase

decreases expression

triptolide results in decreased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

acyl-CoA thioesterase 1

decreases expression
increases expression

triptolide results in decreased expression of ACOT1 mRNA
triptolide results in increased expression of ACOT1 protein

PMID:31241159 PMID:32519852

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA thioesterase 2

increases expression

triptolide results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 3

increases expression

triptolide results in increased expression of ACOT3 mRNA

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA thioesterase 9

increases expression

triptolide results in increased expression of ACOT9 mRNA

NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559

G

acyl-CoA oxidase 2

decreases expression
increases expression

triptolide results in decreased expression of ACOX2 mRNA
triptolide results in increased expression of ACOX2 protein

PMID:31241159 PMID:32519852

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acyl-CoA synthetase long-chain family member 5

decreases expression

triptolide results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase medium-chain family member 1

decreases expression

triptolide results in decreased expression of ACSM1 protein

NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495

G

acyl-CoA synthetase medium-chain family member 2

decreases expression

triptolide results in decreased expression of ACSM2 protein

NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116

G

acyl-CoA synthetase short-chain family member 2

decreases expression

triptolide results in decreased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin, beta

decreases expression

triptolide results in decreased expression of ACTB mRNA; triptolide results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

adenosine deaminase

increases expression

triptolide results in increased expression of ADA protein

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 11

decreases expression

triptolide results in decreased expression of ADAM11 mRNA

NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562

G

ADAM metallopeptidase domain 1a

increases expression

triptolide results in increased expression of ADAM1A mRNA

NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase domain 2

increases expression

triptolide results in increased expression of ADAM2 mRNA

NCBI chr15:40,242,651...40,284,025
Ensembl chr15:40,242,783...40,283,952

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

increases expression

triptolide results in increased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

adhesion G protein-coupled receptor E1

decreases expression
multiple interactions

triptolide results in decreased expression of ADGRE1 mRNA
STING1 protein affects the reaction [triptolide results in decreased expression of ADGRE1 mRNA]

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

adhesion G protein-coupled receptor F1

decreases expression

triptolide results in decreased expression of ADGRF1 mRNA

NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

triptolide results in decreased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

ADP-dependent glucokinase

increases expression

triptolide results in increased expression of ADPGK mRNA

PMID:23639586 PMID:32835833

NCBI chr 8:59,699,400...59,727,352
Ensembl chr 8:59,699,388...59,727,351

G

apoptosis enhancing nuclease

increases expression

triptolide results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

AFG2 AAA ATPase homolog A

increases expression

triptolide results in increased expression of AFG2A mRNA

NCBI chr 2:120,306,417...120,497,707
Ensembl chr 2:120,306,412...120,497,705

G

afamin

increases expression
decreases expression

triptolide results in increased expression of AFM protein
triptolide results in decreased expression of AFM mRNA

PMID:32519852 PMID:32835833

NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870

G

arylformamidase

decreases expression

triptolide results in decreased expression of AFMID mRNA

NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718

G

1-acylglycerol-3-phosphate O-acyltransferase 5

increases expression

triptolide results in increased expression of AGPAT5 mRNA

NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560

G

alkylglycerone phosphate synthase

increases expression

triptolide results in increased expression of AGPS protein

NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830

G

adenosylhomocysteinase

decreases expression

triptolide results in decreased expression of AHCY mRNA

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

apoptosis inducing factor, mitochondria associated 1

decreases expression

triptolide results in decreased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aldo-keto reductase family 1 member B1

increases expression

triptolide results in increased expression of AKR1B1 protein

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

decreases expression

triptolide results in decreased expression of AKR1B10 protein

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

decreases expression

triptolide results in decreased expression of AKR1C6 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 7, member A2

increases expression

triptolide results in increased expression of AKR7A2 protein

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
triptolide results in decreased phosphorylation of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased phosphorylation of AKT1 protein]

PMID:21717513 PMID:32061799

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression

triptolide results in decreased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

increases expression

triptolide results in increased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member L1

decreases expression

triptolide results in decreased expression of ALDH1L1 mRNA

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldolase, fructose-bisphosphate B

decreases expression

triptolide results in decreased expression of ALDOB mRNA

PMID:23639586 PMID:32835833

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression

triptolide results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alpha-methylacyl-CoA racemase

affects expression

triptolide affects the expression of AMACR protein

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

alpha-1-microglobulin/bikunin precursor

increases expression

triptolide results in increased expression of AMBP protein

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

anti-Mullerian hormone

increases expression

triptolide results in increased expression of AMH mRNA

NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282

G

ankyrin repeat and MYND domain containing 1

increases expression

triptolide results in increased expression of ANKMY1 mRNA

NCBI chr 9:93,423,664...93,476,651
Ensembl chr 9:93,423,963...93,477,236

G

ankyrin repeat domain 13a

increases expression

triptolide results in increased expression of ANKRD13A mRNA

NCBI chr12:41,798,196...41,828,327
Ensembl chr12:41,798,199...41,829,327

G

anoctamin 6

increases expression

triptolide results in increased expression of ANO6 protein

NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589

G

acidic nuclear phosphoprotein 32 family member E

increases expression

triptolide results in increased expression of ANP32E protein

NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054

G

alanyl aminopeptidase, membrane

affects expression

triptolide affects the expression of ANPEP protein

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A13

increases expression

triptolide results in increased expression of ANXA13 protein

NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907

G

annexin A9

increases expression

triptolide results in increased expression of ANXA9 mRNA

NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374

G

amine oxidase, copper containing 2, pseudogene 1

increases expression

triptolide results in increased expression of AOC2 mRNA

NCBI chr10:86,267,007...86,268,473

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

triptolide results in increased expression of APAF1 protein
NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]

PMID:25169008 PMID:26990902

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apurinic/apyrimidinic endodeoxyribonuclease 2

affects expression

triptolide affects the expression of APEX2 mRNA

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

apolipoprotein A1

increases expression

triptolide results in increased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

aquaporin 1

increases expression

triptolide results in increased expression of AQP1 protein

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 2

increases expression

triptolide results in increased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 4

decreases expression

triptolide results in decreased expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 8

decreases expression

triptolide results in decreased expression of AQP8 mRNA

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

G

activity-regulated cytoskeleton-associated protein

increases expression

triptolide results in increased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

arginine and glutamate rich 1

increases expression

triptolide results in increased expression of ARGLU1 protein

NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349

G

Rho guanine nucleotide exchange factor 16

decreases expression

triptolide results in decreased expression of ARHGEF16 mRNA

NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212

G

Rho guanine nucleotide exchange factor 37

decreases expression

triptolide results in decreased expression of ARHGEF37 mRNA

NCBI chr18:54,935,256...55,001,017
Ensembl chr18:54,949,110...55,000,669

G

AT-rich interaction domain 1A

increases expression

triptolide results in increased expression of ARID1A mRNA

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 5A

increases expression

triptolide results in increased expression of ARID5A mRNA

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

ADP-ribosylation factor like GTPase 8B

decreases expression

triptolide results in decreased expression of ARL8B protein

NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596

G

armadillo repeat containing 9

increases expression

triptolide results in increased expression of ARMC9 protein

NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860

G

arrestin, beta 1

increases expression

triptolide results in increased expression of ARRB1 protein

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

achaete-scute family bHLH transcription factor 3

increases expression

triptolide results in increased expression of ASCL3 mRNA

NCBI chr 1:163,755,306...163,755,951
Ensembl chr 1:163,754,956...163,759,682

G

asialoglycoprotein receptor 1

decreases expression

triptolide results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

argininosuccinate lyase

decreases expression

triptolide results in decreased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

triptolide results in increased expression of ASNS protein

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

decreases expression

triptolide results in decreased expression of ASS1 protein
triptolide results in decreased expression of ASS1 mRNA

PMID:32519852 PMID:32835833

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 3

increases expression

triptolide results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

decreases expression
multiple interactions
increases expression

triptolide results in decreased expression of ATF4 mRNA
STING1 protein affects the reaction [triptolide results in increased expression of ATF4 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of ATF4 mRNA]
triptolide results in increased expression of ATF4 mRNA; triptolide results in increased expression of ATF4 protein

PMID:23639586 PMID:36520315

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 5

decreases expression

triptolide results in decreased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

activating transcription factor 6

decreases expression
increases expression
multiple interactions

triptolide results in decreased expression of ATF6 protein
triptolide results in increased expression of ATF6 mRNA
STING1 protein affects the reaction [triptolide results in increased expression of ATF6 mRNA]; STING1 protein affects the reaction [triptolide results in increased expression of ATF6 protein]

PMID:26990902 PMID:36520315

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

activating transcription factor 6 beta

decreases expression

triptolide results in decreased expression of ATF6B protein

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

autophagy related 12

increases expression

triptolide results in increased expression of ATG12 protein

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 5

increases expression

triptolide results in increased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

increases expression

triptolide results in increased expression of ATG7 protein

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATPase phospholipid transporting 11A

increases expression

triptolide results in increased expression of ATP11A protein

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

G

ATP synthase F1 subunit alpha

multiple interactions
decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]
triptolide results in decreased expression of ATP5F1A mRNA; triptolide results in decreased expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit epsilon

decreases expression

triptolide results in decreased expression of ATP5F1E protein

NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450

G

ATP synthase membrane subunit c locus 3

increases expression

triptolide results in increased expression of ATP5MC3 protein

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase membrane subunit e

increases expression

triptolide results in increased expression of ATP5ME protein

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit j, pseudogene 1

decreases expression

triptolide results in decreased expression of ATP5MJ protein

NCBI chr 1:168,472,019...168,472,630
Ensembl chr 1:168,472,329...168,472,610

G

ATPase H+ transporting V0 subunit a1

increases expression

triptolide results in increased expression of ATP6V0A1 protein

NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895

G

ATPase H+ transporting V0 subunit a4

increases expression

triptolide results in increased expression of ATP6V0A4 protein

NCBI chr 4:66,760,163...66,842,126
Ensembl chr 4:66,760,159...66,842,110

G

ATPase H+ transporting V0 subunit C

increases expression

triptolide results in increased expression of ATP6V0C protein

NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500

G

ATPase H+ transporting V0 subunit D1

increases expression

triptolide results in increased expression of ATP6V0D1 protein

NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450

G

ATPase, class I, type 8B, member 5

increases expression

triptolide results in increased expression of ATP8B5 mRNA

NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056

G

beta-1,4-galactosyltransferase 1

increases expression

triptolide results in increased expression of B4GALT1 mRNA

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

BAG cochaperone 3

increases expression

triptolide results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BAI1-associated protein 3

increases expression

triptolide results in increased expression of BAIAP3 mRNA

NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein]
TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAK1 protein]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
affects expression

NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]; Quercetin inhibits the reaction [triptolide affects the expression of BAX protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of BAX protein]
ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]; mitoquinone inhibits the reaction [triptolide results in increased expression of BAX protein]; tariquidar promotes the reaction [triptolide results in increased expression of BAX protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAX protein]
triptolide results in increased expression of BAX mRNA; triptolide results in increased expression of BAX protein

PMID:25169008 PMID:26134275 PMID:26277538 PMID:26990902 PMID:30009776 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

triptolide results in increased expression of BBC3 protein

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
affects expression
increases expression

triptolide results in decreased expression of BCL2 protein
Lithium Chloride inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [triptolide affects the expression of BCL2 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; tariquidar promotes the reaction [triptolide results in decreased expression of BCL2 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
triptolide results in increased expression of BCL2 protein

PMID:25169008 PMID:26134275 PMID:26277538 PMID:26990902 PMID:30009776 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions
decreases expression

triptolide results in increased expression of BCL2L1 protein
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]
TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]

PMID:26990902 PMID:30009776

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 14

increases expression

triptolide results in increased expression of BCL2L14 mRNA

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

triptolide results in decreased expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

G

beclin 1

increases expression

triptolide results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

beaded filament structural protein 1

increases expression

triptolide results in increased expression of BFSP1 mRNA

NCBI chr 3:131,195,087...131,252,668
Ensembl chr 3:131,195,087...131,229,337

G

basic helix-loop-helix family, member e40

decreases expression

triptolide results in decreased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

BH3 interacting domain death agonist

increases expression

triptolide results in increased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 3

decreases expression

triptolide results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

biliverdin reductase A

affects expression

triptolide affects the expression of BLVRA protein

NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033

G

Bcl2 modifying factor

decreases expression

triptolide results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BOP1 ribosomal biogenesis factor

increases expression

triptolide results in increased expression of BOP1 mRNA

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

barttin CLCNK type accessory subunit beta

decreases expression

triptolide results in decreased expression of BSND protein

NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571

G

bone marrow stromal cell antigen 2

increases expression

triptolide results in increased expression of BST2 protein

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

B-TFIID TATA-box binding protein associated factor 1

increases expression

triptolide results in increased expression of BTAF1 mRNA

NCBI chr 1:234,653,219...234,743,903
Ensembl chr 1:234,653,156...234,743,903

G

BTB domain containing 10

increases expression

triptolide results in increased expression of BTBD10 mRNA

NCBI chr 1:167,431,311...167,489,320
Ensembl chr 1:167,431,329...167,489,916

G

BTG anti-proliferation factor 3

increases expression

triptolide results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

butyrophilin-like 9

increases expression

triptolide results in increased expression of BTNL9 mRNA

NCBI chr10:33,466,059...33,489,229
Ensembl chr10:33,470,536...33,489,025

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression
increases expression

triptolide results in decreased expression of BUB1 mRNA
triptolide results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

triptolide results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

BUB3 mitotic checkpoint protein

decreases expression

triptolide results in decreased expression of BUB3 mRNA

NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036

G

similar to human chromosome 21 open reading frame 91

increases expression

triptolide results in increased expression of D16ERTD472E mRNA

NCBI chr11:17,229,129...17,262,307
Ensembl chr11:17,229,138...17,262,483

G

complement C1q A chain

increases expression

triptolide results in increased expression of C1QA protein

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C3

increases expression

triptolide results in increased expression of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C4A

increases expression

triptolide results in increased expression of C4A protein

NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080

G

ciliary associated calcium binding coiled-coil 1

decreases expression

triptolide results in decreased expression of CABCOCO1 mRNA

NCBI chr20:20,058,492...20,167,973
Ensembl chr20:20,058,454...20,167,725

G

calcium binding tyrosine phosphorylation regulated

increases expression

triptolide results in increased expression of CABYR mRNA

NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840

G

caldesmon 1

decreases expression

triptolide results in decreased expression of CALD1 protein

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin binding transcription activator 2

increases expression

triptolide results in increased expression of CAMTA2 mRNA

NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558

G

capping actin protein, gelsolin like

increases expression

triptolide results in increased expression of CAPG protein

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calpain 1

increases expression

triptolide results in increased expression of CAPN1 protein

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

increases expression

triptolide results in increased expression of CAPN2 protein

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

calcyphosine

increases expression

triptolide results in increased expression of TNFRSF23 mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 1

increases expression

triptolide results in increased expression of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 14

decreases expression

triptolide results in decreased expression of CAR14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

carbonic anhydrase 3

increases expression

triptolide results in increased expression of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

carbonic anhydrase 9

multiple interactions

triptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

calcium responsive transcription factor

increases expression

triptolide results in increased expression of CARF mRNA

NCBI chr 9:61,502,368...61,552,433
Ensembl chr 9:61,506,956...61,550,462

G

calcium regulated heat stable protein 1

decreases expression

triptolide results in decreased expression of CARHSP1 protein

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

capping protein regulator and myosin 1 linker 1

decreases expression

triptolide results in decreased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

capping protein regulator and myosin 1 linker 2

increases expression

triptolide results in increased expression of RLTPR mRNA

NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965

G

caspase 1

multiple interactions

[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

increases expression

triptolide results in increased expression of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; TP53 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased activity of and results in increased cleavage of CASP3 protein
triptolide results in increased activity of CASP3 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP3 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]; mitoquinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; TRAJ18 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased expression of and results in increased activity of CASP3 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]

PMID:12533674 PMID:15972136 PMID:19233258 PMID:21640813 PMID:23639586 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein; GW 4064 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein]

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases activity
increases expression

triptolide results in increased activity of CASP7 protein
triptolide results in increased expression of CASP7 protein

PMID:21640813 PMID:32519852

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form; triptolide results in increased expression of and results in increased activity of CASP8 protein

PMID:26990902 PMID:30633930

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity
increases expression
increases cleavage

pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP9 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
triptolide results in increased expression of and results in increased activity of CASP9 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
triptolide results in increased cleavage of CASP9 protein

PMID:26277538 PMID:26990902 PMID:30009776 PMID:32835833

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytosolic arginine sensor for mTORC1 subunit 1

increases expression

triptolide results in increased expression of CASTOR1 protein

NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548

G

catalase

decreases activity
multiple interactions

triptolide results in decreased activity of CAT protein
Chlormethiazole inhibits the reaction [triptolide results in decreased activity of CAT protein]; pyrazole promotes the reaction [triptolide results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

triptolide results in increased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CACN subunit beta associated regulatory protein

increases expression

triptolide results in increased expression of CBARP mRNA

NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204

G

Cbl proto-oncogene C

decreases expression

triptolide results in decreased expression of CBLC mRNA

NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755

G

carbonyl reductase 3

increases expression

triptolide results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

coiled-coil domain containing 120

increases expression

triptolide results in increased expression of CCDC120 mRNA

NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743

G

coiled-coil domain containing 15

increases expression

triptolide results in increased expression of CCDC15 mRNA

NCBI chr 8:36,991,147...37,068,849
Ensembl chr 8:36,998,867...37,068,919

G

coiled-coil domain containing 180

increases expression

triptolide results in increased expression of CCDC180 mRNA

NCBI chr 5:60,154,883...60,223,508
Ensembl chr 5:60,154,910...60,223,522

G

coiled-coil domain containing 196

increases expression

triptolide results in increased expression of CCDC196 protein

NCBI chr 6:96,913,960...96,939,415
Ensembl chr 6:96,915,869...96,931,141

G

coiled-coil domain containing 62

increases expression

triptolide results in increased expression of CCDC62 mRNA

NCBI chr12:32,623,170...32,659,912
Ensembl chr12:32,623,170...32,660,017

G

coiled-coil domain containing 86

increases expression

triptolide results in increased expression of CCDC86 mRNA

NCBI chr 1:207,590,167...207,596,547
Ensembl chr 1:207,590,168...207,596,544

G

C-C motif chemokine ligand 11

increases expression
multiple interactions

triptolide results in increased expression of CCL11 mRNA
IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

triptolide promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
triptolide results in increased expression of CCL2 mRNA

PMID:30633930 PMID:32835833

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A1

decreases expression

triptolide results in decreased expression of CCNA1 protein

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

increases expression

triptolide results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression
decreases expression

triptolide results in increased expression of CCNB1 mRNA
triptolide results in decreased expression of CCNB1 protein

PMID:12533674 PMID:23639586

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

triptolide results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression

triptolide results in decreased expression of CCND1 mRNA
triptolide results in decreased expression of CCND1 protein

PMID:12533674 PMID:23639586 PMID:26990902

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

increases expression

triptolide results in increased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

increases expression

triptolide results in increased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

increases expression

triptolide results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G1

increases expression

triptolide results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD1d1 molecule

increases expression
multiple interactions

triptolide results in increased expression of CD1D1 protein
STING1 protein affects the reaction [triptolide results in increased expression of CD1D1 protein]

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

CD24 molecule

multiple interactions

triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD24 protein]

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD36 molecule

increases expression

triptolide results in increased expression of CD36 protein

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions
affects expression

STING1 protein affects the reaction [triptolide affects the expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

multiple interactions

triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD44 protein]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd47 molecule

increases expression

triptolide results in increased expression of CD47 protein

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CD59b molecule

increases expression

triptolide results in increased expression of CD59 protein

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

Cd68 molecule

multiple interactions
decreases expression

STING1 protein affects the reaction [triptolide results in decreased expression of CD68 mRNA]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd69 molecule

multiple interactions
increases expression

STING1 protein affects the reaction [triptolide results in increased expression of CD69 protein]

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

Cd80 molecule

multiple interactions

triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

multiple interactions
increases expression

triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein]
triptolide results in increased expression of CD86 protein

PMID:15663903 PMID:36520315

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 16

decreases expression

triptolide results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 25B

increases expression

triptolide results in increased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 42

decreases expression

triptolide results in decreased expression of CDC42 mRNA; triptolide results in decreased expression of CDC42 protein

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cell division cycle 45

increases expression

triptolide results in increased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cyclin-dependent kinase 1

increases expression
decreases expression

triptolide results in increased expression of CDK1 mRNA
triptolide results in decreased expression of CDK1 protein

PMID:12533674 PMID:23639586

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression
increases expression

triptolide results in decreased expression of CDK2 mRNA
triptolide results in increased expression of CDK2 protein
triptolide results in decreased expression of CDK2 protein

PMID:12533674 PMID:23639586 PMID:26990902

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

increases expression

triptolide results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

increases expression

triptolide results in increased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 7

increases expression

triptolide results in increased expression of CDK7 mRNA

NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase-like 3

increases expression

triptolide results in increased expression of CDKL3 mRNA

NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268

G

cyclin-dependent kinase inhibitor 1A

increases expression
affects expression
multiple interactions

triptolide results in increased expression of CDKN1A mRNA
triptolide results in increased expression of CDKN1A mRNA; triptolide results in increased expression of CDKN1A protein
triptolide affects the expression of CDKN1A protein
NFE2L2 protein inhibits the reaction [triptolide affects the expression of CDKN1A protein]; sulforaphane inhibits the reaction [triptolide affects the expression of CDKN1A protein]

PMID:23639586 PMID:26990902 PMID:32835833 PMID:36990132

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

triptolide results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2C

increases expression

triptolide results in increased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cerebral dopamine neurotrophic factor

increases expression

triptolide results in increased expression of CDNF mRNA

NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639

G

centrosomal protein 170B

increases expression

triptolide results in increased expression of CEP170B mRNA

NCBI chr 6:131,780,935...131,806,658
Ensembl chr 6:131,778,957...131,806,658

G

centrosomal protein 63

increases expression

triptolide results in increased expression of CEP63 mRNA

NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177

G

carboxylesterase 1D

increases expression

triptolide results in increased expression of CES1D protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 4A

decreases expression

triptolide results in decreased expression of CES4A mRNA

NCBI chr19:33,011,731...33,030,119
Ensembl chr19:33,011,731...33,029,545

G

CFAP20 domain containing

decreases expression

triptolide results in decreased expression of CFAP20DC mRNA

NCBI chr15:16,231,248...16,476,978
Ensembl chr15:16,231,299...16,476,977

G

complement factor B

decreases expression

triptolide results in decreased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

complement factor H

increases expression
decreases expression

triptolide results in increased expression of CFH protein
triptolide results in decreased expression of CFH mRNA

PMID:32519852 PMID:32835833

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

cofilin 2

increases expression

triptolide results in increased expression of CFL2 protein

NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674

G

cyclic GMP-AMP synthase

increases expression

triptolide results in increased expression of CGAS mRNA; triptolide results in increased expression of CGAS protein

NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496

G

coiled-coil-helix-coiled-coil-helix domain containing 3

increases expression

triptolide results in increased expression of CHCHD3 protein

NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

triptolide results in increased expression of CHCHD6 protein

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

choline kinase alpha

increases expression

triptolide results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

cholinergic receptor nicotinic alpha 4 subunit

decreases expression

triptolide results in decreased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

circadian associated repressor of transcription

decreases expression

triptolide results in decreased expression of CIART mRNA

NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313

G

cell death-inducing DFFA-like effector c

increases expression

triptolide results in increased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

ciliary microtubule associated protein 1B

decreases expression

triptolide results in decreased expression of CIMAP1B mRNA

NCBI chr 7:120,444,232...120,447,294
Ensembl chr 7:120,444,232...120,446,749

G

cytoskeleton associated protein 2

increases expression

triptolide results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

cardiotrophin-like cytokine factor 1

increases expression

triptolide results in increased expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

chloride voltage-gated channel Kb

increases expression

triptolide results in increased expression of CLCNKB protein

NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153

G

claudin 11

decreases expression
multiple interactions

triptolide results in decreased expression of CLDN11 mRNA; triptolide results in decreased expression of CLDN11 protein
mitoquinone inhibits the reaction [triptolide results in decreased expression of CLDN11 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of CLDN11 protein]

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

C-type lectin domain containing 11A

increases expression

triptolide results in increased expression of CLEC11A mRNA

NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633

G

calmin

decreases expression

triptolide results in decreased expression of CLMN mRNA

NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

affects expression

triptolide affects the expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

clusterin

increases expression

triptolide results in increased expression of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

clusterin associated protein 1

increases expression

triptolide results in increased expression of CLUAP1 mRNA

NCBI chr10:11,587,963...11,619,711
Ensembl chr10:11,588,017...11,619,711

G

cytidine monophospho-N-acetylneuraminic acid hydroxylase

decreases expression

triptolide results in decreased expression of CMAH mRNA

NCBI chr17:40,557,161...40,642,350
Ensembl chr17:40,583,667...40,642,275

G

cytidine/uridine monophosphate kinase 2

increases expression

triptolide results in increased expression of CMPK2 protein

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

triptolide results in decreased expression of CNBP protein

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

2',3'-cyclic nucleotide 3' phosphodiesterase

increases expression
decreases expression

triptolide results in increased expression of CNP protein
triptolide results in decreased expression of CNP mRNA

PMID:32519852 PMID:32835833

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

component of oligomeric golgi complex 5

decreases expression

triptolide results in decreased expression of COG5 protein

NCBI chr 6:48,242,470...48,545,185
Ensembl chr 6:48,242,482...48,529,009

G

collagen type XI alpha 2 chain

increases expression

triptolide results in increased expression of COL11A2 mRNA

NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985

G

collagen type XII alpha 1 chain

increases expression

triptolide results in increased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type XX alpha 1 chain

increases expression

triptolide results in increased expression of COL20A1 mRNA

NCBI chr 3:168,102,475...168,134,759
Ensembl chr 3:168,084,560...168,135,309

G

collagen type VII alpha 1 chain

increases expression

triptolide results in increased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

catechol-O-methyltransferase

decreases expression

triptolide results in decreased expression of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

increases expression

triptolide results in increased expression of CP protein

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carbamoyl-phosphate synthase 1

decreases expression

triptolide results in decreased expression of CPS1 mRNA

NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033

G

cleavage and polyadenylation specific factor 2

decreases expression

triptolide results in decreased expression of CPSF2 protein

NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921

G

carnitine palmitoyltransferase 1A

increases expression

triptolide results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 1B

decreases expression

triptolide results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 2

decreases expression

triptolide results in decreased expression of CPT2 mRNA

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cereblon

increases expression

triptolide results in increased expression of CRBN protein

NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938

G

cAMP responsive element binding protein 3-like 4

increases expression

triptolide results in increased expression of CREB3L4 mRNA

NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932

G

cAMP responsive element modulator

decreases expression

triptolide results in decreased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cysteine-rich protein 2

increases expression

triptolide results in increased expression of CRIP2 mRNA

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065

G

CRK proto-oncogene, adaptor protein

decreases expression
increases expression

triptolide results in decreased expression of CRK mRNA
triptolide results in increased expression of CRK mRNA

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

C-reactive protein

increases expression
decreases expression

triptolide results in increased expression of CRP protein
triptolide results in decreased expression of CRP mRNA

PMID:32519852 PMID:32835833

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cryptochrome circadian regulator 1

increases expression

triptolide results in increased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

crystallin, alpha B

increases expression

triptolide results in increased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

chondroitin sulfate proteoglycan 5

decreases expression

triptolide results in decreased expression of CSPG5 mRNA

NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758

G

cardiotrophin 1

decreases expression

triptolide results in decreased expression of CTF1 mRNA

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

CTP synthase 1

increases expression

triptolide results in increased expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

C-X-C motif chemokine ligand 11

affects expression

triptolide affects the expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 2

increases expression
multiple interactions

triptolide results in increased expression of CXCL2 mRNA
IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; triptolide inhibits the reaction [Chlorine results in increased expression of CXCL1 protein]

PMID:20348278 PMID:24949944

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

decreases expression

triptolide results in decreased expression of CXCR4 protein

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b5 reductase 3

decreases expression

triptolide results in decreased expression of CYB5R3 mRNA

NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298

G

cytochrome c, somatic

multiple interactions
affects localization

TRAJ18 protein affects the reaction [triptolide affects the localization of CYCS protein]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide affects the localization of CYCS protein]

PMID:31557070 PMID:36520315

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression

triptolide results in decreased expression of and results in decreased activity of CYP11A1 protein
triptolide results in decreased expression of CYP11A1 mRNA
[Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA

PMID:22592319 PMID:31557376

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

[Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

[Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions
decreases expression

[Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA
triptolide results in decreased expression of CYP17A1 mRNA

PMID:31557376 PMID:32835833

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 26, subfamily a, polypeptide 1

affects expression

triptolide affects the expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

triptolide results in decreased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

triptolide results in increased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 1

multiple interactions

TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP2A1 mRNA]

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 3

decreases expression

triptolide results in decreased expression of CYP2A4 mRNA

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression

triptolide results in decreased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases expression

TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP2B10 mRNA]

PMID:32835833 PMID:32987112

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

triptolide results in decreased expression of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression

triptolide results in decreased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases expression

triptolide results in decreased expression of CYP2C8 protein

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

triptolide results in increased expression of CYP2E1 mRNA; triptolide results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 39, subfamily a, polypeptide 1

decreases expression

triptolide results in decreased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
decreases expression

CYP3A2 affects the metabolism of triptolide
triptolide results in decreased expression of CYP3A4 protein

PMID:20223271 PMID:33600922

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression
decreases activity

triptolide results in decreased expression of CYP3A23-3A1 mRNA
triptolide results in decreased activity of CYP3A23-3A1 protein

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

triptolide results in decreased expression of CYP4F14 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 51

decreases expression

triptolide results in decreased expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions
decreases expression

[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP7A1 mRNA]

PMID:32987112 PMID:36328986

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions
decreases expression

[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP8B1 protein; TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP8B1 mRNA]

PMID:32835833 PMID:32987112 PMID:36328986

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

D-box binding PAR bZIP transcription factor

decreases expression

triptolide results in decreased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

doublecortin-like kinase 3

decreases expression

triptolide results in decreased expression of DCLK3 mRNA

NCBI chr 8:111,401,544...111,453,999
Ensembl chr 8:111,401,358...111,453,999

G

DNA damage-induced apoptosis suppressor

increases expression

triptolide results in increased expression of DDIAS mRNA

NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

triptolide results in increased expression of DDIT3 mRNA; triptolide results in increased expression of DDIT3 protein
STING1 protein affects the reaction [triptolide results in increased expression of DDIT3 mRNA]; STING1 protein affects the reaction [triptolide results in increased expression of DDIT3 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of DDIT3 mRNA]

PMID:26990902 PMID:27022166 PMID:36520315

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4-like

increases expression

triptolide results in increased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DDRGK domain containing 1

decreases expression

triptolide results in decreased expression of DDRGK1 protein

NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680

G

DEAD-box helicase 17

increases expression

triptolide results in increased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

defensin beta 1

decreases expression

triptolide results in decreased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

DENN domain containing 1A

increases expression

triptolide results in increased expression of DENND1A protein

NCBI chr 3:21,564,749...22,052,057
Ensembl chr 3:21,564,749...22,052,062

G

DEPP autophagy regulator 1

decreases expression

triptolide results in decreased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

desmin

multiple interactions

triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

D-glutamate cyclase

decreases expression

triptolide results in decreased expression of DGLUCY protein

NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910

G

7-dehydrocholesterol reductase

decreases expression

triptolide results in decreased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 7

decreases expression

triptolide results in decreased expression of DHRS7 mRNA

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

dehydrogenase/reductase 7B

increases expression

triptolide results in increased expression of DHRS7B protein

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076

G

dehydrogenase/reductase (SDR family) member 7-like 1

decreases expression

triptolide results in decreased expression of DHRS7L1 protein

NCBI chr 6:91,289,200...91,312,010
Ensembl chr 6:91,289,200...91,312,010

G

DExH-box helicase 29

increases expression

triptolide results in increased expression of DHX29 mRNA

NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445

G

DEAH-box helicase 37

increases expression

triptolide results in increased expression of DHX37 mRNA

NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802

G

DEAH-box helicase 38

increases expression

triptolide results in increased expression of DHX38 mRNA

NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140

G

DEXH-box helicase 58

increases expression

triptolide results in increased expression of DHX58 protein

NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525

G

iodothyronine deiodinase 1

decreases expression

triptolide results in decreased expression of DIO1 mRNA

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

DIX domain containing 1

decreases expression

triptolide results in decreased expression of DIXDC1 mRNA

NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090

G

dynein, axonemal, heavy chain 10

increases expression

triptolide results in increased expression of DNAH10 mRNA

NCBI chr12:31,823,451...31,946,857
Ensembl chr12:31,822,733...32,007,069

G

dynein, axonemal, heavy chain 5

increases expression

triptolide results in increased expression of DNAH5 mRNA

NCBI chr 2:78,937,788...79,255,551
Ensembl chr 2:78,937,800...79,254,890

G

dynein axonemal intermediate chain 7

increases expression

triptolide results in increased expression of DNAI7 mRNA

NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980

G

DnaJ heat shock protein family (Hsp40) member B12

increases expression

triptolide results in increased expression of DNAJB12 protein

NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427

G

DnaJ heat shock protein family (Hsp40) member C6

decreases expression

triptolide results in decreased expression of DNAJC6 protein

NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448

G

dynein heavy chain domain 1

increases expression

triptolide results in increased expression of DNHD1 mRNA

NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858

G

dynamin 1-like

multiple interactions
decreases expression
increases expression

mitoquinone inhibits the reaction [triptolide results in decreased expression of DNM1L protein]
triptolide results in increased expression of DRP1 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide results in increased expression of DRP1 protein]

PMID:30836114 PMID:31557070

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dipeptidase 1

increases expression

triptolide results in increased expression of DPEP1 protein

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dipeptidylpeptidase 4

affects expression

triptolide affects the expression of DPP4 protein

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dystrobrevin binding protein 1

decreases expression

triptolide results in decreased expression of DTNBP1 protein

NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661

G

deltex E3 ubiquitin ligase 4

increases expression

triptolide results in increased expression of DTX4 mRNA

NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818

G

dual specificity phosphatase 1

decreases expression

triptolide results in decreased expression of DUSP1 protein

NCBI chr10:16,680,478...16,683,275

G

dynein cytoplasmic 2 heavy chain 1

increases expression

triptolide results in increased expression of DYNC2H1 protein

NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183

G

dynein light chain LC8-type 1

increases expression

triptolide results in increased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

E2F transcription factor 1

increases expression

triptolide results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

increases expression

triptolide results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

glutamyl-tRNA synthetase 2, mitochondrial

increases expression

triptolide results in increased expression of EARS2 mRNA

NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836

G

ethylmalonyl-CoA decarboxylase 1

decreases expression

triptolide results in decreased expression of ECHDC1 mRNA

NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319

G

enoyl CoA hydratase domain containing 2

decreases expression

triptolide results in decreased expression of ECHDC2 protein

NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859

G

ectodysplasin A2 receptor

increases expression

triptolide results in increased expression of EDA2R mRNA

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

eukaryotic translation elongation factor 1 epsilon 1

increases expression

triptolide results in increased expression of EEF1E1 mRNA

NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720

G

ephrin B3

increases expression

triptolide results in increased expression of EFNB3 mRNA

NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471

G

epidermal growth factor receptor

decreases expression

triptolide results in decreased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

EH-domain containing 2

increases expression

triptolide results in increased expression of EHD2 protein

NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

triptolide results in increased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

eukaryotic translation initiation factor 2-alpha kinase 2

increases expression

triptolide results in increased expression of EIF2AK2 protein

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

triptolide results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2B subunit delta

increases expression

triptolide results in increased expression of EIF2B4 protein

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 2 subunit alpha

affects phosphorylation
multiple interactions

triptolide affects the phosphorylation of EIF2S1 protein
TRAJ18 protein affects the reaction [triptolide affects the phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E

increases expression

triptolide results in increased expression of EIF4E mRNA

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 3

decreases expression

triptolide results in decreased expression of EIF4EBP3 mRNA

NCBI chr18:28,263,089...28,268,033
Ensembl chr18:28,162,311...28,268,024

G

EARP complex and GARP complex interacting protein 1

increases expression

triptolide results in increased expression of EIPR1 protein

NCBI chr 6:45,388,451...45,502,089
Ensembl chr 6:45,388,376...45,502,083

G

E74 like ETS transcription factor 3

increases expression

triptolide results in increased expression of ELF3 mRNA

NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481

G

ELOVL fatty acid elongase 2

decreases expression

triptolide results in decreased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 5

decreases expression

triptolide results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

ELOVL fatty acid elongase 6

decreases expression

triptolide results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

ER membrane protein complex subunit 3

increases expression

triptolide results in increased expression of EMC3 protein

NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029

G

ER membrane protein complex subunit 8

increases expression

triptolide results in increased expression of EMC8 protein

NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543

G

essential meiotic structure-specific endonuclease subunit 2

increases expression

triptolide results in increased expression of EME2 mRNA

NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968

G

ectodermal-neural cortex 1

increases expression

triptolide results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

endonuclease domain containing 1

increases expression

triptolide results in increased expression of ENDOD1 mRNA

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

G

endonuclease G

increases expression

triptolide results in increased expression of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

enolase 3

increases expression

triptolide results in increased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

glutamyl aminopeptidase

affects expression

triptolide affects the expression of ENPEP protein

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

ER lipid raft associated 1

increases expression

triptolide results in increased expression of ERLIN1 protein

NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394

G

endoplasmic reticulum metallopeptidase 1

increases expression

triptolide results in increased expression of ERMP1 protein

NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909

G

extra spindle pole bodies like 1, separase

increases expression

triptolide results in increased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

estrogen-related receptor beta

increases expression

triptolide results in increased expression of ESRRB protein

NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791

G

exocyst complex component 4

increases expression

triptolide results in increased expression of EXOC4 mRNA

NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723

G

exosome component 9

increases expression

triptolide results in increased expression of EXOSC9 mRNA

NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

triptolide results in decreased expression of EZH2 protein

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor XI

decreases expression

triptolide results in decreased expression of F11 mRNA

NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437

G

F2R like thrombin or trypsin receptor 3

increases expression

triptolide results in increased expression of F2RL3 mRNA

NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472

G

coagulation factor V

increases expression

triptolide results in increased expression of F5 protein

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

coagulation factor IX

increases expression

triptolide results in increased expression of F9 protein

NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835

G

fatty acid binding protein 1

decreases expression

triptolide results in decreased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 4

increases expression

triptolide results in increased expression of FABP4 protein

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

decreases expression

triptolide results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

fatty acid desaturase 1

decreases expression

triptolide results in decreased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

fatty acid desaturase 2

decreases expression

triptolide results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

family with sequence similarity 107, member A

decreases expression

triptolide results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

FAM161 centrosomal protein B

increases expression

triptolide results in increased expression of FAM161B mRNA

NCBI chr 6:103,990,603...104,007,754
Ensembl chr 6:103,992,170...104,018,776

G

family with sequence similarity 210, member B

increases expression

triptolide results in increased expression of FAM210B protein

NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397

G

family with sequence similarity 47, member E

decreases expression

triptolide results in decreased expression of FAM47E mRNA

NCBI chr14:15,485,537...15,521,599
Ensembl chr14:15,485,127...15,521,775

G

family with sequence similarity 83, member H

increases expression

triptolide results in increased expression of FAM83H mRNA

NCBI chr 7:107,716,431...107,724,619
Ensembl chr 7:107,716,431...107,728,672

G

Fas cell surface death receptor

increases expression

triptolide results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions
increases expression

IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]
triptolide results in increased expression of FASL mRNA; triptolide results in increased expression of FASL protein

PMID:24949944 PMID:26990902

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

triptolide results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillin 2

decreases expression

triptolide results in decreased expression of FBN2 protein

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

fructose-bisphosphatase 2

decreases expression

triptolide results in decreased expression of FBP2 mRNA

NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698

G

F-box and leucine-rich repeat protein 4

increases expression

triptolide results in increased expression of FBXL4 protein

NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443

G

F-box protein 7

increases expression

triptolide results in increased expression of FBXO7 protein

NCBI chr 7:17,809,224...17,837,549
Ensembl chr 7:17,809,231...17,837,530

G

farnesyl diphosphate farnesyl transferase 1

increases expression

triptolide results in increased expression of FDFT1 protein

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

decreases expression

triptolide results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

fetuin B

increases expression

triptolide results in increased expression of FETUB protein

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

G

free fatty acid receptor 4

increases expression

triptolide results in increased expression of FFAR4 mRNA

NCBI chr 1:235,873,576...235,891,597
Ensembl chr 1:235,873,576...235,891,597

G

fibrinogen alpha chain

increases expression

triptolide results in increased expression of FGA protein

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen beta chain

increases expression

triptolide results in increased expression of FGB protein

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibroblast growth factor 1

decreases expression

triptolide results in decreased expression of FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor receptor-like 1

decreases expression

triptolide results in decreased expression of FGFRL1 mRNA

NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928

G

fibrinogen gamma chain

increases expression

triptolide results in increased expression of FGG protein

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

four-jointed box kinase 1

increases expression

triptolide results in increased expression of FJX1 protein

NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321

G

FKBP prolyl isomerase 11

decreases expression

triptolide results in decreased expression of FKBP11 mRNA

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

FKBP prolyl isomerase 5

decreases expression

triptolide results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

formin 1

decreases expression

triptolide results in decreased expression of FMN1 mRNA

NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220

G

flavin containing dimethylaniline monoxygenase 5

affects expression

triptolide affects the expression of FMO5 protein

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

folliculin interacting protein 2

decreases expression

triptolide results in decreased expression of FNIP2 mRNA

NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901

G

forkhead box O3

decreases phosphorylation

triptolide results in decreased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P3

decreases expression

triptolide results in decreased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

FERM domain containing 4B

decreases expression

triptolide results in decreased expression of FRMD4B mRNA

NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197

G

ferritin heavy chain 1

increases expression

triptolide results in increased expression of FTH1 protein

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

increases expression

triptolide results in increased expression of FTL1 protein

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

far upstream element binding protein 1

increases expression

triptolide results in increased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

FUN14 domain containing 2

decreases expression

triptolide results in decreased expression of FUNDC2 protein

NCBI chr18:128,473...138,232
Ensembl chr18:132,248...138,345

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions
increases expression

Lithium Chloride inhibits the reaction [triptolide results in increased expression of FYN protein]

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

glucose-6-phosphatase catalytic subunit 1

decreases expression
multiple interactions

triptolide results in decreased expression of G6PC1 mRNA
Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of G6PC1 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of G6PC1 mRNA]

PMID:23639586 PMID:30633930 PMID:32835833

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases expression

triptolide results in increased expression of G6PDX mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

alpha glucosidase

increases expression

triptolide results in increased expression of GAA protein

NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836

G

gamma-aminobutyric acid type B receptor subunit 2

decreases expression

triptolide results in decreased expression of GABBR2 mRNA

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

growth arrest and DNA-damage-inducible, beta

increases expression

triptolide results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

decreases expression

triptolide results in decreased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

galactose-3-O-sulfotransferase 1

decreases expression

triptolide results in decreased expression of GAL3ST1 mRNA

NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388

G

galactokinase 1

decreases expression

triptolide results in decreased expression of GALK1 mRNA

NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337

G

galactose mutarotase

decreases expression

triptolide results in decreased expression of GALM mRNA

NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310

G

polypeptide N-acetylgalactosaminyltransferase 11

increases expression

triptolide results in increased expression of GALNT11 protein

NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140

G

polypeptide N-acetylgalactosaminyltransferase 3

increases expression

triptolide results in increased expression of GALNT3 protein

NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268

G

polypeptide N-acetylgalactosaminyltransferase 7

increases expression

triptolide results in increased expression of GALNT7 protein

NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690

G

guanidinoacetate N-methyltransferase

decreases expression

triptolide results in decreased expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778

G

golgi associated RAB2 interactor 5A

increases expression

triptolide results in increased expression of GARIN5A mRNA

NCBI chr 1:94,988,959...94,995,971
Ensembl chr 1:94,988,613...94,993,539

G

growth arrest-specific 1

decreases expression

triptolide results in decreased expression of GAS1 mRNA

NCBI chr17:4,482,168...4,485,153

G

growth arrest-specific 2 like 1

increases expression

triptolide results in increased expression of GAS2L1 mRNA

NCBI chr14:79,955,350...79,961,830
Ensembl chr14:79,950,555...79,961,438

G

golgi associated kinase 1A

decreases expression

triptolide results in decreased expression of FAM198A mRNA

NCBI chr 8:121,610,779...121,643,742
Ensembl chr 8:121,610,787...121,642,942

G

1,4-alpha-glucan branching enzyme 1

decreases expression

triptolide results in decreased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein 2

increases expression

triptolide results in increased expression of GBP2 protein

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

G

glucokinase

decreases expression

triptolide results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

decreases expression
multiple interactions

triptolide results in decreased expression of GCLC protein
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

growth differentiation factor 9

increases expression

triptolide results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

GTPase, IMAP family member 4

increases expression

triptolide results in increased expression of GIMAP4 protein

NCBI chr 4:77,636,401...77,643,315
Ensembl chr 4:77,636,401...77,643,306

G

gap junction protein, alpha 1

decreases expression
multiple interactions

triptolide results in decreased expression of GJA1 mRNA; triptolide results in decreased expression of GJA1 protein
mitoquinone inhibits the reaction [triptolide results in decreased expression of GJA1 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of GJA1 protein]

PMID:20020930 PMID:30836114

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycosylated lysosomal membrane protein

decreases expression

triptolide results in decreased expression of GLMP protein

NCBI chr 2:173,794,273...173,797,863
Ensembl chr 2:173,794,255...173,799,960

G

glutaminase

increases expression

triptolide results in increased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

GDP-mannose 4, 6-dehydratase

increases expression

triptolide results in increased expression of GMDS protein

NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961

G

glycine N-methyltransferase

decreases expression

triptolide results in decreased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

gon-4 like

increases expression

triptolide results in increased expression of GON4L mRNA

NCBI chr 2:174,233,461...174,306,636
Ensembl chr 2:174,233,461...174,306,634

G

glutamic-oxaloacetic transaminase 1

decreases expression

triptolide results in decreased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycoprotein V (platelet)

increases expression

triptolide results in increased expression of GP5 mRNA

NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705

G

glycosylphosphatidylinositol anchor attachment 1

increases expression

triptolide results in increased expression of GPAA1 protein

NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484

G

G patch domain and KOW motifs

increases expression

triptolide results in increased expression of GPKOW mRNA

NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384

G

G protein-coupled receptor 12

decreases expression

triptolide results in decreased expression of GPR12 mRNA

NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973

G

G protein-coupled receptor 146

decreases expression

triptolide results in decreased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

G protein-coupled receptor associated sorting protein family member 3

decreases expression

triptolide results in decreased expression of BHLHB9 mRNA

NCBI chr X:98,847,591...98,854,949
Ensembl chr X:98,817,593...98,854,545

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

triptolide results in increased activity of GPT protein
4-phenylbutyric acid inhibits the reaction [triptolide results in increased expression of GPT protein]; [triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; Chlormethiazole inhibits the reaction [triptolide results in increased activity of GPT protein]; IL12B protein affects the reaction [triptolide results in increased expression of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; pyrazole promotes the reaction [triptolide results in increased activity of GPT protein]; STING1 protein affects the reaction [triptolide results in increased expression of GPT protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of GPT protein]
catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]; catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]; Chlormethiazole inhibits the reaction [triptolide results in increased activity of GPT protein]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; pyrazole promotes the reaction [triptolide results in increased activity of GPT protein]; Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]
[Atorvastatin co-treated with triptolide] results in increased expression of GPT protein

PMID:23836259 PMID:26134275 PMID:30682494 PMID:32987112 PMID:33600922 More...

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions
increases expression

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX1 mRNA]
triptolide results in increased expression of GPX1 protein

PMID:31241159 PMID:32519852

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

multiple interactions
increases expression

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX2 mRNA]

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

multiple interactions
increases expression

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX3 mRNA]

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

increases expression
multiple interactions

triptolide results in increased expression of GPX4 mRNA
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

growth factor receptor bound protein 2

decreases expression

triptolide results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

gremlin 2, DAN family BMP antagonist

decreases expression

triptolide results in decreased expression of GREM2 mRNA

NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615

G

grainyhead-like transcription factor 1

increases expression

triptolide results in increased expression of GRHL1 mRNA

NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301

G

glutamate ionotropic receptor kainate type subunit 5

increases expression

triptolide results in increased expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate-rich WD repeat containing 1

increases expression

triptolide results in increased expression of GRWD1 mRNA

NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201

G

gasdermin D

increases expression
multiple interactions

triptolide results in increased expression of GSDMD protein
[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein; [triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein]

PMID:32519852 PMID:36328986

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

Lithium Chloride inhibits the reaction [triptolide results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

general transcription factor IIF subunit 1

increases expression

triptolide results in increased expression of GTF2F1 mRNA

NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423

G

GTP binding protein 4

increases expression

triptolide results in increased expression of GTPBP4 mRNA

NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009

G

G-2 and S-phase expressed 1

increases expression

triptolide results in increased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

glucuronidase, beta

multiple interactions
decreases activity

resveratrol inhibits the reaction [triptolide results in decreased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

glycogen synthase 2

decreases expression

triptolide results in decreased expression of GYS2 mRNA

NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228

G

H1.10 linker histone

increases expression

triptolide results in increased expression of H1F10 mRNA

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

H1.4 linker histone, cluster member

increases expression

triptolide results in increased expression of H1F4 mRNA

NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403

G

H2A.J histone

increases expression

triptolide results in increased expression of H2AJ mRNA

NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006

G

H2A.X variant histone

increases expression
increases phosphorylation

triptolide results in increased expression of H2AX mRNA
triptolide results in increased phosphorylation of H2AX protein
triptolide results in increased expression of H2AX protein

PMID:31218727 PMID:32835833 PMID:36990132

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

H2A.Z variant histone 1

decreases expression

triptolide results in decreased expression of H2AZ1 protein

NCBI chr 2:226,355,668...226,357,984
Ensembl chr 2:226,355,708...226,358,485

G

H2B clustered histone 6

increases expression

triptolide results in increased expression of H2BC6 mRNA

NCBI chr17:41,520,775...41,521,238

G

H3 clustered histone 1

increases expression

triptolide results in increased expression of H3C4 mRNA

NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases expression

triptolide results in decreased expression of HAAO mRNA

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

hydroxyacid oxidase 1

decreases expression

triptolide results in decreased expression of HAO1 mRNA

NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721

G

hemoglobin alpha, adult chain 2

increases expression

triptolide results in increased expression of HBA-A2 protein; triptolide results in increased expression of HBA1 protein

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

increases expression

triptolide results in increased expression of HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

histone deacetylase 1

increases expression

triptolide results in increased expression of HDAC1 mRNA

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 1-like

increases expression

triptolide results in increased expression of HDAC1L protein

NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593

G

histone deacetylase 2

increases expression

triptolide results in increased expression of HDAC2 protein

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 6

increases expression

triptolide results in increased expression of HDAC6 mRNA; triptolide results in increased expression of HDAC6 protein

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

increases expression

triptolide results in increased expression of HERC6 protein

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

homocysteine inducible ER protein with ubiquitin like domain 1

decreases expression

triptolide results in decreased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions
increases expression

triptolide results in decreased expression of HES1 protein
Fenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]
triptolide results in decreased expression of HES1 mRNA; triptolide results in decreased expression of HES1 protein

PMID:30394310 PMID:31241159

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes family bHLH transcription factor 6

decreases expression

triptolide results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

HEXIM P-TEFb complex subunit 1

increases expression

triptolide results in increased expression of HEXIM1 mRNA

NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189

G

HIG1 hypoxia inducible domain family, member 2A-like 1

increases expression

triptolide results in increased expression of HIGD2AL1 protein

NCBI chr12:2,777,094...2,777,581
Ensembl chr12:2,777,231...2,777,551

G

heat shock protein nuclear import factor hikeshi

increases expression

triptolide results in increased expression of HIKESHI protein

NCBI chr 1:143,825,399...143,849,361
Ensembl chr 1:143,825,923...143,849,363

G

histone cluster 1 H2a family member I like 1

increases expression

triptolide results in increased expression of H3C6 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109

G

histone cluster 1 H4 family member B

increases expression

triptolide results in increased expression of H4C9 mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

G

histone cluster 2 H2B family member E

increases expression

triptolide results in increased expression of H2BC21 mRNA

NCBI chr 2:183,780,583...183,783,030

G

histone cluster 2 H3 family member C2

increases expression

triptolide results in increased expression of H3C14 mRNA

NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752

G

hexokinase 2

increases expression
decreases expression

triptolide results in increased expression of HK2 mRNA
triptolide results in decreased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

triptolide results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression
decreases expression
affects expression
multiple interactions

triptolide results in increased expression of HMOX1 mRNA
triptolide results in decreased expression of HMOX1 mRNA; triptolide results in decreased expression of HMOX1 protein
triptolide affects the expression of HMOX1 mRNA
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]
[triptolide co-treated with catalpol co-treated with Saponins] results in increased expression of HMOX1 protein; [triptolide co-treated with catalpol] results in increased expression of HMOX1 protein; [triptolide co-treated with Saponins] results in increased expression of HMOX1 protein
mitoquinone inhibits the reaction [triptolide results in decreased expression of HMOX1 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]

PMID:23639586 PMID:25169008 PMID:30682494 PMID:30836114

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine N-methyltransferase

decreases expression

triptolide results in decreased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

haptoglobin

increases expression

triptolide results in increased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

4-hydroxyphenylpyruvate dioxygenase

decreases expression

triptolide results in decreased expression of HPD mRNA

NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766

G

hemopexin

increases expression

triptolide results in increased expression of HPX protein

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

HRas proto-oncogene, GTPase

decreases expression

triptolide results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

histidine-rich glycoprotein

increases expression
decreases expression

triptolide results in increased expression of HRG protein
triptolide results in decreased expression of HRG mRNA

PMID:32519852 PMID:32835833

NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

multiple interactions

[Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock transcription factor 2 binding protein

increases expression

triptolide results in increased expression of HSF2BP mRNA

NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242

G

heat shock protein 90 alpha family class A member 1

increases expression

triptolide results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1A

decreases response to substance

HSPA1A results in decreased susceptibility to triptolide

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

triptolide results in increased expression of HSPA1B protein

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

increases expression

triptolide results in increased expression of HSPA2 protein

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4 like

affects expression

triptolide affects the expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family A (Hsp70) member 5

decreases expression
multiple interactions
increases expression

triptolide results in decreased expression of HSPA5 protein
STING1 protein affects the reaction [triptolide results in increased expression of HSPA5 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 mRNA]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 protein]
triptolide results in increased expression of HSPA5 mRNA; triptolide results in increased expression of HSPA5 protein

PMID:26990902 PMID:27022166 PMID:36520315

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

decreases expression

triptolide results in decreased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

HtrA serine peptidase 4

decreases expression

triptolide results in decreased expression of HTRA4 mRNA

NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074

G

intercellular adhesion molecule 1

decreases expression
multiple interactions
increases expression

triptolide results in decreased expression of ICAM1 mRNA; triptolide results in decreased expression of ICAM1 protein
TRAJ18 protein affects the reaction [triptolide results in increased expression of ICAM1 protein]
triptolide results in increased expression of ICAM1 mRNA; triptolide results in increased expression of ICAM1 protein

PMID:17931847 PMID:32835833 PMID:32987112

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

triptolide results in decreased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

alpha-L-iduronidase

increases expression

triptolide results in increased expression of IDUA mRNA

NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522

G

immediate early response 5

increases expression

triptolide results in increased expression of IER5 mRNA

NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227

G

interferon-induced protein with tetratricopeptide repeats 1

increases expression

triptolide results in increased expression of IFIT1 protein

NCBI chr 1:232,152,038...232,154,103
Ensembl chr 1:232,127,170...232,154,435

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

triptolide results in increased expression of IFIT2 protein

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

triptolide results in increased expression of IFIT3 protein

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon beta 1

increases expression

triptolide results in increased expression of IFNB1 mRNA

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions
increases secretion

triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]
triptolide results in increased secretion of IFNG protein
IL12B protein affects the reaction [triptolide results in increased secretion of IFNG protein]

PMID:15663903 PMID:36520315

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

immunoglobulin superfamily, DCC subclass, member 3

increases expression

triptolide results in increased expression of IGDCC3 protein

NCBI chr 8:65,661,165...65,707,961
Ensembl chr 8:65,661,196...65,707,959

G

insulin-like growth factor 1

decreases expression

triptolide results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2 mRNA binding protein 3

decreases expression

triptolide results in decreased expression of IGF2BP3 mRNA

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

insulin-like growth factor binding protein 1

decreases expression

triptolide results in decreased expression of IGFBP1 mRNA

PMID:23639586 PMID:32835833

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 4

decreases expression

triptolide results in decreased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

gamma-2a immunoglobulin heavy chain

increases expression

triptolide results in increased expression of IGG-2A protein

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
decreases phosphorylation

TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of IKBKB protein]
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

increases expression

triptolide results in increased expression of IL10 mRNA

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions
affects secretion

triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]
IL12B protein affects the reaction [triptolide results in increased expression of GPT protein]; IL12B protein affects the reaction [triptolide results in increased secretion of IFNG protein]; IL12B protein affects the reaction [triptolide results in increased secretion of IL4 protein]; STING1 protein affects the reaction [triptolide affects the secretion of IL12B protein]

PMID:15663903 PMID:36520315

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

increases expression

triptolide results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

multiple interactions
increases expression
decreases expression

IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]
triptolide results in increased expression of IL17A mRNA; triptolide results in increased expression of IL17A protein
triptolide results in decreased expression of IL17A mRNA

PMID:24949944 PMID:36520315 PMID:38115356

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

decreases expression
multiple interactions

triptolide results in decreased expression of IL18 mRNA
[triptolide co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased secretion of IL18 protein

PMID:32835833 PMID:36328986

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
increases expression

[triptolide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL1B mRNA]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:24949944 PMID:30633930 PMID:31241159 PMID:36328986

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

increases secretion
multiple interactions

triptolide results in increased secretion of IL4 protein
IL12B protein affects the reaction [triptolide results in increased secretion of IL4 protein]; STING1 protein affects the reaction [triptolide results in increased secretion of IL4 protein]

PMID:32987112 PMID:36520315

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression
affects expression

Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 protein]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
triptolide results in increased expression of IL6 mRNA; triptolide results in increased expression of IL6 protein
triptolide affects the expression of IL6 mRNA
Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 protein]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 protein]

PMID:30633930 PMID:31241159 PMID:34758665 PMID:36520315

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

IMP U3 small nucleolar ribonucleoprotein 4

increases expression

triptolide results in increased expression of IMP4 mRNA

NCBI chr 9:36,654,127...36,659,265
Ensembl chr 9:36,654,401...36,660,075

G

inositol monophosphatase 2

decreases expression

triptolide results in decreased expression of IMPA2 mRNA

NCBI chr18:60,834,206...60,867,575
Ensembl chr18:60,834,246...60,865,641

G

inosine monophosphate dehydrogenase 2

increases expression

triptolide results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

innate immunity activator

increases expression

triptolide results in increased expression of INAVA mRNA

NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729

G

inhibitor of CDK, cyclin A1 interacting protein 1

affects expression

triptolide affects the expression of INCA1 mRNA

NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114

G

inhibitor of carbonic anhydrase

increases expression

triptolide results in increased expression of INHCA protein

NCBI chr 8:103,836,846...103,874,980
Ensembl chr 8:103,823,196...103,874,985

G

inka box actin regulator 2

increases expression

triptolide results in increased expression of FAM212B mRNA

NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642

G

indolethylamine N-methyltransferase

decreases expression

triptolide results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

INSC, spindle orientation adaptor protein

affects expression

triptolide affects the expression of INSC mRNA

NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433

G

insulin induced gene 1

decreases expression

triptolide results in decreased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor

increases expression

triptolide results in increased expression of INSR protein

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

integrator complex subunit 2

increases expression

triptolide results in increased expression of INTS2 mRNA

NCBI chr10:71,031,647...71,079,138
Ensembl chr10:71,031,647...71,079,076

G

importin 13

increases expression

triptolide results in increased expression of IPO13 mRNA

NCBI chr 5:131,433,770...131,454,044
Ensembl chr 5:131,433,776...131,454,043

G

interferon regulatory factor 3

increases expression

triptolide results in increased expression of IRF3 protein

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

immunity-related GTPase M

increases expression

triptolide results in increased expression of IRGM protein

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

insulin receptor substrate 1

increases degradation
multiple interactions

triptolide results in increased degradation of IRS1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein]; triptolide results in decreased expression of and results in decreased phosphorylation of IRS1 protein

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

iron-sulfur cluster assembly 1

decreases expression

triptolide results in decreased expression of ISCA1 protein

NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955

G

iron-sulfur cluster assembly enzyme

decreases expression

triptolide results in decreased expression of ISCU protein

NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150

G

inositol-3-phosphate synthase 1

increases expression

triptolide results in increased expression of ISYNA1 protein

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

integrin subunit alpha 5

increases expression

triptolide results in increased expression of ITGA5 protein
triptolide results in increased expression of ITGA5 mRNA

PMID:32519852 PMID:32835833

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha M

increases expression

triptolide results in increased expression of ITGAM mRNA

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

inter-alpha trypsin inhibitor, heavy chain 3

increases expression

triptolide results in increased expression of ITIH3 protein

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

inter-alpha-trypsin inhibitor heavy chain 4

increases expression

triptolide results in increased expression of ITIH4 protein

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

triptolide results in increased expression of ITPR3 protein

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

Janus kinase 2

multiple interactions

triptolide results in decreased expression of and results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

junctophilin 1

decreases expression

triptolide results in decreased expression of JPH1 mRNA

NCBI chr 5:2,030,227...2,137,171
Ensembl chr 5:2,030,281...2,125,284

G

Jupiter microtubule associated homolog 1

increases expression

triptolide results in increased expression of JPT1 mRNA

NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

triptolide results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium channel tetramerization domain containing 18

increases expression

triptolide results in increased expression of KCTD18 mRNA

NCBI chr 9:59,502,220...59,566,857
Ensembl chr 9:59,502,232...59,566,857

G

Kelch-like ECH-associated protein 1

decreases expression

triptolide results in decreased expression of KEAP1 protein

PMID:30682494 PMID:36990132

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KH-type splicing regulatory protein

decreases expression

triptolide results in decreased expression of KHSRP protein

NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451

G

kinesin family member 20A

increases expression

triptolide results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 21A

increases expression

triptolide results in increased expression of KIF21A protein

NCBI chr 7:122,062,523...122,179,051
Ensembl chr 7:122,062,537...122,178,999

G

kinesin family member C3

increases expression

triptolide results in increased expression of KIFC3 mRNA

NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451

G

kinesin light chain 1

increases expression

triptolide results in increased expression of KLC1 mRNA

NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031

G

kelch-like family member 26

increases expression

triptolide results in increased expression of KLHL26 mRNA

NCBI chr16:18,952,123...18,977,328
Ensembl chr16:18,952,234...18,977,328

G

kallikrein B1

decreases expression

triptolide results in decreased expression of KLKB1 mRNA

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 1

increases expression

triptolide results in increased expression of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

kininogen 2

increases expression

triptolide results in increased expression of MAP1 protein

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

KRAS proto-oncogene, GTPase

increases expression

triptolide results in increased expression of KRAS mRNA

NCBI chr 4:178,185,418...178,218,484

G

kynurenine aminotransferase 1

decreases expression

triptolide results in decreased expression of KYAT1 mRNA

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

kynurenine aminotransferase 3

decreases expression

triptolide results in decreased expression of KYAT3 mRNA

NCBI chr 2:231,701,881...231,747,462
Ensembl chr 2:231,701,963...231,747,227

G

L1 cell adhesion molecule

increases expression

triptolide results in increased expression of L1CAM protein

NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

decreases expression

triptolide results in decreased expression of LAMTOR1 protein

NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179

G

lecithin cholesterol acyltransferase

increases expression

triptolide results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LIM domain binding 3

increases expression

triptolide results in increased expression of LDB3 mRNA

NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532

G

lactate dehydrogenase A

decreases expression

triptolide results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leptin receptor

decreases expression

triptolide results in decreased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

LETM1 domain containing 1

increases expression

triptolide results in increased expression of LETMD1 protein

NCBI chr 7:131,584,241...131,597,797
Ensembl chr 7:131,584,259...131,597,796

G

leucine-rich repeat LGI family, member 4

increases expression

triptolide results in increased expression of LGI4 mRNA

NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874

G

lipase G, endothelial type

decreases expression

triptolide results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lipopolysaccharide-induced TNF factor

increases expression

triptolide results in increased expression of LITAF mRNA

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

lamin A/C

increases expression

triptolide results in increased expression of LMNA mRNA

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

LON peptidase N-terminal domain and ring finger 3

increases expression

triptolide results in increased expression of LONRF3 mRNA

NCBI chr X:115,565,214...115,603,886
Ensembl chr X:115,565,267...115,598,809

G

lysyl oxidase-like 4

increases expression

triptolide results in increased expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

G

lipin 1

decreases expression

triptolide results in decreased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

leupaxin

increases expression

triptolide results in increased expression of LPXN mRNA

NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084

G

leucine rich repeat containing 14

increases expression

triptolide results in increased expression of LRRC14 mRNA

NCBI chr 7:108,430,755...108,437,118
Ensembl chr 7:108,430,792...108,437,111

G

leucine rich repeat containing 51

increases expression

triptolide results in increased expression of LRRC51 mRNA

NCBI chr 1:156,278,617...156,297,838
Ensembl chr 1:156,278,618...156,297,773

G

LRRN4 C-terminal like

increases expression

triptolide results in increased expression of LRRN4CL mRNA

NCBI chr 1:205,743,580...205,759,879

G

leucine-rich repeats and transmembrane domains 1

decreases expression

triptolide results in decreased expression of LRTM1 mRNA

NCBI chr16:4,210,343...4,217,843

G

LTO1 maturation factor of ABCE1

increases expression

triptolide results in increased expression of ORAOV1 mRNA

NCBI chr 1:200,074,247...200,080,951
Ensembl chr 1:200,074,253...200,088,061

G

lymphocyte antigen 6 family member E

increases expression

triptolide results in increased expression of LY6E protein

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

mab-21 like 3

increases expression

triptolide results in increased expression of MAB21L3 mRNA

NCBI chr 2:189,248,895...189,271,652
Ensembl chr 2:189,248,895...189,271,652

G

mitotic arrest deficient 2 like 1

increases expression

triptolide results in increased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor B

decreases expression

triptolide results in decreased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAF bZIP transcription factor F

affects expression

triptolide affects the expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

microtubule-associated protein 1 light chain 3 beta

increases expression

triptolide results in increased expression of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 1S

increases expression

triptolide results in increased expression of MAP1S mRNA

NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988

G

mitogen-activated protein kinase kinase 6

decreases expression

triptolide results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen-activated protein kinase kinase kinase 20

increases expression

triptolide results in increased expression of MAP3K20 mRNA

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

MAP7 domain containing 1

increases expression

triptolide results in increased expression of MAP7D1 mRNA

NCBI chr 5:138,527,944...138,552,537
Ensembl chr 5:138,527,401...138,552,499

G

mitogen activated protein kinase 1

multiple interactions

triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

triptolide inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8 interacting protein 3

increases expression

triptolide results in increased expression of MAPK8IP3 mRNA

NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273

G

microtubule associated serine/threonine kinase 3

increases expression

triptolide results in increased expression of MAST3 protein

NCBI chr16:18,636,764...18,663,852
Ensembl chr16:18,636,787...18,663,852

G

muscleblind-like splicing regulator 1

increases expression

triptolide results in increased expression of MBNL1 protein

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

methylmalonyl CoA epimerase

increases expression

triptolide results in increased expression of MCEE protein

NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

triptolide results in increased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance complex component 6

increases expression

triptolide results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

MAPK regulated co-repressor interacting protein 1

increases expression

triptolide results in increased expression of MCRIP1 mRNA

NCBI chr10:105,820,656...105,828,146
Ensembl chr10:105,820,656...105,828,271

G

MDM2 proto-oncogene

increases expression
decreases expression

triptolide results in increased expression of MDM2 mRNA
triptolide results in decreased expression of MDM2 protein

PMID:32835833 PMID:36990132

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

decreases expression

triptolide results in decreased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

mediator complex subunit 23

increases expression

triptolide results in increased expression of MED23 protein

NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463

G

meprin A subunit alpha

increases expression

triptolide results in increased expression of MEP1A protein

NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147

G

meprin A subunit beta

increases expression

triptolide results in increased expression of MEP1B protein

NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840

G

mitofusin 1

decreases expression

triptolide results in decreased expression of MFN1 protein

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

decreases expression
multiple interactions

triptolide results in decreased expression of MFN2 protein
mitoquinone inhibits the reaction [triptolide results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

MFSD2 lysolipid transporter A, lysophospholipid

decreases expression

triptolide results in decreased expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

major facilitator superfamily domain containing 4B2

decreases expression

triptolide results in decreased expression of MFSD4B1 mRNA

NCBI chr20:43,344,601...43,353,061
Ensembl chr20:43,344,601...43,353,061

G

microtubule associated monooxygenase, calponin and LIM domain containing 2

increases expression

triptolide results in increased expression of MICAL2 mRNA

NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719

G

microtubule associated monooxygenase, calponin and LIM domain containing 3

increases expression

triptolide results in increased expression of MICAL3 mRNA

NCBI chr 4:154,152,776...154,353,274
Ensembl chr 4:154,153,834...154,302,590

G

microRNA 141

multiple interactions

[triptolide co-treated with tariquidar] results in increased activity of MIR141 protein

NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332

G

marker of proliferation Ki-67

decreases expression

triptolide results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mixed lineage kinase domain like pseudokinase

multiple interactions
increases expression

[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein; [triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form]; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein]
triptolide results in increased expression of MLKL mRNA

PMID:30633930 PMID:32835833

NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502

G

monocyte to macrophage differentiation-associated 2

decreases expression

triptolide results in decreased expression of MMD2 mRNA

NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773

G

membrane metallo-endopeptidase

increases expression
decreases expression

triptolide results in increased expression of MME protein
triptolide results in decreased expression of MME mRNA

PMID:32519852 PMID:32835833

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 12

increases expression

triptolide results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 2

decreases expression

triptolide results in decreased expression of MMP2 mRNA; triptolide results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

triptolide results in decreased expression of MMP9 protein
triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]

PMID:25200491 PMID:26420756

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

monoacylglycerol O-acyltransferase 2

increases expression

triptolide results in increased expression of MOGAT2 mRNA

NCBI chr 1:153,521,813...153,545,756
Ensembl chr 1:153,521,815...153,545,756

G

Mov10 RNA helicase

decreases expression

triptolide results in decreased expression of MOV10 mRNA

NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083

G

mitochondrial pyruvate carrier 1

decreases expression

triptolide results in decreased expression of MPC1 protein

NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400

G

myeloperoxidase

multiple interactions

[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of MPO mRNA]

PMID:30633930 PMID:36328986

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MAGUK p55 scaffold protein 7

increases expression

triptolide results in increased expression of MPP7 mRNA

NCBI chr17:55,439,939...55,706,810
Ensembl chr17:55,442,696...55,706,748

G

melanoregulin

increases expression

triptolide results in increased expression of MREG mRNA

NCBI chr 9:73,786,727...73,842,081
Ensembl chr 9:73,787,267...73,842,087

G

mitochondrial ribosomal protein S5

increases expression

triptolide results in increased expression of MRPS5 protein

NCBI chr 3:114,821,046...114,837,291
Ensembl chr 3:114,821,046...114,837,291

G

methylsterol monooxygenase 1

decreases expression

triptolide results in decreased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

increases expression

triptolide results in increased expression of ND1 protein

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

metallothionein 1

decreases expression

triptolide results in decreased expression of MT1 protein

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

increases expression

triptolide results in increased expression of MT1M protein

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metadherin

increases expression

triptolide results in increased expression of MTDH mRNA

NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413

G

mechanistic target of rapamycin kinase

multiple interactions

triptolide results in increased expression of and results in increased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

murinoglobulin 1

increases expression

triptolide results in increased expression of MUG1 protein

NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051

G

murinoglobulin 2

decreases expression

triptolide results in decreased expression of MUG2 mRNA

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

G

mevalonate diphosphate decarboxylase

increases expression
decreases expression

triptolide results in increased expression of MVD protein
triptolide results in decreased expression of MVD mRNA

PMID:32519852 PMID:32835833

NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971

G

MX dynamin like GTPase 1

increases expression

triptolide results in increased expression of MX1 protein

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MYB proto-oncogene like 1

increases expression

triptolide results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYB proto-oncogene like 2

increases expression

triptolide results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

triptolide results in decreased expression of MYC mRNA
triptolide results in decreased expression of MYC protein
triptolide results in increased expression of MYC mRNA

PMID:12533674 PMID:23639586 PMID:32835833

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

Mycbp associated protein

increases expression

triptolide results in increased expression of MYCBPAP mRNA

NCBI chr10:79,450,319...79,470,977
Ensembl chr10:79,450,324...79,470,828

G

MYCL proto-oncogene, bHLH transcription factor

decreases expression

triptolide results in decreased expression of MYCL mRNA

NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582

G

myosin heavy chain 1

decreases expression

triptolide results in decreased expression of MYH1 mRNA

NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295

G

myosin heavy chain 2

decreases expression

triptolide results in decreased expression of MYH2 mRNA

NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236

G

myosin heavy chain 4

decreases expression

triptolide results in decreased expression of MYH4 mRNA

NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295

G

myosin heavy chain 7

decreases expression

triptolide results in decreased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myosin heavy chain 7B

increases expression

triptolide results in increased expression of MYH7B mRNA

NCBI chr 3:144,076,911...144,122,714
Ensembl chr 3:144,098,190...144,122,084

G

myosin light chain 9

decreases expression

triptolide results in decreased expression of MYL9 protein

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase

multiple interactions

triptolide inhibits the reaction [Luteolin inhibits the reaction [decabromobiphenyl ether results in increased expression of MYLK protein]]

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

myosin XIX

increases expression

triptolide results in increased expression of MYO19 mRNA

NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450

G

myosin VC

increases expression

triptolide results in increased expression of MYO5C protein

NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483

G

myomesin 1

increases expression

triptolide results in increased expression of MYOM1 mRNA

NCBI chr 9:110,916,156...111,039,344
Ensembl chr 9:110,915,943...111,039,344

G

myelin regulatory factor-like

increases expression

triptolide results in increased expression of MYRFL mRNA

NCBI chr 7:52,403,324...52,519,907
Ensembl chr 7:52,403,650...52,519,907

G

N-acetylated alpha-linked acidic dipeptidase-like 2

decreases expression

triptolide results in decreased expression of NAALADL2 mRNA

NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689

G

nicotinamide phosphoribosyltransferase

decreases expression

triptolide results in decreased expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

N-acetyltransferase 8 (GCN5-related) family member 4

increases expression

triptolide results in increased expression of NAT8F4 mRNA

NCBI chr 4:118,326,092...118,332,591
Ensembl chr 4:118,325,874...118,332,658

G

N-acetyltransferase 8 (GCN5-related) family member 5

affects expression

triptolide affects the expression of NAT8F5 mRNA

NCBI chr 4:118,260,323...118,285,038
Ensembl chr 4:118,260,252...118,285,704

G

neurobeachin-like 2

increases expression

triptolide results in increased expression of NBEAL2 mRNA

NCBI chr 8:110,603,220...110,633,612
Ensembl chr 8:110,599,389...110,633,707

G

nuclear cap binding protein subunit 1

increases expression

triptolide results in increased expression of NCBP1 mRNA

NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089

G

nuclear receptor coactivator 6

increases expression

triptolide results in increased expression of NCOA6 protein

NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268

G

nuclear receptor co-repressor 2

increases expression

triptolide results in increased expression of NCOR2 mRNA

NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319

G

NADPH dependent diflavin oxidoreductase 1

increases expression

triptolide results in increased expression of NDOR1 mRNA

NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860

G

NADH:ubiquinone oxidoreductase subunit A7

increases expression

triptolide results in increased expression of NDUFA7 protein

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit B8

multiple interactions
decreases expression

7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]
triptolide results in decreased expression of NDUFB8 mRNA; triptolide results in decreased expression of NDUFB8 protein

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

NADH:ubiquinone oxidoreductase subunit B9

increases expression

triptolide results in increased expression of NDUFB9 protein

NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009

G

NADH:ubiquinone oxidoreductase subunit S4

increases expression

triptolide results in increased expression of NDUFS4 protein

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

NADH:ubiquinone oxidoreductase core subunit S8

decreases expression

triptolide results in decreased expression of NDUFS8 mRNA

NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511

G

NADH:ubiquinone oxidoreductase subunit V3

increases expression

triptolide results in increased expression of NDUFV3 protein

NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074

G

NECAP endocytosis associated 1

decreases expression

triptolide results in decreased expression of NECAP1 protein

NCBI chr 4:156,103,935...156,119,068
Ensembl chr 4:156,103,988...156,119,068

G

neuropilin and tolloid like 2

increases expression

triptolide results in increased expression of NETO2 mRNA

NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases response to substance
affects localization
decreases expression
affects expression
decreases phosphorylation
increases expression

Acetylcysteine inhibits the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in increased ubiquitination of NFE2L2 protein]; Lithium Chloride affects the reaction [triptolide affects the expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; triptolide affects the expression of and results in increased ubiquitination of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to triptolide
triptolide affects the localization of NFE2L2 protein
triptolide results in decreased expression of NFE2L2 protein
triptolide affects the expression of NFE2L2 mRNA; triptolide affects the expression of NFE2L2 protein
triptolide results in decreased phosphorylation of NFE2L2 protein
[catalpol co-treated with Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [catalpol co-treated with triptolide] affects the localization of NFE2L2 protein; [Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein; [triptolide co-treated with Saponins] results in increased expression of NFE2L2 protein; catalpol inhibits the reaction [Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]]; catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; NFE2L2 protein inhibits the reaction [triptolide affects the expression of CDKN1A protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of TP53 protein]; Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]]; triptolide affects the reaction [NFE2L2 protein binds to TP53 protein]; triptolide results in decreased expression of and affects the localization of NFE2L2 protein
Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 protein]; mitoquinone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NFE2L2 protein]; triptolide results in decreased expression of and affects the localization of NFE2L2 protein
triptolide results in increased expression of NFE2L2 mRNA; triptolide results in increased expression of NFE2L2 protein

PMID:22820427 PMID:25169008 PMID:30682494 PMID:30836114 PMID:30926361 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation

TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor epsilon

increases expression

triptolide results in increased expression of NFKBIE mRNA

NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437

G

nerve growth factor

increases expression
increases secretion

triptolide results in increased expression of NGF mRNA; triptolide results in increased expression of NGF protein
triptolide results in increased secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

niban apoptosis regulator 1

increases expression

triptolide results in increased expression of FAM129A protein

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

nucleolar protein interacting with the FHA domain of MKI67

increases expression

triptolide results in increased expression of NIFK mRNA

NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896

G

NIPA-like domain containing 1

decreases expression

triptolide results in decreased expression of NIPAL1 mRNA

NCBI chr14:35,537,641...35,561,656
Ensembl chr14:35,540,324...35,561,659

G

notchless homolog 1

increases expression

triptolide results in increased expression of NLE1 mRNA

NCBI chr10:67,834,059...67,844,771
Ensembl chr10:67,834,062...67,842,658

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

[triptolide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein; [triptolide co-treated with TNF protein] results in increased expression of NLRP3 mRNA; [triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein]
triptolide results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nicotinamide N-methyltransferase

decreases expression

triptolide results in decreased expression of NNMT mRNA

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

nicotinamide nucleotide transhydrogenase

increases expression

triptolide results in increased expression of NNT protein

NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823

G

NOC2-like nucleolar associated transcriptional repressor

increases expression

triptolide results in increased expression of NOC2L mRNA

NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949

G

nucleolar protein 6

increases expression

triptolide results in increased expression of NOL6 mRNA

NCBI chr 5:56,259,919...56,270,540
Ensembl chr 5:56,260,830...56,270,336

G

nucleolar and coiled-body phosphoprotein 1

increases expression

triptolide results in increased expression of NOLC1 mRNA

NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088

G

NOP2 nucleolar protein

increases expression

triptolide results in increased expression of NOP2 mRNA

NCBI chr 4:157,932,731...157,944,462
Ensembl chr 4:157,932,716...157,944,459

G

NOP56 ribonucleoprotein

increases expression

triptolide results in increased expression of NOP56 mRNA

NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841

G

NOP58 ribonucleoprotein

increases expression

triptolide results in increased expression of NOP58 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

NOP9 nucleolar protein

increases expression

triptolide results in increased expression of NOP9 mRNA

NCBI chr15:29,243,853...29,252,220
Ensembl chr15:29,243,862...29,252,220

G

notch receptor 1

multiple interactions
decreases expression
increases expression

NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein]
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of TXNIP protein]
triptolide results in decreased expression of NOTCH1 mRNA; triptolide results in decreased expression of NOTCH1 protein; triptolide results in decreased expression of NOTCH1 protein modified form

PMID:30394310 PMID:31241159 PMID:32835833

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 3

increases expression
multiple interactions

triptolide results in increased expression of NOTCH3 mRNA; triptolide results in increased expression of NOTCH3 protein
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein]

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

NADPH oxidase 4

decreases expression

triptolide results in decreased expression of NOX4 mRNA

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NPHS2 stomatin family member, podocin

multiple interactions

triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

nucleophosmin/nucleoplasmin 2

increases expression

triptolide results in increased expression of NPM2 mRNA

NCBI chr15:45,722,282...45,729,336
Ensembl chr15:45,722,400...45,729,726

G

NPR3-like, GATOR1 complex subunit

increases expression

triptolide results in increased expression of NPRL3 mRNA

NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions
increases expression
affects expression

triptolide results in decreased expression of NQO1 mRNA; triptolide results in decreased expression of NQO1 protein
NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]
[triptolide co-treated with catalpol] results in increased expression of NQO1 protein; [triptolide co-treated with Saponins] results in increased expression of NQO1 protein; catalpol promotes the reaction [[triptolide co-treated with Saponins] results in increased expression of NQO1 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NQO1 protein]
mitoquinone inhibits the reaction [triptolide results in decreased expression of NQO1 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of NQO1 protein]
triptolide results in increased expression of NQO1 protein
triptolide affects the expression of NQO1 protein

PMID:25169008 PMID:30682494 PMID:30836114 PMID:32519852 PMID:36990132

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression
multiple interactions

triptolide results in decreased expression of NR0B2 mRNA
[triptolide co-treated with Lipopolysaccharides] results in decreased expression of NR0B2 protein; [triptolide co-treated with TNF protein] results in decreased expression of NR0B2 protein; GW 4064 inhibits the reaction [[triptolide co-treated with T