CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | Triptolide |
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Accession: | CHEBI:9747
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browse the term
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Definition: | An oxacycle that has formula C20H24O6. |
Synonyms: | related_synonym: | Formula=C20H24O6; InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1; InChIKey=DFBIRQPKNDILPW-CIVMWXNOSA-N; SMILES=CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O |
| xref: | CAS:38748-32-2; KEGG:C09204; KNApSAcK:C00003494; LINCS:LSM-5518 |
| xref_mesh: | MESH:C001899 |
| xref: | Wikipedia:Triptolide |
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Aaas |
aladin WD repeat nucleoporin |
increases expression |
ISO |
triptolide results in increased expression of AAAS mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
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Aadac |
arylacetamide deacetylase |
decreases expression |
ISO |
triptolide results in decreased expression of AADAC mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
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Abca4 |
ATP binding cassette subfamily A member 4 |
increases expression |
ISO |
triptolide results in increased expression of ABCA4 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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Abcb11 |
ATP binding cassette subfamily B member 11 |
increases expression decreases expression multiple interactions |
EXP ISO |
triptolide results in increased expression of ABCB11 protein triptolide results in decreased expression of ABCB11 mRNA triptolide results in decreased expression of ABCB11 protein [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein] |
CTD |
PMID:32519852 PMID:32987112 PMID:36328986 PMID:36990132 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases response to substance increases expression decreases expression |
ISO EXP |
[ABCB1A mutant form co-treated with triptolide] results in increased abundance of Malondialdehyde; ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein] ABCB1A protein results in decreased susceptibility to triptolide triptolide results in increased expression of ABCB1A protein triptolide results in decreased expression of ABCB1A protein |
CTD |
PMID:26134275 PMID:32519852 PMID:33600922 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b |
ATP-binding cassette, sub-family B member 1B |
decreases expression increases expression |
EXP ISO |
triptolide results in decreased expression of ABCB1B mRNA triptolide results in increased expression of ABCB1B mRNA |
CTD |
PMID:32835833 PMID:33600922 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcc2 |
ATP binding cassette subfamily C member 2 |
affects expression decreases expression multiple interactions |
ISO |
triptolide affects the expression of ABCC2 protein triptolide results in decreased expression of ABCC2 protein [triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 protein |
CTD |
PMID:36328986 PMID:36990132 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression decreases expression |
ISO |
triptolide results in increased expression of ABCC4 mRNA triptolide results in decreased expression of ABCC4 protein |
CTD |
PMID:32835833 PMID:36990132 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcd2 |
ATP binding cassette subfamily D member 2 |
decreases expression |
ISO |
triptolide results in decreased expression of ABCD2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression |
EXP |
triptolide results in increased expression of ABCG2 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abhd2 |
abhydrolase domain containing 2, acylglycerol lipase |
increases expression |
ISO |
triptolide results in increased expression of ABHD2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
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Abhd5 |
abhydrolase domain containing 5, lysophosphatidic acid acyltransferase |
increases expression |
ISO |
triptolide results in increased expression of ABHD5 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447
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Abtb2 |
ankyrin repeat and BTB domain containing 2 |
increases expression |
ISO |
triptolide results in increased expression of ABTB2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548
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Acaa1b |
acetyl-Coenzyme A acyltransferase 1B |
decreases expression |
EXP |
triptolide results in decreased expression of ACAA1B protein |
CTD |
PMID:32519852 |
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NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
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Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation |
ISO |
triptolide results in increased phosphorylation of ACACA protein |
CTD |
PMID:29723566 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acacb |
acetyl-CoA carboxylase beta |
decreases expression |
ISO |
triptolide results in decreased expression of ACACB mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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Acly |
ATP citrate lyase |
decreases expression |
ISO |
triptolide results in decreased expression of ACLY mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Acot1 |
acyl-CoA thioesterase 1 |
decreases expression increases expression |
ISO EXP |
triptolide results in decreased expression of ACOT1 mRNA triptolide results in increased expression of ACOT1 protein |
CTD |
PMID:31241159 PMID:32519852 |
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NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
triptolide results in increased expression of ACOT2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acot3 |
acyl-CoA thioesterase 3 |
increases expression |
ISO |
triptolide results in increased expression of ACOT3 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427 Ensembl chr 6:103,682,596...103,688,427
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Acot9 |
acyl-CoA thioesterase 9 |
increases expression |
ISO |
triptolide results in increased expression of ACOT9 mRNA |
CTD |
PMID:32835833 |
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NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559
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Acox2 |
acyl-CoA oxidase 2 |
decreases expression increases expression |
ISO EXP |
triptolide results in decreased expression of ACOX2 mRNA triptolide results in increased expression of ACOX2 protein |
CTD |
PMID:31241159 PMID:32519852 |
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NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
decreases expression |
ISO |
triptolide results in decreased expression of ACSL5 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acsm1 |
acyl-CoA synthetase medium-chain family member 1 |
decreases expression |
EXP |
triptolide results in decreased expression of ACSM1 protein |
CTD |
PMID:32519852 |
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NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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Acsm2 |
acyl-CoA synthetase medium-chain family member 2 |
decreases expression |
EXP |
triptolide results in decreased expression of ACSM2 protein |
CTD |
PMID:32519852 |
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NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
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Acss2 |
acyl-CoA synthetase short-chain family member 2 |
decreases expression |
ISO |
triptolide results in decreased expression of ACSS2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Actb |
actin, beta |
decreases expression |
EXP |
triptolide results in decreased expression of ACTB mRNA; triptolide results in decreased expression of ACTB protein |
CTD |
PMID:27554044 |
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NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Ada |
adenosine deaminase |
increases expression |
EXP |
triptolide results in increased expression of ADA protein |
CTD |
PMID:32519852 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Adam11 |
ADAM metallopeptidase domain 11 |
decreases expression |
ISO |
triptolide results in decreased expression of ADAM11 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
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Adam1a |
ADAM metallopeptidase domain 1a |
increases expression |
ISO |
triptolide results in increased expression of ADAM1A mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
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Adam2 |
ADAM metallopeptidase domain 2 |
increases expression |
ISO |
triptolide results in increased expression of ADAM2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr15:40,242,651...40,284,025
Ensembl chr15:40,242,783...40,283,952
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Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
increases expression |
ISO |
triptolide results in increased expression of ADAMTS1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adgre1 |
adhesion G protein-coupled receptor E1 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of ADGRE1 mRNA STING1 protein affects the reaction [triptolide results in decreased expression of ADGRE1 mRNA] |
CTD |
PMID:36520315 |
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NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Adgrf1 |
adhesion G protein-coupled receptor F1 |
decreases expression |
ISO |
triptolide results in decreased expression of ADGRF1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704
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Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
decreases expression |
EXP |
triptolide results in decreased expression of ADH1 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Adpgk |
ADP-dependent glucokinase |
increases expression |
EXP ISO |
triptolide results in increased expression of ADPGK mRNA |
CTD |
PMID:23639586 PMID:32835833 |
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NCBI chr 8:59,699,400...59,727,352
Ensembl chr 8:59,699,388...59,727,351
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Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
triptolide results in increased expression of AEN mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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Afg2a |
AFG2 AAA ATPase homolog A |
increases expression |
ISO |
triptolide results in increased expression of AFG2A mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:120,306,417...120,497,707
Ensembl chr 2:120,306,412...120,497,705
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Afm |
afamin |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of AFM protein triptolide results in decreased expression of AFM mRNA |
CTD |
PMID:32519852 PMID:32835833 |
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NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870
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Afmid |
arylformamidase |
decreases expression |
ISO |
triptolide results in decreased expression of AFMID mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718
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Agpat5 |
1-acylglycerol-3-phosphate O-acyltransferase 5 |
increases expression |
ISO |
triptolide results in increased expression of AGPAT5 mRNA |
CTD |
PMID:32835833 |
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NCBI chr16:70,939,480...70,985,745
Ensembl chr16:70,943,135...70,985,560
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Agps |
alkylglycerone phosphate synthase |
increases expression |
EXP |
triptolide results in increased expression of AGPS protein |
CTD |
PMID:32519852 |
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NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
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Ahcy |
adenosylhomocysteinase |
decreases expression |
ISO |
triptolide results in decreased expression of AHCY mRNA |
CTD |
PMID:32835833 |
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NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
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Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
decreases expression |
ISO |
triptolide results in decreased expression of AIFM1 protein |
CTD |
PMID:26990902 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
EXP |
triptolide results in increased expression of AKR1B1 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10 |
aldo-keto reductase family 1 member B10 |
decreases expression |
EXP |
triptolide results in decreased expression of AKR1B10 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases expression |
ISO |
triptolide results in decreased expression of AKR1C6 mRNA |
CTD |
PMID:32835833 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr7a2 |
aldo-keto reductase family 7, member A2 |
increases expression |
EXP |
triptolide results in increased expression of AKR7A2 protein |
CTD |
PMID:32519852 |
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NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
EXP ISO |
triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] triptolide results in decreased phosphorylation of AKT1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:21717513 PMID:32061799 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2 |
AKT serine/threonine kinase 2 |
decreases expression |
EXP |
triptolide results in decreased expression of AKT2 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alb |
albumin |
increases expression |
EXP |
triptolide results in increased expression of ALB protein |
CTD |
PMID:32519852 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1l1 |
aldehyde dehydrogenase 1 family, member L1 |
decreases expression |
ISO |
triptolide results in decreased expression of ALDH1L1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
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Aldob |
aldolase, fructose-bisphosphate B |
decreases expression |
EXP ISO |
triptolide results in decreased expression of ALDOB mRNA |
CTD |
PMID:23639586 PMID:32835833 |
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NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
triptolide results in decreased expression of ALDOC mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
[triptolide co-treated with FASL protein] results in increased expression of ALPL protein |
CTD |
PMID:37944651 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Amacr |
alpha-methylacyl-CoA racemase |
affects expression |
EXP |
triptolide affects the expression of AMACR protein |
CTD |
PMID:32519852 |
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NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
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Ambp |
alpha-1-microglobulin/bikunin precursor |
increases expression |
EXP |
triptolide results in increased expression of AMBP protein |
CTD |
PMID:32519852 |
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NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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Amh |
anti-Mullerian hormone |
increases expression |
ISO |
triptolide results in increased expression of AMH mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Ankmy1 |
ankyrin repeat and MYND domain containing 1 |
increases expression |
ISO |
triptolide results in increased expression of ANKMY1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:93,423,664...93,476,651
Ensembl chr 9:93,423,963...93,477,236
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Ankrd13a |
ankyrin repeat domain 13a |
increases expression |
ISO |
triptolide results in increased expression of ANKRD13A mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:41,798,196...41,828,327
Ensembl chr12:41,798,199...41,829,327
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Ano6 |
anoctamin 6 |
increases expression |
EXP |
triptolide results in increased expression of ANO6 protein |
CTD |
PMID:32519852 |
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NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589
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Anp32e |
acidic nuclear phosphoprotein 32 family member E |
increases expression |
EXP |
triptolide results in increased expression of ANP32E protein |
CTD |
PMID:32519852 |
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NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054
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Anpep |
alanyl aminopeptidase, membrane |
affects expression |
EXP |
triptolide affects the expression of ANPEP protein |
CTD |
PMID:32519852 |
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NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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Anxa13 |
annexin A13 |
increases expression |
EXP |
triptolide results in increased expression of ANXA13 protein |
CTD |
PMID:32519852 |
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NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907
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Anxa9 |
annexin A9 |
increases expression |
ISO |
triptolide results in increased expression of ANXA9 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
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Aoc2-ps1 |
amine oxidase, copper containing 2, pseudogene 1 |
increases expression |
ISO |
triptolide results in increased expression of AOC2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:86,267,007...86,268,473
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression multiple interactions |
ISO EXP |
triptolide results in increased expression of APAF1 protein NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein] |
CTD |
PMID:25169008 PMID:26990902 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apex2 |
apurinic/apyrimidinic endodeoxyribonuclease 2 |
affects expression |
ISO |
triptolide affects the expression of APEX2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439
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G |
Apoa1 |
apolipoprotein A1 |
increases expression |
EXP |
triptolide results in increased expression of APOA1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Aqp1 |
aquaporin 1 |
increases expression |
EXP |
triptolide results in increased expression of AQP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Aqp2 |
aquaporin 2 |
increases expression |
EXP |
triptolide results in increased expression of AQP2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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G |
Aqp4 |
aquaporin 4 |
decreases expression |
ISO |
triptolide results in decreased expression of AQP4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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G |
Aqp8 |
aquaporin 8 |
decreases expression |
ISO |
triptolide results in decreased expression of AQP8 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
increases expression |
ISO |
triptolide results in increased expression of ARC mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Arglu1 |
arginine and glutamate rich 1 |
increases expression |
EXP |
triptolide results in increased expression of ARGLU1 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349
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G |
Arhgef16 |
Rho guanine nucleotide exchange factor 16 |
decreases expression |
ISO |
triptolide results in decreased expression of ARHGEF16 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212
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G |
Arhgef37 |
Rho guanine nucleotide exchange factor 37 |
decreases expression |
ISO |
triptolide results in decreased expression of ARHGEF37 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:54,935,256...55,001,017
Ensembl chr18:54,949,110...55,000,669
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G |
Arid1a |
AT-rich interaction domain 1A |
increases expression |
ISO |
triptolide results in increased expression of ARID1A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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G |
Arid5a |
AT-rich interaction domain 5A |
increases expression |
ISO |
triptolide results in increased expression of ARID5A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
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G |
Arl8b |
ARF like GTPase 8B |
decreases expression |
EXP |
triptolide results in decreased expression of ARL8B protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596
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G |
Armc9 |
armadillo repeat containing 9 |
increases expression |
EXP |
triptolide results in increased expression of ARMC9 protein |
CTD |
PMID:32519852 |
|
NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860
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G |
Arrb1 |
arrestin, beta 1 |
increases expression |
EXP |
triptolide results in increased expression of ARRB1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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|
G |
Ascl3 |
achaete-scute family bHLH transcription factor 3 |
increases expression |
ISO |
triptolide results in increased expression of ASCL3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:163,755,306...163,755,951
Ensembl chr 1:163,754,956...163,759,682
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|
G |
Asgr1 |
asialoglycoprotein receptor 1 |
decreases expression |
ISO |
triptolide results in decreased expression of ASGR1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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G |
Asl |
argininosuccinate lyase |
decreases expression |
ISO |
triptolide results in decreased expression of ASL mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
EXP |
triptolide results in increased expression of ASNS protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Ass1 |
argininosuccinate synthase 1 |
decreases expression |
EXP ISO |
triptolide results in decreased expression of ASS1 protein triptolide results in decreased expression of ASS1 mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
triptolide results in increased expression of ATF3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
decreases expression multiple interactions increases expression |
EXP ISO |
triptolide results in decreased expression of ATF4 mRNA STING1 protein affects the reaction [triptolide results in increased expression of ATF4 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of ATF4 mRNA] triptolide results in increased expression of ATF4 mRNA; triptolide results in increased expression of ATF4 protein |
CTD |
PMID:23639586 PMID:36520315 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf5 |
activating transcription factor 5 |
decreases expression |
ISO |
triptolide results in decreased expression of ATF5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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G |
Atf6 |
activating transcription factor 6 |
decreases expression increases expression multiple interactions |
ISO |
triptolide results in decreased expression of ATF6 protein triptolide results in increased expression of ATF6 mRNA STING1 protein affects the reaction [triptolide results in increased expression of ATF6 mRNA]; STING1 protein affects the reaction [triptolide results in increased expression of ATF6 protein] |
CTD |
PMID:26990902 PMID:36520315 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atf6b |
activating transcription factor 6 beta |
decreases expression |
ISO |
triptolide results in decreased expression of ATF6B protein |
CTD |
PMID:26990902 |
|
NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
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G |
Atg12 |
autophagy related 12 |
increases expression |
ISO |
triptolide results in increased expression of ATG12 protein |
CTD |
PMID:26990902 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg5 |
autophagy related 5 |
increases expression |
ISO |
triptolide results in increased expression of ATG5 protein |
CTD |
PMID:26990902 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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|
G |
Atg7 |
autophagy related 7 |
increases expression |
ISO |
triptolide results in increased expression of ATG7 protein |
CTD |
PMID:26990902 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Atp11a |
ATPase phospholipid transporting 11A |
increases expression |
EXP |
triptolide results in increased expression of ATP11A protein |
CTD |
PMID:32519852 |
|
NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions decreases expression |
EXP ISO |
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]] triptolide results in decreased expression of ATP5F1A mRNA; triptolide results in decreased expression of ATP5F1A protein |
CTD |
PMID:36436616 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
decreases expression |
EXP |
triptolide results in decreased expression of ATP5F1E protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp5mc3 |
ATP synthase membrane subunit c locus 3 |
increases expression |
EXP |
triptolide results in increased expression of ATP5MC3 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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G |
Atp5me |
ATP synthase membrane subunit e |
increases expression |
EXP |
triptolide results in increased expression of ATP5ME protein |
CTD |
PMID:32519852 |
|
NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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G |
Atp5mj |
ATP synthase membrane subunit j |
decreases expression |
EXP |
triptolide results in decreased expression of ATP5MJ protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:131,018,737...131,024,488
Ensembl chr 1:168,472,329...168,472,610 Ensembl chr 1:168,472,329...168,472,610
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G |
Atp6v0a1 |
ATPase H+ transporting V0 subunit a1 |
increases expression |
EXP |
triptolide results in increased expression of ATP6V0A1 protein |
CTD |
PMID:32519852 |
|
NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
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G |
Atp6v0a4 |
ATPase H+ transporting V0 subunit a4 |
increases expression |
EXP |
triptolide results in increased expression of ATP6V0A4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:66,760,163...66,842,126
Ensembl chr 4:66,760,159...66,842,110
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G |
Atp6v0c |
ATPase H+ transporting V0 subunit C |
increases expression |
EXP |
triptolide results in increased expression of ATP6V0C protein |
CTD |
PMID:32519852 |
|
NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500
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G |
Atp6v0d1 |
ATPase H+ transporting V0 subunit D1 |
increases expression |
EXP |
triptolide results in increased expression of ATP6V0D1 protein |
CTD |
PMID:32519852 |
|
NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
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G |
Atp8b5 |
ATPase, class I, type 8B, member 5 |
increases expression |
ISO |
triptolide results in increased expression of ATP8B5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
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G |
B4galt1 |
beta-1,4-galactosyltransferase 1 |
increases expression |
ISO |
triptolide results in increased expression of B4GALT1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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G |
Bag3 |
BAG cochaperone 3 |
increases expression |
ISO |
triptolide results in increased expression of BAG3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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G |
Baiap3 |
BAI1-associated protein 3 |
increases expression |
ISO |
triptolide results in increased expression of BAIAP3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions increases expression |
EXP ISO |
pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAK1 protein] |
CTD |
PMID:30009776 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression affects expression |
EXP ISO |
NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]; Quercetin inhibits the reaction [triptolide affects the expression of BAX protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of BAX protein] ABCB1A mutant form promotes the reaction [triptolide results in increased expression of BAX protein]; mitoquinone inhibits the reaction [triptolide results in increased expression of BAX protein]; tariquidar promotes the reaction [triptolide results in increased expression of BAX protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of BAX protein] triptolide results in increased expression of BAX mRNA; triptolide results in increased expression of BAX protein |
CTD |
PMID:25169008 PMID:26134275 PMID:26277538 PMID:26990902 PMID:30009776 PMID:30836114 PMID:32835833 More...
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|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
EXP |
triptolide results in increased expression of BBC3 protein |
CTD |
PMID:30009776 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions affects expression increases expression |
EXP ISO |
triptolide results in decreased expression of BCL2 protein Lithium Chloride inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [triptolide affects the expression of BCL2 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in decreased expression of BCL2 protein] ABCB1A mutant form promotes the reaction [triptolide results in decreased expression of BCL2 protein]; FASL protein promotes the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; tariquidar promotes the reaction [triptolide results in decreased expression of BCL2 protein]; TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2 protein] triptolide results in increased expression of BCL2 protein |
CTD |
PMID:25169008 PMID:26134275 PMID:26277538 PMID:26990902 PMID:30009776 PMID:30394310 PMID:30836114 PMID:30926361 PMID:37944651 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression multiple interactions decreases expression |
ISO EXP |
triptolide results in increased expression of BCL2L1 protein pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein] TRP53 gene mutant form inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein] |
CTD |
PMID:26990902 PMID:30009776 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l14 |
Bcl2-like 14 |
increases expression |
ISO |
triptolide results in increased expression of BCL2L14 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
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G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of BDH2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
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G |
Becn1 |
beclin 1 |
increases expression |
ISO |
triptolide results in increased expression of BECN1 protein |
CTD |
PMID:26990902 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bfsp1 |
beaded filament structural protein 1 |
increases expression |
ISO |
triptolide results in increased expression of BFSP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:131,195,087...131,252,668
Ensembl chr 3:131,195,087...131,229,337
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
decreases expression |
ISO |
triptolide results in decreased expression of BHLHE40 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Bid |
BH3 interacting domain death agonist |
increases expression |
ISO |
triptolide results in increased expression of BID protein |
CTD |
PMID:26990902 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
triptolide results in decreased expression of BIRC3 mRNA |
CTD |
PMID:15972136 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Blvra |
biliverdin reductase A |
affects expression |
EXP |
triptolide affects the expression of BLVRA protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
ISO |
triptolide results in decreased expression of BMF mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bop1 |
BOP1 ribosomal biogenesis factor |
increases expression |
ISO |
triptolide results in increased expression of BOP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931
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G |
Bsnd |
barttin CLCNK type accessory subunit beta |
decreases expression |
EXP |
triptolide results in decreased expression of BSND protein |
CTD |
PMID:32519852 |
|
NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
increases expression |
EXP |
triptolide results in increased expression of BST2 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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G |
Btaf1 |
B-TFIID TATA-box binding protein associated factor 1 |
increases expression |
ISO |
triptolide results in increased expression of BTAF1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:234,653,219...234,743,903
Ensembl chr 1:234,653,156...234,743,903
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G |
Btbd10 |
BTB domain containing 10 |
increases expression |
ISO |
triptolide results in increased expression of BTBD10 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:167,431,311...167,489,320
Ensembl chr 1:167,431,329...167,489,916
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G |
Btg3 |
BTG anti-proliferation factor 3 |
increases expression |
ISO |
triptolide results in increased expression of BTG3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
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G |
Btnl9 |
butyrophilin-like 9 |
increases expression |
ISO |
triptolide results in increased expression of BTNL9 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:33,466,059...33,489,229
Ensembl chr10:33,470,536...33,489,025
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|
G |
Bub1 |
BUB1 mitotic checkpoint serine/threonine kinase |
decreases expression increases expression |
EXP |
triptolide results in decreased expression of BUB1 mRNA triptolide results in increased expression of BUB1 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
increases expression |
EXP |
triptolide results in increased expression of BUB1B mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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G |
Bub3 |
BUB3 mitotic checkpoint protein |
decreases expression |
EXP |
triptolide results in decreased expression of BUB3 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036
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G |
C11h21orf91 |
similar to human chromosome 21 open reading frame 91 |
increases expression |
ISO |
triptolide results in increased expression of D16ERTD472E mRNA |
CTD |
PMID:32835833 |
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NCBI chr11:17,229,129...17,262,307
Ensembl chr11:17,229,138...17,262,483
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G |
C1qa |
complement C1q A chain |
increases expression |
EXP |
triptolide results in increased expression of C1QA protein |
CTD |
PMID:32519852 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C3 |
complement C3 |
increases expression |
EXP |
triptolide results in increased expression of C3 protein |
CTD |
PMID:32519852 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4a |
complement C4A |
increases expression |
EXP |
triptolide results in increased expression of C4A protein |
CTD |
PMID:32519852 |
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NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
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G |
Cabcoco1 |
ciliary associated calcium binding coiled-coil 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CABCOCO1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr20:20,058,492...20,167,973
Ensembl chr20:20,058,454...20,167,725
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G |
Cabyr |
calcium binding tyrosine phosphorylation regulated |
increases expression |
ISO |
triptolide results in increased expression of CABYR mRNA |
CTD |
PMID:32835833 |
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NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840
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G |
Cald1 |
caldesmon 1 |
decreases expression |
EXP |
triptolide results in decreased expression of CALD1 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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G |
Camta2 |
calmodulin binding transcription activator 2 |
increases expression |
ISO |
triptolide results in increased expression of CAMTA2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558
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G |
Capg |
capping actin protein, gelsolin like |
increases expression |
EXP |
triptolide results in increased expression of CAPG protein |
CTD |
PMID:32519852 |
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NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
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G |
Capn1 |
calpain 1 |
increases expression |
ISO |
triptolide results in increased expression of CAPN1 protein |
CTD |
PMID:26990902 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn2 |
calpain 2 |
increases expression |
ISO |
triptolide results in increased expression of CAPN2 protein |
CTD |
PMID:26990902 |
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NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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G |
Caps |
calcyphosine |
increases expression |
ISO |
triptolide results in increased expression of TNFRSF23 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647
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G |
Car1 |
carbonic anhydrase 1 |
increases expression |
EXP |
triptolide results in increased expression of CA1 protein |
CTD |
PMID:32519852 |
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NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car14 |
carbonic anhydrase 14 |
decreases expression |
ISO |
triptolide results in decreased expression of CAR14 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693
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G |
Car3 |
carbonic anhydrase 3 |
increases expression |
EXP |
triptolide results in increased expression of CA3 protein |
CTD |
PMID:32519852 |
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NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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G |
Car9 |
carbonic anhydrase 9 |
multiple interactions |
ISO |
triptolide inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein] |
CTD |
PMID:24842335 |
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NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Carf |
calcium responsive transcription factor |
increases expression |
ISO |
triptolide results in increased expression of CARF mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:61,502,368...61,552,433
Ensembl chr 9:61,506,956...61,550,462
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G |
Carhsp1 |
calcium regulated heat stable protein 1 |
decreases expression |
EXP |
triptolide results in decreased expression of CARHSP1 protein |
CTD |
PMID:32519852 |
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NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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G |
Carmil1 |
capping protein regulator and myosin 1 linker 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CARMIL1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
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G |
Carmil2 |
capping protein regulator and myosin 1 linker 2 |
increases expression |
ISO |
triptolide results in increased expression of RLTPR mRNA |
CTD |
PMID:32835833 |
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NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA; [triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of CASP1 protein] |
CTD |
PMID:36328986 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
increases expression |
ISO |
triptolide results in increased expression of CASP12 protein |
CTD |
PMID:26990902 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases cleavage increases expression |
ISO EXP |
NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; TP53 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased activity of and results in increased cleavage of CASP3 protein triptolide results in increased activity of CASP3 protein 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP3 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased cleavage of CASP3 protein] [triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]; CASP3 inhibits the reaction [[triptolide co-treated with FASL protein] results in increased cleavage of XIAP protein]; FASL protein promotes the reaction [triptolide results in increased cleavage of and results in increased activity of CASP3 protein]; mitoquinone inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; TRAJ18 protein affects the reaction [triptolide results in increased cleavage of CASP3 protein]; triptolide results in increased cleavage of and results in increased activity of CASP3 protein; triptolide results in increased expression of and results in increased activity of CASP3 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased cleavage of CASP3 protein] |
CTD |
PMID:12533674 PMID:15972136 PMID:19233258 PMID:21640813 PMID:23639586 PMID:25169008 PMID:26277538 PMID:26990902 PMID:30009776 PMID:30394310 PMID:30633930 PMID:30836114 PMID:30926361 PMID:31557070 PMID:32835833 PMID:36520315 PMID:36990132 PMID:37944651 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein; GW 4064 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of CASP4 protein] |
CTD |
PMID:36328986 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
increases activity increases expression |
ISO EXP |
triptolide results in increased activity of CASP7 protein triptolide results in increased expression of CASP7 protein |
CTD |
PMID:21640813 PMID:32519852 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form; triptolide results in increased expression of and results in increased activity of CASP8 protein |
CTD |
PMID:26990902 PMID:30633930 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity increases expression increases cleavage |
EXP ISO |
pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]; Quercetin inhibits the reaction [triptolide results in increased activity of CASP9 protein]; Val-Pro-Met-Leu-Lys inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form] triptolide results in increased expression of and results in increased activity of CASP9 protein; TRP53 gene mutant form inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form] triptolide results in increased cleavage of CASP9 protein |
CTD |
PMID:26277538 PMID:26990902 PMID:30009776 PMID:32835833 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Castor1 |
cytosolic arginine sensor for mTORC1 subunit 1 |
increases expression |
EXP |
triptolide results in increased expression of CASTOR1 protein |
CTD |
PMID:32519852 |
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NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
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G |
Cat |
catalase |
decreases activity multiple interactions |
ISO |
triptolide results in decreased activity of CAT protein Chlormethiazole inhibits the reaction [triptolide results in decreased activity of CAT protein]; pyrazole promotes the reaction [triptolide results in decreased activity of CAT protein] |
CTD |
PMID:34758665 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
increases expression |
EXP |
triptolide results in increased expression of CAV1 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cbarp |
CACN subunit beta associated regulatory protein |
increases expression |
ISO |
triptolide results in increased expression of CBARP mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204
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G |
Cblc |
Cbl proto-oncogene C |
decreases expression |
EXP |
triptolide results in decreased expression of CBLC mRNA |
CTD |
PMID:23639586 |
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NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
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G |
Cbr3 |
carbonyl reductase 3 |
increases expression |
ISO |
triptolide results in increased expression of CBR3 mRNA |
CTD |
PMID:32835833 |
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NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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G |
Ccdc120 |
coiled-coil domain containing 120 |
increases expression |
ISO |
triptolide results in increased expression of CCDC120 mRNA |
CTD |
PMID:32835833 |
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NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743
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G |
Ccdc15 |
coiled-coil domain containing 15 |
increases expression |
ISO |
triptolide results in increased expression of CCDC15 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 8:36,991,147...37,068,849
Ensembl chr 8:36,998,867...37,068,919
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G |
Ccdc180 |
coiled-coil domain containing 180 |
increases expression |
ISO |
triptolide results in increased expression of CCDC180 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 5:60,154,883...60,223,508
Ensembl chr 5:60,154,910...60,223,522
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G |
Ccdc196 |
coiled-coil domain containing 196 |
increases expression |
EXP |
triptolide results in increased expression of CCDC196 protein |
CTD |
PMID:32519852 |
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NCBI chr 6:96,913,960...96,939,415
Ensembl chr 6:96,915,869...96,931,141
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G |
Ccdc62 |
coiled-coil domain containing 62 |
increases expression |
ISO |
triptolide results in increased expression of CCDC62 mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:32,623,170...32,659,912
Ensembl chr12:32,623,170...32,660,017
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G |
Ccdc86 |
coiled-coil domain containing 86 |
increases expression |
ISO |
triptolide results in increased expression of CCDC86 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:207,590,167...207,596,547
Ensembl chr 1:207,590,168...207,596,544
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G |
Ccl11 |
C-C motif chemokine ligand 11 |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of CCL11 mRNA IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA] |
CTD |
PMID:24949944 |
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NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
triptolide promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] triptolide results in increased expression of CCL2 mRNA |
CTD |
PMID:30633930 PMID:32835833 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
triptolide results in decreased expression of CCNA1 protein |
CTD |
PMID:12533674 |
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NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccna2 |
cyclin A2 |
increases expression |
EXP |
triptolide results in increased expression of CCNA2 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of CCNB1 mRNA triptolide results in decreased expression of CCNB1 protein |
CTD |
PMID:12533674 PMID:23639586 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb2 |
cyclin B2 |
increases expression |
EXP |
triptolide results in increased expression of CCNB2 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
EXP ISO |
triptolide results in decreased expression of CCND1 mRNA triptolide results in decreased expression of CCND1 protein |
CTD |
PMID:12533674 PMID:23639586 PMID:26990902 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
increases expression |
EXP |
triptolide results in increased expression of CCND2 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne1 |
cyclin E1 |
increases expression |
ISO |
triptolide results in increased expression of CCNE1 protein |
CTD |
PMID:26990902 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccne2 |
cyclin E2 |
increases expression |
EXP |
triptolide results in increased expression of CCNE2 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Ccng1 |
cyclin G1 |
increases expression |
ISO |
triptolide results in increased expression of CCNG1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Cd1d1 |
CD1d1 molecule |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of CD1D1 protein STING1 protein affects the reaction [triptolide results in increased expression of CD1D1 protein] |
CTD |
PMID:36520315 |
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NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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G |
Cd24 |
CD24 molecule |
multiple interactions |
ISO |
triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD24 protein] |
CTD |
PMID:24842335 |
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NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662
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G |
Cd36 |
CD36 molecule |
increases expression |
EXP |
triptolide results in increased expression of CD36 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40 |
CD40 molecule |
multiple interactions affects expression |
ISO |
STING1 protein affects the reaction [triptolide affects the expression of CD40 protein] |
CTD |
PMID:36520315 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd44 |
CD44 molecule |
multiple interactions |
ISO |
triptolide inhibits the reaction [cobaltous chloride results in increased expression of CD44 protein] |
CTD |
PMID:24842335 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd47 |
Cd47 molecule |
increases expression |
EXP |
triptolide results in increased expression of CD47 protein |
CTD |
PMID:32519852 |
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NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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G |
Cd59b |
CD59b molecule |
increases expression |
EXP |
triptolide results in increased expression of CD59 protein |
CTD |
PMID:32519852 |
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NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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G |
Cd68 |
Cd68 molecule |
multiple interactions decreases expression |
ISO |
STING1 protein affects the reaction [triptolide results in decreased expression of CD68 mRNA] |
CTD |
PMID:36520315 |
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NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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G |
Cd69 |
Cd69 molecule |
multiple interactions increases expression |
ISO |
STING1 protein affects the reaction [triptolide results in increased expression of CD69 protein] |
CTD |
PMID:36520315 |
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NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein] |
CTD |
PMID:15663903 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
multiple interactions increases expression |
ISO |
triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein] triptolide results in increased expression of CD86 protein |
CTD |
PMID:15663903 PMID:36520315 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cdc16 |
cell division cycle 16 |
decreases expression |
EXP |
triptolide results in decreased expression of CDC16 mRNA |
CTD |
PMID:23639586 |
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NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
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G |
Cdc25b |
cell division cycle 25B |
increases expression |
EXP |
triptolide results in increased expression of CDC25B mRNA |
CTD |
PMID:23639586 |
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NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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G |
Cdc42 |
cell division cycle 42 |
decreases expression |
EXP |
triptolide results in decreased expression of CDC42 mRNA; triptolide results in decreased expression of CDC42 protein |
CTD |
PMID:27554044 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdc45 |
cell division cycle 45 |
increases expression |
EXP |
triptolide results in increased expression of CDC45 mRNA |
CTD |
PMID:23639586 |
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NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of CDK1 mRNA triptolide results in decreased expression of CDK1 protein |
CTD |
PMID:12533674 PMID:23639586 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression increases expression |
EXP ISO |
triptolide results in decreased expression of CDK2 mRNA triptolide results in increased expression of CDK2 protein triptolide results in decreased expression of CDK2 protein |
CTD |
PMID:12533674 PMID:23639586 PMID:26990902 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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|
G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
triptolide results in increased expression of CDK4 protein |
CTD |
PMID:26990902 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdk6 |
cyclin-dependent kinase 6 |
increases expression |
ISO |
triptolide results in increased expression of CDK6 protein |
CTD |
PMID:26990902 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
|
|
G |
Cdk7 |
cyclin-dependent kinase 7 |
increases expression |
EXP |
triptolide results in increased expression of CDK7 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
|
|
G |
Cdkl3 |
cyclin-dependent kinase-like 3 |
increases expression |
ISO |
triptolide results in increased expression of CDKL3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression affects expression multiple interactions |
EXP ISO |
triptolide results in increased expression of CDKN1A mRNA triptolide results in increased expression of CDKN1A mRNA; triptolide results in increased expression of CDKN1A protein triptolide affects the expression of CDKN1A protein NFE2L2 protein inhibits the reaction [triptolide affects the expression of CDKN1A protein]; sulforaphane inhibits the reaction [triptolide affects the expression of CDKN1A protein] |
CTD |
PMID:23639586 PMID:26990902 PMID:32835833 PMID:36990132 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
triptolide results in increased expression of CDKN1B protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
increases expression |
EXP |
triptolide results in increased expression of CDKN2C mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
|
|
G |
Cdnf |
cerebral dopamine neurotrophic factor |
increases expression |
ISO |
triptolide results in increased expression of CDNF mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639
|
|
G |
Cep170b |
centrosomal protein 170B |
increases expression |
ISO |
triptolide results in increased expression of CEP170B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:131,780,935...131,806,658
Ensembl chr 6:131,778,957...131,806,658
|
|
G |
Cep63 |
centrosomal protein 63 |
increases expression |
ISO |
triptolide results in increased expression of CEP63 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177
|
|
G |
Ces1d |
carboxylesterase 1D |
increases expression |
EXP |
triptolide results in increased expression of CES1D protein |
CTD |
PMID:32519852 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Ces4a |
carboxylesterase 4A |
decreases expression |
ISO |
triptolide results in decreased expression of CES4A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr19:33,011,731...33,030,119
Ensembl chr19:33,011,731...33,029,545
|
|
G |
Cfap20dc |
CFAP20 domain containing |
decreases expression |
ISO |
triptolide results in decreased expression of CFAP20DC mRNA |
CTD |
PMID:32835833 |
|
NCBI chr15:16,231,248...16,476,978
Ensembl chr15:16,231,299...16,476,977
|
|
G |
Cfb |
complement factor B |
decreases expression |
ISO |
triptolide results in decreased expression of CFB mRNA |
CTD |
PMID:32835833 |
|
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
|
|
G |
Cfh |
complement factor H |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of CFH protein triptolide results in decreased expression of CFH mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
|
|
G |
Cfl2 |
cofilin 2 |
increases expression |
EXP |
triptolide results in increased expression of CFL2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674
|
|
G |
Cgas |
cyclic GMP-AMP synthase |
increases expression |
ISO |
triptolide results in increased expression of CGAS mRNA; triptolide results in increased expression of CGAS protein |
CTD |
PMID:36520315 |
|
NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496
|
|
G |
Chchd3 |
coiled-coil-helix-coiled-coil-helix domain containing 3 |
increases expression |
EXP |
triptolide results in increased expression of CHCHD3 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847
|
|
G |
Chchd6 |
coiled-coil-helix-coiled-coil-helix domain containing 6 |
increases expression |
EXP |
triptolide results in increased expression of CHCHD6 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
|
|
G |
Chka |
choline kinase alpha |
increases expression |
ISO |
triptolide results in increased expression of CHKA mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
|
|
G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
decreases expression |
ISO |
triptolide results in decreased expression of CHRNA4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
|
|
G |
Ciart |
circadian associated repressor of transcription |
decreases expression |
ISO |
triptolide results in decreased expression of CIART mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:183,419,819...183,424,845
Ensembl chr 2:183,419,819...183,423,313
|
|
G |
Cidec |
cell death-inducing DFFA-like effector c |
increases expression |
ISO |
triptolide results in increased expression of CIDEC mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
|
|
G |
Cimap1b |
ciliary microtubule associated protein 1B |
decreases expression |
ISO |
triptolide results in decreased expression of CIMAP1B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:120,444,232...120,447,294
Ensembl chr 7:120,444,232...120,446,749
|
|
G |
Ckap2 |
cytoskeleton associated protein 2 |
increases expression |
ISO |
triptolide results in increased expression of CKAP2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
|
|
G |
Clcf1 |
cardiotrophin-like cytokine factor 1 |
increases expression |
ISO |
triptolide results in increased expression of CLCF1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
|
|
G |
Clcnkb |
chloride voltage-gated channel Kb |
increases expression |
EXP |
triptolide results in increased expression of CLCNKB protein |
CTD |
PMID:32519852 |
|
NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
|
|
G |
Cldn11 |
claudin 11 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of CLDN11 mRNA; triptolide results in decreased expression of CLDN11 protein mitoquinone inhibits the reaction [triptolide results in decreased expression of CLDN11 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of CLDN11 protein] |
CTD |
PMID:30836114 |
|
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
|
|
G |
Clec11a |
C-type lectin domain containing 11A |
increases expression |
ISO |
triptolide results in increased expression of CLEC11A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633
|
|
G |
Clmn |
calmin |
decreases expression |
ISO |
triptolide results in decreased expression of CLMN mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272
|
|
G |
Clpx |
caseinolytic mitochondrial matrix peptidase chaperone subunit X |
affects expression |
ISO |
triptolide affects the expression of CLPX mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082
|
|
G |
Clu |
clusterin |
increases expression |
EXP |
triptolide results in increased expression of CLU protein |
CTD |
PMID:32519852 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
|
|
G |
Cluap1 |
clusterin associated protein 1 |
increases expression |
ISO |
triptolide results in increased expression of CLUAP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:11,587,963...11,619,711
Ensembl chr10:11,588,017...11,619,711
|
|
G |
Cmah |
cytidine monophospho-N-acetylneuraminic acid hydroxylase |
decreases expression |
ISO |
triptolide results in decreased expression of CMAH mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:40,557,161...40,642,350
Ensembl chr17:40,583,667...40,642,275
|
|
G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
increases expression |
EXP |
triptolide results in increased expression of CMPK2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
|
|
G |
Cnbp |
CCHC-type zinc finger, nucleic acid binding protein |
decreases expression |
EXP |
triptolide results in decreased expression of CNBP protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
|
|
G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of CNP protein triptolide results in decreased expression of CNP mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
|
|
G |
Cog5 |
component of oligomeric golgi complex 5 |
decreases expression |
EXP |
triptolide results in decreased expression of COG5 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:48,242,470...48,545,185
Ensembl chr 6:48,242,482...48,529,009
|
|
G |
Col11a2 |
collagen type XI alpha 2 chain |
increases expression |
ISO |
triptolide results in increased expression of COL11A2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985
|
|
G |
Col12a1 |
collagen type XII alpha 1 chain |
increases expression |
ISO |
triptolide results in increased expression of COL12A1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
|
|
G |
Col20a1 |
collagen type XX alpha 1 chain |
increases expression |
ISO |
triptolide results in increased expression of COL20A1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:168,102,475...168,134,759
Ensembl chr 3:168,084,560...168,135,309
|
|
G |
Col7a1 |
collagen type VII alpha 1 chain |
increases expression |
ISO |
triptolide results in increased expression of COL7A1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252
|
|
G |
Comt |
catechol-O-methyltransferase |
decreases expression |
EXP |
triptolide results in decreased expression of COMT protein |
CTD |
PMID:32519852 |
|
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
|
|
G |
Cp |
ceruloplasmin |
increases expression |
EXP |
triptolide results in increased expression of CP protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
|
|
G |
Cps1 |
carbamoyl-phosphate synthase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CPS1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
|
|
G |
Cpsf2 |
cleavage and polyadenylation specific factor 2 |
decreases expression |
EXP |
triptolide results in decreased expression of CPSF2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
triptolide results in increased expression of CPT1A mRNA |
CTD |
PMID:29723566 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
ISO |
triptolide results in decreased expression of CPT1B mRNA |
CTD |
PMID:31241159 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
|
|
G |
Cpt2 |
carnitine palmitoyltransferase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of CPT2 mRNA |
CTD |
PMID:31241159 |
|
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
|
|
G |
Crbn |
cereblon |
increases expression |
EXP |
triptolide results in increased expression of CRBN protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
|
|
G |
Creb3l4 |
cAMP responsive element binding protein 3-like 4 |
increases expression |
ISO |
triptolide results in increased expression of CREB3L4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932
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|
G |
Crem |
cAMP responsive element modulator |
decreases expression |
EXP |
triptolide results in decreased expression of CREM mRNA |
CTD |
PMID:23639586 |
|
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
|
|
G |
Crip2 |
cysteine-rich protein 2 |
increases expression |
ISO |
triptolide results in increased expression of CRIP2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
|
|
G |
Crk |
CRK proto-oncogene, adaptor protein |
decreases expression increases expression |
EXP |
triptolide results in decreased expression of CRK mRNA triptolide results in increased expression of CRK mRNA |
CTD |
PMID:23639586 |
|
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
|
|
G |
Crp |
C-reactive protein |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of CRP protein triptolide results in decreased expression of CRP mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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|
G |
Cry1 |
cryptochrome circadian regulator 1 |
increases expression |
ISO |
triptolide results in increased expression of CRY1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
|
|
G |
Cryab |
crystallin, alpha B |
increases expression |
ISO |
triptolide results in increased expression of CRYAB mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
|
|
G |
Cspg5 |
chondroitin sulfate proteoglycan 5 |
decreases expression |
ISO |
triptolide results in decreased expression of CSPG5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758
|
|
G |
Ctf1 |
cardiotrophin 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CTF1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
|
|
G |
Ctps1 |
CTP synthase 1 |
increases expression |
ISO |
triptolide results in increased expression of CTPS1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
|
|
G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
affects expression |
ISO |
triptolide affects the expression of CXCL11 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of CXCL2 mRNA IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA] |
CTD |
PMID:24949944 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions increases expression |
ISO |
IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; triptolide inhibits the reaction [Chlorine results in increased expression of CXCL1 protein] |
CTD |
PMID:20348278 PMID:24949944 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression |
ISO |
triptolide results in decreased expression of CXCR4 protein |
CTD |
PMID:26420756 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
|
|
G |
Cyb5r3 |
cytochrome b5 reductase 3 |
decreases expression |
ISO |
triptolide results in decreased expression of CYB5R3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions affects localization |
ISO EXP |
TRAJ18 protein affects the reaction [triptolide affects the localization of CYCS protein] 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide affects the localization of CYCS protein] |
CTD |
PMID:31557070 PMID:36520315 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions decreases expression |
EXP ISO |
triptolide results in decreased expression of and results in decreased activity of CYP11A1 protein triptolide results in decreased expression of CYP11A1 mRNA [Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:22592319 PMID:31557376 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
|
|
G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
multiple interactions |
ISO |
[Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA |
CTD |
PMID:31557376 |
|
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
|
|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA |
CTD |
PMID:31557376 |
|
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions decreases expression |
ISO |
[Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA triptolide results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:31557376 PMID:32835833 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
affects expression |
ISO |
triptolide affects the expression of CYP26A1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP27A1 mRNA |
CTD |
PMID:32987112 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
increases expression |
ISO |
triptolide results in increased expression of CYP27B1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP2A1 mRNA] |
CTD |
PMID:32987112 |
|
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP2A4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases expression |
EXP |
triptolide results in decreased expression of CYP2B1 mRNA |
CTD |
PMID:33600922 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions decreases expression |
ISO |
TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP2B10 mRNA] |
CTD |
PMID:32835833 PMID:32987112 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases expression |
EXP |
triptolide results in decreased expression of CYP2C11 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP2C29 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases expression |
EXP |
triptolide results in decreased expression of CYP2C8 protein |
CTD |
PMID:33600922 |
|
|
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
ISO |
triptolide results in increased expression of CYP2E1 mRNA; triptolide results in increased expression of CYP2E1 protein |
CTD |
PMID:34758665 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp39a1 |
cytochrome P450, family 39, subfamily a, polypeptide 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP39A1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing decreases expression |
EXP |
CYP3A2 affects the metabolism of triptolide triptolide results in decreased expression of CYP3A4 protein |
CTD |
PMID:20223271 PMID:33600922 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
decreases expression decreases activity |
EXP |
triptolide results in decreased expression of CYP3A23-3A1 mRNA triptolide results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:33600922 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp4f1 |
cytochrome P450, family 4, subfamily f, polypeptide 1 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP4F14 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
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G |
Cyp51 |
cytochrome P450, family 51 |
decreases expression |
ISO |
triptolide results in decreased expression of CYP51 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions decreases expression |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP7A1 mRNA] |
CTD |
PMID:32987112 PMID:36328986 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
multiple interactions decreases expression |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP8B1 protein; TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP8B1 mRNA] |
CTD |
PMID:32835833 PMID:32987112 PMID:36328986 |
|
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
decreases expression |
ISO |
triptolide results in decreased expression of DBP mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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G |
Dclk3 |
doublecortin-like kinase 3 |
decreases expression |
ISO |
triptolide results in decreased expression of DCLK3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:111,401,544...111,453,999
Ensembl chr 8:111,401,358...111,453,999
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G |
Ddias |
DNA damage-induced apoptosis suppressor |
increases expression |
ISO |
triptolide results in increased expression of DDIAS mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of DDIT3 mRNA; triptolide results in increased expression of DDIT3 protein STING1 protein affects the reaction [triptolide results in increased expression of DDIT3 mRNA]; STING1 protein affects the reaction [triptolide results in increased expression of DDIT3 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of DDIT3 mRNA] |
CTD |
PMID:26990902 PMID:27022166 PMID:36520315 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
increases expression |
ISO |
triptolide results in increased expression of DDIT4L mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Ddrgk1 |
DDRGK domain containing 1 |
decreases expression |
EXP |
triptolide results in decreased expression of DDRGK1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680
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G |
Ddx17 |
DEAD-box helicase 17 |
increases expression |
ISO |
triptolide results in increased expression of DDX17 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
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G |
Defb1 |
defensin beta 1 |
decreases expression |
ISO |
triptolide results in decreased expression of DEFB1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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G |
Dennd1a |
DENN domain containing 1A |
increases expression |
EXP |
triptolide results in increased expression of DENND1A protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:21,564,749...22,052,057
Ensembl chr 3:21,564,749...22,052,062
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G |
Depp1 |
DEPP autophagy regulator 1 |
decreases expression |
ISO |
triptolide results in decreased expression of DEPP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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G |
Des |
desmin |
multiple interactions |
EXP |
triptolide inhibits the reaction [Puromycin Aminonucleoside results in increased expression of DES protein] |
CTD |
PMID:18509322 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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G |
Dglucy |
D-glutamate cyclase |
decreases expression |
EXP |
triptolide results in decreased expression of DGLUCY protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
decreases expression |
ISO |
triptolide results in decreased expression of DHCR7 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhrs7 |
dehydrogenase/reductase 7 |
decreases expression |
ISO |
triptolide results in decreased expression of DHRS7 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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G |
Dhrs7b |
dehydrogenase/reductase 7B |
increases expression |
EXP |
triptolide results in increased expression of DHRS7B protein |
CTD |
PMID:32519852 |
|
NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
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G |
Dhrs7l1 |
dehydrogenase/reductase (SDR family) member 7-like 1 |
decreases expression |
EXP |
triptolide results in decreased expression of DHRS7L1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:91,289,200...91,312,010
Ensembl chr 6:91,289,200...91,312,010 Ensembl chr 6:91,289,200...91,312,010
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G |
Dhx29 |
DExH-box helicase 29 |
increases expression |
ISO |
triptolide results in increased expression of DHX29 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445
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G |
Dhx37 |
DEAH-box helicase 37 |
increases expression |
ISO |
triptolide results in increased expression of DHX37 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
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G |
Dhx38 |
DEAH-box helicase 38 |
increases expression |
ISO |
triptolide results in increased expression of DHX38 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
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G |
Dhx58 |
DEXH-box helicase 58 |
increases expression |
EXP |
triptolide results in increased expression of DHX58 protein |
CTD |
PMID:32519852 |
|
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of DIO1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dixdc1 |
DIX domain containing 1 |
decreases expression |
ISO |
triptolide results in decreased expression of DIXDC1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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G |
Dnah10 |
dynein, axonemal, heavy chain 10 |
increases expression |
ISO |
triptolide results in increased expression of DNAH10 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:31,823,451...31,946,857
Ensembl chr12:31,822,733...32,007,069
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G |
Dnah5 |
dynein, axonemal, heavy chain 5 |
increases expression |
ISO |
triptolide results in increased expression of DNAH5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:78,937,788...79,255,551
Ensembl chr 2:78,937,800...79,254,890
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G |
Dnai7 |
dynein axonemal intermediate chain 7 |
increases expression |
ISO |
triptolide results in increased expression of DNAI7 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:178,143,499...178,179,871
Ensembl chr 4:178,143,500...178,179,980
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G |
Dnajb12 |
DnaJ heat shock protein family (Hsp40) member B12 |
increases expression |
EXP |
triptolide results in increased expression of DNAJB12 protein |
CTD |
PMID:32519852 |
|
NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427
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G |
Dnajc6 |
DnaJ heat shock protein family (Hsp40) member C6 |
decreases expression |
EXP |
triptolide results in decreased expression of DNAJC6 protein |
CTD |
PMID:32519852 |
|
NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448
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G |
Dnhd1 |
dynein heavy chain domain 1 |
increases expression |
ISO |
triptolide results in increased expression of DNHD1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858
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G |
Dnm1l |
dynamin 1-like |
multiple interactions decreases expression increases expression |
ISO EXP |
mitoquinone inhibits the reaction [triptolide results in decreased expression of DNM1L protein] triptolide results in increased expression of DRP1 protein 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [triptolide results in increased expression of DRP1 protein] |
CTD |
PMID:30836114 PMID:31557070 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dpep1 |
dipeptidase 1 |
increases expression |
EXP |
triptolide results in increased expression of DPEP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
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G |
Dpp4 |
dipeptidylpeptidase 4 |
affects expression |
EXP |
triptolide affects the expression of DPP4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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G |
Dtnbp1 |
dystrobrevin binding protein 1 |
decreases expression |
EXP |
triptolide results in decreased expression of DTNBP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
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G |
Dtx4 |
deltex E3 ubiquitin ligase 4 |
increases expression |
ISO |
triptolide results in increased expression of DTX4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
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G |
Dusp1 |
dual specificity phosphatase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of DUSP1 protein |
CTD |
PMID:17507666 |
|
NCBI chr10:16,680,478...16,683,275
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G |
Dync2h1 |
dynein cytoplasmic 2 heavy chain 1 |
increases expression |
EXP |
triptolide results in increased expression of DYNC2H1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183
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G |
Dynll1 |
dynein light chain LC8-type 1 |
increases expression |
ISO |
triptolide results in increased expression of DYNLL1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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G |
E2f1 |
E2F transcription factor 1 |
increases expression |
EXP |
triptolide results in increased expression of E2F1 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f3 |
E2F transcription factor 3 |
increases expression |
EXP |
triptolide results in increased expression of E2F3 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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G |
Ears2 |
glutamyl-tRNA synthetase 2, mitochondrial |
increases expression |
ISO |
triptolide results in increased expression of EARS2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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G |
Echdc1 |
ethylmalonyl-CoA decarboxylase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of ECHDC1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319
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G |
Echdc2 |
enoyl CoA hydratase domain containing 2 |
decreases expression |
EXP |
triptolide results in decreased expression of ECHDC2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859
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G |
Eda2r |
ectodysplasin A2 receptor |
increases expression |
ISO |
triptolide results in increased expression of EDA2R mRNA |
CTD |
PMID:32835833 |
|
NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
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G |
Eef1e1 |
eukaryotic translation elongation factor 1 epsilon 1 |
increases expression |
ISO |
triptolide results in increased expression of EEF1E1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720
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G |
Efnb3 |
ephrin B3 |
increases expression |
ISO |
triptolide results in increased expression of EFNB3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
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G |
Egfr |
epidermal growth factor receptor |
decreases expression |
ISO |
triptolide results in decreased expression of EGFR mRNA |
CTD |
PMID:32835833 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Ehd2 |
EH-domain containing 2 |
increases expression |
EXP |
triptolide results in increased expression of EHD2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression |
ISO |
triptolide results in increased expression of EHHADH mRNA |
CTD |
PMID:29723566 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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|
G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
increases expression |
EXP |
triptolide results in increased expression of EIF2AK2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation |
ISO |
triptolide results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:27022166 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2b4 |
eukaryotic translation initiation factor 2B subunit delta |
increases expression |
EXP |
triptolide results in increased expression of EIF2B4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
affects phosphorylation multiple interactions |
ISO |
triptolide affects the phosphorylation of EIF2S1 protein TRAJ18 protein affects the reaction [triptolide affects the phosphorylation of EIF2S1 protein] |
CTD |
PMID:36520315 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
increases expression |
ISO |
triptolide results in increased expression of EIF4E mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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|
G |
Eif4ebp3 |
eukaryotic translation initiation factor 4E binding protein 3 |
decreases expression |
ISO |
triptolide results in decreased expression of EIF4EBP3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:28,263,089...28,268,033
Ensembl chr18:28,162,311...28,268,024
|
|
G |
Eipr1 |
EARP complex and GARP complex interacting protein 1 |
increases expression |
EXP |
triptolide results in increased expression of EIPR1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:45,388,451...45,502,089
Ensembl chr 6:45,388,376...45,502,083
|
|
G |
Elf3 |
E74 like ETS transcription factor 3 |
increases expression |
ISO |
triptolide results in increased expression of ELF3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
|
|
G |
Elovl2 |
ELOVL fatty acid elongase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of ELOVL2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
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|
G |
Elovl5 |
ELOVL fatty acid elongase 5 |
decreases expression |
ISO |
triptolide results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
|
|
G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression |
ISO |
triptolide results in decreased expression of ELOVL6 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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|
G |
Emc3 |
ER membrane protein complex subunit 3 |
increases expression |
EXP |
triptolide results in increased expression of EMC3 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029
|
|
G |
Emc8 |
ER membrane protein complex subunit 8 |
increases expression |
EXP |
triptolide results in increased expression of EMC8 protein |
CTD |
PMID:32519852 |
|
NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543
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|
G |
Eme2 |
essential meiotic structure-specific endonuclease subunit 2 |
increases expression |
ISO |
triptolide results in increased expression of EME2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968
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|
G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
triptolide results in increased expression of ENC1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
|
|
G |
Endod1 |
endonuclease domain containing 1 |
increases expression |
ISO |
triptolide results in increased expression of ENDOD1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892
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|
G |
Endog |
endonuclease G |
increases expression |
ISO |
triptolide results in increased expression of ENDOG protein |
CTD |
PMID:26990902 |
|
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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|
G |
Eno3 |
enolase 3 |
increases expression |
ISO |
triptolide results in increased expression of ENO3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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|
G |
Enpep |
glutamyl aminopeptidase |
affects expression |
EXP |
triptolide affects the expression of ENPEP protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
|
|
G |
Erlin1 |
ER lipid raft associated 1 |
increases expression |
EXP |
triptolide results in increased expression of ERLIN1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
|
|
G |
Ermp1 |
endoplasmic reticulum metallopeptidase 1 |
increases expression |
EXP |
triptolide results in increased expression of ERMP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
|
|
G |
Espl1 |
extra spindle pole bodies like 1, separase |
increases expression |
EXP |
triptolide results in increased expression of ESPL1 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
|
|
G |
Esrrb |
estrogen-related receptor beta |
increases expression |
EXP |
triptolide results in increased expression of ESRRB protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791
|
|
G |
Exoc4 |
exocyst complex component 4 |
increases expression |
ISO |
triptolide results in increased expression of EXOC4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
|
|
G |
Exosc9 |
exosome component 9 |
increases expression |
ISO |
triptolide results in increased expression of EXOSC9 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
|
|
G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
decreases expression |
ISO |
triptolide results in decreased expression of EZH2 protein |
CTD |
PMID:19879315 |
|
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
|
|
G |
F11 |
coagulation factor XI |
decreases expression |
ISO |
triptolide results in decreased expression of F11 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
|
|
G |
F2rl3 |
F2R like thrombin or trypsin receptor 3 |
increases expression |
ISO |
triptolide results in increased expression of F2RL3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472
|
|
G |
F5 |
coagulation factor V |
increases expression |
EXP |
triptolide results in increased expression of F5 protein |
CTD |
PMID:32519852 |
|
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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|
G |
F9 |
coagulation factor IX |
increases expression |
EXP |
triptolide results in increased expression of F9 protein |
CTD |
PMID:32519852 |
|
NCBI chr X:138,352,334...138,396,835
Ensembl chr X:138,352,298...138,396,835
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|
G |
Fabp1 |
fatty acid binding protein 1 |
decreases expression |
ISO |
triptolide results in decreased expression of FABP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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|
G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
EXP |
triptolide results in increased expression of FABP4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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|
G |
Fabp5 |
fatty acid binding protein 5 |
decreases expression |
ISO |
triptolide results in decreased expression of FABP5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
|
|
G |
Fads1 |
fatty acid desaturase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of FADS1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
|
|
G |
Fads2 |
fatty acid desaturase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of FADS2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
|
|
G |
Fam107a |
family with sequence similarity 107, member A |
decreases expression |
ISO |
triptolide results in decreased expression of FAM107A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
|
|
G |
Fam161b |
FAM161 centrosomal protein B |
increases expression |
ISO |
triptolide results in increased expression of FAM161B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:103,990,603...104,007,754
Ensembl chr 6:103,992,170...104,018,776
|
|
G |
Fam210b |
family with sequence similarity 210, member B |
increases expression |
EXP |
triptolide results in increased expression of FAM210B protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397
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|
G |
Fam47e |
family with sequence similarity 47, member E |
decreases expression |
ISO |
triptolide results in decreased expression of FAM47E mRNA |
CTD |
PMID:32835833 |
|
NCBI chr14:15,485,537...15,521,599
Ensembl chr14:15,485,127...15,521,775
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|
G |
Fam83h |
family with sequence similarity 83, member H |
increases expression |
ISO |
triptolide results in increased expression of FAM83H mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:107,716,431...107,724,619
Ensembl chr 7:107,716,431...107,728,672
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|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
triptolide results in increased expression of FAS protein |
CTD |
PMID:26990902 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
[triptolide co-treated with FASL protein] results in decreased expression of MIR137; [triptolide co-treated with FASL protein] results in decreased expression of XIAP mRNA; [triptolide co-treated with FASL protein] results in decreased expression of XIAP protein; [triptolide co-treated with FASL protein] results in increased expression of ALPL protein; [triptolide co-treated with FASL protein] results in increased expression of GOT1 protein; [triptolide co-treated with FASL protein] results in increased expression of GPT protein; [triptolide co-treated with FASL protein] results in increased expression of MIR137; [triptolide co-treated with FASL protein] results in increased expression of XIAP mRNA; CASP3 inhibits the reaction [[triptolide co-treated with FASL protein] results in increased cleavage of XIAP protein]; FASL protein promotes the reaction [triptolide results in decreased expression of BCL2 protein]; FASL protein promotes the reaction [triptolide results in decreased expression of FLIP protein]; FASL protein promotes the reaction [triptolide results in increased cleavage of and results in increased activity of CASP3 protein]; IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]; MIR137 promotes the reaction [[triptolide co-treated with FASL protein] results in decreased expression of XIAP protein] triptolide results in increased expression of FASL mRNA; triptolide results in increased expression of FASL protein |
CTD |
PMID:24949944 PMID:26990902 PMID:37944651 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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|
G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
triptolide results in decreased expression of FASN mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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|
G |
Fbn2 |
fibrillin 2 |
decreases expression |
EXP |
triptolide results in decreased expression of FBN2 protein |
CTD |
PMID:32519852 |
|
NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976
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|
G |
Fbp2 |
fructose-bisphosphatase 2 |
decreases expression |
EXP |
triptolide results in decreased expression of FBP2 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
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|
G |
Fbxl4 |
F-box and leucine-rich repeat protein 4 |
increases expression |
EXP |
triptolide results in increased expression of FBXL4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443
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|
G |
Fbxo7 |
F-box protein 7 |
increases expression |
EXP |
triptolide results in increased expression of FBXO7 protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:17,809,224...17,837,549
Ensembl chr 7:17,809,231...17,837,530
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|
G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
triptolide results in increased expression of FDFT1 protein |
CTD |
PMID:32519852 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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|
G |
Fdps |
farnesyl diphosphate synthase |
decreases expression |
ISO |
triptolide results in decreased expression of FDPS mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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|
G |
Fetub |
fetuin B |
increases expression |
EXP |
triptolide results in increased expression of FETUB protein |
CTD |
PMID:32519852 |
|
NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
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|
G |
Ffar4 |
free fatty acid receptor 4 |
increases expression |
ISO |
triptolide results in increased expression of FFAR4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:235,873,576...235,891,597
Ensembl chr 1:235,873,576...235,891,597
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|
G |
Fga |
fibrinogen alpha chain |
increases expression |
EXP |
triptolide results in increased expression of FGA protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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|
G |
Fgb |
fibrinogen beta chain |
increases expression |
EXP |
triptolide results in increased expression of FGB protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
|
|
G |
Fgf1 |
fibroblast growth factor 1 |
decreases expression |
EXP |
triptolide results in decreased expression of FGF1 protein |
CTD |
PMID:32519852 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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|
G |
Fgfrl1 |
fibroblast growth factor receptor-like 1 |
decreases expression |
ISO |
triptolide results in decreased expression of FGFRL1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928
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|
G |
Fgg |
fibrinogen gamma chain |
increases expression |
EXP |
triptolide results in increased expression of FGG protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
|
|
G |
Fjx1 |
four-jointed box kinase 1 |
increases expression |
EXP |
triptolide results in increased expression of FJX1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321
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|
G |
Fkbp11 |
FKBP prolyl isomerase 11 |
decreases expression |
ISO |
triptolide results in decreased expression of FKBP11 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303
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|
G |
Fkbp5 |
FKBP prolyl isomerase 5 |
decreases expression |
ISO |
triptolide results in decreased expression of FKBP5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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|
G |
Fmn1 |
formin 1 |
decreases expression |
ISO |
triptolide results in decreased expression of FMN1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
|
|
G |
Fmo5 |
flavin containing dimethylaniline monoxygenase 5 |
affects expression |
EXP |
triptolide affects the expression of FMO5 protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
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|
G |
Fnip2 |
folliculin interacting protein 2 |
decreases expression |
ISO |
triptolide results in decreased expression of FNIP2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
|
|
G |
Foxo3 |
forkhead box O3 |
decreases phosphorylation |
ISO |
triptolide results in decreased phosphorylation of FOXO3 protein |
CTD |
PMID:32061799 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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|
G |
Foxp3 |
forkhead box P3 |
decreases expression |
ISO |
triptolide results in decreased expression of FOXP3 mRNA |
CTD |
PMID:24949944 |
|
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
|
|
G |
Frmd4b |
FERM domain containing 4B |
decreases expression |
ISO |
triptolide results in decreased expression of FRMD4B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
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|
G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
EXP |
triptolide results in increased expression of FTH1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
|
|
G |
Ftl1 |
ferritin light chain 1 |
increases expression |
EXP |
triptolide results in increased expression of FTL1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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|
G |
Fubp1 |
far upstream element binding protein 1 |
increases expression |
ISO |
triptolide results in increased expression of FUBP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
|
|
G |
Fundc2 |
FUN14 domain containing 2 |
decreases expression |
EXP |
triptolide results in decreased expression of FUNDC2 protein |
CTD |
PMID:32519852 |
|
NCBI chr18:128,473...138,232
Ensembl chr18:132,248...138,345
|
|
G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions increases expression |
EXP |
Lithium Chloride inhibits the reaction [triptolide results in increased expression of FYN protein] |
CTD |
PMID:30926361 |
|
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
|
|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression multiple interactions |
EXP ISO |
triptolide results in decreased expression of G6PC1 mRNA Lipopolysaccharides promotes the reaction [triptolide results in decreased expression of G6PC1 mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in decreased expression of G6PC1 mRNA] |
CTD |
PMID:23639586 PMID:30633930 PMID:32835833 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO |
triptolide results in increased expression of G6PDX mRNA |
CTD |
PMID:32835833 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gaa |
alpha glucosidase |
increases expression |
EXP |
triptolide results in increased expression of GAA protein |
CTD |
PMID:32519852 |
|
NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836
|
|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
decreases expression |
ISO |
triptolide results in decreased expression of GABBR2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
|
|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression |
ISO |
triptolide results in increased expression of GADD45B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
|
|
G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
decreases expression |
EXP |
triptolide results in decreased expression of GADD45G mRNA |
CTD |
PMID:23639586 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
|
|
G |
Gal3st1 |
galactose-3-O-sulfotransferase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of GAL3ST1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
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G |
Galk1 |
galactokinase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of GALK1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
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G |
Galm |
galactose mutarotase |
decreases expression |
EXP |
triptolide results in decreased expression of GALM mRNA |
CTD |
PMID:23639586 |
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NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310
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G |
Galnt11 |
polypeptide N-acetylgalactosaminyltransferase 11 |
increases expression |
EXP |
triptolide results in increased expression of GALNT11 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140
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G |
Galnt3 |
polypeptide N-acetylgalactosaminyltransferase 3 |
increases expression |
EXP |
triptolide results in increased expression of GALNT3 protein |
CTD |
PMID:32519852 |
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NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
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G |
Galnt7 |
polypeptide N-acetylgalactosaminyltransferase 7 |
increases expression |
EXP |
triptolide results in increased expression of GALNT7 protein |
CTD |
PMID:32519852 |
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NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690
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G |
Gamt |
guanidinoacetate N-methyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of GAMT mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778
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G |
Garin5a |
golgi associated RAB2 interactor 5A |
increases expression |
ISO |
triptolide results in increased expression of GARIN5A mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:94,988,959...94,995,971
Ensembl chr 1:94,988,613...94,993,539
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G |
Gas1 |
growth arrest-specific 1 |
decreases expression |
ISO |
triptolide results in decreased expression of GAS1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr17:4,482,168...4,485,153
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G |
Gas2l1 |
growth arrest-specific 2 like 1 |
increases expression |
ISO |
triptolide results in increased expression of GAS2L1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr14:79,955,350...79,961,830
Ensembl chr14:79,950,555...79,961,438
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G |
Gask1a |
golgi associated kinase 1A |
decreases expression |
ISO |
triptolide results in decreased expression of FAM198A mRNA |
CTD |
PMID:32835833 |
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NCBI chr 8:121,610,779...121,643,742
Ensembl chr 8:121,610,787...121,642,942
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G |
Gbe1 |
1,4-alpha-glucan branching enzyme 1 |
decreases expression |
ISO |
triptolide results in decreased expression of GBE1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
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G |
Gbp2 |
guanylate binding protein 2 |
increases expression |
EXP |
triptolide results in increased expression of GBP2 protein |
CTD |
PMID:32519852 |
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NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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G |
Gck |
glucokinase |
decreases expression |
EXP |
triptolide results in decreased expression of GCK mRNA |
CTD |
PMID:23639586 |
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NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression multiple interactions |
ISO EXP |
triptolide results in decreased expression of GCLC protein NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein] |
CTD |
PMID:25169008 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gdf9 |
growth differentiation factor 9 |
increases expression |
ISO |
triptolide results in increased expression of GDF9 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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G |
Gimap4 |
GTPase, IMAP family member 4 |
increases expression |
EXP |
triptolide results in increased expression of GIMAP4 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:77,636,401...77,643,315
Ensembl chr 4:77,636,401...77,643,306
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression multiple interactions |
ISO EXP |
triptolide results in decreased expression of GJA1 mRNA; triptolide results in decreased expression of GJA1 protein mitoquinone inhibits the reaction [triptolide results in decreased expression of GJA1 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of GJA1 protein] |
CTD |
PMID:20020930 PMID:30836114 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Glmp |
glycosylated lysosomal membrane protein |
decreases expression |
EXP |
triptolide results in decreased expression of GLMP protein |
CTD |
PMID:32519852 |
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NCBI chr 2:173,794,273...173,797,863
Ensembl chr 2:173,794,255...173,799,960
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G |
Gls |
glutaminase |
increases expression |
ISO |
triptolide results in increased expression of GLS mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
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G |
Gmds |
GDP-mannose 4, 6-dehydratase |
increases expression |
EXP |
triptolide results in increased expression of GMDS protein |
CTD |
PMID:32519852 |
|
NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961
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G |
Gnmt |
glycine N-methyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of GNMT mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
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G |
Gon4l |
gon-4 like |
increases expression |
ISO |
triptolide results in increased expression of GON4L mRNA |
CTD |
PMID:32835833 |
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NCBI chr 2:174,233,461...174,306,636
Ensembl chr 2:174,233,461...174,306,634
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of GOT1 mRNA [triptolide co-treated with FASL protein] results in increased expression of GOT1 protein |
CTD |
PMID:32835833 PMID:37944651 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gp5 |
glycoprotein V (platelet) |
increases expression |
ISO |
triptolide results in increased expression of GP5 mRNA |
CTD |
PMID:32835833 |
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NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
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G |
Gpaa1 |
glycosylphosphatidylinositol anchor attachment 1 |
increases expression |
EXP |
triptolide results in increased expression of GPAA1 protein |
CTD |
PMID:32519852 |
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NCBI chr 7:108,051,896...108,055,479
Ensembl chr 7:108,051,861...108,055,484
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G |
Gpkow |
G patch domain and KOW motifs |
increases expression |
ISO |
triptolide results in increased expression of GPKOW mRNA |
CTD |
PMID:32835833 |
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NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384
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G |
Gpr12 |
G protein-coupled receptor 12 |
decreases expression |
ISO |
triptolide results in decreased expression of GPR12 mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
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G |
Gpr146 |
G protein-coupled receptor 146 |
decreases expression |
ISO |
triptolide results in decreased expression of GPR146 mRNA |
CTD |
PMID:32835833 |
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NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
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G |
Gprasp3 |
G protein-coupled receptor associated sorting protein family member 3 |
decreases expression |
ISO |
triptolide results in decreased expression of BHLHB9 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr X:98,847,591...98,854,949
Ensembl chr X:98,817,593...98,854,545
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G |
Gpt |
glutamic--pyruvic transaminase |
increases activity multiple interactions increases expression |
ISO EXP |
triptolide results in increased activity of GPT protein 4-phenylbutyric acid inhibits the reaction [triptolide results in increased expression of GPT protein]; [triptolide co-treated with FASL protein] results in increased expression of GPT protein; [triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein; ABCB1A mutant form promotes the reaction [triptolide results in increased activity of GPT protein]; Chlormethiazole inhibits the reaction [triptolide results in increased activity of GPT protein]; IL12B protein affects the reaction [triptolide results in increased expression of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; pyrazole promotes the reaction [triptolide results in increased activity of GPT protein]; STING1 protein affects the reaction [triptolide results in increased expression of GPT protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of GPT protein] catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]; catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]; Chlormethiazole inhibits the reaction [triptolide results in increased activity of GPT protein]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; pyrazole promotes the reaction [triptolide results in increased activity of GPT protein]; Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]] [Atorvastatin co-treated with triptolide] results in increased expression of GPT protein |
CTD |
PMID:23836259 PMID:26134275 PMID:30682494 PMID:32987112 PMID:33600922 PMID:33832337 PMID:34758665 PMID:36328986 PMID:36520315 PMID:36990132 PMID:37944651 More...
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions increases expression |
ISO EXP |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX1 mRNA] triptolide results in increased expression of GPX1 protein |
CTD |
PMID:31241159 PMID:32519852 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions increases expression |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX2 mRNA] |
CTD |
PMID:31241159 |
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NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions increases expression |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX3 mRNA] |
CTD |
PMID:31241159 |
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NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of GPX4 mRNA Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA] |
CTD |
PMID:31241159 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
triptolide results in decreased expression of GRB2 protein |
CTD |
PMID:26420756 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Grem2 |
gremlin 2, DAN family BMP antagonist |
decreases expression |
ISO |
triptolide results in decreased expression of GREM2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615
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G |
Grhl1 |
grainyhead-like transcription factor 1 |
increases expression |
ISO |
triptolide results in increased expression of GRHL1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301
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G |
Grik5 |
glutamate ionotropic receptor kainate type subunit 5 |
increases expression |
ISO |
triptolide results in increased expression of GRIK5 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
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G |
Grwd1 |
glutamate-rich WD repeat containing 1 |
increases expression |
ISO |
triptolide results in increased expression of GRWD1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201
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G |
Gsdmd |
gasdermin D |
increases expression multiple interactions |
EXP ISO |
triptolide results in increased expression of GSDMD protein [triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein; [triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased cleavage of GSDMD protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased cleavage of GSDMD protein] |
CTD |
PMID:32519852 PMID:36328986 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases phosphorylation |
EXP |
Lithium Chloride inhibits the reaction [triptolide results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:30926361 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gtf2f1 |
general transcription factor IIF subunit 1 |
increases expression |
ISO |
triptolide results in increased expression of GTF2F1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
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G |
Gtpbp4 |
GTP binding protein 4 |
increases expression |
ISO |
triptolide results in increased expression of GTPBP4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
ISO |
triptolide results in increased expression of GTSE1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
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G |
Gusb |
glucuronidase, beta |
multiple interactions decreases activity |
ISO |
resveratrol inhibits the reaction [triptolide results in decreased activity of GUSB protein] |
CTD |
PMID:29723566 |
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
Gys2 |
glycogen synthase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of GYS2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228
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G |
H1f10 |
H1.10 linker histone |
increases expression |
ISO |
triptolide results in increased expression of H1F10 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448
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G |
H1f4 |
H1.4 linker histone, cluster member |
increases expression |
ISO |
triptolide results in increased expression of H1F4 mRNA |
CTD |
PMID:32835833 |
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NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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G |
H2ac4 |
H2A clustered histone 4 |
increases expression |
ISO |
triptolide results in increased expression of H2AC6 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381
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G |
H2aj |
H2A.J histone |
increases expression |
ISO |
triptolide results in increased expression of H2AJ mRNA |
CTD |
PMID:32835833 |
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NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006
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G |
H2ax |
H2A.X variant histone |
increases expression increases phosphorylation |
ISO |
triptolide results in increased expression of H2AX mRNA triptolide results in increased phosphorylation of H2AX protein triptolide results in increased expression of H2AX protein |
CTD |
PMID:31218727 PMID:32835833 PMID:36990132 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
H2az1 |
H2A.Z variant histone 1 |
decreases expression |
EXP |
triptolide results in decreased expression of H2AZ1 protein |
CTD |
PMID:32519852 |
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NCBI chr 2:226,355,668...226,357,984
Ensembl chr 2:226,355,708...226,358,485
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G |
H2bc6 |
H2B clustered histone 6 |
increases expression |
ISO |
triptolide results in increased expression of H2BC6 mRNA |
CTD |
PMID:32835833 |
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NCBI chr17:41,520,775...41,521,238
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G |
Haao |
3-hydroxyanthranilate 3,4-dioxygenase |
decreases expression |
ISO |
triptolide results in decreased expression of HAAO mRNA |
CTD |
PMID:32835833 |
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NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
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G |
Hao1 |
hydroxyacid oxidase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of HAO1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721
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G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
increases expression |
EXP |
triptolide results in increased expression of HBA-A2 protein; triptolide results in increased expression of HBA1 protein |
CTD |
PMID:32519852 |
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NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 Ensembl chr10:15,307,815...15,338,392
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G |
Hbb |
hemoglobin subunit beta |
increases expression |
EXP |
triptolide results in increased expression of HBB protein |
CTD |
PMID:32519852 |
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NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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G |
Hdac1 |
histone deacetylase 1 |
increases expression |
EXP |
triptolide results in increased expression of HDAC1 mRNA |
CTD |
PMID:23639586 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac1l |
histone deacetylase 1-like |
increases expression |
EXP |
triptolide results in increased expression of HDAC1L protein |
CTD |
PMID:32519852 |
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NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
EXP |
triptolide results in increased expression of HDAC2 protein |
CTD |
PMID:32519852 |
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NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Hdac6 |
histone deacetylase 6 |
increases expression |
ISO |
triptolide results in increased expression of HDAC6 mRNA; triptolide results in increased expression of HDAC6 protein |
CTD |
PMID:32061799 |
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NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
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G |
Herc6 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
increases expression |
EXP |
triptolide results in increased expression of HERC6 protein |
CTD |
PMID:32519852 |
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NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
decreases expression |
ISO |
triptolide results in decreased expression of HERPUD1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Hes1 |
hes family bHLH transcription factor 1 |
decreases expression multiple interactions increases expression |
ISO |
triptolide results in decreased expression of HES1 protein Fenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein] triptolide results in decreased expression of HES1 mRNA; triptolide results in decreased expression of HES1 protein |
CTD |
PMID:30394310 PMID:31241159 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hes6 |
hes family bHLH transcription factor 6 |
decreases expression |
ISO |
triptolide results in decreased expression of HES6 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
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G |
Hexim1 |
HEXIM P-TEFb complex subunit 1 |
increases expression |
ISO |
triptolide results in increased expression of HEXIM1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189
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G |
Higd2al1 |
HIG1 hypoxia inducible domain family, member 2A-like 1 |
increases expression |
EXP |
triptolide results in increased expression of HIGD2AL1 protein |
CTD |
PMID:32519852 |
|
NCBI chr12:2,777,094...2,777,581
Ensembl chr12:2,777,231...2,777,551
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G |
Hikeshi |
heat shock protein nuclear import factor hikeshi |
increases expression |
EXP |
triptolide results in increased expression of HIKESHI protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:143,825,399...143,849,361
Ensembl chr 1:143,825,923...143,849,363
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G |
Hist1h2ail1 |
histone cluster 1 H2a family member I like 1 |
increases expression |
ISO |
triptolide results in increased expression of H3C11 mRNA; triptolide results in increased expression of H3C6 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109
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G |
Hist1h2bc |
histone cluster 1, H2bc |
increases expression |
ISO |
triptolide results in increased expression of H2BC21 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
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G |
Hist1h4b |
histone cluster 1 H4 family member B |
increases expression |
ISO |
triptolide results in increased expression of H4C9 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
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G |
Hist2h3c2 |
histone cluster 2 H3 family member C2 |
increases expression |
ISO |
triptolide results in increased expression of H3C14 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752
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G |
Hk2 |
hexokinase 2 |
increases expression decreases expression |
ISO |
triptolide results in increased expression of HK2 mRNA triptolide results in decreased expression of HK2 mRNA |
CTD |
PMID:34087332 |
|
NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
[Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA |
CTD |
PMID:31557376 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
increases expression decreases expression affects expression multiple interactions |
EXP ISO |
triptolide results in increased expression of HMOX1 mRNA triptolide results in decreased expression of HMOX1 mRNA; triptolide results in decreased expression of HMOX1 protein triptolide affects the expression of HMOX1 mRNA NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein] [triptolide co-treated with catalpol co-treated with Saponins] results in increased expression of HMOX1 protein; [triptolide co-treated with catalpol] results in increased expression of HMOX1 protein; [triptolide co-treated with Saponins] results in increased expression of HMOX1 protein mitoquinone inhibits the reaction [triptolide results in decreased expression of HMOX1 mRNA]; mitoquinone inhibits the reaction [triptolide results in decreased expression of HMOX1 protein] |
CTD |
PMID:23639586 PMID:25169008 PMID:30682494 PMID:30836114 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnmt |
histamine N-methyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of HNMT mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
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G |
Hp |
haptoglobin |
increases expression |
EXP |
triptolide results in increased expression of HP protein |
CTD |
PMID:32519852 |
|
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hpd |
4-hydroxyphenylpyruvate dioxygenase |
decreases expression |
ISO |
triptolide results in decreased expression of HPD mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766
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G |
Hpx |
hemopexin |
increases expression |
EXP |
triptolide results in increased expression of HPX protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
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G |
Hras |
HRas proto-oncogene, GTPase |
decreases expression |
EXP |
triptolide results in decreased expression of HRAS mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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|
G |
Hrg |
histidine-rich glycoprotein |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of HRG protein triptolide results in decreased expression of HRG mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
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|
G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions |
ISO |
[Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:31557376 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Hsf2bp |
heat shock transcription factor 2 binding protein |
increases expression |
ISO |
triptolide results in increased expression of HSF2BP mRNA |
CTD |
PMID:32835833 |
|
NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242
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|
G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
triptolide results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
decreases response to substance |
ISO |
HSPA1A results in decreased susceptibility to triptolide |
CTD |
PMID:19546256 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
EXP |
triptolide results in increased expression of HSPA1B protein |
CTD |
PMID:32519852 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
EXP |
triptolide results in increased expression of HSPA2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa4l |
heat shock protein family A (Hsp70) member 4 like |
affects expression |
ISO |
triptolide affects the expression of HSPA4L mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression multiple interactions increases expression |
ISO |
triptolide results in decreased expression of HSPA5 protein STING1 protein affects the reaction [triptolide results in increased expression of HSPA5 protein]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 mRNA]; TRAJ18 protein affects the reaction [triptolide results in increased expression of HSPA5 protein] triptolide results in increased expression of HSPA5 mRNA; triptolide results in increased expression of HSPA5 protein |
CTD |
PMID:26990902 PMID:27022166 PMID:36520315 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
EXP |
triptolide results in decreased expression of HSPD1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Htra4 |
HtrA serine peptidase 4 |
decreases expression |
ISO |
triptolide results in decreased expression of HTRA4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions increases expression |
ISO |
triptolide results in decreased expression of ICAM1 mRNA; triptolide results in decreased expression of ICAM1 protein TRAJ18 protein affects the reaction [triptolide results in increased expression of ICAM1 protein] triptolide results in increased expression of ICAM1 mRNA; triptolide results in increased expression of ICAM1 protein |
CTD |
PMID:17931847 PMID:32835833 PMID:32987112 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of IDI1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Idua |
alpha-L-iduronidase |
increases expression |
ISO |
triptolide results in increased expression of IDUA mRNA |
CTD |
PMID:32835833 |
|
NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522
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G |
Ier5 |
immediate early response 5 |
increases expression |
ISO |
triptolide results in increased expression of IER5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227
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G |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
increases expression |
EXP |
triptolide results in increased expression of IFIT2 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
increases expression |
EXP |
triptolide results in increased expression of IFIT3 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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G |
Ifnb1 |
interferon beta 1 |
increases expression |
ISO |
triptolide results in increased expression of IFNB1 mRNA |
CTD |
PMID:36520315 |
|
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions increases secretion |
ISO |
triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD80 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] triptolide results in increased secretion of IFNG protein IL12B protein affects the reaction [triptolide results in increased secretion of IFNG protein] |
CTD |
PMID:15663903 PMID:36520315 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Igdcc3 |
immunoglobulin superfamily, DCC subclass, member 3 |
increases expression |
EXP |
triptolide results in increased expression of IGDCC3 protein |
CTD |
PMID:32519852 |
|
NCBI chr 8:65,661,165...65,707,961
Ensembl chr 8:65,661,196...65,707,959
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|
G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
triptolide results in decreased expression of IGF1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf2bp3 |
insulin-like growth factor 2 mRNA binding protein 3 |
decreases expression |
ISO |
triptolide results in decreased expression of IGF2BP3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
decreases expression |
EXP ISO |
triptolide results in decreased expression of IGFBP1 mRNA |
CTD |
PMID:23639586 PMID:32835833 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp4 |
insulin-like growth factor binding protein 4 |
decreases expression |
ISO |
triptolide results in decreased expression of IGFBP4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
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G |
IgG-2a |
gamma-2a immunoglobulin heavy chain |
increases expression |
EXP |
triptolide results in increased expression of IGG-2A protein |
CTD |
PMID:32519852 |
|
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions decreases phosphorylation |
ISO EXP |
TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of IKBKB protein] pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein] |
CTD |
PMID:31618665 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
increases expression |
ISO |
triptolide results in increased expression of IL10 mRNA |
CTD |
PMID:36520315 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15663903 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions affects secretion |
ISO |
triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] IL12B protein affects the reaction [triptolide results in increased expression of GPT protein]; IL12B protein affects the reaction [triptolide results in increased secretion of IFNG protein]; IL12B protein affects the reaction [triptolide results in increased secretion of IL4 protein]; STING1 protein affects the reaction [triptolide affects the secretion of IL12B protein] |
CTD |
PMID:15663903 PMID:36520315 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
increases expression |
ISO |
triptolide results in increased expression of IL13 mRNA |
CTD |
PMID:36520315 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
multiple interactions increases expression decreases expression |
ISO |
IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA] triptolide results in increased expression of IL17A mRNA; triptolide results in increased expression of IL17A protein triptolide results in decreased expression of IL17A mRNA |
CTD |
PMID:24949944 PMID:36520315 PMID:38115356 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of IL18 mRNA [triptolide co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased secretion of IL18 protein |
CTD |
PMID:32835833 PMID:36328986 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL1B mRNA]; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of IL1B mRNA]; IL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] |
CTD |
PMID:24949944 PMID:30633930 PMID:31241159 PMID:36328986 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
increases secretion multiple interactions |
ISO |
triptolide results in increased secretion of IL4 protein IL12B protein affects the reaction [triptolide results in increased secretion of IL4 protein]; STING1 protein affects the reaction [triptolide results in increased secretion of IL4 protein] |
CTD |
PMID:32987112 PMID:36520315 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression affects expression |
ISO |
Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 protein]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] triptolide results in increased expression of IL6 mRNA; triptolide results in increased expression of IL6 protein triptolide affects the expression of IL6 mRNA Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Chlormethiazole inhibits the reaction [triptolide results in increased expression of IL6 protein]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 mRNA]; pyrazole promotes the reaction [triptolide results in increased expression of IL6 protein] |
CTD |
PMID:30633930 PMID:31241159 PMID:34758665 PMID:36520315 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Imp4 |
IMP U3 small nucleolar ribonucleoprotein 4 |
increases expression |
ISO |
triptolide results in increased expression of IMP4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:36,654,127...36,659,265
Ensembl chr 9:36,654,401...36,660,075
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G |
Impa2 |
inositol monophosphatase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of IMPA2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:60,834,206...60,867,575
Ensembl chr18:60,834,246...60,865,641
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G |
Impdh2 |
inosine monophosphate dehydrogenase 2 |
increases expression |
ISO |
triptolide results in increased expression of IMPDH2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
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G |
Inava |
innate immunity activator |
increases expression |
ISO |
triptolide results in increased expression of INAVA mRNA |
CTD |
PMID:32835833 |
|
NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729
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G |
Inca1 |
inhibitor of CDK, cyclin A1 interacting protein 1 |
affects expression |
ISO |
triptolide affects the expression of INCA1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114
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G |
Inhca |
inhibitor of carbonic anhydrase |
increases expression |
EXP |
triptolide results in increased expression of INHCA protein |
CTD |
PMID:32519852 |
|
NCBI chr 8:103,836,846...103,874,980
Ensembl chr 8:103,823,196...103,874,985
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G |
Inka2 |
inka box actin regulator 2 |
increases expression |
ISO |
triptolide results in increased expression of FAM212B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642
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G |
Inmt |
indolethylamine N-methyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of INMT mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
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G |
Insc |
INSC, spindle orientation adaptor protein |
affects expression |
ISO |
triptolide affects the expression of INSC mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433
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G |
Insig1 |
insulin induced gene 1 |
decreases expression |
ISO |
triptolide results in decreased expression of INSIG1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Insr |
insulin receptor |
increases expression |
EXP |
triptolide results in increased expression of INSR protein |
CTD |
PMID:32519852 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Ints2 |
integrator complex subunit 2 |
increases expression |
ISO |
triptolide results in increased expression of INTS2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:71,031,647...71,079,138
Ensembl chr10:71,031,647...71,079,076
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G |
Ipo13 |
importin 13 |
increases expression |
ISO |
triptolide results in increased expression of IPO13 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:131,433,770...131,454,044
Ensembl chr 5:131,433,776...131,454,043
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G |
Irf3 |
interferon regulatory factor 3 |
increases expression |
ISO |
triptolide results in increased expression of IRF3 protein |
CTD |
PMID:36520315 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Irgm |
immunity-related GTPase M |
increases expression |
EXP |
triptolide results in increased expression of IRGM protein |
CTD |
PMID:32519852 |
|
NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
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|
G |
Irs1 |
insulin receptor substrate 1 |
increases degradation multiple interactions |
ISO |
triptolide results in increased degradation of IRS1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in decreased expression of IRS1 protein]; triptolide results in decreased expression of and results in decreased phosphorylation of IRS1 protein |
CTD |
PMID:32061799 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Isca1 |
iron-sulfur cluster assembly 1 |
decreases expression |
EXP |
triptolide results in decreased expression of ISCA1 protein |
CTD |
PMID:32519852 |
|
NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
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G |
Iscu |
iron-sulfur cluster assembly enzyme |
decreases expression |
EXP |
triptolide results in decreased expression of ISCU protein |
CTD |
PMID:32519852 |
|
NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
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|
G |
Isyna1 |
inositol-3-phosphate synthase 1 |
increases expression |
EXP |
triptolide results in increased expression of ISYNA1 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
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|
G |
Itga5 |
integrin subunit alpha 5 |
increases expression |
EXP ISO |
triptolide results in increased expression of ITGA5 protein triptolide results in increased expression of ITGA5 mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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|
G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
triptolide results in increased expression of ITGAM mRNA |
CTD |
PMID:36520315 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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|
G |
Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
increases expression |
EXP |
triptolide results in increased expression of ITIH3 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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G |
Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
increases expression |
EXP |
triptolide results in increased expression of ITIH4 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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|
G |
Itpr3 |
inositol 1,4,5-trisphosphate receptor, type 3 |
increases expression |
EXP |
triptolide results in increased expression of ITPR3 protein |
CTD |
PMID:32519852 |
|
NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
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|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
triptolide results in decreased expression of and results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:38115356 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Jph1 |
junctophilin 1 |
decreases expression |
ISO |
triptolide results in decreased expression of JPH1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:2,030,227...2,137,171
Ensembl chr 5:2,030,281...2,125,284
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|
G |
Jpt1 |
Jupiter microtubule associated homolog 1 |
increases expression |
ISO |
triptolide results in increased expression of JPT1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
triptolide results in increased expression of JUN mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Kctd18 |
potassium channel tetramerization domain containing 18 |
increases expression |
ISO |
triptolide results in increased expression of KCTD18 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:59,502,220...59,566,857
Ensembl chr 9:59,502,232...59,566,857
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|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression |
ISO |
triptolide results in decreased expression of KEAP1 protein |
CTD |
PMID:30682494 PMID:36990132 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Khsrp |
KH-type splicing regulatory protein |
decreases expression |
EXP |
triptolide results in decreased expression of KHSRP protein |
CTD |
PMID:32519852 |
|
NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451
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G |
Kif20a |
kinesin family member 20A |
increases expression |
ISO |
triptolide results in increased expression of KIF20A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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G |
Kif21a |
kinesin family member 21A |
increases expression |
EXP |
triptolide results in increased expression of KIF21A protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:122,062,523...122,179,051
Ensembl chr 7:122,062,537...122,178,999
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G |
Kifc3 |
kinesin family member C3 |
increases expression |
ISO |
triptolide results in increased expression of KIFC3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr19:9,825,114...9,920,371
Ensembl chr19:9,886,693...9,920,451
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|
G |
Klc1 |
kinesin light chain 1 |
increases expression |
ISO |
triptolide results in increased expression of KLC1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031
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|
G |
Klhl26 |
kelch-like family member 26 |
increases expression |
ISO |
triptolide results in increased expression of KLHL26 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:18,952,123...18,977,328
Ensembl chr16:18,952,234...18,977,328
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|
G |
Klkb1 |
kallikrein B1 |
decreases expression |
ISO |
triptolide results in decreased expression of KLKB1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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|
G |
Kng1 |
kininogen 1 |
increases expression |
EXP |
triptolide results in increased expression of KNG1 protein |
CTD |
PMID:32519852 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Kng2 |
kininogen 2 |
increases expression |
EXP |
triptolide results in increased expression of MAP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
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|
G |
Kras |
KRAS proto-oncogene, GTPase |
increases expression |
EXP |
triptolide results in increased expression of KRAS mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 4:178,185,418...178,218,484
|
|
G |
Kyat1 |
kynurenine aminotransferase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of KYAT1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
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G |
Kyat3 |
kynurenine aminotransferase 3 |
decreases expression |
ISO |
triptolide results in decreased expression of KYAT3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:231,701,881...231,747,462
Ensembl chr 2:231,701,963...231,747,227
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G |
L1cam |
L1 cell adhesion molecule |
increases expression |
EXP |
triptolide results in increased expression of L1CAM protein |
CTD |
PMID:32519852 |
|
NCBI chr X:151,597,270...151,623,776
Ensembl chr X:151,597,277...151,623,857
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|
G |
Lamtor1 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
decreases expression |
EXP |
triptolide results in decreased expression of LAMTOR1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
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|
G |
Lcat |
lecithin cholesterol acyltransferase |
increases expression |
ISO |
triptolide results in increased expression of LCAT mRNA |
CTD |
PMID:32835833 |
|
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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|
G |
Ldb3 |
LIM domain binding 3 |
increases expression |
ISO |
triptolide results in increased expression of LDB3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532
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G |
Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
triptolide results in decreased expression of LDHA mRNA |
CTD |
PMID:34087332 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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|
G |
Lepr |
leptin receptor |
decreases expression |
ISO |
triptolide results in decreased expression of LEPR mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Letmd1 |
LETM1 domain containing 1 |
increases expression |
EXP |
triptolide results in increased expression of LETMD1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:131,584,241...131,597,797
Ensembl chr 7:131,584,259...131,597,796
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|
G |
Lgi4 |
leucine-rich repeat LGI family, member 4 |
increases expression |
ISO |
triptolide results in increased expression of LGI4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874
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G |
Lipg |
lipase G, endothelial type |
decreases expression |
ISO |
triptolide results in decreased expression of LIPG mRNA |
CTD |
PMID:32835833 |
|
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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|
G |
Litaf |
lipopolysaccharide-induced TNF factor |
increases expression |
ISO |
triptolide results in increased expression of LITAF mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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|
G |
Lmna |
lamin A/C |
increases expression |
ISO |
triptolide results in increased expression of LMNA mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
|
|
G |
Lonrf3 |
LON peptidase N-terminal domain and ring finger 3 |
increases expression |
ISO |
triptolide results in increased expression of LONRF3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr X:115,565,214...115,603,886
Ensembl chr X:115,565,267...115,598,809
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|
G |
Loxl4 |
lysyl oxidase-like 4 |
increases expression |
ISO |
triptolide results in increased expression of LOXL4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322
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|
G |
Lpin1 |
lipin 1 |
decreases expression |
ISO |
triptolide results in decreased expression of LPIN1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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G |
Lpxn |
leupaxin |
increases expression |
ISO |
triptolide results in increased expression of LPXN mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084
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|
G |
Lrrc14 |
leucine rich repeat containing 14 |
increases expression |
ISO |
triptolide results in increased expression of LRRC14 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:108,430,755...108,437,118
Ensembl chr 7:108,430,792...108,437,111
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|
G |
Lrrc51 |
leucine rich repeat containing 51 |
increases expression |
ISO |
triptolide results in increased expression of LRRC51 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:156,278,617...156,297,838
Ensembl chr 1:156,278,618...156,297,773
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|
G |
Lrrn4cl |
LRRN4 C-terminal like |
increases expression |
ISO |
triptolide results in increased expression of LRRN4CL mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:205,743,580...205,759,879
|
|
G |
Lrtm1 |
leucine-rich repeats and transmembrane domains 1 |
decreases expression |
ISO |
triptolide results in decreased expression of LRTM1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:4,210,343...4,217,843
|
|
G |
Lto1 |
LTO1 maturation factor of ABCE1 |
increases expression |
ISO |
triptolide results in increased expression of ORAOV1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:200,074,247...200,080,951
Ensembl chr 1:200,074,253...200,088,061
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G |
Ly6e |
lymphocyte antigen 6 family member E |
increases expression |
EXP |
triptolide results in increased expression of LY6E protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
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G |
Mab21l3 |
mab-21 like 3 |
increases expression |
ISO |
triptolide results in increased expression of MAB21L3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:189,248,895...189,271,652
Ensembl chr 2:189,248,895...189,271,652
|
|
G |
Mad2l1 |
mitotic arrest deficient 2 like 1 |
increases expression |
EXP |
triptolide results in increased expression of MAD2L1 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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|
G |
Mafb |
MAF bZIP transcription factor B |
decreases expression |
ISO |
triptolide results in decreased expression of MAFB mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
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G |
Maff |
MAF bZIP transcription factor F |
affects expression |
ISO |
triptolide affects the expression of MAFF mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
ISO |
triptolide results in increased expression of MAP1LC3B protein |
CTD |
PMID:31218727 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Map1s |
microtubule-associated protein 1S |
increases expression |
ISO |
triptolide results in increased expression of MAP1S mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
decreases expression |
ISO |
triptolide results in decreased expression of MAP2K6 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
increases expression |
ISO |
triptolide results in increased expression of MAP3K20 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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G |
Map7d1 |
MAP7 domain containing 1 |
increases expression |
ISO |
triptolide results in increased expression of MAP7D1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:138,527,944...138,552,537
Ensembl chr 5:138,527,401...138,552,499
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21717513 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
triptolide inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of MAPK14 protein] |
CTD |
PMID:17507666 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
triptolide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21717513 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8ip3 |
mitogen-activated protein kinase 8 interacting protein 3 |
increases expression |
ISO |
triptolide results in increased expression of MAPK8IP3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
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G |
Mast3 |
microtubule associated serine/threonine kinase 3 |
increases expression |
EXP |
triptolide results in increased expression of MAST3 protein |
CTD |
PMID:32519852 |
|
NCBI chr16:18,636,764...18,663,852
Ensembl chr16:18,636,787...18,663,852
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|
G |
Mbnl1 |
muscleblind-like splicing regulator 1 |
increases expression |
EXP |
triptolide results in increased expression of MBNL1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
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|
G |
Mcee |
methylmalonyl CoA epimerase |
increases expression |
EXP |
triptolide results in increased expression of MCEE protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
increases expression |
ISO |
triptolide results in increased expression of MCL1 protein |
CTD |
PMID:26990902 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Mcm6 |
minichromosome maintenance complex component 6 |
increases expression |
EXP |
triptolide results in increased expression of MCM6 mRNA |
CTD |
PMID:23639586 |
|
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
|
|
G |
Mcrip1 |
MAPK regulated co-repressor interacting protein 1 |
increases expression |
ISO |
triptolide results in increased expression of MCRIP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:105,820,656...105,828,146
Ensembl chr10:105,820,656...105,828,271
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression decreases expression |
ISO |
triptolide results in increased expression of MDM2 mRNA triptolide results in decreased expression of MDM2 protein |
CTD |
PMID:32835833 PMID:36990132 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Me1 |
malic enzyme 1 |
decreases expression |
ISO |
triptolide results in decreased expression of ME1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
|
|
G |
Med23 |
mediator complex subunit 23 |
increases expression |
EXP |
triptolide results in increased expression of MED23 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
|
|
G |
Mep1a |
meprin A subunit alpha |
increases expression |
EXP |
triptolide results in increased expression of MEP1A protein |
CTD |
PMID:32519852 |
|
NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147
|
|
G |
Mep1b |
meprin A subunit beta |
increases expression |
EXP |
triptolide results in increased expression of MEP1B protein |
CTD |
PMID:32519852 |
|
NCBI chr18:12,366,126...12,392,840
Ensembl chr18:12,365,289...12,392,840
|
|
G |
Mfn1 |
mitofusin 1 |
decreases expression |
EXP |
triptolide results in decreased expression of MFN1 protein |
CTD |
PMID:31557070 |
|
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
|
|
G |
Mfn2 |
mitofusin 2 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of MFN2 protein mitoquinone inhibits the reaction [triptolide results in decreased expression of MFN2 protein] |
CTD |
PMID:30836114 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mfsd2a |
MFSD2 lysolipid transporter A, lysophospholipid |
decreases expression |
ISO |
triptolide results in decreased expression of MFSD2A mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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G |
Mfsd4b2 |
major facilitator superfamily domain containing 4B2 |
decreases expression |
ISO |
triptolide results in decreased expression of MFSD4B1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr20:43,344,601...43,353,061
Ensembl chr20:43,344,601...43,353,061
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G |
Mical2 |
microtubule associated monooxygenase, calponin and LIM domain containing 2 |
increases expression |
ISO |
triptolide results in increased expression of MICAL2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719 Ensembl chr 1:166,345,859...166,471,719
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Mical3 |
microtubule associated monooxygenase, calponin and LIM domain containing 3 |
increases expression |
ISO |
triptolide results in increased expression of MICAL3 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:154,152,776...154,353,274
Ensembl chr 4:154,153,834...154,302,590
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G |
Mir137 |
microRNA 137 |
multiple interactions |
ISO |
[triptolide co-treated with FASL protein] results in decreased expression of MIR137; [triptolide co-treated with FASL protein] results in increased expression of MIR137; MIR137 promotes the reaction [[triptolide co-treated with FASL protein] results in decreased expression of XIAP protein] |
CTD |
PMID:37944651 |
|
NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985
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G |
Mir141 |
microRNA 141 |
multiple interactions |
ISO |
[triptolide co-treated with tariquidar] results in increased activity of MIR141 protein |
CTD |
PMID:26134275 |
|
NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
triptolide results in decreased expression of MKI67 protein |
CTD |
PMID:24842335 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
multiple interactions increases expression |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein; [triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein modified form]; necrostatin-1 inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MLKL protein] triptolide results in increased expression of MLKL mRNA |
CTD |
PMID:30633930 PMID:32835833 |
|
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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Mmd2 |
monocyte to macrophage differentiation-associated 2 |
decreases expression |
ISO |
triptolide results in decreased expression of MMD2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773
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G |
Mme |
membrane metallo-endopeptidase |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of MME protein triptolide results in decreased expression of MME mRNA |
CTD |
PMID:32519852 PMID:32835833 |
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NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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G |
Mmp12 |
matrix metallopeptidase 12 |
increases expression |
ISO |
triptolide results in increased expression of MMP12 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
triptolide results in decreased expression of MMP2 mRNA; triptolide results in decreased expression of MMP2 protein |
CTD |
PMID:26420756 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
triptolide results in decreased expression of MMP9 protein triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; triptolide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein] |
CTD |
PMID:25200491 PMID:26420756 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mogat2 |
monoacylglycerol O-acyltransferase 2 |
increases expression |
ISO |
triptolide results in increased expression of MOGAT2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 1:153,521,813...153,545,756
Ensembl chr 1:153,521,815...153,545,756
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G |
Mov10 |
Mov10 RNA helicase |
decreases expression |
ISO |
triptolide results in decreased expression of MOV10 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
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G |
Mpc1 |
mitochondrial pyruvate carrier 1 |
decreases expression |
EXP |
triptolide results in decreased expression of MPC1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 1:52,437,745...52,449,399
Ensembl chr 1:52,437,741...52,449,400
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of MPO protein]; triptolide promotes the reaction [Lipopolysaccharides results in increased expression of MPO mRNA] |
CTD |
PMID:30633930 PMID:36328986 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mpp7 |
MAGUK p55 scaffold protein 7 |
increases expression |
ISO |
triptolide results in increased expression of MPP7 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr17:55,439,939...55,706,810
Ensembl chr17:55,442,696...55,706,748
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G |
Mreg |
melanoregulin |
increases expression |
ISO |
triptolide results in increased expression of MREG mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:73,786,727...73,842,081
Ensembl chr 9:73,787,267...73,842,087
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G |
Mrps5 |
mitochondrial ribosomal protein S5 |
increases expression |
EXP |
triptolide results in increased expression of MRPS5 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:114,821,046...114,837,291
Ensembl chr 3:114,821,046...114,837,291
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G |
Msmo1 |
methylsterol monooxygenase 1 |
decreases expression |
ISO |
triptolide results in decreased expression of MSMO1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
increases expression |
EXP |
triptolide results in increased expression of ND1 protein |
CTD |
PMID:32519852 |
|
NCBI chr MT:2,740...3,694
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G |
Mt1 |
metallothionein 1 |
decreases expression increases expression |
EXP |
triptolide results in decreased expression of MT1 protein triptolide results in increased expression of MT1M protein |
CTD |
PMID:32519852 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mtdh |
metadherin |
increases expression |
ISO |
triptolide results in increased expression of MTDH mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
triptolide results in increased expression of and results in increased phosphorylation of MTOR protein |
CTD |
PMID:26990902 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mug1 |
murinoglobulin 1 |
increases expression |
EXP |
triptolide results in increased expression of MUG1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
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G |
Mug2 |
murinoglobulin 2 |
decreases expression |
ISO |
triptolide results in decreased expression of MUG2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
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G |
Mvd |
mevalonate diphosphate decarboxylase |
increases expression decreases expression |
EXP ISO |
triptolide results in increased expression of MVD protein triptolide results in decreased expression of MVD mRNA |
CTD |
PMID:32519852 PMID:32835833 |
|
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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G |
Mx1 |
MX dynamin like GTPase 1 |
increases expression |
EXP |
triptolide results in increased expression of MX1 protein |
CTD |
PMID:32519852 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Mybl1 |
MYB proto-oncogene like 1 |
increases expression |
ISO |
triptolide results in increased expression of MYBL1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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G |
Mybl2 |
MYB proto-oncogene like 2 |
increases expression |
ISO |
triptolide results in increased expression of MYBL2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression |
EXP ISO |
triptolide results in decreased expression of MYC mRNA triptolide results in decreased expression of MYC protein triptolide results in increased expression of MYC mRNA |
CTD |
PMID:12533674 PMID:23639586 PMID:32835833 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Mycbpap |
Mycbp associated protein |
increases expression |
ISO |
triptolide results in increased expression of MYCBPAP mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:79,450,319...79,470,977
Ensembl chr10:79,450,324...79,470,828
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G |
Mycl |
MYCL proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
triptolide results in decreased expression of MYCL mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582
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G |
Myh1 |
myosin heavy chain 1 |
decreases expression |
ISO |
triptolide results in decreased expression of MYH1 mRNA |
CTD |
PMID:32061799 |
|
NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295
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G |
Myh2 |
myosin heavy chain 2 |
decreases expression |
ISO |
triptolide results in decreased expression of MYH2 mRNA |
CTD |
PMID:32061799 |
|
NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236
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G |
Myh4 |
myosin heavy chain 4 |
decreases expression |
ISO |
triptolide results in decreased expression of MYH4 mRNA |
CTD |
PMID:32061799 |
|
NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295
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G |
Myh7 |
myosin heavy chain 7 |
decreases expression |
ISO |
triptolide results in decreased expression of MYH7 mRNA |
CTD |
PMID:32061799 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myh7b |
myosin heavy chain 7B |
increases expression |
ISO |
triptolide results in increased expression of MYH7B mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:144,076,911...144,122,714
Ensembl chr 3:144,098,190...144,122,084
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G |
Myl9 |
myosin light chain 9 |
decreases expression |
EXP |
triptolide results in decreased expression of MYL9 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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G |
Mylk |
myosin light chain kinase |
multiple interactions |
ISO |
triptolide inhibits the reaction [Luteolin inhibits the reaction [decabromobiphenyl ether results in increased expression of MYLK protein]] |
CTD |
PMID:33675858 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Myo19 |
myosin XIX |
increases expression |
ISO |
triptolide results in increased expression of MYO19 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
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G |
Myo5c |
myosin VC |
increases expression |
EXP |
triptolide results in increased expression of MYO5C protein |
CTD |
PMID:32519852 |
|
NCBI chr 8:75,989,497...76,066,485
Ensembl chr 8:75,989,528...76,066,483
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G |
Myom1 |
myomesin 1 |
increases expression |
ISO |
triptolide results in increased expression of MYOM1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 9:110,916,156...111,039,344
Ensembl chr 9:110,915,943...111,039,344
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G |
Myrfl |
myelin regulatory factor-like |
increases expression |
ISO |
triptolide results in increased expression of MYRFL mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 7:52,403,324...52,519,907
Ensembl chr 7:52,403,650...52,519,907
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G |
Naaladl2 |
N-acetylated alpha-linked acidic dipeptidase-like 2 |
decreases expression |
ISO |
triptolide results in decreased expression of NAALADL2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689
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G |
Nampt |
nicotinamide phosphoribosyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of NAMPT mRNA |
CTD |
PMID:29723566 |
|
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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G |
Nat8f4 |
N-acetyltransferase 8 (GCN5-related) family member 4 |
increases expression |
ISO |
triptolide results in increased expression of NAT8F4 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:118,326,092...118,332,591
Ensembl chr 4:118,325,874...118,332,658
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G |
Nat8f5 |
N-acetyltransferase 8 (GCN5-related) family member 5 |
affects expression |
ISO |
triptolide affects the expression of NAT8F5 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 4:118,260,323...118,285,038
Ensembl chr 4:118,260,252...118,285,704
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G |
Nbeal2 |
neurobeachin-like 2 |
increases expression |
ISO |
triptolide results in increased expression of NBEAL2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 8:110,603,220...110,633,612
Ensembl chr 8:110,599,389...110,633,707
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G |
Ncbp1 |
nuclear cap binding protein subunit 1 |
increases expression |
ISO |
triptolide results in increased expression of NCBP1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
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G |
Ncoa6 |
nuclear receptor coactivator 6 |
increases expression |
EXP |
triptolide results in increased expression of NCOA6 protein |
CTD |
PMID:32519852 |
|
NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268
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G |
Ncor2 |
nuclear receptor co-repressor 2 |
increases expression |
ISO |
triptolide results in increased expression of NCOR2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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G |
Ndor1 |
NADPH dependent diflavin oxidoreductase 1 |
increases expression |
ISO |
triptolide results in increased expression of NDOR1 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860
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G |
Ndufa7 |
NADH:ubiquinone oxidoreductase subunit A7 |
increases expression |
EXP |
triptolide results in increased expression of NDUFA7 protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
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G |
Ndufb8 |
NADH:ubiquinone oxidoreductase subunit B8 |
multiple interactions decreases expression |
EXP ISO |
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]] triptolide results in decreased expression of NDUFB8 mRNA; triptolide results in decreased expression of NDUFB8 protein |
CTD |
PMID:36436616 |
|
NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
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G |
Ndufb9 |
NADH:ubiquinone oxidoreductase subunit B9 |
increases expression |
EXP |
triptolide results in increased expression of NDUFB9 protein |
CTD |
PMID:32519852 |
|
NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
increases expression |
EXP |
triptolide results in increased expression of NDUFS4 protein |
CTD |
PMID:32519852 |
|
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Ndufs8 |
NADH:ubiquinone oxidoreductase core subunit S8 |
decreases expression |
ISO |
triptolide results in decreased expression of NDUFS8 mRNA |
CTD |
PMID:29723566 |
|
NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
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G |
Ndufv3 |
NADH:ubiquinone oxidoreductase subunit V3 |
increases expression |
EXP |
triptolide results in increased expression of NDUFV3 protein |
CTD |
PMID:32519852 |
|
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 Ensembl chr13:9,612,431...9,623,074
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G |
Necap1 |
NECAP endocytosis associated 1 |
decreases expression |
EXP |
triptolide results in decreased expression of NECAP1 protein |
CTD |
PMID:32519852 |
|
NCBI chr 4:156,103,935...156,119,068
Ensembl chr 4:156,103,988...156,119,068
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G |
Neto2 |
neuropilin and tolloid like 2 |
increases expression |
ISO |
triptolide results in increased expression of NETO2 mRNA |
CTD |
PMID:32835833 |
|
NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases response to substance affects localization decreases expression affects expression decreases phosphorylation increases expression |
EXP ISO |
Acetylcysteine inhibits the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [triptolide affects the expression of NFE2L2 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [triptolide results in increased ubiquitination of NFE2L2 protein]; Lithium Chloride affects the reaction [triptolide affects the expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of GCLC protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of BAX protein]; triptolide affects the expression of and results in increased ubiquitination of NFE2L2 protein NFE2L2 protein results in decreased susceptibility to triptolide triptolide affects the localization of NFE2L2 protein triptolide results in decreased expression of NFE2L2 protein triptolide affects the expression of NFE2L2 mRNA; triptolide affects the expression of NFE2L2 protein triptolide results in decreased phosphorylation of NFE2L2 protein [catalpol co-treated with Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [catalpol co-treated with triptolide] affects the localization of NFE2L2 protein; [Saponins co-treated with triptolide] affects the localization of NFE2L2 protein; [triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein; [triptolide co-treated with Saponins] results in increased expression of NFE2L2 protein; catalpol inhibits the reaction [Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]]; catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [catalpol promotes the reaction [Saponins inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in increased expression of GPT protein]]]; NFE2L2 protein affects the reaction [triptolide results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [triptolide results in increased expression of GPT protein]; NFE2L2 protein inhibits the reaction [triptolide affects the expression of CDKN1A protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]; NFE2L2 protein inhibits the reaction [triptolide results in increased expression of TP53 protein]; Saponins inhibits the reaction [triptolide results in decreased phosphorylation of NFE2L2 protein]; Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NFE2L2 protein]; Saponins promotes the reaction [catalpol inhibits the reaction [triptolide results in decreased expression of NFE2L2 mRNA]]; triptolide affects the reaction [NFE2L2 protein binds to TP53 protein]; triptolide results in decreased expression of and affects the localization of NFE2L2 protein Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 protein]; mitoquinone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NFE2L2 protein]; triptolide results in decreased expression of and affects the localization of NFE2L2 protein triptolide results in increased expression of NFE2L2 mRNA; triptolide results in increased expression of NFE2L2 protein |
CTD |
PMID:22820427 PMID:25169008 PMID:30682494 PMID:30836114 PMID:30926361 PMID:31241159 PMID:32835833 PMID:36990132 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases phosphorylation |
ISO EXP |
TRP53 protein affects the reaction [triptolide results in decreased phosphorylation of NFKBIA protein] |
CTD |
PMID:31618665 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbie |
NFKB inhibitor epsilon |
increases expression |
ISO |
triptolide results in increased expression of NFKBIE mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
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G |
Ngf |
nerve growth factor |
increases expression increases secretion |
EXP |
triptolide results in increased expression of NGF mRNA; triptolide results in increased expression of NGF protein triptolide results in increased secretion of NGF protein |
CTD |
PMID:17401680 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Ngfr |
nerve growth factor receptor |
increases expression |
ISO |
triptolide results in increased expression of TNFRSF10B mRNA; triptolide results in increased expression of TNFRSF10B protein |
CTD |
PMID:26990902 PMID:32835833 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Niban1 |
niban apoptosis regulator 1 |
increases expression |
EXP |
triptolide results in increased expression of FAM129A protein |
CTD |
PMID:32519852 |
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NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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G |
Nifk |
nucleolar protein interacting with the FHA domain of MKI67 |
increases expression |
ISO |
triptolide results in increased expression of NIFK mRNA |
CTD |
PMID:32835833 |
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NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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G |
Nipal1 |
NIPA-like domain containing 1 |
decreases expression |
ISO |
triptolide results in decreased expression of NIPAL1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr14:35,537,641...35,561,656
Ensembl chr14:35,540,324...35,561,659
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G |
Nle1 |
notchless homolog 1 |
increases expression |
ISO |
triptolide results in increased expression of NLE1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr10:67,834,059...67,844,771
Ensembl chr10:67,834,062...67,842,658
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions increases expression |
ISO |
[triptolide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein; [triptolide co-treated with TNF protein] results in increased expression of NLRP3 mRNA; [triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein; GW 4064 inhibits the reaction [[triptolide co-treated with TNF protein] results in increased expression of NLRP3 protein] triptolide results in increased expression of NLRP3 mRNA |
CTD |
PMID:36328986 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nnmt |
nicotinamide N-methyltransferase |
decreases expression |
ISO |
triptolide results in decreased expression of NNMT mRNA |
CTD |
PMID:32835833 |
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NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
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G |
Nnt |
nicotinamide nucleotide transhydrogenase |
increases expression |
EXP |
triptolide results in increased expression of NNT protein |
CTD |
PMID:32519852 |
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NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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G |
Noc2l |
NOC2-like nucleolar associated transcriptional repressor |
increases expression |
ISO |
triptolide results in increased expression of NOC2L mRNA |
CTD |
PMID:32835833 |
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NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949
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G |
Nol6 |
nucleolar protein 6 |
increases expression |
ISO |
triptolide results in increased expression of NOL6 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 5:56,259,919...56,270,540
Ensembl chr 5:56,260,830...56,270,336
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G |
Nolc1 |
nucleolar and coiled-body phosphoprotein 1 |
increases expression |
ISO |
triptolide results in increased expression of NOLC1 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088
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G |
Nop2 |
NOP2 nucleolar protein |
increases expression |
ISO |
triptolide results in increased expression of NOP2 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 4:157,932,731...157,944,462
Ensembl chr 4:157,932,716...157,944,459
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G |
Nop56 |
NOP56 ribonucleoprotein |
increases expression |
ISO |
triptolide results in increased expression of NOP56 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841
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G |
Nop58 |
NOP58 ribonucleoprotein |
increases expression |
ISO |
triptolide results in increased expression of NOP58 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
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G |
Nop9 |
NOP9 nucleolar protein |
increases expression |
ISO |
triptolide results in increased expression of NOP9 mRNA |
CTD |
PMID:32835833 |
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NCBI chr15:29,243,853...29,252,220
Ensembl chr15:29,243,862...29,252,220
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G |
Notch1 |
notch receptor 1 |
multiple interactions decreases expression increases expression |
ISO |
NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein] Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of BCL2 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of TXN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of CASP3 protein modified form]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein]; NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of TXNIP protein] triptolide results in decreased expression of NOTCH1 mRNA; triptolide results in decreased expression of NOTCH1 protein; triptolide results in decreased expression of NOTCH1 protein modified form |
CTD |
PMID:30394310 PMID:31241159 PMID:32835833 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Notch3 |
notch receptor 3 |
increases expression multiple interactions |
ISO |
triptolide results in increased expression of NOTCH3 mRNA; triptolide results in increased expression of NOTCH3 protein Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein] |
CTD |
PMID:31241159 |
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NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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G |
Nox4 |
NADPH oxidase 4 |
decreases expression |
ISO |
triptolide results in decreased expression of NOX4 mRNA |
CTD |
PMID:32835833 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO EXP |
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 protein] |
CTD |
PMID:18509322 |
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NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
multiple interactions |
ISO EXP |
triptolide inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS2 protein] |
CTD |
PMID:18509322 |
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NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
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G |
Npm2 |
nucleophosmin/nucleoplasmin 2 |
increases expression |
ISO |
triptolide results in increased expression of NPM2 mRNA |
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