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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimetrexate
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Accession:CHEBI:9737 term browser browse the term
Definition:A quinazoline that has formula C19H23N5O3.
Synonyms:related_synonym: 2,4-diamino-5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazolin-1-ium;   CI-898;   Formula=C19H23N5O3;   Formula=C19H24N5O3;   InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)/p+1;   InChIKey=NOYPYLRCIDNJJB-UHFFFAOYSA-O;   JB-11;   SMILES=CC1=C2C(=CC=C1CNC3=CC(OC)=C(C(=C3)OC)OC)N=C(N=C2N)N;   trimetrexate glucuronate;   trimetrexate hydrate
 alt_id: CHEBI:46138
 xref: CAS:52128-35-5;   Drug_Central:2757;   KEGG:C11154;   KEGG:D06238
 xref_mesh: MESH:D016597
 xref: PDBeChem:TMQ


show annotations for term's descendants           Sort by:
trimetrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS gene mutant form results in increased susceptibility to Trimetrexate CTD PMID:24688052 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases response to substance ISO SLC19A1 protein results in decreased susceptibility to Trimetrexate CTD PMID:12396629 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            antifungal drug 5948
              trimetrexate 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      p-block molecular entity 19817
                        carbon group molecular entity 19757
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      quinazolines 563
                                        trimetrexate 4
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