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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trazodone
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Accession:CHEBI:9654 term browser browse the term
Definition:An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Synonyms:exact_synonym: 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
 related_synonym: 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one;   Formula=C19H22ClN5O;   InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2;   InChIKey=PHLBKPHSAVXXEF-UHFFFAOYSA-N;   SMILES=Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1;   trazodona;   trazodonum
 xref: Beilstein:628010;   CAS:19794-93-5;   DrugBank:DB00656;   Drug_Central:2717;   KEGG:C07156;   KEGG:D08626;   LINCS:LSM-3580
 xref_mesh: MESH:D014196
 xref: Patent:US3381009;   Wikipedia:Trazodone


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trazodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Trazodone results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Cat catalase affects activity ISO Trazodone affects the activity of CAT protein CTD PMID:19798453 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Trazodone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone
Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol]		 CTD PMID:12584149 PMID:19501153 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ereg epiregulin increases expression ISO Trazodone results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
affects binding
increases expression		 EXP
ISO		 Trazodone results in decreased expression of HTR1A protein
Trazodone binds to HTR1A protein
Trazodone results in increased expression of HTR1A protein		 CTD PMID:1589591 PMID:7855217 PMID:12127910 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Trazodone binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Trazodone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Trazodone results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 increases expression ISO Trazodone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Trazodone results in decreased activity of KCNH2 protein CTD PMID:15740727 PMID:26187900 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases activity ISO Trazodone results in decreased activity of KCNQ1 protein CTD PMID:26187900 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Trazodone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Trazodone inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; Trazodone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17637181 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Trazodone results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 Trazodone inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Trazodone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Trazodone results in increased expression of PTGS2 mRNA		 CTD PMID:17637181 PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Trazodone results in decreased activity of SCN5A protein CTD PMID:26187900 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Trazodone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Trazodone results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Trazodone results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone CTD PMID:19501153 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Trazodone results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type increases expression EXP Trazodone results in increased expression of TNNT3 protein CTD PMID:29774748 NCBI chr 1:197,652,535...197,669,736
Ensembl chr 1:197,652,431...197,669,535 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        pharmacological role 19098
          neurotransmitter agent 16808
            adrenergic agent 9185
              adrenergic antagonist 2653
                trazodone 24
                  trazodone hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  azane 17886
                                    ammonia 17885
                                      organic amino compound 17885
                                        tertiary amino compound 10158
                                          N-alkylpiperazine 3412
                                            trazodone 24
                                              trazodone hydrochloride 0
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