Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trazodone
go back to main search page
Accession:CHEBI:9654 term browser browse the term
Definition:An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Synonyms:related_synonym: 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one;   2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one;   trazodona;   trazodonum
 xref: Beilstein:628010;   CAS:19794-93-5;   DrugBank:DB00656
 xref_mesh: MESH:D014196
 xref: Patent:US3381009;   drugcentral:2717;   kegg.compound:C07156;   kegg.drug:D08626;   lincs.smallmolecule:LSM-3580;   wikipedia.en:Trazodone
 chemrof_formula: C19H22ClN5O
 chemrof_inchi: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
 chemrof_smiles: O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12
 chemrof_inchikey: PHLBKPHSAVXXEF-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
trazodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Trazodone results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261 		JBrowse link
G Cat catalase affects activity ISO Trazodone affects the activity of CAT protein CTD PMID:19798453 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Trazodone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO 		[SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone
Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] 		CTD PMID:12584149 PMID:19501153 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Ereg epiregulin increases expression ISO Trazodone results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
affects binding
increases expression 		EXP
ISO 		Trazodone results in decreased expression of HTR1A protein
Trazodone binds to HTR1A protein
Trazodone results in increased expression of HTR1A protein 		CTD PMID:1589591 PMID:7855217 PMID:12127910 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Trazodone binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:115,452,842...115,682,324 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Trazodone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Trazodone results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il24 interleukin 24 increases expression ISO Trazodone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Trazodone results in decreased activity of KCNH2 protein CTD PMID:15740727 PMID:26187900 PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases activity ISO Trazodone results in decreased activity of KCNQ1 protein CTD PMID:26187900 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:207,721,131...208,054,072 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Trazodone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Trazodone inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; Trazodone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17637181 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Trazodone results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression 		EXP
ISO 		Trazodone inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Trazodone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Trazodone results in increased expression of PTGS2 mRNA 		CTD PMID:17637181 PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Trazodone results in decreased activity of SCN5A protein CTD PMID:26187900 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Trazodone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Trazodone results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Trazodone results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone CTD PMID:19501153 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Trazodone results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type increases expression EXP Trazodone results in increased expression of TNNT3 protein CTD PMID:29774748 NCBI chr 1:207,082,014...207,099,014
Ensembl chr 1:207,081,812...207,099,423 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        pharmacological role 19772
          neurotransmitter agent 16568
            adrenergic agent 8721
              adrenergic antagonist 2675
                trazodone 24
                  trazodone hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                carbocyclic compound 18739
                                  benzenoid aromatic compound 17899
                                    benzenes 17656
                                      chlorobenzenes 15281
                                        monochlorobenzenes 12256
                                          trazodone 24
                                            trazodone hydrochloride 0
paths to the root