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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trandolapril
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Accession:CHEBI:9649 term browser browse the term
Definition:A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.
Synonyms:exact_synonym: (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
 related_synonym: (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester;   Formula=C24H34N2O5;   InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1;   InChIKey=VXFJYXUZANRPDJ-WTNASJBWSA-N;   RU-44570;   RU44570;   SMILES=[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O;   gopten;   mavik;   odrik;   trandolaprilum
 xref: CAS:87679-37-6;   Chemspider:4588590;   DrugBank:DB00519;   Drug_Central:2712;   HMDB:HMDB0014660;   KEGG:D00383
 xref_mesh: MESH:C052035
 xref: PMID:1648489;   PMID:19337528;   PMID:22247843;   PMID:23784370;   PMID:24835355;   PMID:25802524;   PMID:25864194;   PMID:26915813;   PMID:27215243;   PMID:29319234;   PMID:32964020;   PMID:33660934;   PMID:3383998;   PMID:34172790;   PMID:8515499;   PMID:8515500;   PMID:8515501;   PMID:8515502;   PMID:8515504;   PMID:9770740;   Patent:KR20080046630;   Patent:WO2006014916;   Reaxys:8655766;   Wikipedia:Trandolapril


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trandolapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP trandolapril results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] CTD PMID:25445565 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP trandolapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression		 EXP
ISO		 trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]
trandolapril inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
trandolapril results in decreased expression of AGT protein modified form		 CTD PMID:1534315 PMID:27428043 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cat catalase multiple interactions EXP trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:25445565 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 EXP [trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA
trandolapril results in decreased expression of CYBA mRNA		 CTD PMID:17324946 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression		 EXP [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
trandolapril results in decreased expression of NCF1 mRNA; trandolapril results in decreased expression of NCF1 protein		 CTD PMID:17324946 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ren renin multiple interactions
increases expression		 ISO
EXP		 [Bumetanide co-treated with trandolapril] results in increased expression of REN protein
trandolapril results in increased expression of REN protein		 CTD PMID:16635047 PMID:27428043 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP trandolapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP trandolapril results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pro-agent 11567
          prodrug 11311
            trandolapril 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              peptide 11442
                                                oligopeptide 1350
                                                  dipeptide 414
                                                    trandolaprilat 13
                                                      trandolapril 13
paths to the root